LOCUS       NM_178212                574 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 19 (H2ac19), mRNA.
ACCESSION   NM_178212 NM_178217
VERSION     NM_178212.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Goffena,J., Lefcort,F., Zhang,Y., Lehrmann,E., Chaverra,M.,
            Felig,J., Walters,J., Buksch,R., Becker,K.G. and George,L.
  TITLE     Elongator and codon bias regulate protein levels in mammalian
            peripheral neurons
  JOURNAL   Nat Commun 9 (1), 889 (2018)
   PUBMED   29497044
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 574)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   3  (bases 1 to 574)
  AUTHORS   Moss,S.B., Ferry,R.A. and Groudine,M.
  TITLE     An alternative pathway of histone mRNA 3' end formation in mouse
            round spermatids
  JOURNAL   Nucleic Acids Res 22 (15), 3160-3166 (1994)
   PUBMED   8065931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Jun 29, 2022 this sequence version replaced NM_178212.3.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: CK626025.1, BI147818.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC125099.3         35732-36305
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.69 cM"
     gene            1..574
                     /gene="H2ac19"
                     /gene_synonym="H2a-614; H2a-615; Hist2h2aa2"
                     /note="H2A clustered histone 19"
                     /db_xref="GeneID:319192"
                     /db_xref="MGI:MGI:2448283"
     exon            1..574
                     /gene="H2ac19"
                     /gene_synonym="H2a-614; H2a-615; Hist2h2aa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..465
                     /gene="H2ac19"
                     /gene_synonym="H2a-614; H2a-615; Hist2h2aa2"
                     /note="histone cluster 2, H2aa2"
                     /codon_start=1
                     /product="histone H2A type 2-A"
                     /protein_id="NP_835584.1"
                     /db_xref="CCDS:CCDS57241.1"
                     /db_xref="GeneID:319192"
                     /db_xref="MGI:MGI:2448283"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      553..558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ac19"
                     /gene_synonym="H2a-614; H2a-615; Hist2h2aa2"
                     /note="hexamer: GATAAA"
     polyA_site      574
                     /gene="H2ac19"
                     /gene_synonym="H2a-614; H2a-615; Hist2h2aa2"
                     /note="major polyA site"
ORIGIN      
        1 ataaaagggt gaggcgtcgg cgccggagta ccgtttcctg gttgtggccg ttcgtctgtt
       61 tgcgctttcg tgatgtccgg tcgtggcaag caaggaggca aggcccgcgc caaggccaag
      121 tcgcggtctt cccgggccgg gctacagttc ccggtggggc gtgtgcaccg gctgctgcgc
      181 aagggcaact acgcggagcg tgtgggtgcc ggcgcgccgg tatacatggc ggcggtgctg
      241 gagtacctaa cggccgagat cctggagctg gcgggcaacg cggcccgcga caacaagaag
      301 acgcgcatca tcccgcgcca cctgcagctg gccatccgca acgacgagga gctcaacaag
      361 ctgctgggca aagtgacgat cgcgcagggc ggcgtcctgc ccaacatcca ggccgtgctg
      421 ctgcccaaga agacggagag ccaccataag gcgaagggca agtgaggcca ctgctcgcgt
      481 cggcccgcgt ctctgtgata taacccccgc gagctcctaa aaaggctctt ttcagagcca
      541 cccactgaat cagataaaga gttgtgtcac ggta
//
