LOCUS       NM_013549                587 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 18 (H2ac18), mRNA.
ACCESSION   NM_013549
VERSION     NM_013549.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 587)
  AUTHORS   Goffena,J., Lefcort,F., Zhang,Y., Lehrmann,E., Chaverra,M.,
            Felig,J., Walters,J., Buksch,R., Becker,K.G. and George,L.
  TITLE     Elongator and codon bias regulate protein levels in mammalian
            peripheral neurons
  JOURNAL   Nat Commun 9 (1), 889 (2018)
   PUBMED   29497044
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 587)
  AUTHORS   Panda,S., Nilsson,J.A. and Gekara,N.O.
  TITLE     Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation
            of TRAF3 and TRAF6 Complexes
  JOURNAL   Immunity 43 (4), 647-659 (2015)
   PUBMED   26474655
REFERENCE   3  (bases 1 to 587)
  AUTHORS   Deuve,J.L., Bonnet-Garnier,A., Beaujean,N., Avner,P. and Morey,C.
  TITLE     Antagonist Xist and Tsix co-transcription during mouse oogenesis
            and maternal Xist expression during pre-implantation development
            calls into question the nature of the maternal imprint on the X
            chromosome
  JOURNAL   Epigenetics 10 (10), 931-942 (2015)
   PUBMED   26267271
REFERENCE   4  (bases 1 to 587)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   5  (bases 1 to 587)
  AUTHORS   Iwai,T., Murai,J., Yoshikawa,H. and Tsumaki,N.
  TITLE     Smad7 Inhibits chondrocyte differentiation at multiple steps during
            endochondral bone formation and down-regulates p38 MAPK pathways
  JOURNAL   J Biol Chem 283 (40), 27154-27164 (2008)
   PUBMED   18644788
REFERENCE   6  (bases 1 to 587)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 587)
  AUTHORS   Hurt,M.M., Chodchoy,N. and Marzluff,W.F.
  TITLE     The mouse histone H2a.2 gene from chromosome 3
  JOURNAL   Nucleic Acids Res 17 (21), 8876 (1989)
   PUBMED   2587235
REFERENCE   8  (bases 1 to 587)
  AUTHORS   Moss,S.B., Challoner,P.B. and Groudine,M.
  TITLE     Expression of a novel histone 2B during mouse spermiogenesis
  JOURNAL   Dev Biol 133 (1), 83-92 (1989)
   PUBMED   2707490
REFERENCE   9  (bases 1 to 587)
  AUTHORS   Graves,R.A., Wellman,S.E., Chiu,I.M. and Marzluff,W.F.
  TITLE     Differential expression of two clusters of mouse histone genes
  JOURNAL   J Mol Biol 183 (2), 179-194 (1985)
   PUBMED   2989540
REFERENCE   10 (bases 1 to 587)
  AUTHORS   Bhatnagar,Y.M., Faulker,R.D. and McCullar,M.K.
  TITLE     Biochemical and immunological characterization of an H2A variant
            from the mouse testis
  JOURNAL   Biochim Biophys Acta 827 (1), 14-22 (1985)
   PUBMED   2578291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125099.3.
            
            On Jun 29, 2022 this sequence version replaced NM_013549.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: CA317259.1, CB196065.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               AC125099.3         29931-30517         c
FEATURES             Location/Qualifiers
     source          1..587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.69 cM"
     gene            1..587
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
                     /note="H2A clustered histone 18"
                     /db_xref="GeneID:15267"
                     /db_xref="MGI:MGI:96097"
     exon            1..587
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..437
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
                     /note="histone gene complex 2; histone cluster 2, H2aa1"
                     /codon_start=1
                     /product="histone H2A type 2-A"
                     /protein_id="NP_038577.1"
                     /db_xref="CCDS:CCDS57242.1"
                     /db_xref="GeneID:15267"
                     /db_xref="MGI:MGI:96097"
                     /translation="MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERV
                     GAGAPVYMAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     regulatory      525..530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
                     /note="hexamer: GATAAA"
     polyA_site      546
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
                     /note="major polyA site"
     polyA_site      583
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
                     /note="major polyA site"
     polyA_site      587
                     /gene="H2ac18"
                     /gene_synonym="H2a-614; H2a-615; Hist2; Hist2h2aa1"
ORIGIN      
        1 taccgtttcc tggttgtggc cgttcgtctg tttgcgcttt cgtgatgtcc ggtcgtggca
       61 agcaaggagg caaggcccgc gccaaggcca agtcgcggtc ttcccgggcc gggctacagt
      121 tcccggtggg gcgtgtgcac cggctgctgc gcaagggcaa ctacgcggag cgtgtgggtg
      181 ccggcgcgcc ggtatacatg gcggcggtgc tggagtacct aacggccgag atcctggagc
      241 tggcgggcaa cgcggcccgc gacaacaaga agacgcgcat catcccgcgc cacctgcagc
      301 tggccatccg caacgacgag gagctcaaca agctgctggg caaagtgacg atcgcgcagg
      361 gcggcgtcct gcccaacatc caggccgtgc tgctgcccaa gaagacggag agccaccata
      421 aggcgaaggg caagtgaggc cactgctcgc gtcggcccgc gtctctgtga tataaccccc
      481 gcgagctcct aaaaaggctc ttttcagagc cacccactga atcagataaa gagttgtgtc
      541 acggtagccg gtcttggtgg cctttcctgg ccctgcccca aaagtaa
//
