LOCUS       NM_178182                448 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H2A clustered histone 13 (H2ac13), mRNA.
ACCESSION   NM_178182
VERSION     NM_178182.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 448)
  AUTHORS   Ancelin,K., Lange,U.C., Hajkova,P., Schneider,R., Bannister,A.J.,
            Kouzarides,T. and Surani,M.A.
  TITLE     Blimp1 associates with Prmt5 and directs histone arginine
            methylation in mouse germ cells
  JOURNAL   Nat Cell Biol 8 (6), 623-630 (2006)
   PUBMED   16699504
REFERENCE   2  (bases 1 to 448)
  AUTHORS   Fang,J., Chen,T., Chadwick,B., Li,E. and Zhang,Y.
  TITLE     Ring1b-mediated H2A ubiquitination associates with inactive X
            chromosomes and is involved in initiation of X inactivation
  JOURNAL   J Biol Chem 279 (51), 52812-52815 (2004)
   PUBMED   15509584
REFERENCE   3  (bases 1 to 448)
  AUTHORS   de Napoles,M., Mermoud,J.E., Wakao,R., Tang,Y.A., Endoh,M.,
            Appanah,R., Nesterova,T.B., Silva,J., Otte,A.P., Vidal,M.,
            Koseki,H. and Brockdorff,N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
REFERENCE   4  (bases 1 to 448)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 448)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   6  (bases 1 to 448)
  AUTHORS   Gruber,A., Streit,A., Reist,M., Benninger,P., Bohni,R. and
            Schumperli,D.
  TITLE     Structure of a mouse histone-encoding gene cluster
  JOURNAL   Gene 95 (2), 303-304 (1990)
   PUBMED   2249786
REFERENCE   7  (bases 1 to 448)
  AUTHORS   Fecker,L., Ekblom,P., Kurkinen,M. and Ekblom,M.
  TITLE     A genomic clone encoding a novel proliferation-dependent histone
            H2A.1 mRNA enriched in the poly(A)+ fraction
  JOURNAL   Mol Cell Biol 10 (6), 2848-2854 (1990)
   PUBMED   1971418
REFERENCE   8  (bases 1 to 448)
  AUTHORS   Liu,T.J., Liu,L. and Marzluff,W.F.
  TITLE     Mouse histone H2A and H2B genes: four functional genes and a
            pseudogene undergoing gene conversion with a closely linked
            functional gene
  JOURNAL   Nucleic Acids Res 15 (7), 3023-3039 (1987)
   PUBMED   3562244
REFERENCE   9  (bases 1 to 448)
  AUTHORS   Pantazis,P. and Bonner,W.M.
  TITLE     Quantitative determination of histone modification. H2A acetylation
            and phosphorylation
  JOURNAL   J Biol Chem 256 (9), 4669-4675 (1981)
   PUBMED   7217105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589651.8.
            
            On Mar 1, 2014 this sequence version replaced NM_178182.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Two molecules of each of the four core histones (H2A,
            H2B, H3, and H4) form an octamer, around which approximately 146 bp
            of DNA is wrapped in repeating units, called nucleosomes. The
            linker histone, H1, interacts with linker DNA between nucleosomes
            and functions in the compaction of chromatin into higher order
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene lack polyA tails but instead
            contain a palindromic termination element. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC099406.1, AV503808.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               AL589651.8         137402-137849
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 7.93 cM"
     gene            1..448
                     /gene="H2ac13"
                     /gene_synonym="H2a-291A; Hist1h2ai"
                     /note="H2A clustered histone 13"
                     /db_xref="GeneID:319191"
                     /db_xref="MGI:MGI:2448457"
     exon            1..448
                     /gene="H2ac13"
                     /gene_synonym="H2a-291A; Hist1h2ai"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..403
                     /gene="H2ac13"
                     /gene_synonym="H2a-291A; Hist1h2ai"
                     /note="histone 1, H2ai; histone H2A type 1; histone 2,
                     H2ai; histone cluster 1, H2ai"
                     /codon_start=1
                     /product="histone H2A type 1-I"
                     /protein_id="NP_835489.1"
                     /db_xref="CCDS:CCDS26288.1"
                     /db_xref="GeneID:319191"
                     /db_xref="MGI:MGI:2448457"
                     /translation="MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERV
                     GAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHHKAKGK"
     polyA_site      448
                     /gene="H2ac13"
                     /gene_synonym="H2a-291A; Hist1h2ai"
                     /note="major polyA site"
ORIGIN      
        1 cagctgagtt atgtctggac gcggcaagca gggcggcaag gctcgcgcca aggccaagac
       61 tcgctcctcc cgggccggcc tgcagttccc cgtgggccgc gtgcaccggc tgctccgcaa
      121 gggcaactac tcggagcgcg tgggcgccgg cgccccggtg tacctggcgg ccgtgctgga
      181 gtacctgacg gccgagatcc tggagctggc gggcaacgcg gcccgcgaca acaagaagac
      241 gcgcatcatc ccgcgccacc tgcagctggc catccgcaac gacgaggagc tcaacaagct
      301 gctgggccgc gtgaccatcg cgcagggcgg cgtcctgccc aacatccagg ccgtgctgct
      361 gcccaagaag accgagagcc accacaaggc caaggggaag tgaaaccaaa cattacgaat
      421 caccaaaggc tcttttcaga gccactca
//
