LOCUS       NM_175658                477 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Mus musculus H2A clustered histone 1 (H2ac1), mRNA.
ACCESSION   NM_175658
VERSION     NM_175658.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 477)
  AUTHORS   Padavattan,S., Shinagawa,T., Hasegawa,K., Kumasaka,T., Ishii,S. and
            Kumarevel,T.
  TITLE     Structural and functional analyses of nucleosome complexes with
            mouse histone variants TH2a and TH2b, involved in reprogramming
  JOURNAL   Biochem Biophys Res Commun 464 (3), 929-935 (2015)
   PUBMED   26188507
  REMARK    GeneRIF: Crystal structure and functional analyses of nucleosome
            complexes with mouse histone variants TH2a and TH2b, involved in
            reprogramming.
REFERENCE   2  (bases 1 to 477)
  AUTHORS   Shinagawa,T., Huynh,L.M., Takagi,T., Tsukamoto,D., Tomaru,C.,
            Kwak,H.G., Dohmae,N., Noguchi,J. and Ishii,S.
  TITLE     Disruption of Th2a and Th2b genes causes defects in spermatogenesis
  JOURNAL   Development 142 (7), 1287-1292 (2015)
   PUBMED   25742800
  REMARK    GeneRIF: These results suggest that a loss of TH2A and TH2B
            function in chromatin dynamics or a decrease in the total histone
            levels causes defects in both cohesin release and histone
            replacement during spermatogenesis.
REFERENCE   3  (bases 1 to 477)
  AUTHORS   Shinagawa,T., Takagi,T., Tsukamoto,D., Tomaru,C., Huynh,L.M.,
            Sivaraman,P., Kumarevel,T., Inoue,K., Nakato,R., Katou,Y., Sado,T.,
            Takahashi,S., Ogura,A., Shirahige,K. and Ishii,S.
  TITLE     Histone variants enriched in oocytes enhance reprogramming to
            induced pluripotent stem cells
  JOURNAL   Cell Stem Cell 14 (2), 217-227 (2014)
   PUBMED   24506885
REFERENCE   4  (bases 1 to 477)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   5  (bases 1 to 477)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606464.11.
            
            On Jun 19, 2019 this sequence version replaced NM_175658.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-dependent histone that is a member of the histone H2A
            family. Transcripts from this gene contain a palindromic
            termination element. [provided by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC107355.1, SRR5189685.94498.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               AL606464.11        53362-53838
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.0 cM"
     gene            1..477
                     /gene="H2ac1"
                     /gene_synonym="Hist1h2aa; Th2a"
                     /note="H2A clustered histone 1"
                     /db_xref="GeneID:319163"
                     /db_xref="MGI:MGI:2448285"
     exon            1..477
                     /gene="H2ac1"
                     /gene_synonym="Hist1h2aa; Th2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..415
                     /gene="H2ac1"
                     /gene_synonym="Hist1h2aa; Th2a"
                     /note="histone 1, H2aa"
                     /codon_start=1
                     /product="histone cluster 1, H2aa"
                     /protein_id="NP_783589.1"
                     /db_xref="CCDS:CCDS26374.1"
                     /db_xref="GeneID:319163"
                     /db_xref="MGI:MGI:2448285"
                     /translation="MSGPTKRGGKARAKVKSRSSRAGLQFPVGRVHRLLRQGNYAQRI
                     GAGAPVYLAAVLEYLTAEVLELAGNAARDNKKTRITPRHLQLAIRNDEELNKLLGRVT
                     IAQGGVLPNIQAVLLPKKTESHKSQTK"
ORIGIN      
        1 accgctttaa gacttttgaa gaatcatgtc tggtcctaca aagcggggtg gcaaggctcg
       61 tgccaaggtc aagtctcgct cttccagggc aggtttgcag tttcctgtgg gtcgtgtgca
      121 ccggcttctc cgccaaggga actacgcaca acgaattggg gctggtgcac cagtgtatct
      181 ggcggcagtg ctagaatact tgacagctga ggtcctggag ctggcgggca acgcagcccg
      241 ggacaacaag aagacgcgca ttactcctcg ccacctgcag ctggccatcc gcaacgacga
      301 ggagctcaac aagttgcttg gccgcgtgac catcgcgcag ggtggcgtcc tgcccaacat
      361 ccaggccgtg ctgctgccca agaagaccga gagccacaag tcccagacca agtgactcct
      421 gcacaagaca gcaaccatca gtttaaaaca aaaaggctct tttcagagcc accttca
//
