LOCUS       NM_001281531             645 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus H2A.B variant histone 3 (H2ab3), mRNA.
ACCESSION   NM_001281531 XM_889501 XM_911022
VERSION     NM_001281531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 645)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 645)
  AUTHORS   Molaro,A., Wood,A.J., Janssens,D., Kindelay,S.M., Eickbush,M.T.,
            Wu,S., Singh,P., Muller,C.H., Henikoff,S. and Malik,H.S.
  TITLE     Biparental contributions of the H2A.B histone variant control
            embryonic development in mice
  JOURNAL   PLoS Biol 18 (12), e3001001 (2020)
   PUBMED   33362208
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 645)
  AUTHORS   Anuar,N.D., Kurscheid,S., Field,M., Zhang,L., Rebar,E., Gregory,P.,
            Buchou,T., Bowles,J., Koopman,P., Tremethick,D.J. and Soboleva,T.A.
  TITLE     Gene editing of the multi-copy H2A.B gene and its importance for
            fertility
  JOURNAL   Genome Biol 20 (1), 23 (2019)
   PUBMED   30704500
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 645)
  AUTHORS   Shaytan,A.K., Landsman,D. and Panchenko,A.R.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   5  (bases 1 to 645)
  AUTHORS   Ishibashi,T., Li,A., Eirin-Lopez,J.M., Zhao,M., Missiaen,K.,
            Abbott,D.W., Meistrich,M., Hendzel,M.J. and Ausio,J.
  TITLE     H2A.Bbd: an X-chromosome-encoded histone involved in mammalian
            spermiogenesis
  JOURNAL   Nucleic Acids Res 38 (6), 1780-1789 (2010)
   PUBMED   20008104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX005163.13.
            
            On Nov 7, 2015 this sequence version replaced NM_001281531.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: There are no publicly available full-length transcripts
            representing this CCDS in mouse. The CDS structure is based on the
            alignment of paralogous histone H2afb transcripts (BC061062.1).
            
            ##Evidence-Data-START##
            Transcript is intronless :: CA465357.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               BX005163.13        165836-166480       c
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 49.58 cM"
     gene            1..645
                     /gene="H2ab3"
                     /gene_synonym="EG624957; H2A.Bbd3; H2afb3; H2afb3-ps"
                     /note="H2A.B variant histone 3"
                     /db_xref="GeneID:624957"
                     /db_xref="MGI:MGI:3644875"
     exon            1..645
                     /gene="H2ab3"
                     /gene_synonym="EG624957; H2A.Bbd3; H2afb3; H2afb3-ps"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..479
                     /gene="H2ab3"
                     /gene_synonym="EG624957; H2A.Bbd3; H2afb3; H2afb3-ps"
                     /note="H2A histone family, member B3, pseudogene"
                     /codon_start=1
                     /product="H2A histone family, member B3"
                     /protein_id="NP_001268460.1"
                     /db_xref="CCDS:CCDS59774.1"
                     /db_xref="GeneID:624957"
                     /db_xref="MGI:MGI:3644875"
                     /translation="MPRNRENCLRESSGRRHRRSRTSRAELIFAVSLVEQHLREVSRA
                     RRLSDTVPIFLAAILESLTRRLLELAGNEAQRRGTERRITPELLDLAVYSNMELSDVF
                     QFITISQVAPAHR"
     regulatory      620..625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2ab3"
                     /gene_synonym="EG624957; H2A.Bbd3; H2afb3; H2afb3-ps"
                     /note="hexamer: AATAAA"
     polyA_site      645
                     /gene="H2ab3"
                     /gene_synonym="EG624957; H2A.Bbd3; H2afb3; H2afb3-ps"
                     /note="major polyA site"
ORIGIN      
        1 gggagacatt gggcgttgga cttggacttg aggcccacag cccagcagca ggtcagcaga
       61 gagcaatcag gtcagcagaa agcagccaag tggagccaag tcatcctgtg acatcgcact
      121 ctgaggccac catgccaagg aacagggaaa actgtcttcg agagtcttca ggtcgccgcc
      181 accgtcgctc ccgcacctcc agagctgagc taatctttgc tgtgagcctg gtggaacagc
      241 atctgaggga ggttagccgt gcccggaggc tcagtgatac ggtgcccatc ttcctggcag
      301 ccatcctgga gtccctcacc cgcaggttgc tggagcttgc cggcaatgag gcccaacgca
      361 gaggtaccga gaggcgcatc actcctgaac tgctggactt ggctgtctac agcaatatgg
      421 agctaagtga tgtgttccaa ttcatcacca tctcccaggt ggccccggct catcgctagc
      481 tactagcttc tgctgcttct tggctgacct gctcatctgc tagtctgtta taaatcagtt
      541 agtcctgccc agcctttccc acagacagcc ctgaatggct gatcagcttc attctaaccc
      601 tctcccaatt gtgttatcaa ataaagcttt attttggaaa aagaa
//
