LOCUS       NM_001281530             348 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus H2A.B variant histone 2 (H2ab2), mRNA.
ACCESSION   NM_001281530 XM_888672 XM_910275
VERSION     NM_001281530.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 348)
  AUTHORS   Molaro A, Wood AJ, Janssens D, Kindelay SM, Eickbush MT, Wu S,
            Singh P, Muller CH, Henikoff S and Malik HS.
  TITLE     Biparental contributions of the H2A.B histone variant control
            embryonic development in mice
  JOURNAL   PLoS Biol 18 (12), e3001001 (2020)
   PUBMED   33362208
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 348)
  AUTHORS   Anuar ND, Kurscheid S, Field M, Zhang L, Rebar E, Gregory P, Buchou
            T, Bowles J, Koopman P, Tremethick DJ and Soboleva TA.
  TITLE     Gene editing of the multi-copy H2A.B gene and its importance for
            fertility
  JOURNAL   Genome Biol 20 (1), 23 (2019)
   PUBMED   30704500
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 348)
  AUTHORS   Shaytan AK, Landsman D and Panchenko AR.
  TITLE     Nucleosome adaptability conferred by sequence and structural
            variations in histone H2A-H2B dimers
  JOURNAL   Curr Opin Struct Biol 32, 48-57 (2015)
   PUBMED   25731851
  REMARK    Review article
REFERENCE   4  (bases 1 to 348)
  AUTHORS   Ishibashi T, Li A, Eirin-Lopez JM, Zhao M, Missiaen K, Abbott DW,
            Meistrich M, Hendzel MJ and Ausio J.
  TITLE     H2A.Bbd: an X-chromosome-encoded histone involved in mammalian
            spermiogenesis
  JOURNAL   Nucleic Acids Res 38 (6), 1780-1789 (2010)
   PUBMED   20008104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX005233.10.
            
            On or before Dec 1, 2013 this sequence version replaced
            XM_910275.1, XM_888672.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H2A family. [provided by RefSeq,
            Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: There are no publicly available full-length transcripts
            representing this CCDS in mouse. The CDS structure is based on the
            alignment of paralogous histone H2afb transcripts (BC061062.1).
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25731851
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               BX005233.10        178668-179015
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 49.55 cM"
     gene            1..348
                     /gene="H2ab2"
                     /gene_synonym="EG624153; H2A.Bbd4; H2afb2; H2afb2-ps"
                     /note="H2A.B variant histone 2"
                     /db_xref="GeneID:624153"
                     /db_xref="MGI:MGI:3644980"
     CDS             1..348
                     /gene="H2ab2"
                     /gene_synonym="EG624153; H2A.Bbd4; H2afb2; H2afb2-ps"
                     /note="H2A histone family, member B2, pseudogene"
                     /codon_start=1
                     /product="histone H2A"
                     /protein_id="NP_001268459.1"
                     /db_xref="CCDS:CCDS59772.1"
                     /db_xref="GeneID:624153"
                     /db_xref="MGI:MGI:3644980"
                     /translation="MPRNTENCLQRSSGHRQHHSRTSRGELIFAVSLVEQHLREVSRA
                     RRLSDMVPVSLVAILEFLTSRLLELAGNEAQRRGTQRLITPQPLDLEVYSSMELSDVF
                     QFITISQVAPAHR"
     exon            1..348
                     /gene="H2ab2"
                     /gene_synonym="EG624153; H2A.Bbd4; H2afb2; H2afb2-ps"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccaagga acacggagaa ctgtcttcaa aggtcttcag gtcaccgcca acatcactcc
       61 cgcacctcca gaggtgagct gatctttgca gtgagcctgg tggaacagca tctgagggag
      121 gttagccgtg cccggaggct cagtgatatg gtgcccgtct ccctggtagc catcctggag
      181 ttcctcacca gcaggttgct ggagcttgcg ggcaatgagg cccaacgcag aggtacccag
      241 aggctcatca ctcctcaacc gctggacttg gaggtctaca gcagtatgga gctaagtgat
      301 gtgttccaat tcatcaccat ctcccaggtg gccccggctc atcgctag
//
