LOCUS       NM_008208               2178 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus histocompatibility 2, T region locus 3 (H2-T3), mRNA.
ACCESSION   NM_008208
VERSION     NM_008208.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Schilit,S.L.P., Ohtsuka,M., Quadros,R.M. and Gurumurthy,C.B.
  TITLE     Pronuclear Injection-Based Targeted Transgenesis
  JOURNAL   Curr Protoc Hum Genet 91, 15.10.1-15.10.28 (2016)
   PUBMED   27727435
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Van Kaer,L., Algood,H.M.S., Singh,K., Parekh,V.V., Greer,M.J.,
            Piazuelo,M.B., Weitkamp,J.H., Matta,P., Chaturvedi,R., Wilson,K.T.
            and Olivares-Villagomez,D.
  TITLE     CD8alphaalpha innate-type lymphocytes in the intestinal epithelium
            mediate mucosal immunity
  JOURNAL   Immunity 41 (3), 451-464 (2014)
   PUBMED   25220211
  REMARK    Erratum:[Immunity. 2014 Dec 18;41(6):1064]
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Martinez-Naves,E., Lafuente,E.M. and Reche,P.A.
  TITLE     Recognition of the ligand-type specificity of classical and
            non-classical MHC I proteins
  JOURNAL   FEBS Lett 585 (21), 3478-3484 (2011)
   PUBMED   22001201
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Olivares-Villagomez,D., Algood,H.M., Singh,K., Parekh,V.V.,
            Ryan,K.E., Piazuelo,M.B., Wilson,K.T. and Van Kaer,L.
  TITLE     Intestinal epithelial cells modulate CD4 T cell responses via the
            thymus leukemia antigen
  JOURNAL   J Immunol 187 (8), 4051-4060 (2011)
   PUBMED   21900182
  REMARK    GeneRIF: our results provide evidence for an important interaction
            between intestinal epithelial cells and CD4(+) T cells via the
            thymus leukemia antigen, which modulates mucosal immune responses.
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Ohtsuka,M., Ogiwara,S., Miura,H., Mizutani,A., Warita,T., Sato,M.,
            Imai,K., Hozumi,K., Sato,T., Tanaka,M., Kimura,M. and Inoko,H.
  TITLE     Pronuclear injection-based mouse targeted transgenesis for
            reproducible and highly efficient transgene expression
  JOURNAL   Nucleic Acids Res 38 (22), e198 (2010)
   PUBMED   20880997
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Mashimo,H., Chorney,M.J., Pontarotti,P., Fisher,D.A., Hood,L. and
            Nathenson,S.G.
  TITLE     Nucleotide sequence of the BALB/c H-2T region gene, T3d
  JOURNAL   Immunogenetics 36 (5), 326-332 (1992)
   PUBMED   1339405
REFERENCE   7  (bases 1 to 2178)
  AUTHORS   Scholer,H.R., Dressler,G.R., Balling,R., Rohdewohld,H. and Gruss,P.
  TITLE     Oct-4: a germline-specific transcription factor mapping to the
            mouse t-complex
  JOURNAL   EMBO J 9 (7), 2185-2195 (1990)
   PUBMED   2357966
REFERENCE   8  (bases 1 to 2178)
  AUTHORS   Sertic,J., Vincek,V., Ledley,F.D., Figueroa,F. and Klein,J.
  TITLE     Mapping of the L-methylmalonyl-CoA mutase gene to mouse chromosome
            17
  JOURNAL   Genomics 6 (3), 560-564 (1990)
   PUBMED   1970332
REFERENCE   9  (bases 1 to 2178)
  AUTHORS   Obata,Y., Chen,Y.T., Stockert,E. and Old,L.J.
  TITLE     Structural analysis of TL genes of the mouse
  JOURNAL   Proc Natl Acad Sci U S A 82 (16), 5475-5479 (1985)
   PUBMED   2410925
REFERENCE   10 (bases 1 to 2178)
  AUTHORS   Flaherty,L., Sullivan,K. and Zimmerman,D.
  TITLE     The Tla locus: a new allele and antigenic specificity
  JOURNAL   J Immunol 119 (2), 571-575 (1977)
   PUBMED   69663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033602.1, BC125378.1 and CT030728.6.
            
            On Jun 30, 2009 this sequence version replaced NM_008208.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033602.1, BC125378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AK033602.1         2-338
            338-1628            BC125378.1         336-1626
            1629-1665           AK033602.1         1630-1666
            1666-2178           CT030728.6         68624-69136
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.99 cM"
     gene            1..2178
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /note="histocompatibility 2, T region locus 3"
                     /db_xref="GeneID:15043"
                     /db_xref="MGI:MGI:95959"
     exon            1..102
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1178
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /note="H-2 class I histocompatibility antigen, TLA(B)
                     alpha chain; TL antigen; MHC-TLA-T13a; MHC c5/g1L protein;
                     thymus leukemia antigen; MHC thymus leukemia antigen; MHC
                     class I antigen"
                     /codon_start=1
                     /product="H-2 class I histocompatibility antigen, TLA(B)
                     alpha chain precursor"
                     /protein_id="NP_032234.3"
                     /db_xref="CCDS:CCDS28718.1"
                     /db_xref="GeneID:15043"
                     /db_xref="MGI:MGI:95959"
                     /translation="MRMGTMVPGTLLILLAASQGQTQTCPGSHSLRYFYTALSRPAIS
                     EPWYIAVGYLDDTQFVRFNSSGETATYKLSAPWVEQEGPEYWARETEIVTSNAQFFRE
                     NLQTMLDYYNLSQNGSHTIQVMYGCEVEFFGSLFRAYEQHGYDGRDYIALNEDLKTWT
                     AADTAAEITRSKWEQAGYTELRRTYLEGPCKDSLLRYLENRKKTQECTDPPKTHVTHH
                     PRPEGYVTLRCWALRFYPADITLTWQLNGEELIQDTELVETRPAGDGTFQKWAAVVVP
                     LGKEQKYTCHVYHEGLPEPLTLRWEPPQTSMPNRTTVRALLGAMIILGFMSGSVMMWM
                     RKNNGGNGDDNTAAYQNEREHLSLSPRAESEALGVEAGMKDLPSAPPLVS"
     exon            103..372
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /inference="alignment:Splign:2.1.0"
     exon            373..648
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /inference="alignment:Splign:2.1.0"
     exon            649..924
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1038
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..2178
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2054..2059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /note="hexamer: AATGAA"
     polyA_site      2070
                     /gene="H2-T3"
                     /gene_synonym="H-2T3; H2-Tw3; MumuTL; TL"
                     /note="major polyA site"
ORIGIN      
        1 atacaacttc agatttccct aacatgagga tggggaccat ggtgcctggc accctcctga
       61 tcctcctggc tgcctcacaa ggccagaccc agacctgccc aggctcacac tcgctgaggt
      121 acttctacac cgccttgtcc cgacctgcaa tcagcgaacc gtggtacata gctgtgggct
      181 acctggatga cactcagttc gtgcgcttca acagctcagg ggagactgcg acatataagc
      241 taagtgcgcc atgggtggag caagaggggc ccgagtattg ggcgagagag acagagatcg
      301 tcacaagcaa tgcacagttt ttccgcgaga atctgcagac tatgctggac tactacaacc
      361 tgagtcaaaa tggctctcac accatccagg tgatgtatgg ctgtgaggtg gagttcttcg
      421 ggagcctctt ccgcgcttat gagcagcatg gctatgatgg ccgcgattac attgccctca
      481 atgaagatct gaaaacgtgg acagcagcag acacggcagc agagatcacc agaagcaagt
      541 gggagcaggc tggttataca gagctccgta ggacctactt ggagggccca tgcaaggatt
      601 ccctgctcag atacctggag aacagaaaaa agacacagga gtgcacagat cctccaaaaa
      661 cacacgtgac ccatcacccc agacctgaag gttatgtcac cctgagatgc tgggccctgc
      721 gcttctaccc tgctgacatc accctgacct ggcagttgaa tggggaggaa ttgattcagg
      781 acacggagct tgtggagacc aggcctgcag gggatggaac cttccagaag tgggcagctg
      841 tggtggtgcc gcttgggaag gagcagaaat acacatgtca tgtgtaccat gaggggctgc
      901 ctgagcctct caccctgaga tgggagcctc ctcagaccag tatgcccaac aggaccactg
      961 ttcgtgctct ccttggagct atgatcatct taggttttat gagcggaagt gttatgatgt
     1021 ggatgagaaa gaacaatggt ggaaacggag acgataacac tgctgcatat cagaatgaga
     1081 gggaacactt gtccctgagc cctcgggctg aatctgaggc actcggggtg gaagctggga
     1141 tgaaggatct tccttctgcc ccaccattgg tctcctgaca atgtcttgtt acttcttcta
     1201 ctgcaggcaa ggacagcttc tctcttgtct ctggatactt gaaaaggtga cacctgggag
     1261 cctgggattg gggctgaggc aaactggaaa ggactgggtc actgggcctt tcctatttaa
     1321 acctttgaac gagaggaagg cctttgagat gttttcacat tgactgccct gactcttgtt
     1381 cttcatcttg ggacagctgc cacatgggac tgagtcacta gttctgactt ctgaacagtg
     1441 gaatcacttt gggcagccgt gcctgccgtt ttatgctttt gactatgcat acaatgggaa
     1501 aatctggaga gcacagcctg cccctgcaca ccaagactca gaccctacat tagctgtcat
     1561 cccttgcaca gccaaccttc ctggtcctca ggcattgggg gacatcttca tcctgtcagc
     1621 tccacgctgt cctgggcgtg tgtctcctca cacggcacag tgtgtctact catttccaca
     1681 ctgaacatga gaatcagaat gtggatgtca ggcagtggtg ggcaggccat taatcctagc
     1741 acttgggagg cagaggcagg cagatttctg agttcgaggg cagcctggtt tacagagtga
     1801 gttccaggac agacagggct acacggagaa actctatctt ggggggaaaa aaaagacaga
     1861 aagaaaaaaa aaagaatctg aatgtggagg ctggagagaa gtctcagtgg ttaagagcac
     1921 tgagttcttt tcctgaggcc ctgaattcaa tccccagcaa ccacatggtg gctcacaacc
     1981 atatgtaata gcatgcaatg ccttcttctg gtgtgttgga agtcacctac agtgtactca
     2041 cctacatgaa ataaatgaat cttaagaaaa gtatgagtgt gaactccttg acctgagcag
     2101 ttcacttgtg ggtaaattaa aggattgaga atatctgagt attgtggagg aaataaatgg
     2161 cagcatggag gaccttcc
//
