LOCUS       NM_010398               1317 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus histocompatibility 2, T region locus 23 (H2-T23),
            mRNA.
ACCESSION   NM_010398 XM_006543387 XM_619461
VERSION     NM_010398.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1317)
  AUTHORS   Kim,H.J., Nakagawa,H., Choi,J.Y., Che,X., Divris,A., Liu,Q.,
            Wight,A.E., Zhang,H., Saad,A., Solhjou,Z., Deban,C., Azzi,J.R. and
            Cantor,H.
  TITLE     A narrow T cell receptor repertoire instructs thymic
            differentiation of MHC class Ib-restricted CD8+ regulatory T cells
  JOURNAL   J Clin Invest 134 (1), e170512 (2024)
   PUBMED   37934601
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1317)
  AUTHORS   Middelburg,J., Ghaffari,S., Schoufour,T.A.W., Sluijter,M.,
            Schaap,G., Goynuk,B., Sala,B.M., Al-Tamimi,L., Scheeren,F.,
            Franken,K.L.M.C., Akkermans,J.J.L.L., Cabukusta,B., Joosten,S.A.,
            Derksen,I., Neefjes,J., van der Burg,S.H., Achour,A.,
            Wijdeven,R.H.M., Weidanz,J. and van Hall,T.
  TITLE     The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by
            inflammatory signals, whereas LILRB1/2 receptors are peptide
            indifferent
  JOURNAL   Cell Rep 42 (12), 113516 (2023)
   PUBMED   38048225
REFERENCE   3  (bases 1 to 1317)
  AUTHORS   Manoharan Valerio,M., Arana,K., Guan,J., Chan,S.W., Yang,X.,
            Kurd,N., Lee,A., Shastri,N., Coscoy,L. and Robey,E.A.
  TITLE     The promiscuous development of an unconventional Qa1b-restricted T
            cell population
  JOURNAL   Front Immunol 14, 1250316 (2023)
   PUBMED   38022509
  REMARK    GeneRIF: The promiscuous development of an unconventional
            Qa1b-restricted T cell population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1317)
  AUTHORS   Won,H.Y., Liman,N., Park,J.Y. and Park,J.H.
  TITLE     Cytokine receptor gammac effectuates the generation of
            proinflammatory innate CD8 T cells by non-classical MHC-I molecules
  JOURNAL   J Autoimmun 138, 103059 (2023)
   PUBMED   37216869
REFERENCE   5  (bases 1 to 1317)
  AUTHORS   Marin,I.A., Gutman-Wei,A.Y., Chew,K.S., Raissi,A.J., Djurisic,M.
            and Shatz,C.J.
  TITLE     The nonclassical MHC class I Qa-1 expressed in layer 6 neurons
            regulates activity-dependent plasticity via microglial CD94/NKG2 in
            the cortex
  JOURNAL   Proc Natl Acad Sci U S A 119 (23), e2203965119 (2022)
   PUBMED   35648829
  REMARK    GeneRIF: The nonclassical MHC class I Qa-1 expressed in layer 6
            neurons regulates activity-dependent plasticity via microglial
            CD94/NKG2 in the cortex.
REFERENCE   6  (bases 1 to 1317)
  AUTHORS   Attaya,M., Jameson,S., Martinez,C.K., Hermel,E., Aldrich,C.,
            Forman,J., Lindahl,K.F., Bevan,M.J. and Monaco,J.J.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
REFERENCE   7  (bases 1 to 1317)
  AUTHORS   Ito,K., Van Kaer,L., Bonneville,M., Hsu,S., Murphy,D.B. and
            Tonegawa,S.
  TITLE     Recognition of the product of a novel MHC TL region gene (27b) by a
            mouse gamma delta T cell receptor
  JOURNAL   Cell 62 (3), 549-561 (1990)
   PUBMED   2379238
REFERENCE   8  (bases 1 to 1317)
  AUTHORS   Nakayama,K., Tokito,S., Jaulin,C., Delarbre,C., Kourilsky,P.,
            Nakauchi,H. and Gachelin,G.
  TITLE     Comparative structure of two duplicated T1a class I genes (T10c and
            37) of the murine H-2d MHC. Implications on the evolution of the
            T1a region
  JOURNAL   J Immunol 144 (6), 2400-2408 (1990)
   PUBMED   1968929
REFERENCE   9  (bases 1 to 1317)
  AUTHORS   Aldrich,C.J., Jenkins,R.N. and Rich,R.R.
  TITLE     Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire:
            definition of the Qa-1d and Qa-1c alloantigens and cross-reactivity
            with H-2
  JOURNAL   J Immunol 136 (2), 383-388 (1986)
   PUBMED   2416805
REFERENCE   10 (bases 1 to 1317)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC112970.18.
            
            On or before Jan 5, 2014 this sequence version replaced
            XM_006543387.1, NM_010398.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11284.1, AK133502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC112970.18        17249-17341
            94-363              AC112970.18        17528-17797
            364-639             AC112970.18        18037-18312
            640-915             AC112970.18        18853-19128
            916-1032            AC112970.18        19256-19372
            1033-1062           AC112970.18        19550-19579
            1063-1317           AC112970.18        19719-19973
FEATURES             Location/Qualifiers
     source          1..1317
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.86 cM"
     gene            1..1317
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /note="histocompatibility 2, T region locus 23"
                     /db_xref="GeneID:15040"
                     /db_xref="MGI:MGI:95957"
     exon            1..93
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1106
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /note="H-2 class I histocompatibility antigen, D-37 alpha
                     chain; MHC class I antigen Qa1; MHC classIb Qa1; MHC class
                     II antigen K"
                     /codon_start=1
                     /product="H-2 class I histocompatibility antigen, D-37
                     alpha chain precursor"
                     /protein_id="NP_034528.1"
                     /db_xref="CCDS:CCDS28715.1"
                     /db_xref="GeneID:15040"
                     /db_xref="MGI:MGI:95957"
                     /translation="MLLFAHLLQLLVSATVPTQSSPHSLRYFTTAVSRPGLGEPRFII
                     VGYVDDTQFVRFDSDAENPRMEPRARWIEQEGPEYWERETWKARDMGRNFRVNLRTLL
                     GYYNQSNDESHTLQWMYGCDVGPDGRLLRGYCQEAYDGQDYISLNEDLRSWTANDIAS
                     QISKHKSEAVDEAHQQRAYLQGPCVEWLHRYLRLGNETLQRSDPPKAHVTHHPRSEDE
                     VTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQY
                     YTCHVYHEGLPEPLTLRWEPPPSTVSNMVIIAVLVVLGAVIILGAVVAFVMKRRRHIG
                     VKGCYAHVLGSKSFQTSDWPQKA"
     exon            94..363
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
     exon            364..639
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
     exon            640..915
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1032
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1062
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1317
                     /gene="H2-T23"
                     /gene_synonym="37b; 37c; H-2T23; H2-K1; H2-Qa1; Qa-1;
                     Qa-1(b); Qa1; Qed-1; T18c; T18c(37); T23b; T23d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcaggttc ctcacagacc cagggggtga ggatgttgct ttttgcccac ttgcttcagc
       61 tgctggtcag cgccacagtc ccgacccaga gtagcccaca ctcgctgcgg tatttcacca
      121 ccgccgtgtc ccggcccggc ctcggggagc cccggttcat cattgtcggc tacgtggacg
      181 acacgcagtt cgtgcgcttc gacagcgacg cggaaaatcc gaggatggag cctcgggcgc
      241 ggtggattga gcaggagggg ccggagtatt gggagcggga gacttggaaa gccagggaca
      301 tggggaggaa cttcagagta aacctgagga ccctgctcgg ctactacaat cagagtaacg
      361 acgaatctca cacgctgcag tggatgtacg gctgcgacgt ggggcccgat gggcgcctgc
      421 tccgcgggta ttgtcaggag gcctacgatg gccaggatta catctccctg aacgaggacc
      481 tgcgttcctg gaccgcgaat gacatagcct cacagatctc taagcacaag tcagaggcag
      541 tcgatgaggc ccaccaacag agggcatacc tgcaaggtcc ttgcgtggag tggctccata
      601 gatacctacg gctgggaaat gagacactgc agcgctcaga ccctccaaag gcacatgtga
      661 cccatcaccc tagatctgaa gatgaagtca ccctgaggtg ctgggccctg ggcttctacc
      721 ctgctgacat caccctgacc tggcagttga atggggagga gctgacccag gacatggagc
      781 ttgtggagac caggcctgca ggggatggaa ccttccagaa gtgggcagct gtcgtggtgc
      841 ctcttgggaa ggagcagtat tacacatgcc atgtgtacca tgaggggctg cctgagcccc
      901 tcaccctgag atgggagcct cctccatcca ctgtctccaa catggtaatc atagctgttc
      961 tggttgtcct tggagctgtg atcatccttg gagctgtggt ggcttttgtg atgaagagga
     1021 ggagacacat aggtgtaaaa ggatgctatg ctcatgttct aggcagcaag agcttccaga
     1081 cctctgactg gcctcagaag gcatgaaaat ccctgggggg gctggtgaga tggctcagtg
     1141 ggtaagagca ctgactgctc ttctgaaggt ccagagttca aatcccagca accacatggt
     1201 ggctcacaac catccgtaac gagatctgac tccctcttct ggagtgtctg aagacagcta
     1261 caatgtactt acatataata aataaataaa taaataaata aataaataaa taaataa
//
