LOCUS       NM_010397               1815 bp    mRNA    linear   ROD 27-MAR-2020
DEFINITION  Mus musculus histocompatibility 2, T region locus 22 (H2-T22),
            transcript variant 1, mRNA.
ACCESSION   NM_010397
VERSION     NM_010397.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Fahl SP, Coffey F, Kain L, Zarin P, Dunbrack RL Jr, Teyton L,
            Zuniga-Pflucker JC, Kappes DJ and Wiest DL.
  TITLE     Role of a selecting ligand in shaping the murine gammadelta-TCR
            repertoire
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 115 (8), 1889-1894 (2018)
   PUBMED   29432160
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Liu J, Shen Y, Li M, Lv D, Zhang A, Peng Y, Miao F and Zhang J.
  TITLE     Spatial-Temporal Expression of Non-classical MHC Class I Molecules
            in the C57 Mouse Brain
  JOURNAL   Neurochem. Res. 40 (7), 1487-1496 (2015)
   PUBMED   26040564
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Ohtsuka M, Inoko H, Kulski JK and Yoshimura S.
  TITLE     Major histocompatibility complex (Mhc) class Ib gene duplications,
            organization and expression patterns in mouse strain C57BL/6
  JOURNAL   BMC Genomics 9, 178 (2008)
   PUBMED   18416856
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Adams EJ, Chien YH and Garcia KC.
  TITLE     Structure of a gammadelta T cell receptor in complex with the
            nonclassical MHC T22
  JOURNAL   Science 308 (5719), 227-231 (2005)
   PUBMED   15821084
  REMARK    GeneRIF: 3.4 A structure of the murine gammadelta TCR G8 bound to
            its major histocompatibility complex (MHC) class Ib ligand, T22
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Landel CP, Stabley DL and Bundesen LQ.
  TITLE     PCR identification of class I major histocompatibility complex
            genes transcribed in mouse blastocyst and placenta
  JOURNAL   J. Reprod. Immunol. 33 (1), 31-43 (1997)
   PUBMED   9185075
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Spaner D, Cohen BL, Miller RG and Phillips RA.
  TITLE     Antigen-presenting cells for naive transgenic gamma delta T cells.
            Potent activation by activated alpha beta T cells
  JOURNAL   J. Immunol. 155 (8), 3866-3876 (1995)
   PUBMED   7561093
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Ito K, Van Kaer L, Bonneville M, Hsu S, Murphy DB and Tonegawa S.
  TITLE     Recognition of the product of a novel MHC TL region gene (27b) by a
            mouse gamma delta T cell receptor
  JOURNAL   Cell 62 (3), 549-561 (1990)
   PUBMED   2379238
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Richards S, Bucan M, Brorson K, Kiefer MC, Hunt SW 3rd, Lehrach H
            and Lindahl KF.
  TITLE     Genetic and molecular mapping of the Hmt region of mouse
  JOURNAL   EMBO J. 8 (12), 3749-3757 (1989)
   PUBMED   2573520
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Transy,C., Nash,S.R., David-Watine,B., Cochet,M., Hunt,S.W. 3rd,
            Hood,L.E. and Kourilsky,P.
  TITLE     A low polymorphic mouse H-2 class I gene from the Tla complex is
            expressed in a broad variety of cell types
  JOURNAL   J. Exp. Med. 166 (2), 341-361 (1987)
   PUBMED   3036997
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   Steinmetz,M., Winoto,A., Minard,K. and Hood,L.
  TITLE     Clusters of genes encoding mouse transplantation antigens
  JOURNAL   Cell 28 (3), 489-498 (1982)
   PUBMED   6280871
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133985.1, M35245.1 and AW491949.1.
            
            [WARNING] On Sep 26, 2023 this sequence was replaced by
            NM_010397.6.
            
            On Jan 13, 2018 this sequence version replaced NM_010397.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35245.1, M35243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK133985.1         2-41
            41-1798             M35245.1           1-1758
            1799-1815           AW491949.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.87 cM"
     gene            1..1815
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /note="histocompatibility 2, T region locus 22"
                     /db_xref="GeneID:15039"
                     /db_xref="MGI:MGI:95956"
     exon            1..401
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1456
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MHC classIb T22; histocompatibility 2, T region
                     locus 17"
                     /codon_start=1
                     /product="histocompatibility 2, T region locus 22 isoform
                     1 precursor"
                     /protein_id="NP_034527.1"
                     /db_xref="CCDS:CCDS37608.1"
                     /db_xref="GeneID:15039"
                     /db_xref="MGI:MGI:95956"
                     /translation="MSWVLRAAVVCALLLQLDARPSWTRIPLGSHSLRYFYTAVSRPG
                     LGEPWFIIVGYVDDMQVLRFSSKEETPRMAPWLEQEEADNWEQQTRIVTIQGQLSERN
                     LMTLVHFYNKSMDDSHTLQWLQGCDVEPDRHLCLWYNQLAYDSEDLPTLNENPSSCTV
                     GNSTVPHISQDLKSHCSDLLQKYLEKGKERLLRSDPPKAHVTRHPRPEGDVTLRCWAL
                     GFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWAAVVVPLGKEQSYTCHVYHE
                     GLPEPLILRWEPAWYQKPWIWIVAMVFILFIICLCVVCICMKKNAGGRGRRDTQEAGR
                     DSPQDSSKTVVDDEEMGVCFWKIKSCKTCLGHSPGTSVGESLLSP"
     exon            402..662
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            663..899
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1175
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1280
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1313
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1360
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1430
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1800
                     /gene="H2-T22"
                     /gene_synonym="27b; H-2T17; H-2T22; H2-T17; T22b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttaccgcc ctgctctctc tgcgaccctc ctctccccag gcagggttga gagcaagaag
       61 gtgcaggatg taggcctgca gaattgtcag acccagtggc ggcttttgcc actggaagaa
      121 tttccaacat aaaacagagg atcagtttgg gacaatcgat tctgcgacca gaggtagtgt
      181 catttggtta cttttaaaat tcagattttc tggtgttttc caatcactcg cgactgtaat
      241 ttgaagttgg gttctgagat aatacaatcg ctgtcgctct agtttataaa gctgtccaag
      301 atctgcccag tcccagatgt cctgggtcct cagggccgct gtggtctgcg cccttctcct
      361 gcagctggat gccagaccat cctggactcg gatccctttg ggttcacact cgcttaggta
      421 tttctacacc gctgtgtccc ggcctggcct tggggagccc tggttcataa tcgtcggcta
      481 tgtggacgac atgcaggtcc tgcgcttcag cagcaaggag gagactccga ggatggcacc
      541 ctggctggag caggaggaag cagataactg ggagcagcag actcgtatag tcacaattca
      601 aggacagctg tctgaaagga atctgatgac cctggttcat ttttacaaca agagcatgga
      661 cgactctcac acactacagt ggctgcaagg ctgcgatgtg gagccagatc ggcacctgtg
      721 tctctggtac aaccagctcg cctatgatag cgaggatctc cccaccctga acgaaaaccc
      781 aagttcctgt acagtgggaa acagcactgt acctcacatc tctcaggacc tgaagagcca
      841 ctgctcagat ctgctgcaga aatacctgga aaaagggaag gagaggctgc tgcgttcaga
      901 ccctccaaag gcacatgtga cccgtcaccc cagacctgaa ggtgatgtca ccctgaggtg
      961 ttgggccctg ggcttctacc ctgctgacat caccctgacc tggcagttga atggggagga
     1021 gctgacccag gacatggagc ttgtggagac caggcctgca ggggatggaa ccttccagaa
     1081 gtgggcagct gtggtggtgc ctcttgggaa agagcagagt tacacatgcc atgtgtacca
     1141 tgaggggctg cctgagcccc tcatcctgag atgggagcct gcatggtacc aaaagccttg
     1201 gatttggatt gttgccatgg ttttcatttt gttcatcatt tgtctctgtg tggtttgcat
     1261 atgcatgaag aagaatgcag gtgggagagg aaggcgtgac acccaagaag caggcagaga
     1321 cagtccccaa gactctagca agactgttgt ggatgatgag gagatggggg tttgcttttg
     1381 gaagattaag tcctgtaaaa cttgtctagg ccactcccca ggaacttcag ttggcgagtc
     1441 tttactgtca ccttgactgg atttaggatc atctgggaga tgcccctttg agtggctggg
     1501 ctgtgaggac agcaggccag ttcttgccac cctggacaga aacacatctc acctttctgg
     1561 ctcaaggatc tgaacacctg tctcttgcct actcggcttc tagtcaggca ttttgtcacc
     1621 ttgtcaaggg tcccagggac acaaagctcc ctcctctcac ccacagcact ctgggtccta
     1681 ccctcagtgc ttcagggaca tttaatcagg tcaaattggg atcaatggct ttgatgcaga
     1741 aaagaactgt ggactaatag agatagggtt taattaaaaa atatatcttt ttaattttaa
     1801 aaaaaaaaaa aaaaa
//
