LOCUS       NM_010394               1536 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus histocompatibility 2, Q region locus 7 (H2-Q7),
            transcript variant 1, mRNA.
ACCESSION   NM_010394 XM_001004111
VERSION     NM_010394.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1536)
  AUTHORS   Ohtsuka,M., Inoko,H., Kulski,J.K. and Yoshimura,S.
  TITLE     Major histocompatibility complex (Mhc) class Ib gene duplications,
            organization and expression patterns in mouse strain C57BL/6
  JOURNAL   BMC Genomics 9, 178 (2008)
   PUBMED   18416856
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1536)
  AUTHORS   Haston,C.K., Tomko,T.G., Godin,N., Kerckhoff,L. and Hallett,M.T.
  TITLE     Murine candidate bleomycin induced pulmonary fibrosis
            susceptibility genes identified by gene expression and sequence
            analysis of linkage regions
  JOURNAL   J Med Genet 42 (6), 464-473 (2005)
   PUBMED   15937080
REFERENCE   3  (bases 1 to 1536)
  AUTHORS   Chiang,E.Y. and Stroynowski,I.
  TITLE     A nonclassical MHC class I molecule restricts CTL-mediated
            rejection of a syngeneic melanoma tumor
  JOURNAL   J Immunol 173 (7), 4394-4401 (2004)
   PUBMED   15383569
REFERENCE   4  (bases 1 to 1536)
  AUTHORS   Chiang,E.Y., Henson,M. and Stroynowski,I.
  TITLE     Correction of defects responsible for impaired Qa-2 class Ib MHC
            expression on melanoma cells protects mice from tumor growth
  JOURNAL   J Immunol 170 (9), 4515-4523 (2003)
   PUBMED   12707328
REFERENCE   5  (bases 1 to 1536)
  AUTHORS   Kumanovics,A., Madan,A., Qin,S., Rowen,L., Hood,L. and Fischer
            Lindahl,K.
  TITLE     QUOD ERAT FACIENDUM: sequence analysis of the H2-D and H2-Q regions
            of 129/SvJ mice
  JOURNAL   Immunogenetics 54 (7), 479-489 (2002)
   PUBMED   12389096
REFERENCE   6  (bases 1 to 1536)
  AUTHORS   Wu,L., Exley,G.E. and Warner,C.M.
  TITLE     Differential expression of Ped gene candidates in preimplantation
            mouse embryos
  JOURNAL   Biol Reprod 59 (4), 941-952 (1998)
   PUBMED   9746747
REFERENCE   7  (bases 1 to 1536)
  AUTHORS   Tian,Z., Xu,Y. and Warner,C.M.
  TITLE     Removal of Qa-2 antigen alters the Ped gene phenotype of
            preimplantation mouse embryos
  JOURNAL   Biol Reprod 47 (2), 271-276 (1992)
   PUBMED   1327207
REFERENCE   8  (bases 1 to 1536)
  AUTHORS   Warner,C.M., Brownell,M.S. and Rothschild,M.F.
  TITLE     Analysis of litter size and weight in mice differing in Ped gene
            phenotype and the Q region of the H-2 complex
  JOURNAL   J Reprod Immunol 19 (3), 303-313 (1991)
   PUBMED   1865393
REFERENCE   9  (bases 1 to 1536)
  AUTHORS   Uehara,H., Abe,K., Flaherty,L., Bennett,D. and Artzt,K.
  TITLE     Molecular organization of the D-Qa region of t-haplotypes suggests
            that recombination is an important mechanism for generating genetic
            diversity of the major histocompatibility complex
  JOURNAL   Mamm Genome 1 (2), 92-99 (1991)
   PUBMED   1686840
REFERENCE   10 (bases 1 to 1536)
  AUTHORS   Ulker,N., Lewis,K.D., Hood,L.E. and Stroynowski,I.
  TITLE     Activated T cells transcribe an alternatively spliced mRNA encoding
            a soluble form of Qa-2 antigen
  JOURNAL   EMBO J 9 (12), 3839-3847 (1990)
   PUBMED   2249652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974466.14.
            
            On Oct 26, 2010 this sequence version replaced NM_010394.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05389.1, SRR5286962.1409.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               CR974466.14        187109-187238
            131-400             CR974466.14        187406-187675
            401-676             CR974466.14        187863-188138
            677-961             CR974466.14        190221-190505
            962-1078            CR974466.14        190632-190748
            1079-1111           CR974466.14        190921-190953
            1112-1536           CR974466.14        191303-191727
FEATURES             Location/Qualifiers
     source          1..1536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.67 cM"
     gene            1..1536
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /note="histocompatibility 2, Q region locus 7"
                     /db_xref="GeneID:15018"
                     /db_xref="MGI:MGI:95936"
     exon            1..130
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1071
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; H-2 class I histocompatibility antigen, Q7
                     alpha chain; class Ib MHC antigen Qa-2; QA-2 antigen"
                     /codon_start=1
                     /product="H-2 class I histocompatibility antigen, Q7 alpha
                     chain isoform 1 precursor"
                     /protein_id="NP_034524.3"
                     /db_xref="CCDS:CCDS28697.1"
                     /db_xref="GeneID:15018"
                     /db_xref="MGI:MGI:95936"
                     /translation="MALTMLLLLVAAALTLIETRAGQHSLQYFHTAVSRPGLGEPWFI
                     SVGYVDDTQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQIAKGHEQSFRGSLRTA
                     QSYYNQSKGGSHTLQWMYGCDMGSDGRLLRGYLQFAYEGRDYIALNEDLKTWTAVDMA
                     AQITRRKWEQAGIAEKDQAYLEGTCMQSLRRYLQLGKETLLRTDPPKAHVTHHPRSYG
                     AVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQ
                     NYTCHVNHEGLPEPLTLRWGRWEPPPYTVSNMATIAVVVDLGAVAIIGAVVAFVMNRR
                     "
     exon            131..400
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     exon            401..676
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     exon            677..961
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1078
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1111
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1536
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /note="hexamer: AATAAA"
     polyA_site      1533
                     /gene="H2-Q7"
                     /gene_synonym="H-2Q7; Ped; Q9; Qa-2; Qa-7; Qa7"
                     /note="major polyA site"
ORIGIN      
        1 cgggagcggg ttgtaaagtc cacgctgccc acaggagtca gtcgaccgga atcccccagg
       61 ggagcaatgg ctctaacaat gctgctcttg ctggtggcgg ccgccctgac cctgatcgag
      121 acccgcgcgg gccaacactc gctgcaatat ttccacaccg ctgtgtcccg gcccggcctc
      181 ggggagccct ggttcatctc tgtcggctac gtggacgaca cgcagttcgt gcgcttcgac
      241 agcgatgcgg aaaatccgag gatggagccg cgggcgcggt ggatggagca ggaggggccg
      301 gagtattggg agcgggagac acagatcgcc aagggccatg agcagagttt ccgagggagc
      361 ctgaggaccg cacagagcta ctacaaccag agcaagggcg gctctcacac actccagtgg
      421 atgtatggct gtgacatggg gtccgacggg cgcctcctcc gcgggtacct gcagttcgcc
      481 tatgaaggcc gcgattacat cgccctgaac gaagacctga aaacgtggac ggcggtggac
      541 atggcggcac agatcacccg acgcaagtgg gagcaggctg gtattgcaga gaaagaccag
      601 gcctacctgg agggcacgtg catgcagtcg ctccgcagat acctgcagct cgggaaggag
      661 acgctgctgc gcacagatcc cccaaaggca catgtgaccc atcaccccag gtcttatggt
      721 gctgtcaccc tgaggtgctg ggccctgggc ttctaccctg ctgacatcac cctgacttgg
      781 cagttgaatg gggaggagct gacccaggac atggagcttg tggagaccag gcctgcaggg
      841 gatggaacct tccagaagtg ggcatctgtg gtggtgcctc ttgggaagga gcagaattac
      901 acatgccatg tgaaccatga ggggctgcct gagcccctta ccctgagatg ggggagatgg
      961 gagcctcctc catacactgt ctccaacatg gcgaccattg ctgttgtggt tgaccttgga
     1021 gctgtggcca tcattggagc tgtggtggct tttgtgatga ataggaggtg aaacacaggt
     1081 ggacaaggag gggactgtgc tccagctcca gcatgaagac agctgcctgg actgcactga
     1141 gtgacagacg atgtgttcat gtctctcctg tgacatccag agccctcagt tctctttaga
     1201 caacagtgtc tcatgttccc tgtgagccta tggactcaat gtgaggaact gtggagccca
     1261 gcctgccctg cacacctgga ccctgtccct gcactgccct gttcccttcc acagccaacc
     1321 ttcctgttcc agccaaacac tgggtacatc tacatcctgt cagctccatg ctgccccgag
     1381 ctccagctcc atactttcac acgaagagta tgtgaccttg attgttatca tcttgagctg
     1441 agggttgatt gcttgttaat ttaatggttg agaatactta gcatttttct cttttttaaa
     1501 aaaataaata aatggcagat ggagaacctt tcagga
//
