LOCUS       NM_207648               2118 bp    mRNA    linear   ROD 17-OCT-2021
DEFINITION  Mus musculus histocompatibility 2, Q region locus 6 (H2-Q6),
            transcript variant 2, mRNA.
ACCESSION   NM_207648 XM_003946319
VERSION     NM_207648.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H,
            Stuart JM and Gu W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Ohtsuka M, Inoko H, Kulski JK and Yoshimura S.
  TITLE     Major histocompatibility complex (Mhc) class Ib gene duplications,
            organization and expression patterns in mouse strain C57BL/6
  JOURNAL   BMC Genomics 9, 178 (2008)
   PUBMED   18416856
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Kumanovics A, Madan A, Qin S, Rowen L, Hood L and Fischer Lindahl
            K.
  TITLE     QUOD ERAT FACIENDUM: sequence analysis of the H2-D and H2-Q regions
            of 129/SvJ mice
  JOURNAL   Immunogenetics 54 (7), 479-489 (2002)
   PUBMED   12389096
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Wu L, Exley GE and Warner CM.
  TITLE     Differential expression of Ped gene candidates in preimplantation
            mouse embryos
  JOURNAL   Biol Reprod 59 (4), 941-952 (1998)
   PUBMED   9746747
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Cai W, Cao W, Wu L, Exley GE, Waneck GL, Karger BL and Warner CM.
  TITLE     Sequence and transcription of Qa-2-encoding genes in mouse
            lymphocytes and blastocysts
  JOURNAL   Immunogenetics 45 (2), 97-107 (1996)
   PUBMED   8952959
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Brorson KA, Hunt SW 3rd, Hunkapiller T, Sun YH, Cheroutre H,
            Nickerson DA and Hood L.
  TITLE     Comparison of exon 5 sequences from 35 class I genes of the BALB/c
            mouse
  JOURNAL   J Exp Med 170 (6), 1837-1858 (1989)
   PUBMED   2584927
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Matsuura A, Schloss R, Shen FW, Tung JS, Hunt SW 3rd, Fisher DA,
            Hood LE and Boyse EA.
  TITLE     Expression of the Q8/9d gene by T cells of the mouse
  JOURNAL   Immunogenetics 30 (3), 156-161 (1989)
   PUBMED   2789189
REFERENCE   8  (bases 1 to 2118)
  AUTHORS   Devlin,J.J., Weiss,E.H., Paulson,M. and Flavell,R.A.
  TITLE     Duplicated gene pairs and alleles of class I genes in the Qa2
            region of the murine major histocompatibility complex: a comparison
  JOURNAL   EMBO J 4 (12), 3203-3207 (1985)
   PUBMED   3004940
REFERENCE   9  (bases 1 to 2118)
  AUTHORS   Widacki,S.M., Flaherty,L. and Cook,R.G.
  TITLE     Biochemical characterization of the molecules reactive with Qa-6
            antiserum and the monoclonal antibody 20-8-4: evidence for
            structural similarity with the Qa-2 molecule
  JOURNAL   J Immunol 135 (5), 3333-3339 (1985)
   PUBMED   2413118
REFERENCE   10 (bases 1 to 2118)
  AUTHORS   Flaherty,L., DiBiase,K., Lynes,M.A., Seidman,J.G., Weinberger,O.
            and Rinchik,E.M.
  TITLE     Characterization of a Q subregion gene in the murine major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 82 (5), 1503-1507 (1985)
   PUBMED   2983348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974466.14.
            
            On Feb 22, 2019 this sequence version replaced NM_207648.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                CR974466.14        172804-172894
            92-361              CR974466.14        173062-173331
            362-637             CR974466.14        173525-173800
            638-913             CR974466.14        175818-176093
            914-1029            CR974466.14        176221-176336
            1030-1062           CR974466.14        176514-176546
            1063-2118           CR974466.14        176954-178009
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.66 cM"
     gene            1..2118
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /note="histocompatibility 2, Q region locus 6"
                     /db_xref="GeneID:110557"
                     /db_xref="MGI:MGI:95935"
     exon            1..91
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1008
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; put. Q8 antigen; MHC class II antigen K"
                     /codon_start=1
                     /product="histocompatibility 2, Q region locus 6 isoform a
                     precursor"
                     /protein_id="NP_997531.1"
                     /db_xref="CCDS:CCDS37598.1"
                     /db_xref="GeneID:110557"
                     /db_xref="MGI:MGI:95935"
                     /translation="MALTTLLLLVAAALTLIETRAGPHSLRYFHTAVSWPGLVEPRFI
                     IVGYVDNKQFVRFDSDAENPRMEPRARWMEQEGPEYWERETQKAKGHEESFRVSLRTA
                     QRYYNQSKGGSHTLQWMYGCDVGSDERLLRGYLQFAYEGRDYIALNEDLKTWTAADMA
                     AQITLHKWEQAGIAERDRAYLEGACVQSLRRYLQLRKETLLCTDPPKAHVTHHPRSYG
                     AVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQ
                     NYTCHVNHEGLPEPLTLRWEPPPSTVSNMANVAILVVLVAWPSLELWWIL"
     exon            92..361
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
     exon            362..637
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
     exon            638..913
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1029
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1062
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..2118
                     /gene="H2-Q6"
                     /gene_synonym="0610037M15Rik; H-2Q6; H2-K1; Qa-6; Qa6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgacctg aatccccgag aggagcaatg gctctaacaa cgctgctctt gctggtggcg
       61 gccgccctga ccctgatcga gacccgcgcg ggcccacact cgctgcggta tttccacact
      121 gctgtgtcct ggcccggcct cgtggagccc cggttcatta tcgtcggcta cgtggacaac
      181 aagcagttcg tgcgcttcga cagcgacgcg gaaaatccga ggatggagcc gcgggcgcgg
      241 tggatggagc aggaggggcc ggagtattgg gagcgggaga cacagaaagc caagggccat
      301 gaggagagtt tccgagtgag cctgaggacc gcacagagat actacaacca gagcaagggc
      361 ggctctcaca cactccagtg gatgtatggc tgtgacgtgg ggtccgacga gcgcctcctc
      421 cgcgggtacc tgcagttcgc ctatgaaggc cgcgattaca tcgccctgaa cgaagacctg
      481 aaaacctgga cggcggcgga catggctgca cagatcaccc tacacaagtg ggagcaggct
      541 ggtattgcag agagagaccg ggcctacctg gagggcgctt gcgtgcagtc gctccgcaga
      601 tacctgcagc tccggaagga gacgctgctg tgcacagatc ccccaaaggc acatgtgacc
      661 catcacccca ggtcttatgg tgctgtcacc ctgaggtgct gggccctggg cttctaccct
      721 gctgacatca ccctgacttg gcagttgaat ggggaggagc tgacccagga catggagctt
      781 gtggagacca ggcctgcagg ggatggaacc ttccagaagt gggcatctgt ggtggtgcct
      841 cttgggaagg agcagaatta cacatgccat gtgaaccatg aggggctgcc tgagcctctc
      901 accctgagat gggagcctcc tccatccact gtctccaaca tggcgaacgt agctattctg
      961 gttgtccttg tagcttggcc atcattggag ctgtggtgga ttttgtgatg aagagaagga
     1021 gacacacagg tggacaagga ggggactatg ctctggctcc agagaacagt gtctgatgtt
     1081 ccctgtgagc ctatgggctc aatgtgaaga attgtggagc ccagccttcg cctacacacc
     1141 aggaccctgt ctctgcattg ccctgtgttc ccttccaccg ccaaccttcc tggtctgcag
     1201 tggaaactaa gggttctttg gaaagtcggt tggatggcgt tgtgctgggg caaacacatg
     1261 aaggagtgtt tccttaaagt ggatacaggt gtgaaatcct aaggccgact cctgaaggaa
     1321 catttcactg aagcagacac aggagagagg atgttctgtt aaacaagcat gtgaaaggat
     1381 gcgtgatgaa ggattctttg ctaaagacac acttatattg gtctgcctta cattgtgtag
     1441 tggagctgca ttggtcgggg cgccatagag agaaacgcac ccaaaaattc tgatagtatt
     1501 ctgcagttga tgcttccaag gacatgagct tattggatgc ctgtgctgag gcaagacgct
     1561 tggaggacac atgatgactg gagagtataa ataggactcc atggagtgac tgagacagag
     1621 tttgccttgc tggtacagtg tgtgtcttgt gtcttcactg ttcttcactt ccataagaga
     1681 ggtacagcaa agaacttctc ctggtattcc tgctggtcct tcctgctggc cctagctgag
     1741 gcctggctgt ctctgctagg tcctatcact tctgttgcta acctgactct actgaactga
     1801 acaactgcta tatccctgag gtgttttcaa gtggatggag ctgccactgc tgacctgtga
     1861 attgaactgc caacgtccag acaactcaca tgagagttgc tcccaagtgt agtctcccct
     1921 cccccagcct gaaacctgct tgctcagggg tggagcttcc tgctcattcg ttctgccacg
     1981 cccactgcta gaacctgcgg agccacacac gtgcaccttt ctactggacc agagattatt
     2041 cggcgggaat cgggtcccct cccccttcct tcataactag tgtcgcaaca ataaaatttg
     2101 agctttgatc agaatgga
//
