LOCUS       NM_001143689            1793 bp    mRNA    linear   ROD 19-FEB-2022
DEFINITION  Mus musculus histocompatibility 2, Q region locus 4 (H2-Q4), mRNA.
ACCESSION   NM_001143689 XR_032175 XR_032223 XR_034205
VERSION     NM_001143689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Swanson PA 2nd, Pack CD, Hadley A, Wang CR, Stroynowski I, Jensen
            PE and Lukacher AE.
  TITLE     An MHC class Ib-restricted CD8 T cell response confers antiviral
            immunity
  JOURNAL   J Exp Med 205 (7), 1647-1657 (2008)
   PUBMED   18541714
REFERENCE   2  (bases 1 to 1793)
  AUTHORS   Ohtsuka M, Inoko H, Kulski JK and Yoshimura S.
  TITLE     Major histocompatibility complex (Mhc) class Ib gene duplications,
            organization and expression patterns in mouse strain C57BL/6
  JOURNAL   BMC Genomics 9, 178 (2008)
   PUBMED   18416856
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1793)
  AUTHORS   Wang Q and Flaherty L.
  TITLE     Developmental expression of the mouse MHC Q genes
  JOURNAL   Eur J Immunogenet 23 (2), 121-127 (1996)
   PUBMED   8732475
REFERENCE   4  (bases 1 to 1793)
  AUTHORS   Litaker W, Peace-Brewer A and Frelinger JA.
  TITLE     A physical map of the Q region of B1O.P
  JOURNAL   Mamm Genome 7 (3), 200-205 (1996)
   PUBMED   8833240
REFERENCE   5  (bases 1 to 1793)
  AUTHORS   Montagutelli X, Serikawa T and Guenet JL.
  TITLE     PCR-analyzed microsatellites: data concerning laboratory and
            wild-derived mouse inbred strains
  JOURNAL   Mamm Genome 1 (4), 255-259 (1991)
   PUBMED   1794054
REFERENCE   6  (bases 1 to 1793)
  AUTHORS   Uehara H, Abe K, Flaherty L, Bennett D and Artzt K.
  TITLE     Molecular organization of the D-Qa region of t-haplotypes suggests
            that recombination is an important mechanism for generating genetic
            diversity of the major histocompatibility complex
  JOURNAL   Mamm Genome 1 (2), 92-99 (1991)
   PUBMED   1686840
REFERENCE   7  (bases 1 to 1793)
  AUTHORS   Palmer,M.J. and Frelinger,J.A.
  TITLE     Widespread transcription of a Qa region gene in adult mice
  JOURNAL   J Exp Med 166 (1), 95-108 (1987)
   PUBMED   2439640
REFERENCE   8  (bases 1 to 1793)
  AUTHORS   Landolfi,N.F., Rich,R.R., Bevan,M.J. and Cook,R.G.
  TITLE     Analysis of the Qa-4 allodeterminant
  JOURNAL   Immunogenetics 21 (5), 511-516 (1985)
   PUBMED   2581893
REFERENCE   9  (bases 1 to 1793)
  AUTHORS   Kincade,P.W., Flaherty,L., Lee,G., Watanabe,T. and Michaelson,J.
  TITLE     Qa antigen expression on functional lymphoid, myeloid, and stem
            cells in adult mice
  JOURNAL   J Immunol 124 (6), 2879-2885 (1980)
   PUBMED   6966299
REFERENCE   10 (bases 1 to 1793)
  AUTHORS   Hammerling,G.J., Hammerling,U. and Flaherty,L.
  TITLE     Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla
            region and identified by monoclonal antibodies
  JOURNAL   J Exp Med 150 (1), 108-116 (1979)
   PUBMED   312902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037574.1 and AB267092.2.
            
            On or before Jan 4, 2009 this sequence version replaced
            XR_032175.1, XR_034205.1, XR_032223.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037574.1, SRR7345562.137122.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               AK037574.1         2-489
            489-489             AB267092.2         291-291
            490-1793            AK037574.1         491-1794
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.65 cM"
     gene            1..1793
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /note="histocompatibility 2, Q region locus 4"
                     /db_xref="GeneID:15015"
                     /db_xref="MGI:MGI:95933"
     exon            1..91
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1092
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /note="MHC class I like protein GS10; MHC class II antigen
                     D"
                     /codon_start=1
                     /product="histocompatibility 2, Q region locus 4
                     precursor"
                     /protein_id="NP_001137161.1"
                     /db_xref="CCDS:CCDS50087.1"
                     /db_xref="GeneID:15015"
                     /db_xref="MGI:MGI:95933"
                     /translation="MASTMLLLLVAVAQTLIEIRAAPRPAPLPARSPAGGPGRSSGSH
                     RALPPGPHLLSYFYTSVSRPGLGEPRFISVGYVDNTEFVRFDSDAENPRYEPRAPWME
                     QEGPEYWERETQKAKGNEQIFRVNLRTLLSYYNQSAGGSHTIQVISGCEVGSDGRLLR
                     GYQQFAYDGRDYIALNEDLKTWTAADMAAQITRRKWEQAGATEKSKAYLEGACVQSLR
                     RYLELGKETLLRTDPPKAHVTCHHRSDGDVTLRCWALGFYPANIILTWQLNGEELTQD
                     MELVETRPSGDGTFQKWASVVVPLGKEQNYTCHVHHEGLPEPLTLRWEPPPSTVSNMA
                     NVAVLVVLGAWPSLQLWWLL"
     exon            92..445
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..721
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..997
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1113
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1793
                     /gene="H2-Q4"
                     /gene_synonym="H-2Q4; H2-D1; H2-Gs10; Qa-4; Qa4; Qat-4;
                     Qb-1; Qb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgcccag aatcccagag gggagcaatg gcgtcaacaa tgctgcttct gctggtggca
       61 gtcgcccaga ccctgatcga gatccgcgcg gccccgcgcc ctgctcccct cccggcccgc
      121 tcacccgccg ggggtcccgg aaggagttcg gggtctcacc gcgccctgcc tccaggccca
      181 cacttgctga gttatttcta cacctccgtg tcccggccgg gccttgggga gccccggttc
      241 atctctgtcg gttacgtgga caacacggag ttcgtgcgct tcgacagcga cgcggagaat
      301 ccgagatatg agccgcgggc accgtggatg gagcaggagg ggccggagta ttgggagcgg
      361 gaaacacaga aagccaaggg caatgagcag attttccgag tgaacctgag gaccctgctc
      421 agctactaca accagagcgc gggcggctct cacactattc aggtgatctc tggctgtgaa
      481 gtggggtccg acgggcgcct cctccgcggg taccagcagt tcgcctacga cggccgcgat
      541 tacatcgccc tgaacgaaga cctgaaaacg tggacggcgg cggacatggc ggcacagatc
      601 acccgacgca agtgggagca ggctggtgct acagagaaaa gcaaggccta cctggagggc
      661 gcgtgcgtgc agtccctccg cagatacctg gagctcggga aggagacgct gctgcgcaca
      721 gatcctccaa aggcacatgt gacatgtcac cacagatctg acggtgatgt caccctgagg
      781 tgctgggccc tgggcttcta ccctgctaac atcatcctga cctggcagtt gaatggggag
      841 gagctgaccc aggacatgga gcttgtggag accaggcctt caggggatgg aaccttccag
      901 aagtgggcat ctgtggtggt gcctcttggg aaggagcaga attacacatg ccatgtgcac
      961 catgaggggc tgcctgagcc cctcaccctg agatgggagc ctcctccatc cactgtctcc
     1021 aacatggcga acgtagctgt tctggttgtc cttggagctt ggccatcatt gcagctgtgg
     1081 tggcttttgt gatgaagaga aggagacaca cagagaacag cgcctgatgt tccctgtgag
     1141 cctatgggct caatgtgaag aattgtggag cccagccttc gcctacacac caggaccctg
     1201 tctctgcatt gccctgtgtt cccttccacc gccaaccttc cgggtctgca gtggaaacta
     1261 agggttcttt ggaaagtcgg ttggatggtg ttgtgctggg gcaaacacat gaaggagtgt
     1321 ttccttaaag tggatacagg tgtgaaaggc taaggccgac tcctgaagga acatttcact
     1381 gaagcagaca caggagagag gatgttctgt aaaacaagca tgtgaaagga tgcgatgcgt
     1441 gatgaaggat tctttgctaa agacacaatt atggatctgc aaccctatag gtggaacaac
     1501 attatgaact aaccagtacc ccggagctct tgactctagc tgcatatgta tcaaaagatg
     1561 gcctagtcgg ccatcactgg aaagagaggc ccattggaca agcaaacttt atatgcccca
     1621 gtacagggga acgccagggc caaaaagggg gagtgggtgg gtaggggagt gggggtgggt
     1681 gggtatgggg gacttttgat atagcattgg aaatgtaaat gagctaaata cctaataaaa
     1741 aatggaaaaa aaaaaagaaa actgacatat taaaaaaaaa aaaagacaca ctt
//
