LOCUS       NM_010392               2032 bp    mRNA    linear   ROD 13-AUG-2022
DEFINITION  Mus musculus histocompatibility 2, Q region locus 2 (H2-Q2),
            transcript variant 1, mRNA.
ACCESSION   NM_010392 XM_006523697
VERSION     NM_010392.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   Swanson PA 2nd, Pack CD, Hadley A, Wang CR, Stroynowski I, Jensen
            PE and Lukacher AE.
  TITLE     An MHC class Ib-restricted CD8 T cell response confers antiviral
            immunity
  JOURNAL   J Exp Med 205 (7), 1647-1657 (2008)
   PUBMED   18541714
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Ohtsuka M, Inoko H, Kulski JK and Yoshimura S.
  TITLE     Major histocompatibility complex (Mhc) class Ib gene duplications,
            organization and expression patterns in mouse strain C57BL/6
  JOURNAL   BMC Genomics 9, 178 (2008)
   PUBMED   18416856
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Guidry PA and Stroynowski I.
  TITLE     The murine family of gut-restricted class Ib MHC includes
            alternatively spliced isoforms of the proposed HLA-G homolog,
            'blastocyst MHC'
  JOURNAL   J Immunol 175 (8), 5248-5259 (2005)
   PUBMED   16210630
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Kumanovics A, Madan A, Qin S, Rowen L, Hood L and Fischer Lindahl
            K.
  TITLE     QUOD ERAT FACIENDUM: sequence analysis of the H2-D and H2-Q regions
            of 129/SvJ mice
  JOURNAL   Immunogenetics 54 (7), 479-489 (2002)
   PUBMED   12389096
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Litaker W, Peace-Brewer A and Frelinger JA.
  TITLE     A physical map of the Q region of B1O.P
  JOURNAL   Mamm Genome 7 (3), 200-205 (1996)
   PUBMED   8833240
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Uehara H, Abe K, Flaherty L, Bennett D and Artzt K.
  TITLE     Molecular organization of the D-Qa region of t-haplotypes suggests
            that recombination is an important mechanism for generating genetic
            diversity of the major histocompatibility complex
  JOURNAL   Mamm Genome 1 (2), 92-99 (1991)
   PUBMED   1686840
REFERENCE   7  (bases 1 to 2032)
  AUTHORS   Brorson KA, Hunt SW 3rd, Hunkapiller T, Sun YH, Cheroutre H,
            Nickerson DA and Hood L.
  TITLE     Comparison of exon 5 sequences from 35 class I genes of the BALB/c
            mouse
  JOURNAL   J Exp Med 170 (6), 1837-1858 (1989)
   PUBMED   2584927
REFERENCE   8  (bases 1 to 2032)
  AUTHORS   Prochazka M, Serreze DV, Worthen SM and Leiter EH.
  TITLE     Genetic control of diabetogenesis in NOD/Lt mice. Development and
            analysis of congenic stocks
  JOURNAL   Diabetes 38 (11), 1446-1455 (1989)
   PUBMED   2576007
REFERENCE   9  (bases 1 to 2032)
  AUTHORS   Ostrand-Rosenberg S, Nickerson DA, Clements VK, Garcia EP,
            Lamouse-Smith E, Hood L and Stroynowski I.
  TITLE     Embryonal carcinoma cells express Qa and Tla class I genes of the
            major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 86 (13), 5084-5088 (1989)
   PUBMED   2740345
REFERENCE   10 (bases 1 to 2032)
  AUTHORS   Kuhner MK and Goodenow RS.
  TITLE     DNA sequences of mouse H-2 and Qa genes
  JOURNAL   Immunogenetics 30 (6), 458-464 (1989)
   PUBMED   2592022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974466.14.
            
            On or before Feb 22, 2019 this sequence version replaced
            XM_006523697.3, NM_010392.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1841050.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CR974466.14        90261-90350
            91-360              CR974466.14        90554-90823
            361-636             CR974466.14        91067-91342
            637-912             CR974466.14        92709-92984
            913-1029            CR974466.14        93112-93228
            1030-1062           CR974466.14        93408-93440
            1063-1111           CR974466.14        93614-93662
            1112-2032           CR974466.14        93798-94718
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.64 cM"
     gene            1..2032
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /note="histocompatibility 2, Q region locus 2"
                     /db_xref="GeneID:15013"
                     /db_xref="MGI:MGI:95931"
     exon            1..90
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1109
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; class Ib major histocompatibility complex; MHC
                     classIb like protein GS14-2; MHC class II antigen K; MHC
                     class II antigen D"
                     /codon_start=1
                     /product="histocompatibility 2, Q region locus 2 isoform 1
                     precursor"
                     /protein_id="NP_034522.2"
                     /db_xref="CCDS:CCDS28696.1"
                     /db_xref="GeneID:15013"
                     /db_xref="MGI:MGI:95931"
                     /translation="MALRRLLLLLVAALKLTETRAGSHSLRYFTTAVSRPGLGEPRFI
                     IVGYVDDTQFVRFDSDAENPRMEPRAPWMEQEGPEYWERNTQVSKENEQSFRVSLGTA
                     LSYYNQSKGGSHTLQWLVGCDLGPDGSLLRGYEQSAYDGRDYLALNEDLITWTAADLA
                     ALKTRSKLEQAGLAEKRRAYLEVDCLTWLRRYLELGKETLLHTDPPKAHVTHHPSSQG
                     DVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPSGDGTFQKWASVMVPFGEEP
                     RYTCHVEHEGLPEPLTLRWEPPPSTDSYMVIIAVLVVLGAVIIIGAVVAFVMKRGRNT
                     GGKVRDYAQDPGRDSPQSSDISLLEL"
     exon            91..360
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..636
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..912
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1029
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1062
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1111
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..2032
                     /gene="H2-Q2"
                     /gene_synonym="Gm11132; gs14-2; H-2Q2; H2-D1; H2-K1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgccctg tatcccagat ggggcaatgg cgctgcgaag gctgctcctg ctgttggtgg
       61 ccgccctgaa actgactgag acacgcgcgg gctcacactc gctgcggtat ttcaccaccg
      121 ccgtgtcccg gcctggcctc ggggagcccc ggttcattat cgtcggctac gtggacgaca
      181 cgcagttcgt gcgcttcgac agcgacgcgg agaatccgag gatggagccg cgggcgccgt
      241 ggatggagca ggaggggccg gagtattggg agcggaacac acaggtctcc aaggaaaatg
      301 agcagagttt ccgagtgagc ctggggaccg cactgagcta ctacaaccag agcaagggag
      361 gctctcacac tctccagtgg ttggttggct gtgacctggg gccagacgga agcctactcc
      421 gagggtatga gcagtctgcc tacgatggcc gcgattacct cgccctgaat gaggatctga
      481 taacgtggac agcggcggac ctggcagcac tgaagacccg aagcaagttg gagcaggctg
      541 gtcttgcaga gaagcgcagg gcctacctgg aggtcgattg cttgacgtgg ctccgcagat
      601 acctggagct cgggaaggag acgctgctgc acacagatcc cccaaaggcg catgtgaccc
      661 atcaccccag ttctcaaggt gatgtcaccc tgaggtgctg ggccctgggc ttctaccctg
      721 ctgacatcac cctgacctgg cagttgaatg gggaggacct gacccaggac atggagcttg
      781 tggagaccag gccttcaggg gatggaacct tccagaagtg ggcatctgtg atggtgcctt
      841 ttggggagga gcctagatac acatgccatg tggaacatga ggggctgcct gagcccctca
      901 ccctgagatg ggagcctcct ccatccactg actcttacat ggtgatcatt gctgttctgg
      961 ttgtccttgg agctgtgatc atcattggag ctgtggtggc ttttgtgatg aaaagaggga
     1021 gaaacacagg tggaaaagta agagactacg ctcaagatcc aggcagggac agcccccaga
     1081 gctctgatat ctctctccta gaattgtaaa gcatgaagac agctgcctgg agtagactga
     1141 gtgacagcca gtgtgttcag gtctctcctg tgacatcaag agtctttaga catcagcttt
     1201 ctttagaaaa tggtgtctca tgttctctgc cacaccaacc ccagtagcag ccatgtgaca
     1261 agttgcacag actgaggtat acttcaaaag aaggaggcct cctggaacca gttgtggaac
     1321 tcttggccag agtattatat tgagtcatag ttctcatggc aattgattta ttttgttttc
     1381 gcttattcct tttcttattt acatgttcct ggtagcctag gctaagattt taagtgaaag
     1441 taatgggtta gaaaccatcc ctagagatgg ggtcactaac atgaccttat ctggggaaac
     1501 caactcttta cttttgaaat tatttacaaa attatataat agtattatga cagataaaaa
     1561 cttttccaac aataaaattt catgtggcta catgtgtgtt attggaggtg ggctttggca
     1621 tatggtaaag aaaatcttaa ataaaaagaa ttaacctagt ttaaatttaa gcactgaaaa
     1681 aaatcaggca ttagatgtta aataataatt gaccataaag atttattaac atatcttgaa
     1741 catatgccag ttgccttgga tgactgccgc actgcttaga ttcttttaga gttgttatac
     1801 ttcaatcatt tctactcctc atgatgtcac ctgttctgtt tgtgattcac tgaacccatc
     1861 tttacagagt tgtaatgttt tcttggtttt tgtgctttac tgtgcataat ggtaatgatg
     1921 gtatttgtga ttgcttcact ggacacatct tcaaagtgtt gtaatatttg ctcttttaat
     1981 gtttaaaaac ccctgcttga gagctgcaaa atacaatcag attcatactg cc
//
