LOCUS       NM_010391               1473 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus histocompatibility 2, Q region locus 10 (H2-Q10),
            mRNA.
ACCESSION   NM_010391
VERSION     NM_010391.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1473)
  AUTHORS   Goodall,K.J., Nguyen,A., Andrews,D.M. and Sullivan,L.C.
  TITLE     Ribosylation of the CD8alphabeta heterodimer permits binding of the
            nonclassical major histocompatibility molecule, H2-Q10
  JOURNAL   J Biol Chem 297 (4), 101141 (2021)
   PUBMED   34478713
  REMARK    GeneRIF: Ribosylation of the CD8alphabeta heterodimer permits
            binding of the nonclassical major histocompatibility molecule,
            H2-Q10.
REFERENCE   2  (bases 1 to 1473)
  AUTHORS   Goodall,K.J., Nguyen,A., Matsumoto,A., McMullen,J.R., Eckle,S.B.,
            Bertolino,P., Sullivan,L.C. and Andrews,D.M.
  TITLE     Multiple receptors converge on H2-Q10 to regulate NK and
            gammadeltaT-cell development
  JOURNAL   Immunol Cell Biol 97 (3), 326-339 (2019)
   PUBMED   30537346
  REMARK    GeneRIF: These data demonstrate that H2-Q10 has multiple roles in
            the development of immune subsets and identify an overlap of
            recognition within the class Ib MHC that is likely to be relevant
            to the regulation of immunity.
REFERENCE   3  (bases 1 to 1473)
  AUTHORS   Sullivan,L.C., Berry,R., Sosnin,N., Widjaja,J.M., Deuss,F.A.,
            Balaji,G.R., LaGruta,N.L., Mirams,M., Trapani,J.A., Rossjohn,J.,
            Brooks,A.G. and Andrews,D.M.
  TITLE     Recognition of the Major Histocompatibility Complex (MHC) Class Ib
            Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C
  JOURNAL   J Biol Chem 291 (36), 18740-18752 (2016)
   PUBMED   27385590
  REMARK    GeneRIF: This docking mode was conserved with that previously
            observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of
            Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar
            energetic footprints focused around residues located within the
            Ly49C beta4-stand and L5 loop, which contact the underside of the
            peptide-binding platform floor.
REFERENCE   4  (bases 1 to 1473)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1473)
  AUTHORS   Ohtsuka,M., Inoko,H., Kulski,J.K. and Yoshimura,S.
  TITLE     Major histocompatibility complex (Mhc) class Ib gene duplications,
            organization and expression patterns in mouse strain C57BL/6
  JOURNAL   BMC Genomics 9, 178 (2008)
   PUBMED   18416856
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1473)
  AUTHORS   Uehara,H., Abe,K., Flaherty,L., Bennett,D. and Artzt,K.
  TITLE     Molecular organization of the D-Qa region of t-haplotypes suggests
            that recombination is an important mechanism for generating genetic
            diversity of the major histocompatibility complex
  JOURNAL   Mamm Genome 1 (2), 92-99 (1991)
   PUBMED   1686840
REFERENCE   7  (bases 1 to 1473)
  AUTHORS   Brorson,K.A., Hunt,S.W. 3rd, Hunkapiller,T., Sun,Y.H.,
            Cheroutre,H., Nickerson,D.A. and Hood,L.
  TITLE     Comparison of exon 5 sequences from 35 class I genes of the BALB/c
            mouse
  JOURNAL   J Exp Med 170 (6), 1837-1858 (1989)
   PUBMED   2584927
REFERENCE   8  (bases 1 to 1473)
  AUTHORS   Weiss,E.H., Bevec,D., Messer,G., Schwemmle,S., Grosshaus,C.,
            Steinmetz,M. and Schmidt,W.
  TITLE     Organization of the AKR Qa region: structure of a divergent class I
            sequence, Q5k
  JOURNAL   J Immunogenet 16 (4-5), 283-290 (1989)
   PUBMED   2639903
REFERENCE   9  (bases 1 to 1473)
  AUTHORS   Watts,S., Davis,A.C., Gaut,B., Wheeler,C., Hill,L. and
            Goodenow,R.S.
  TITLE     Organization and structure of the Qa genes of the major
            histocompatibility complex of the C3H mouse: implications for Qa
            function and class I evolution
  JOURNAL   EMBO J 8 (6), 1749-1759 (1989)
   PUBMED   2767053
REFERENCE   10 (bases 1 to 1473)
  AUTHORS   Lew,A.M., Maloy,W.L. and Coligan,J.E.
  TITLE     Characteristics of the expression of the murine soluble class I
            molecule (Q10)
  JOURNAL   J Immunol 136 (1), 254-258 (1986)
   PUBMED   3940270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU467494.10.
            
            On Jun 22, 2007 this sequence version replaced NM_010391.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131620.1, BC011215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 3940270
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                CU467494.10        49158-49248
            92-361              CU467494.10        49445-49714
            362-637             CU467494.10        49895-50170
            638-913             CU467494.10        52152-52427
            914-1017            CU467494.10        52555-52658
            1018-1050           CU467494.10        52837-52869
            1051-1473           CU467494.10        53210-53632
FEATURES             Location/Qualifiers
     source          1..1473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.68 cM"
     gene            1..1473
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /note="histocompatibility 2, Q region locus 10"
                     /db_xref="GeneID:15007"
                     /db_xref="MGI:MGI:95929"
     exon            1..91
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..996
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /note="H-2 class I histocompatibility antigen, Q10 alpha
                     chain; MHC class I transplantation antigen; MHC class II
                     antigen K"
                     /codon_start=1
                     /product="H-2 class I histocompatibility antigen, Q10
                     alpha chain precursor"
                     /protein_id="NP_034521.1"
                     /db_xref="CCDS:CCDS37599.1"
                     /db_xref="GeneID:15007"
                     /db_xref="MGI:MGI:95929"
                     /translation="MGAMAPRTLLLLLAAALAPTQTQAGSHSMRYFETSVSRPGLGEP
                     RFIIVGYVDDTQFVRFDSDAETPRMEPRAPWMEQEGPEYWERETQRAKGNEQSFHVSL
                     RTLLGYYNQSESGSHTIQWMYGCKVGSDGRFLRGYLQYAYDGRDYIALNEDLKTWTAA
                     DVAAIITRRKWEQAGAAEYYRAYLEAECVEWLLRYLELGKETLLRTDPPKTHVTHHPG
                     SEGDVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLG
                     KEQNYTCHVYHEGLPEPLTLRWEPPPSTDSIMSHIADLLWPSLKLWWYL"
     exon            92..361
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     exon            362..637
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     exon            638..913
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1017
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1050
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1473
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1446..1451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /note="hexamer: AATAAA"
     polyA_site      1467
                     /gene="H2-Q10"
                     /gene_synonym="H-2Q10; H2-K1; Q10; Qa10"
                     /note="major polyA site"
ORIGIN      
        1 agacgccccg gatcccagat gggggcgatg gcgccgcgca cgctgctcct gctgctggcg
       61 gctgccctgg ccccgaccca gacccaggca ggctcacact ccatgaggta tttcgaaacc
      121 tccgtttccc ggccgggcct tggggagccc cggttcatta ttgtcggtta cgtggacgac
      181 acgcagttcg tgcgcttcga cagcgacgcg gagactccga ggatggagcc gcgggcgcct
      241 tggatggagc aggaggggcc ggagtattgg gagcgggaga cacagagagc caagggcaat
      301 gagcagagtt tccatgtgag cctgaggacc ctgctcggct actacaacca gagcgagagc
      361 ggctctcaca cgatccagtg gatgtatggc tgtaaagtgg ggtccgacgg gcgcttcctc
      421 cgcgggtacc tgcaatacgc atacgacggc cgcgattaca ttgccctgaa cgaagacctg
      481 aaaacgtgga cggcagcgga cgtggcggcg attatcaccc gacgcaagtg ggagcaggct
      541 ggtgctgcag agtattacag ggcctacctg gaggccgagt gcgtggagtg gctcctcaga
      601 tacctggagc tcgggaagga gacgctgctg cgcacagatc ccccaaagac acatgtgacc
      661 catcacccag gatctgaagg tgatgtcacc ctgaggtgtt gggccctggg cttctaccct
      721 gctgacatca ccctgacctg gcagttgaat ggggaggagc tgacccagga catggaactg
      781 gtggagacca ggcctgcagg ggatggaacc ttccagaagt gggcatctgt ggtggtgcct
      841 cttgggaagg agcagaatta cacatgccat gtgtaccatg aggggctgcc tgagcccctc
      901 accctgagat gggaacctcc tccttccact gactctatca tgtcacacat tgctgatctg
      961 ctgtggccat cattaaagct ctggtggtat ttgtgatgaa gagaaggaga aacacaggta
     1021 gaaaaagagg ggactatgct cccgctccag tgtgaagaca cctgactgga gtggactgag
     1081 tgacaaccag tgtgttcagg tctctcctgt gacatccaga gccctcagtt ctctttagac
     1141 aacagtgtct gatgttctct gtgttcctgt gggctcaatg tgaagaactg tgtagcccag
     1201 cctgccctgc acaccaggac cctgtccctg cattgcttgc tcccttctac agtcagcctt
     1261 ccaactccag ccaaacactg ggagacatct gcatcctgtg agctccacgc taccctaagc
     1321 tgcagctcct cacttccaca ctgagaataa gaatctggat gtgaacttta ttgttcatat
     1381 ccttgatctg agggttgatt gacaggtaaa ctaaagaatt aagaatactt agagtttgtg
     1441 gaggaaataa atggcagatg gagaaccttc cag
//
