LOCUS       NM_010390               2055 bp    mRNA    linear   ROD 16-APR-2022
DEFINITION  Mus musculus histocompatibility 2, Q region locus 1 (H2-Q1),
            transcript variant 1, mRNA.
ACCESSION   NM_010390
VERSION     NM_010390.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Stocks BT, Wilson CS, Marshall AF, Brewer LA and Moore DJ.
  TITLE     Host Expression of the CD8 Treg/NK Cell Restriction Element Qa-1 is
            Dispensable for Transplant Tolerance
  JOURNAL   Sci Rep 7 (1), 11181 (2017)
   PUBMED   28894277
  REMARK    GeneRIF: The data show that CD8 Treg/NK cell restriction element
            Qa-1 does not regulate the primary cellular or humoral alloresponse
            and is not required for long-term transplant tolerance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Liu J, Shen Y, Li M, Lv D, Zhang A, Peng Y, Miao F and Zhang J.
  TITLE     Spatial-Temporal Expression of Non-classical MHC Class I Molecules
            in the C57 Mouse Brain
  JOURNAL   Neurochem Res 40 (7), 1487-1496 (2015)
   PUBMED   26040564
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Zeng L, Sullivan LC, Vivian JP, Walpole NG, Harpur CM, Rossjohn J,
            Clements CS and Brooks AG.
  TITLE     A structural basis for antigen presentation by the MHC class Ib
            molecule, Qa-1b
  JOURNAL   J Immunol 188 (1), 302-310 (2012)
   PUBMED   22131332
  REMARK    GeneRIF: data illustrate the structural homology between Qa-1(b)
            and HLA-E and provide a structural basis for understanding peptide
            repertoire selection and the specificity of the interaction of
            Qa-1(b) with CD94-NKG2 receptors.
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Oliveira CC, van Veelen PA, Querido B, de Ru A, Sluijter M, Laban
            S, Drijfhout JW, van der Burg SH, Offringa R and van Hall T.
  TITLE     The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of
            antigen-processing defects
  JOURNAL   J Exp Med 207 (1), 207-221 (2010)
   PUBMED   20038604
  REMARK    Erratum:[J Exp Med. 2010 Mar 15;207(3):671. Drijfhout, Jan W
            [added]]
REFERENCE   5  (bases 1 to 2055)
  AUTHORS   Swanson PA 2nd, Pack CD, Hadley A, Wang CR, Stroynowski I, Jensen
            PE and Lukacher AE.
  TITLE     An MHC class Ib-restricted CD8 T cell response confers antiviral
            immunity
  JOURNAL   J Exp Med 205 (7), 1647-1657 (2008)
   PUBMED   18541714
REFERENCE   6  (bases 1 to 2055)
  AUTHORS   Uehara H, Abe K, Flaherty L, Bennett D and Artzt K.
  TITLE     Molecular organization of the D-Qa region of t-haplotypes suggests
            that recombination is an important mechanism for generating genetic
            diversity of the major histocompatibility complex
  JOURNAL   Mamm Genome 1 (2), 92-99 (1991)
   PUBMED   1686840
REFERENCE   7  (bases 1 to 2055)
  AUTHORS   Rubocki RJ, Lee DR, Lie WR, Myers NB and Hansen TH.
  TITLE     Molecular evidence that the H-2D and H-2L genes arose by
            duplication. Differences between the evolution of the class I genes
            in mice and humans
  JOURNAL   J Exp Med 171 (6), 2043-2061 (1990)
   PUBMED   2351932
REFERENCE   8  (bases 1 to 2055)
  AUTHORS   Klein J, Benoist C, David CS, Demant P, Lindahl KF, Flaherty L,
            Flavell RA, Hammerling U, Hood LE, Hunt SW 3rd et al.
  TITLE     Revised nomenclature of mouse H-2 genes
  JOURNAL   Immunogenetics 32 (3), 147-149 (1990)
   PUBMED   2228044
REFERENCE   9  (bases 1 to 2055)
  AUTHORS   Aldrich,C.J., Jenkins,R.N. and Rich,R.R.
  TITLE     Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire:
            definition of the Qa-1d and Qa-1c alloantigens and cross-reactivity
            with H-2
  JOURNAL   J Immunol 136 (2), 383-388 (1986)
   PUBMED   2416805
REFERENCE   10 (bases 1 to 2055)
  AUTHORS   Hammerling,G.J., Hammerling,U. and Flaherty,L.
  TITLE     Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla
            region and identified by monoclonal antibodies
  JOURNAL   J Exp Med 150 (1), 108-116 (1979)
   PUBMED   312902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974466.14 and U96752.1.
            
            On Dec 9, 2017 this sequence version replaced NM_010390.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CR974466.14        68501-68511
            12-1708             U96752.1           1-1697
            1709-1709           CR974466.14        72727-72727
            1710-1744           U96752.1           1699-1733
            1745-1745           CR974466.14        72763-72763
            1746-2055           U96752.1           1734-2043
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.63 cM"
     gene            1..2055
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /note="histocompatibility 2, Q region locus 1"
                     /db_xref="GeneID:15006"
                     /db_xref="MGI:MGI:95928"
     exon            1..79
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1122
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MHC class II antigen D"
                     /codon_start=1
                     /product="histocompatibility 2, Q region locus 1 isoform 1
                     precursor"
                     /protein_id="NP_034520.2"
                     /db_xref="CCDS:CCDS50086.1"
                     /db_xref="GeneID:15006"
                     /db_xref="MGI:MGI:95928"
                     /translation="MALGRLLLLLAAALTLTKTGAGSHSLRYFETSVSRPGFGKPRFI
                     SVGYVDDTQFVRFDSDAKNPRYEPRAPWMEQEGPEYWERNTRRVKGSEKRFQESLSTL
                     LSYYNQSKGGIHTFQKLSGCDLGSDGRLQSGYLQFAYDGLDYIALNEDLETWTAADVA
                     AQETRRKWEQAGAAEKHRTYLEGKCLMWLHRYLELGKEMLLRTDPPKAHVTHHPRSQG
                     DVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQ
                     NYTCHVYHEGLPEPLTLRWEPPPYTVSNMVIIAVLVVLGAVIVIGAVVIIGVMVSFVM
                     KRRRNKGGQGEDCALAPSRDSAQSSDISLLDCKA"
     exon            80..349
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..625
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..901
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1036
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1069
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1117
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2035
                     /gene="H2-Q1"
                     /gene_synonym="15006; H-2Q1; H2-D1; Q1; Q1b; Q1d; Q1k;
                     Qa-1; Qa1; Qed-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attccagatg gggcaatggc actgggaagg ctgctcctgc tgctggcagc cgccctgacc
       61 ctgaccaaaa ccggagcggg ctcacactcg ctgcggtatt tcgagacctc ggtgtcccgg
      121 cccggcttcg ggaagccccg gttcatctct gtcggctacg tggacgacac gcagtttgtg
      181 cgcttcgaca gcgacgcgaa gaatccgaga tatgagccgc gggcgccgtg gatggagcag
      241 gaggggccgg agtattggga acggaacaca cggagagtca agggcagtga gaagagattc
      301 caagagagcc tgagcaccct gctcagctac tacaaccaga gcaagggcgg cattcacacc
      361 ttccagaagt tgtctggctg tgatctgggg tcagatgggc gccttcaaag cgggtacctg
      421 cagttcgcct atgatggcct tgattacatc gccctgaatg aagacctgga aacctggaca
      481 gcagcagatg tggcagctca ggaaacccga cgcaagtggg agcaggctgg tgctgctgag
      541 aaacacagga cctacctgga gggcaagtgc ctgatgtggc tccacagata cctggagctc
      601 gggaaggaga tgctgctgcg cacagacccc ccaaaggcac atgtgactca tcaccccaga
      661 tctcaaggtg atgtcaccct gaggtgctgg gccctgggct tctaccctgc tgacatcacc
      721 ctgacctggc agttgaatgg ggaggagctg acccaggaca tggagcttgt ggagaccagg
      781 cctgcagggg atggaacctt ccagaagtgg gcatctgtgg tggtgcctct tgggaaggag
      841 cagaattaca catgccatgt gtaccatgag gggctgcctg agcccctcac cctgagatgg
      901 gagcctcctc catacactgt ttccaacatg gtaatcatag ctgttctggt tgtccttgga
      961 gctgtgatag tcattggagc tgtggtcatc attggagtta tggtgtcttt tgtgatgaag
     1021 aggaggagaa acaaaggtgg acaaggagag gactgtgctc tggctccaag cagggacagc
     1081 gcccagagct ctgatatctc tctcctagat tgtaaagcat gaagacagct gcctggagta
     1141 gactgagtga tagccagtgt gttcaggtct ctcctgtgac atcaagagtc tttagacatc
     1201 agctttcttt agaaaatggt gtctcatgtt ctctgccaca ccaaccccag tagcagccat
     1261 gtgacaagtt gcacagactg aggtatactt caaaagaagg aggcctcctg gaaccagttg
     1321 tggaactctt ggccagagta ttatattgag tcttagttct catggcaatt gatttatttt
     1381 gttttctctt attccttttc ttatttacat gttcctcgta acctaggcta agatctcatg
     1441 tgaaagtaat gggttagaaa ccatccctag aattggggtc actaacatga ccttatctgg
     1501 ggaaaccaac gctttacttt agaaattatt tacaaaatta tataatagta ttacacagat
     1561 aaaaactttt ccaacaataa aatttcatgt ggctacatgt gtgttatcgg aggtgggctt
     1621 tggcatgtgg taaagaaagt cttaaataaa aagaattaac atagtttaaa tttaagcact
     1681 gaaaaaaatc aggcattaga tgttaaataa taattgacca taaagattta ttaacatgtc
     1741 ttgaacatat gccagtagcc ttggatgact gccccacaac ttatattctt ttagagttgt
     1801 tatacttcaa tcatttctac tcttcatgat gtcacctgtt ctgtttgtga ttcactgaac
     1861 acatctttac agagttgtaa tgtttgcctg atttttgtgc tttcctgtgc caaatgataa
     1921 tgatggtatt tgtgattgct tcactggaca catcttcaaa gtgttgtaat atttgctctt
     1981 ttaatgttta aaaacccctg cttgagagct gcaaaataca ctcggattca tactgaaaaa
     2041 aaaaaaaaaa aaaaa
//
