LOCUS       NM_010389               2670 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus histocompatibility 2, O region beta locus (H2-Ob),
            mRNA.
ACCESSION   NM_010389
VERSION     NM_010389.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Cullum,E., Perez-Betancourt,Y., Shi,M., Gkika,E., Schneewind,O.,
            Missiakas,D. and Golovkina,T.
  TITLE     Deficiency in non-classical major histocompatibility class II-like
            molecule, H2-O confers protection against Staphylococcus aureus in
            mice
  JOURNAL   PLoS Pathog 20 (6), e1012306 (2024)
   PUBMED   38843309
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Song,N., Welsh,R.A. and Sadegh-Nasseri,S.
  TITLE     Proper development of long-lived memory CD4 T cells requires HLA-DO
            function
  JOURNAL   Front Immunol 14, 1277609 (2023)
   PUBMED   37908352
  REMARK    GeneRIF: Proper development of long-lived memory CD4 T cells
            requires HLA-DO function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Lee,J., Cullum,E., Stoltz,K., Bachmann,N., Strong,Z., Millick,D.D.,
            Denzin,L.K., Chang,A., Tarakanova,V., Chervonsky,A.V. and
            Golovkina,T.
  TITLE     Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but
            Controls Murine Gammaherpesvirus MHV68
  JOURNAL   J Immunol 207 (12), 2944-2951 (2021)
   PUBMED   34810225
REFERENCE   4  (bases 1 to 2670)
  AUTHORS   Cullum,E., Graves,A.M., Tarakanova,V.L., Denzin,L.K. and
            Golovkina,T.
  TITLE     MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob
            Gene and Additional Loci
  JOURNAL   J Immunol 207 (1), 5-14 (2021)
   PUBMED   34135064
REFERENCE   5  (bases 1 to 2670)
  AUTHORS   Toulmin,S.A., Bhadiadra,C., Paris,A.J., Lin,J.H., Katzen,J.,
            Basil,M.C., Morrisey,E.E., Worthen,G.S. and Eisenlohr,L.C.
  TITLE     Type II alveolar cell MHCII improves respiratory viral disease
            outcomes while exhibiting limited antigen presentation
  JOURNAL   Nat Commun 12 (1), 3993 (2021)
   PUBMED   34183650
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2670)
  AUTHORS   Karlsson,L. and Peterson,P.A.
  TITLE     The alpha chain gene of H-2O has an unexpected location in the
            major histocompatibility complex
  JOURNAL   J Exp Med 176 (2), 477-483 (1992)
   PUBMED   1354242
REFERENCE   7  (bases 1 to 2670)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Aberrant convergence of the neural folds in the mouse mutant vl
  JOURNAL   Teratology 45 (1), 105-112 (1992)
   PUBMED   1731393
REFERENCE   8  (bases 1 to 2670)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
REFERENCE   9  (bases 1 to 2670)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
REFERENCE   10 (bases 1 to 2670)
  AUTHORS   Harton,J.A., Litaker,W., Frelinger,J.A. and Bishop,G.A.
  TITLE     Structure function analysis of the H-2 Abp gene
  JOURNAL   Immunogenetics 34 (6), 358-365 (1991)
   PUBMED   1748486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205160.1, AK155650.1, AK053233.1 and AF027865.1.
            
            On Jan 28, 2006 this sequence version replaced NM_010389.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155650.1, AK155144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY205160.1         2-27
            27-450              AK155650.1         27-450
            451-821             AK053233.1         500-870
            822-862             AK155650.1         822-862
            863-2670            AF027865.1         78950-80757
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2670
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /note="histocompatibility 2, O region beta locus"
                     /db_xref="GeneID:15002"
                     /db_xref="MGI:MGI:95925"
     exon            1..158
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..883
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /note="H2-IA-beta-2 antigen"
                     /codon_start=1
                     /product="histocompatibility 2, O region beta locus
                     precursor"
                     /protein_id="NP_034519.2"
                     /db_xref="CCDS:CCDS37582.1"
                     /db_xref="GeneID:15002"
                     /db_xref="MGI:MGI:95925"
                     /translation="MGAGRAPWVVALLVNLMRLDSFMIEGRDSPENFVIQAKADCYFT
                     NGTEKVHLLVRFIFNLEEYLHFDSDLGMFVALTELGEPDADQWNKRLDLLETSRAAVN
                     MVCRQKYKLGAPFTVERNVPPEVTVYPERTPLLQQHNLLLCSVTGFYPGDISVKWFRN
                     GQEERSGVMSTGLVRNGDWTFQTTVMLEMIPELGDIYSCLVEHPGLLRPVSVAWMAQS
                     EYSWKKILSGAAVFLLGLIVFLVGVVIHLKAQKASVETQPGNEASRESLHSQP"
     exon            159..428
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..710
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..821
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..850
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..2670
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /note="hexamer: AATAAA"
     polyA_site      2670
                     /gene="H2-Ob"
                     /gene_synonym="A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob;
                     H2-Ab; H2-Ab2; H2-IAb2; Ob; vic1"
                     /note="major polyA site"
ORIGIN      
        1 gtgtggaaga cagctctatt ctaaataggt gtatcagtct cttcattgcc cctttgtccc
       61 ctccagaatg ggcgctggga gggccccctg ggtggtggct ctgttggtga acctcatgag
      121 gctggattcc ttcatgattg aaggcagaga ctccccagag aattttgtga ttcaggcaaa
      181 ggcggactgt tacttcacca atggtacaga aaaggttcac ttgctggtca ggttcatctt
      241 caacctggag gagtatttac acttcgacag tgacctgggg atgtttgtgg ctctgacgga
      301 gctgggggaa cctgatgctg accagtggaa caaacgcctg gatctcctgg agacgagcag
      361 agctgctgtg aacatggtct gcaggcagaa gtacaagctg ggggccccct tcactgtgga
      421 gagaaatgtg cctccagagg tgacagtgta tccagagagg accccgttgc tgcagcagca
      481 caacctgctg ctctgctctg tgacaggctt ctaccccggg gacataagtg tcaagtggtt
      541 ccggaatgga caggaggaga ggtctggggt catgtccact ggccttgtta ggaatggaga
      601 ctggaccttc cagacaacag taatgctgga aatgatccca gagcttggtg acatctacag
      661 ctgcctcgtg gagcaccccg gcctcctgag acctgtttct gtggcatgga tggctcagtc
      721 tgaatattcc tggaaaaaga tactgagtgg agctgcagtg ttcctgcttg ggctgattgt
      781 cttcctggtg ggggttgtta tccatctcaa ggctcagaaa gcatctgtgg agactcagcc
      841 tggcaatgag gcctcaagag agagtctcca ttctcaaccc tagtaagatc ctaatggaag
      901 cctctccccc agagcctgaa gaagtgtgac agggctgagg attcgggttg gcaaaggatg
      961 ctggctcttc agtctgtgag atgtggtcat ggaccttccc tttgtcctgt acctcagtag
     1021 tccctcgttt ccaggacatg gtccagaaac ttccttagga cctaactcat tccacaccca
     1081 agttgctttg gcccaatcct aaccctgtga ctgtggagcc ccaagatttc tatcttccaa
     1141 ccacagcttc tagtcttcca tacagtcacc ttaaaaatcc ttattgtaaa aataaagcag
     1201 tcacaggcaa ccgcagtgaa gtataaatca atgacttgtt caaggcaaaa cccgtgtcat
     1261 cacttgctca ggtcaaaaca caaacagtgg tggtctctgt ggaattcctt atgtgcctca
     1321 gccaataaac acccacagca cacactatcc acgtggggtg attagataca gccaagcata
     1381 cacttatgta tacaagaatc catggtcttt cttgtctccc agactttcag atgttttacg
     1441 tcatcttttc tttctgatag gattaaagct gttgagaagg ctcagcctcc aaggtgaagg
     1501 gttcccacgc tgagatgttg ttgcctacat acatggtgcc atctgataca cgtggtgcca
     1561 tctgacacac tggctgccat ctgacacact cttttaccct ttgtgttttc tatgagttag
     1621 catctgatgc agacttgggg tgagactcta gtctgattgt tttggagtct ggaggaggcc
     1681 atgacctttt ctggagttac agtgtatctc cttgtttttc ctttcatgat gttacaacaa
     1741 gcatcgatgc taattggccc atctgctaat ttactgggga tggctacatt gtgacagtct
     1801 atttctagga ttctttattt atagcatatt gttggctctg ctcaatgtta gctgcagtag
     1861 aagttcaaag ctaatggtgg taaaactgtt ggcatcttaa agtgagtcta gcctgcaggg
     1921 tgctaccgtt gtgtccagtg ctgcaggatt ctgaaacaaa gcactaattt cacttaatag
     1981 tgaccttagt ggagcaatgc attcactggt ttacaaagtc ttgacacctg agtaacatct
     2041 ttttaataag ttgacagttg ggagtgtttc tgctgtatgt agatgggaag gctgttgtaa
     2101 aaattgcttg agttgtgagt aaaactgagc atgcttcatt caatacagca tcattttgtc
     2161 tttgtagaag atatttctta ttaacctttt attgtttgag aattttatac atgagtatta
     2221 tgtgttttga tcaaatccac ccccattcac tcccttctaa tttttccttt ctcctgatca
     2281 catttacctc ccaacttcat atgcgttttt gctttaattc actaagtcaa tgtagttctg
     2341 ctaggattac atgggggcag gtccatctgc ccttaggagc acattcttga agaacatgga
     2401 gtttccctct gcctcagccg tcaactcctc ctcagctaag gttgacactt cacaaatccc
     2461 acctacccat gctgggagtg tggaatgctt gatcttggac atttagaagc gttctaactg
     2521 acttttagct tgttttgcaa taaattacag tttagttggt agtggatttt ctggtgtatt
     2581 ttcattgtct gaagggatac tattttgtct tgaatggtct caacatttgt tctacaatgt
     2641 caataaagaa catccactgt ttgaagtaga
//
