LOCUS       NM_008206               1064 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus histocompatibility 2, O region alpha locus (H2-Oa),
            mRNA.
ACCESSION   NM_008206
VERSION     NM_008206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1064)
  AUTHORS   Song,N., Welsh,R.A. and Sadegh-Nasseri,S.
  TITLE     Proper development of long-lived memory CD4 T cells requires HLA-DO
            function
  JOURNAL   Front Immunol 14, 1277609 (2023)
   PUBMED   37908352
  REMARK    GeneRIF: Proper development of long-lived memory CD4 T cells
            requires HLA-DO function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1064)
  AUTHORS   Lee,J., Cullum,E., Stoltz,K., Bachmann,N., Strong,Z., Millick,D.D.,
            Denzin,L.K., Chang,A., Tarakanova,V., Chervonsky,A.V. and
            Golovkina,T.
  TITLE     Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but
            Controls Murine Gammaherpesvirus MHV68
  JOURNAL   J Immunol 207 (12), 2944-2951 (2021)
   PUBMED   34810225
REFERENCE   3  (bases 1 to 1064)
  AUTHORS   Cullum,E., Graves,A.M., Tarakanova,V.L., Denzin,L.K. and
            Golovkina,T.
  TITLE     MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob
            Gene and Additional Loci
  JOURNAL   J Immunol 207 (1), 5-14 (2021)
   PUBMED   34135064
REFERENCE   4  (bases 1 to 1064)
  AUTHORS   Welsh,R.A., Song,N., Foss,C.A., Boronina,T., Cole,R.N. and
            Sadegh-Nasseri,S.
  TITLE     Lack of the MHC class II chaperone H2-O causes susceptibility to
            autoimmune diseases
  JOURNAL   PLoS Biol 18 (2), e3000590 (2020)
   PUBMED   32069316
  REMARK    GeneRIF: Mouse MHC class II chaperone H2-O antigen affects the
            repertoire of presented self-peptides by B cells and thymic
            epithelium. H2-O induces differential effects on epitope
            presentation and thymic selection, thereby altering CD4 T-cell
            precursor frequencies. Lack of H2-O increases autoreactivity and
            susceptibility to autoimmune disease development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1064)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1064)
  AUTHORS   Liljedahl,M., Winqvist,O., Surh,C.D., Wong,P., Ngo,K., Teyton,L.,
            Peterson,P.A., Brunmark,A., Rudensky,A.Y., Fung-Leung,W.P. and
            Karlsson,L.
  TITLE     Altered antigen presentation in mice lacking H2-O
  JOURNAL   Immunity 8 (2), 233-243 (1998)
   PUBMED   9492004
REFERENCE   7  (bases 1 to 1064)
  AUTHORS   Arimura,Y., Koda,T., Kishi,M. and Kakinuma,M.
  TITLE     Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb
            and H2-Oa
  JOURNAL   Immunogenetics 43 (3), 152-155 (1996)
   PUBMED   8550099
REFERENCE   8  (bases 1 to 1064)
  AUTHORS   Ikegami,H., Makino,S., Yamato,E., Kawaguchi,Y., Ueda,H.,
            Sakamoto,T., Takekawa,K. and Ogihara,T.
  TITLE     Identification of a new susceptibility locus for insulin-dependent
            diabetes mellitus by ancestral haplotype congenic mapping
  JOURNAL   J Clin Invest 96 (4), 1936-1942 (1995)
   PUBMED   7560085
REFERENCE   9  (bases 1 to 1064)
  AUTHORS   Karlsson,L. and Peterson,P.A.
  TITLE     The alpha chain gene of H-2O has an unexpected location in the
            major histocompatibility complex
  JOURNAL   J Exp Med 176 (2), 477-483 (1992)
   PUBMED   1354242
REFERENCE   10 (bases 1 to 1064)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC138996.1, AK020594.1 and CO795887.1.
            
            On Apr 1, 2009 this sequence version replaced NM_008206.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M95514.1, AK020594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               BC138996.1         40-147
            109-1046            AK020594.1         106-1043
            1047-1064           CO795887.1         472-489
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1064
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /note="histocompatibility 2, O region alpha locus"
                     /db_xref="GeneID:15001"
                     /db_xref="MGI:MGI:95924"
     exon            1..150
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /inference="alignment:Splign:2.1.0"
     exon            151..399
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /inference="alignment:Splign:2.1.0"
     exon            400..681
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /inference="alignment:Splign:2.1.0"
     exon            682..817
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1049
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1029..1034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /note="hexamer: ACTAAA"
     polyA_site      1048
                     /gene="H2-Oa"
                     /gene_synonym="H-2Oa"
                     /note="major polyA site"
ORIGIN      
        1 tttcttttta cctcgatctt gctcccttgc ttcccaaaca gacgttgtta gagccactca
       61 ccccagcaat ggtccttttt gtggagctgg tcccggtact cctaaccgca atgagcttcc
      121 tgagtccccg aggagtaagg gccatcaagg ccgaccacat gggctcctat ggaccggcct
      181 tctaccaatc ttacgacgct tctggacagt tcacacacga atttgacggg gaacaaattt
      241 tctccgtgga tctgaagaac gaggaggtcg tgtggcgtct gcctgagttt ggagacttcg
      301 cccactcgga ctttcagagt gggctgatga gcatttccat gatcaaagct catctggaca
      361 tcttggtgga acgctccaac cgaaccagag ctgtcagcgt gcctcccaga gtgaccgttc
      421 tccccaagac tcgtgtggag ctcggaaagc ccaacgtcct catctgcatc gtggatgata
      481 tcttcccgcc tgtgatcaat gtcacctggc tgcgcaacag ccagcccatc actaagggag
      541 tggcccagac cagcttctac tctcagccta accacaggtt ccggaagttc cactacctga
      601 ccttcgtgcc ctctgcggag gatgtgtacg actgcaaggt ggaacactgg ggcctggata
      661 caccgctcct ccagcactgg gagccccaag tgcttacccc accaccggac accatagaga
      721 ccctgatctg tggcctgggc ctggttctcg gccttatggg ctgcctcctg ggcaccgtgc
      781 tcatgatcac aggcacacgc aggcccagta tccgcaggta acttctcttc tgagaaaccc
      841 ttgagagatg attcctggcg gacttctgga agcttctgcg tgctcagcgg cagcctgtga
      901 cagtgttgac ctcgagtggc atcaacctct gttcaccaaa tcccaggaga acattgtggg
      961 cgcagtctcc tgccctggta ccccatttca ctcacagctc cagtgccatc cacagctctg
     1021 gcagccgcac taaattctct taagagtcca aaaaaaaaaa aaaa
//
