LOCUS       NM_013819               1425 bp    mRNA    linear   ROD 14-JUL-2023
DEFINITION  Mus musculus histocompatibility 2, M region locus 3 (H2-M3), mRNA.
ACCESSION   NM_013819
VERSION     NM_013819.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Tamoutounour S, Han SJ, Deckers J, Constantinides MG, Hurabielle C,
            Harrison OJ, Bouladoux N, Linehan JL, Link VM, Vujkovic-Cvijin I,
            Perez-Chaparro PJ, Rosshart SP, Rehermann B, Lazarevic V and
            Belkaid Y.
  TITLE     Keratinocyte-intrinsic MHCII expression controls microbiota-induced
            Th1 cell responses
  JOURNAL   Proc Natl Acad Sci U S A 116 (47), 23643-23652 (2019)
   PUBMED   31672911
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Tanoue T, Morita S, Plichta DR, Skelly AN, Suda W, Sugiura Y,
            Narushima S, Vlamakis H, Motoo I, Sugita K, Shiota A, Takeshita K,
            Yasuma-Mitobe K, Riethmacher D, Kaisho T, Norman JM, Mucida D,
            Suematsu M, Yaguchi T, Bucci V, Inoue T, Kawakami Y, Olle B,
            Roberts B, Hattori M, Xavier RJ, Atarashi K and Honda K.
  TITLE     A defined commensal consortium elicits CD8 T cells and anti-cancer
            immunity
  JOURNAL   Nature 565 (7741), 600-605 (2019)
   PUBMED   30675064
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Linehan JL, Harrison OJ, Han SJ, Byrd AL, Vujkovic-Cvijin I,
            Villarino AV, Sen SK, Shaik J, Smelkinson M, Tamoutounour S,
            Collins N, Bouladoux N, Dzutsev A, Rosshart SP, Arbuckle JH, Wang
            CR, Kristie TM, Rehermann B, Trinchieri G, Brenchley JM, O'Shea JJ
            and Belkaid Y.
  TITLE     Non-classical Immunity Controls Microbiota Impact on Skin Immunity
            and Tissue Repair
  JOURNAL   Cell 172 (4), 784-796 (2018)
   PUBMED   29358051
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Johnson LR, Weizman OE, Rapp M, Way SS and Sun JC.
  TITLE     Epitope-Specific Vaccination Limits Clonal Expansion of
            Heterologous Naive T Cells during Viral Challenge
  JOURNAL   Cell Rep 17 (3), 636-644 (2016)
   PUBMED   27732841
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Lybarger L, Yu YY, Chun T, Wang CR, Grandea AG 3rd, Van Kaer L and
            Hansen TH.
  TITLE     Tapasin enhances peptide-induced expression of H2-M3 molecules, but
            is not required for the retention of open conformers
  JOURNAL   J Immunol 167 (4), 2097-2105 (2001)
   PUBMED   11489993
  REMARK    GeneRIF: The association of H2-M3 molecules with the
            peptide-loading complex of the endoplasmic reticulum is
            dramatically decreased by incubation of live cells with exogenous
            M3 ligands.
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Chiu NM, Chun T, Fay M, Mandal M and Wang CR.
  TITLE     The majority of H2-M3 is retained intracellularly in a
            peptide-receptive state and traffics to the cell surface in the
            presence of N-formylated peptides
  JOURNAL   J Exp Med 190 (3), 423-434 (1999)
   PUBMED   10430630
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Wang CR, Loveland BE and Lindahl KF.
  TITLE     H-2M3 encodes the MHC class I molecule presenting the maternally
            transmitted antigen of the mouse
  JOURNAL   Cell 66 (2), 335-345 (1991)
   PUBMED   1855254
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Ito K, Van Kaer L, Bonneville M, Hsu S, Murphy DB and Tonegawa S.
  TITLE     Recognition of the product of a novel MHC TL region gene (27b) by a
            mouse gamma delta T cell receptor
  JOURNAL   Cell 62 (3), 549-561 (1990)
   PUBMED   2379238
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Richards S, Bucan M, Brorson K, Kiefer MC, Hunt SW 3rd, Lehrach H
            and Lindahl KF.
  TITLE     Genetic and molecular mapping of the Hmt region of mouse
  JOURNAL   EMBO J 8 (12), 3749-3757 (1989)
   PUBMED   2573520
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Brorson KA, Richards S, Hunt SW 3rd, Cheroutre H, Lindahl KF and
            Hood L.
  TITLE     Analysis of a new class I gene mapping to the Hmt region of the
            mouse
  JOURNAL   Immunogenetics 30 (4), 273-283 (1989)
   PUBMED   2793207
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA481305.1, U18797.1 and AI451265.1.
            
            [WARNING] On Sep 19, 2023 this sequence was replaced by
            NM_013819.3.
            
            On Aug 2, 2006 this sequence version replaced NM_013819.1.
            
            CCDS Note: The transcript for this CCDS representation is a
            candidate for nonsense-mediated mRNA decay (NMD) based on the stop
            codon being present 69 nts from the last splice site. However, it
            is likely that NMD escape occurs because the protein is known to be
            functional and is supported by publication data, including PMIDs
            10430630 and 11489993.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031984.1, U18797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 10430630, 11489993
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CA481305.1         38-65
            29-1334             U18797.1           1-1306
            1335-1425           AI451265.1         8-98                c
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..1425
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /note="histocompatibility 2, M region locus 3"
                     /db_xref="GeneID:14991"
                     /db_xref="MGI:MGI:95915"
     exon            1..101
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1039
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /note="MHC class I-b antigen M3"
                     /codon_start=1
                     /product="histocompatibility 2, M region locus 3
                     precursor"
                     /protein_id="NP_038847.1"
                     /db_xref="CCDS:CCDS37617.1"
                     /db_xref="GeneID:14991"
                     /db_xref="MGI:MGI:95915"
                     /translation="MGSSSNRALLHMVVVSLAVTQTGSGSHSLRYFHTAVSRPGRGEP
                     QYISVGYVDDVQFQRCDSIEEIPRMEPRAPWMEKERPEYWKELKLKVKNIAQSARANL
                     RTLLRYYNQSEGGSHILQWMVSCEVGPDMRLLGAHYQAAYDGSDYITLNEDLSSWTAV
                     DMVSQITKSRLESAGTAEYFRAYVEGECLELLHRFLRNGKEILQRADPPKAHVAHHPR
                     PKGDVTLRCWALGFYPADITLTWQKDEEDLTQDMELVETRPSGDGTFQKWAAVVVPSG
                     EEQRYTCYVHHEGLTEPLALKWGRSSQSSVVIMVIVASLVLLGGVITIVVVCKRRGAG
                     ER"
     exon            102..371
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..647
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..923
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1028
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1061
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1108
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1425
                     /gene="H2-M3"
                     /gene_synonym="H-2M3; Hmt; M3a; MuprM3; MuprM301;
                     MuprM302; R4B2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatctaatc agggctacca cgggaaggat ggggtcctca agcaaccgcg ctctcctgca
       61 catggtggtg gtctctttgg ctgttaccca aacaggttct ggctcacatt cactgcgcta
      121 tttccacact gcggtgtcac ggccgggccg tggggagccc cagtatatct ctgtgggcta
      181 tgttgacgac gtgcagtttc agcgctgtga tagcattgag gaaattccga ggatggaacc
      241 tcgtgcacct tggatggaga aggaaagacc agagtactgg aaggagctga aactcaaggt
      301 caagaatatt gcacaaagtg ccagagcaaa ccttcggacc ctgctccgct actacaacca
      361 gagtgaaggc ggctctcaca tcctgcagtg gatggtttcc tgtgaggtag ggccagacat
      421 gcgccttctt ggagcccact atcaggctgc gtatgatggc tcagattaca tcaccctgaa
      481 tgaagacctg agctcctgga ctgcagtgga catggtgtct cagatcacga agagccgttt
      541 agagtcagct ggcacagcag agtacttcag ggcctatgtg gagggagagt gcctggagct
      601 gctccacaga ttcctgcgga atggcaagga gattcttcag cgagcagatc ccccaaaggc
      661 acatgtggcc catcacccga gacccaaagg tgatgttacc ttgaggtgct gggctctggg
      721 cttctaccct gctgacatca ccctgacctg gcagaaggat gaagaggacc tgacccagga
      781 catggagctt gtggaaacga ggccttcagg ggatggaacc ttccagaagt gggcagctgt
      841 ggtggtgcct tctggagagg agcagagata cacatgttat gtgcaccatg aggggctaac
      901 cgagcccctt gccctgaaat ggggaagatc gtctcaatca tctgtcgtca tcatggtcat
      961 cgttgctagt ctggttctcc tgggaggtgt gatcactatt gttgtggtgt gcaagaggag
     1021 gggtgcaggg gaaagatgaa tcagttatac tcagactgcc agcaggaaca gtgattaagt
     1081 tctgatgctt ctttcaccat ttagaaagtt ggcatctcat ggtgtgtctc ctgtcagcac
     1141 agtgtgacaa agtgagcagc ccagggcatc cctgaggact gagtctcctc tccatacctg
     1201 tgtctcctcc ttttctcacc tgtaccacag ggggatccag gacttcttca tcccttgtgg
     1261 aactttaggt ttctatgggc agcttcttcc ctattgaaaa ataaggatgt agatatagct
     1321 ttattattat tatttttttt tttaccttct cgataaaagc tgtacttcat gctgttaaaa
     1381 gtgtaagatt tgtacattgg aaaggaaata aaacatgaaa actca
//
