LOCUS       NM_001403362            1657 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus histocompatibility 2, K1, K region (H2-K1), transcript
            variant 3, mRNA.
ACCESSION   NM_001403362 XM_006523676
VERSION     NM_001403362.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1657)
  AUTHORS   Racine,J.J., Bachman,J.F., Zhang,J.G., Misherghi,A., Khadour,R.,
            Kaisar,S., Bedard,O., Jenkins,C., Abbott,A., Forte,E., Rainer,P.,
            Rosenthal,N., Sattler,S. and Serreze,D.V.
  TITLE     Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8
            Develop Severe Myocarditis and Myositis in Response to Anti-PD-1
            Immune Checkpoint Inhibitor Cancer Therapy
  JOURNAL   J Immunol 212 (8), 1287-1306 (2024)
   PUBMED   38426910
REFERENCE   2  (bases 1 to 1657)
  AUTHORS   Dong,H., He,X., Zhang,L., Chen,W., Lin,Y.C., Liu,S.B., Wang,H.,
            Nguyen,L.X.T., Li,M., Zhu,Y., Zhao,D., Ghoda,L., Serody,J.,
            Vincent,B., Luznik,L., Gojo,I., Zeidner,J., Su,R., Chen,J.,
            Sharma,R., Pirrotte,P., Wu,X., Hu,W., Han,W., Shen,B., Kuo,Y.H.,
            Jin,J., Salhotra,A., Wang,J., Marcucci,G., Luo,Y.L. and Li,L.
  TITLE     Targeting PRMT9-mediated arginine methylation suppresses cancer
            stem cell maintenance and elicits cGAS-mediated anticancer immunity
  JOURNAL   Nat Cancer 5 (4), 601-624 (2024)
   PUBMED   38413714
REFERENCE   3  (bases 1 to 1657)
  AUTHORS   Kim,H.J., Nakagawa,H., Choi,J.Y., Che,X., Divris,A., Liu,Q.,
            Wight,A.E., Zhang,H., Saad,A., Solhjou,Z., Deban,C., Azzi,J.R. and
            Cantor,H.
  TITLE     A narrow T cell receptor repertoire instructs thymic
            differentiation of MHC class Ib-restricted CD8+ regulatory T cells
  JOURNAL   J Clin Invest 134 (1), e170512 (2024)
   PUBMED   37934601
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1657)
  AUTHORS   Zanvit,P., van Dyk,D., Fazenbaker,C., McGlinchey,K., Luo,W.,
            Pezold,J.M., Meekin,J., Chang,C.Y., Carrasco,R.A., Breen,S.,
            Cheung,C.S., Endlich-Frazier,A., Clark,B., Chu,N.J., Vantellini,A.,
            Martin,P.L., Hoover,C.E., Riley,K., Sweet,S.M., Chain,D., Kim,Y.J.,
            Tu,E., Harder,N., Phipps,S., Damschroder,M., Gilbreth,R.N.,
            Cobbold,M., Moody,G. and Bosco,E.E.
  TITLE     Antitumor activity of AZD0754, a dnTGFbetaRII-armored,
            STEAP2-targeted CAR-T cell therapy, in prostate cancer
  JOURNAL   J Clin Invest 133 (22), e169655 (2023)
   PUBMED   37966111
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1657)
  AUTHORS   Manoharan Valerio,M., Arana,K., Guan,J., Chan,S.W., Yang,X.,
            Kurd,N., Lee,A., Shastri,N., Coscoy,L. and Robey,E.A.
  TITLE     The promiscuous development of an unconventional Qa1b-restricted T
            cell population
  JOURNAL   Front Immunol 14, 1250316 (2023)
   PUBMED   38022509
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1657)
  AUTHORS   Hasenkrug,K.J., Kesari,K.V. and Nathenson,S.G.
  TITLE     Unique biochemical properties of a mutant MHC class I molecule,
            H-2Ksm1
  JOURNAL   Mol Immunol 29 (12), 1493-1500 (1992)
   PUBMED   1280760
REFERENCE   7  (bases 1 to 1657)
  AUTHORS   Zheng,J.H., Natsuume-Sakai,S., Takahashi,M. and Nonaka,M.
  TITLE     Insertion of the B2 sequence into intron 13 is the only defect of
            the H-2k C4 gene which causes low C4 production
  JOURNAL   Nucleic Acids Res 20 (19), 4975-4979 (1992)
   PUBMED   1329034
REFERENCE   8  (bases 1 to 1657)
  AUTHORS   Fremont,D.H., Matsumura,M., Stura,E.A., Peterson,P.A. and
            Wilson,I.A.
  TITLE     Crystal structures of two viral peptides in complex with murine MHC
            class I H-2Kb
  JOURNAL   Science 257 (5072), 919-927 (1992)
   PUBMED   1323877
REFERENCE   9  (bases 1 to 1657)
  AUTHORS   Yeom,Y.I., Abe,K. and Artzt,K.
  TITLE     Evolution of the mouse H-2K region: a hot spot of mutation
            associated with genes transcribed in embryos and/or germ cells
  JOURNAL   Genetics 130 (3), 629-638 (1992)
   PUBMED   1348042
REFERENCE   10 (bases 1 to 1657)
  AUTHORS   Eicher,E.M., Cherry,M. and Flaherty,L.
  TITLE     Autosomal phosphoglycerate kinase linked to mouse major
            histocompatibility complex
  JOURNAL   Mol Gen Genet 158 (3), 225-228 (1978)
   PUBMED   628373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5.
            
            On Mar 29, 2022 this sequence version replaced XM_006523676.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.30845.1,
                                           SRR7345562.3086516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                CR974462.5         93366-93456         c
            92-421              CR974462.5         92906-93235         c
            422-697             CR974462.5         92443-92718         c
            698-973             CR974462.5         90457-90732         c
            974-1093            CR974462.5         90210-90329         c
            1094-1126           CR974462.5         89999-90031         c
            1127-1165           CR974462.5         89788-89826         c
            1166-1657           CR974462.5         89184-89675         c
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1657
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /note="histocompatibility 2, K1, K region"
                     /db_xref="GeneID:14972"
                     /db_xref="MGI:MGI:95904"
     exon            1..91
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1197
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; H-2 class I histocompatibility antigen, K-B
                     alpha chain; H-2 class I histocompatibility antigen, K-D
                     alpha chain; H-2 class I histocompatibility antigen, K-K
                     alpha chain; H-2 class I histocompatibility antigen, K-Q
                     alpha chain; H-2K(B); H-2K(K); H-2K(Q); MHC class I heavy
                     chain heavy chain; H-2 class I histocompatibility antigen,
                     K-W28 alpha chain; MHC class I H2-K-b-alpha-2 cell surface
                     glycoprotein; MHC H2-K transplantation antigen; MHC class
                     I heavy chain H2-K; class I major histocompatibility
                     antigen H-2Kd; MHC class I antigen; MHC class II antigen
                     K; MHC class II antigen D; MHC class I heavy chain
                     maturation peptide; histocompatibility 2, K region,
                     promoter 1"
                     /codon_start=1
                     /product="H-2 class I histocompatibility antigen, K-W28
                     alpha chain isoform 3 precursor"
                     /protein_id="NP_001390291.1"
                     /db_xref="GeneID:14972"
                     /db_xref="MGI:MGI:95904"
                     /translation="MVPCTLLLLLAAALAPTQTRAARAAARGLVRWSGSHRAPPPGPH
                     SLRYFVTAVSRPGLGEPRYMEVGYVDDTEFVRFDSDAENPRYEPRARWMEQEGPEYWE
                     RETQKAKGNEQSFRVDLRTLLGYYNQSKGGSHTIQVISGCEVGSDGRLLRGYQQYAYD
                     GCDYIALNEDLKTWTAADMAALITKHKWEQAGEAERLRAYLEGTCVEWLRRYLKNGNA
                     TLLRTDSPKAHVTHHSRPEDKVTLRCWALGFYPADITLTWQLNGEELIQDMELVETRP
                     AGDGTFQKWASVVVPLGKEQYYTCHVYHQGLPEPLTLRWEPPPSTVSNMATVAVLVVL
                     GAAIVTGAVVAFVMKMRRRNTGGKGGDYALAPGSQTSDLSLPDCKVMVHDPHSLA"
     exon            92..421
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     exon            422..697
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     exon            698..973
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1093
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1126
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1165
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1657
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /note="hexamer: AATAAA"
     polyA_site      1645
                     /gene="H2-K1"
                     /gene_synonym="H-2K; H-2K(d); H2-D1; H2-K; K-f"
                     /note="major polyA site"
ORIGIN      
        1 agaagtcgcg aatcgccgac aggtgcgatg gtaccgtgca cgctgctcct gctgttggcg
       61 gccgccctgg ctccgactca gacccgcgcg gcccgcgcag ccgcccgggg tctggtgagg
      121 tggtccgggt ctcaccgcgc gccgccccca ggcccacact cgctgaggta tttcgtcacc
      181 gccgtgtccc ggcccggcct cggggagccc cggtacatgg aagtcggcta cgtggacgac
      241 acggagttcg tgcgcttcga cagcgacgcg gagaatccga gatatgagcc gcgggcgcgg
      301 tggatggagc aggaggggcc cgagtattgg gagcgggaga cacagaaagc caagggcaat
      361 gagcagagtt tccgagtgga cctgaggacc ctgctcggct actacaacca gagcaagggc
      421 ggctctcaca ctattcaggt gatctctggc tgtgaagtgg ggtccgacgg gcgactcctc
      481 cgcgggtacc agcagtacgc ctacgacggc tgcgattaca tcgccctgaa cgaagacctg
      541 aaaacgtgga cggcggcgga catggcggcg ctgatcacca aacacaagtg ggagcaggct
      601 ggtgaagcag agagactcag ggcctacctg gagggcacgt gcgtggagtg gctccgcaga
      661 tacctgaaga acgggaacgc gacgctgctg cgcacagatt ccccaaaggc ccatgtgacc
      721 catcacagca gacctgaaga taaagtcacc ctgaggtgct gggccctggg cttctaccct
      781 gctgacatca ccctgacctg gcagttgaat ggggaggagc tgatccagga catggagctt
      841 gtggagacca ggcctgcagg ggatggaacc ttccagaagt gggcatctgt ggtggtgcct
      901 cttgggaagg agcagtatta cacatgccat gtgtaccatc aggggctgcc tgagcccctc
      961 accctgagat gggagcctcc tccatccact gtctccaaca tggcgaccgt tgctgttctg
     1021 gttgtccttg gagctgcaat agtcactgga gctgtggtgg cttttgtgat gaagatgaga
     1081 aggagaaaca caggtggaaa aggaggggac tatgctctgg ctccaggctc ccagacctct
     1141 gatctgtctc tcccagattg taaagtgatg gttcatgacc ctcattctct agcgtgaaga
     1201 cagctgcctg gagtggactt ggtgacagac aatgtcttct catatctcct gtgacatcca
     1261 gagccctcag ttctctttag tcaagtgtct gatgttccct gtgagcctat ggactcaatg
     1321 tgaagaactg tggagcccag tccacccctc tacaccagga ccctgtccct gcactgctct
     1381 gtcttccctt ccacagccaa ccttgctggt tcagccaaac actgagggac atctgtagcc
     1441 tgtcagctcc atgctaccct gacctgcaac tcctcacttc cacactgaga ataataattt
     1501 gaatgtaacc ttgattgtta tcatcttgac ctagggctga tttcttgtta atttcatgga
     1561 ttgagaatgc ttagaggttt tgtttgtttg tttgattgat ttgttttttt gaagaaataa
     1621 atgatagatg aataaacttc cagaatctgg gtcacta
//
