LOCUS       NM_001033978            3380 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus histocompatibility 2, class II antigen E beta2
            (H2-Eb2), mRNA.
ACCESSION   NM_001033978 XM_355009 XM_359279 XM_901539 XM_903948
VERSION     NM_001033978.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Monzon-Casanova,E., Rudolf,R., Starick,L., Muller,I., Sollner,C.,
            Muller,N., Westphal,N., Miyoshi-Akiyama,T., Uchiyama,T.,
            Berberich,I., Walter,L. and Herrmann,T.
  TITLE     The Forgotten: Identification and Functional Characterization of
            MHC Class II Molecules H2-Eb2 and RT1-Db2
  JOURNAL   J Immunol 196 (3), 988-999 (2016)
   PUBMED   26740108
  REMARK    GeneRIF: our findings suggest that the H2-E2 or RT1-D2 molecules
            could function as Ag-presenting molecules for a particular class of
            Ags, as modulators of Ag presentation like nonclassical
            nonpolymorphic class II molecules
REFERENCE   3  (bases 1 to 3380)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3380)
  AUTHORS   Subramanian,S., Yim,Y.S., Liu,K., Tus,K., Zhou,X.J. and
            Wakeland,E.K.
  TITLE     Epistatic suppression of systemic lupus erythematosus: fine mapping
            of Sles1 to less than 1 mb
  JOURNAL   J Immunol 175 (2), 1062-1072 (2005)
   PUBMED   16002707
REFERENCE   5  (bases 1 to 3380)
  AUTHORS   Eckels,D.D., Bian,T., Gill,J.C. and Sonderstrup,G.
  TITLE     Epitopes of the NS3 protein of hepatitis C virus: recognition in
            HLA-DR4 transgenic mice
  JOURNAL   Immunol Cell Biol 80 (1), 106-112 (2002)
   PUBMED   11869368
REFERENCE   6  (bases 1 to 3380)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 3380)
  AUTHORS   Padgett,K.A., Shreffler,D.C. and Saha,B.K.
  TITLE     Molecular mapping of murine I region recombinants. III. Crossing
            over at two discrete sites within the beta 1-beta 2 intron of the E
            beta gene
  JOURNAL   J Immunol 147 (8), 2764-2770 (1991)
   PUBMED   1918991
REFERENCE   8  (bases 1 to 3380)
  AUTHORS   Acha-Orbea,H. and Scarpellino,L.
  TITLE     Nonobese diabetic and nonobese nondiabetic mice have unique MHC
            class II haplotypes
  JOURNAL   Immunogenetics 34 (1), 57-59 (1991)
   PUBMED   1855817
REFERENCE   9  (bases 1 to 3380)
  AUTHORS   Prochazka,M., Serreze,D.V., Worthen,S.M. and Leiter,E.H.
  TITLE     Genetic control of diabetogenesis in NOD/Lt mice. Development and
            analysis of congenic stocks
  JOURNAL   Diabetes 38 (11), 1446-1455 (1989)
   PUBMED   2576007
REFERENCE   10 (bases 1 to 3380)
  AUTHORS   Delovitch,T.L., Murphy,D.B. and McDevitt,H.O.
  TITLE     Immunochemical evidence for three Ia loci in the I-region of the
            H-2 complex
  JOURNAL   J Exp Med 146 (6), 1549-1560 (1977)
   PUBMED   72779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137912.1 and CR974457.17.
            
            On Apr 14, 2010 this sequence version replaced NM_001033978.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137912.1, BC150834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-777               AK137912.1         2-778
            778-3380            CR974457.17        18874-21476
FEATURES             Location/Qualifiers
     source          1..3380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..3380
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="histocompatibility 2, class II antigen E beta2"
                     /db_xref="GeneID:381091"
                     /db_xref="MGI:MGI:95902"
     exon            1..117
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..881
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="H-2 class II histocompatibility antigen E-a/k
                     beta-2; MHC class II E-beta-2; MHC class II antigen E
                     beta2; MHC class II antigen beta chain"
                     /codon_start=1
                     /product="histocompatibility 2, class II antigen E beta2
                     precursor"
                     /protein_id="NP_001029150.1"
                     /db_xref="CCDS:CCDS28646.1"
                     /db_xref="GeneID:381091"
                     /db_xref="MGI:MGI:95902"
                     /translation="MVSLWLPRGLCVAAVILSLMMLTPPVILVRDPRPRFLEQLKAEC
                     HYFNGKERVWSVTRFIYNQEEFARFNSDFGKFLAVTELGRPIVEYLNTQKDMLDNYRA
                     SVDRCRNNYDLVDIFMLNLKAEPKVTVYPAKTQPLEHHNLLVCSVIDFYPGSIEVRWF
                     RNGEEEKTGVVSTGLIQNRDWTYQTLVMLEMVPRGGEVYTCQVEHPSLTSPVTVEWRA
                     RSTSAQNKLLSGVMGMALGLFILAVGLFFYLRNLRAGSVSHGAGEGAESFTSRLTGSG
                     SECHMGPGLSI"
     exon            118..384
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..666
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..777
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..3380
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="major polyA site"
     regulatory      2181..2186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="hexamer: ATTAAA"
     polyA_site      2203
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="major polyA site"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="hexamer: ATTAAA"
     polyA_site      2433
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="hexamer: CATAAA"
     polyA_site      3328
                     /gene="H2-Eb2"
                     /gene_synonym="A130038H09Rik; H-2Eb2; Ia-5; Ia5; Iebeta2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcctctc ctcaagcatg gtgtctctgt ggctccccag aggcctctgt gtggcagctg
       61 tgatcctgag tctgatgatg ctgacccctc cggtgatttt agtcagggac ccacgaccac
      121 gttttctgga gcagttgaag gctgagtgtc actacttcaa tgggaaggag cgtgtgtgga
      181 gtgtgaccag attcatctat aaccaggaag agtttgcccg ctttaacagt gactttggga
      241 agttcctggc agtgactgag ctggggcggc ccatagttga gtacttgaac acccagaagg
      301 acatgctgga caattatcgt gcctcagtag acaggtgcag aaataactat gaccttgtgg
      361 atatcttcat gttgaactta aaagctgagc ccaaggtgac tgtgtaccct gcaaagacac
      421 agcctctgga acaccataac ctcctggtct gctctgtgat tgacttctac cctggcagca
      481 ttgaagtcag atggttccgg aatggcgagg aggagaagac tggagttgtg tccactggac
      541 tgatccaaaa tagagactgg acctaccaga ccctggtgat gctggagatg gttcctcggg
      601 gtggagaggt ttacacctgc caggtggagc atcccagcct gaccagccct gtcacagtgg
      661 agtggagggc tcggtccaca tctgcacaga acaagttgtt gagcggagtc atgggcatgg
      721 cgctaggtct gttcatcctc gcagtggggc tgttcttcta tttaaggaat ctgagagcag
      781 gatcagtgtc tcatggtgct ggtgaaggag ctgaaagttt cacatccaga ttgacaggca
      841 gtgggagtga atgccacatg gggcctgggt tgagcatctg agacctggaa gccagccctc
      901 agtgacacac tttctccaag actacacctg ctccagaatg ccatatctcc taatagtgcc
      961 actcccactg atcctatggg aaccattttc tttcaaacta ccacattgcc tctcatttaa
     1021 aaacttgcac atggcttgtt agagcagcta agtactacag atgtcatgaa gacagctaga
     1081 aactttttgg atgagtttaa agaggacctg tgacttggtt caaatgatgg gtgtctgctc
     1141 ctctgtgaac ctgcgctgag caggatcctg agagtcagtc tcagtcatgt ttgaagaatt
     1201 agtttcaaaa gtaagaagct agcagtcgcc agtcagctgt ggtgcatgcc tttaatccca
     1261 gcacttggga agcagaggga ggtggatctc tgagtttgag gctagcctgg tctactgagt
     1321 gtgttccagg acagccagag ccacacagag aaaccctgtc tgaaaagaag gagaaggaga
     1381 aggaggagga ggagggggag gaggaggggg aggaggagga ggaggagaag aagcagctag
     1441 caatcagtca taaatctatt taagcctagt tattgatgat ccagggtgat ttacacacaa
     1501 tcacatagaa ttcattttat gttagggcaa attcaagtct ctgttatgca tatggtaaga
     1561 ttcattatgc atttacataa actagatttt ctgataggaa tttgatgagc ttagagtgat
     1621 gttagatgtg tctgacacca aattggtagc ttcaccttag attcaataat ttccttatct
     1681 aataaaactt catggtttac atgtggagtt gaaatactgc ttaatgattc cctttatcag
     1741 taatagagat aaggaatgga tacaaaccag caagtataaa caaacaaaca aacaaacaaa
     1801 tatgttcact ctggttttcc aagcagtttg tatttacaga gtgatctaga gagaatatcg
     1861 tgagtacgtt ccatcttcct gtcgccaagt ctactcttcc ctgtgattag ctacatttat
     1921 attttgctat gatagtttat acttttctaa acaaaaatct tcctagtatg ttgctagtgc
     1981 tgtctgaatg tgcacacaca tatatttttt gatgaaaaat attgtgtact tgtatgtaca
     2041 gacataaaat tctcttcagc agcagcatgc agttgaaagt tgacattttt taatactatt
     2101 gttgaaagta acatggtagt gactttggtt tcatttgttt ctgccagaat tttatttaga
     2161 atgattttgt aacctacatt attaaacttc gtattaatat ctgttttttt cttcctatgt
     2221 atctgattat atgtagagga agcgatgaca attttgtatt cttagacatt ctaatccttt
     2281 ttgtgtattt atttggccat ttgtttcatt gccccattgc atattgttct agataccatg
     2341 tgggatagct ttggatatcc taaccccatg tctgatgtga gaagcaaggc agatgtcttt
     2401 tccaagatca attaaattgc tttttactac agatttcctg agaaaccaga tctctcaaaa
     2461 agaaacaaaa aagaaccaca actttaagac ccagtgcaaa gtccaccacc atccctttta
     2521 tgagtttatg tgggtgaata agtattgttt tatatccatc tctcaattag tacaaattgc
     2581 attaactgat tctcaaatgt tgcaccactc tggcctttct acatagattg atgtctctgg
     2641 atttagtctc taatactttc tcaatagcta agggcacaca cagcagcagc cattgtctct
     2701 gctcctgact gtgtgtgagt gtattccaag cattcattct ctccgtcctt gactctgcat
     2761 gtctatagtc caagcatcca ttctctttgt ccttgactct gcatgtctat agtccaagca
     2821 tccattctct ttgctcctga atgtgcatgg agtgcccttg tgtttctgcc ttgatgttac
     2881 agcagatgtg gctggaatct ggaattgtca atcaatcaat tccatcttcc atcagttgct
     2941 tttgtcagag tgtttgtcat ggtgacagaa aggaagctaa atggactaaa cctggaagca
     3001 gagcccctgg ggctggaaga agggactgag gaagaccttc accagcccga ctccactgac
     3061 ctatttctga agccaagcta accacttcct taatttcaca atcagccact gtagaggatc
     3121 tgaaacatga gactctgcca tagaacccag gctggccctc agtgtcccct ggccatttcc
     3181 taatgcaaag gatgttgtta ccagtggtca ttaccagtgt ccacaatcgc ccctgctctg
     3241 tcattgtcat tagttaccca aggccaggcc ctcacttttg agatttgttc tgctaaggat
     3301 aagcataaaa gccattacaa gagccaaata ataattctca ttctttcctt ttaataaatc
     3361 tgtttggaga gttcatacat
//
