LOCUS       NM_010382               1669 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus histocompatibility 2, class II antigen E beta
            (H2-Eb1), mRNA.
ACCESSION   NM_010382
VERSION     NM_010382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Siret,C., van Lessen,M., Bavais,J., Jeong,H.W., Reddy Samawar,S.K.,
            Kapupara,K., Wang,S., Simic,M., de Fabritus,L., Tchoghandjian,A.,
            Fallet,M., Huang,H., Sarrazin,S., Sieweke,M.H., Stumm,R.,
            Sorokin,L., Adams,R.H., Schulte-Merker,S., Kiefer,F. and van de
            Pavert,S.A.
  TITLE     Deciphering the heterogeneity of the Lyve1+ perivascular
            macrophages in the mouse brain
  JOURNAL   Nat Commun 13 (1), 7366 (2022)
   PUBMED   36450771
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   Hosseini,S., Moody,S.C., Fietz,D., Indumathy,S., Schuppe,H.C.,
            Hedger,M.P. and Loveland,K.L.
  TITLE     The changing landscape of immune cells in the fetal mouse testis
  JOURNAL   Histochem Cell Biol 158 (4), 345-368 (2022)
   PUBMED   35829816
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 1669)
  AUTHORS   Laherty,C.D., O'Rourke,K., Wolf,F.W., Katz,R., Seldin,M.F. and
            Dixit,V.M.
  TITLE     Characterization of mouse thrombospondin 2 sequence and expression
            during cell growth and development
  JOURNAL   J Biol Chem 267 (5), 3274-3281 (1992)
   PUBMED   1371115
REFERENCE   8  (bases 1 to 1669)
  AUTHORS   Malstrom,C.E., Kotsenas,A.L. and Jones,B.
  TITLE     Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B
            cell lymphoma
  JOURNAL   Immunogenetics 36 (4), 238-247 (1992)
   PUBMED   1353478
REFERENCE   9  (bases 1 to 1669)
  AUTHORS   Bryda,E.C., DePari,J.A., Sant'Angelo,D.B., Murphy,D.B. and
            Passmore,H.C.
  TITLE     Multiple sites of crossing over within the Eb recombinational
            hotspot in the mouse
  JOURNAL   Mamm Genome 2 (2), 123-129 (1992)
   PUBMED   1347471
REFERENCE   10 (bases 1 to 1669)
  AUTHORS   Murphy,D.B., Herzenberg,L.A., Okumura,K., Herzenberg,L.A. and
            McDevitt,H.O.
  TITLE     A new I subregion (I-J) marked by a locus (Ia-4) controlling
            surface determinants on suppressor T lymphocytes
  JOURNAL   J Exp Med 144 (3), 699-712 (1976)
   PUBMED   1085338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202562.1, AK160485.1 and CAAA01111730.1.
            
            On Sep 15, 2006 this sequence version replaced NM_010382.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155968.1, AK005018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY202562.1         1-56
            57-1192             AK160485.1         2-1137
            1193-1669           CAAA01111730.1     11513-11989
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1669
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /note="histocompatibility 2, class II antigen E beta"
                     /db_xref="GeneID:14969"
                     /db_xref="MGI:MGI:95901"
     exon            1..181
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /inference="alignment:Splign:2.1.0"
     exon            182..451
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..733
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /inference="alignment:Splign:2.1.0"
     exon            734..844
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /inference="alignment:Splign:2.1.0"
     exon            845..868
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1669
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1174..1179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /note="hexamer: AATAAA"
     polyA_site      1195
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /note="major polyA site"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /note="hexamer: AATAAA"
     polyA_site      1669
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
ORIGIN      
        1 ttattatctt agcaatgagt aaagagaata aagttacagt ctgaagcttg ccttcccctc
       61 tgactcctgt gtctcctctc ctgcagcatg gtgtggctcc ccagagttcc ctgtgtggca
      121 gctgtgatcc tgttgctgac agtgctgagc cctccagtgg ctttggtcag agactccaga
      181 ccatggtttt tggaatactg taaatctgag tgtcatttct acaacgggac gcagcgcgtg
      241 cggcttctgg aaagatactt ctacaacctg gaggagaacc tgcgcttcga cagcgacgtg
      301 ggcgagttcc gcgcggtgac cgagctgggg cggccagacg ccgagaactg gaacagccag
      361 ccggagttcc tggagcaaaa gcgggccgag gtggacacgg tgtgcagaca caactatgag
      421 atctcggata aattccttgt gcggcggaga gttgagccta cggtgactgt gtaccccaca
      481 aagacacagc ccctggaaca ccacaacctc ctggtctgct ctgtgagtga cttctaccct
      541 ggcaacattg aagtcagatg gttccggaat ggcaaggagg agaaaacagg aattgtgtcc
      601 acgggcctgg tccgaaatgg agactggacc ttccagacac tggtgatgct ggagacggtt
      661 cctcagagtg gagaggttta cacctgccag gtggagcatc ccagcctgac cgaccctgtc
      721 acggtcgagt ggaaagcaca atccacatct gcacagaaca agatgttgag tggagttggg
      781 ggcttcgtgc tgggcctgct cttcctggga gcggggctgt tcatctactt caggaaccag
      841 aaaggacagt ctggacttca gccaacagga ctcctgagct gagatgaagt aacaaggctg
      901 aaggaaggaa ttccccccgt gtctccatgc catgaaaaca tgtcctgctt ggcccacatc
      961 cctccagaga cactgctctt ccaggacctg gctcctcctg attctccacc ctggagatct
     1021 gtgctcctga tggctgttta tccctgaccc aggccttgca gctcccagga cagaggcccc
     1081 actcttcaca tctcctgtcc ccttttgtcc cttgcctttt gtctggcact tctgagccag
     1141 tctgctgtca tatgcttttt tacatttttc tcaaataaac aaataatgaa agtcatctgc
     1201 ttcatagagt ttcaagcaga agaaacagta aaaagaaaga caggacccac tataagacac
     1261 tgttcatgca taattgtaga tgccagcagc tacatgaact gggctcctga aaggaaagct
     1321 ggggctgtat gggtgggggg ggggtggcga gagaagaatg agaccaagac aaagtttctg
     1381 atgaaggtcc aatgtttaca ttttgaatct gaacctaaag cggcggggga cccatcccct
     1441 actatgccag gttctcctgg cttgtcagaa tctcctcagg aaaacaaact cagcctctca
     1501 gcagatgtgg caggacaata gatgttccct acgtcagaag actccaccct atgtgggcta
     1561 gcaggctgtg gcatgaacaa ggtctaaatc agcctgctca aggctgggag aaggcacaca
     1621 taataagcat gggagttatt gtataagaaa taaattcagt tttaattca
//
