LOCUS       NP_034512                264 aa            linear   ROD 27-APR-2025
DEFINITION  H-2 class II histocompatibility antigen, I-E beta chain precursor
            [Mus musculus].
ACCESSION   NP_034512
VERSION     NP_034512.2
DBSOURCE    REFSEQ: accession NM_010382.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 264)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 264)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   3  (residues 1 to 264)
  AUTHORS   Siret,C., van Lessen,M., Bavais,J., Jeong,H.W., Reddy Samawar,S.K.,
            Kapupara,K., Wang,S., Simic,M., de Fabritus,L., Tchoghandjian,A.,
            Fallet,M., Huang,H., Sarrazin,S., Sieweke,M.H., Stumm,R.,
            Sorokin,L., Adams,R.H., Schulte-Merker,S., Kiefer,F. and van de
            Pavert,S.A.
  TITLE     Deciphering the heterogeneity of the Lyve1+ perivascular
            macrophages in the mouse brain
  JOURNAL   Nat Commun 13 (1), 7366 (2022)
   PUBMED   36450771
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 264)
  AUTHORS   Hosseini,S., Moody,S.C., Fietz,D., Indumathy,S., Schuppe,H.C.,
            Hedger,M.P. and Loveland,K.L.
  TITLE     The changing landscape of immune cells in the fetal mouse testis
  JOURNAL   Histochem Cell Biol 158 (4), 345-368 (2022)
   PUBMED   35829816
REFERENCE   5  (residues 1 to 264)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 264)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (residues 1 to 264)
  AUTHORS   Laherty,C.D., O'Rourke,K., Wolf,F.W., Katz,R., Seldin,M.F. and
            Dixit,V.M.
  TITLE     Characterization of mouse thrombospondin 2 sequence and expression
            during cell growth and development
  JOURNAL   J Biol Chem 267 (5), 3274-3281 (1992)
   PUBMED   1371115
REFERENCE   8  (residues 1 to 264)
  AUTHORS   Malstrom,C.E., Kotsenas,A.L. and Jones,B.
  TITLE     Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B
            cell lymphoma
  JOURNAL   Immunogenetics 36 (4), 238-247 (1992)
   PUBMED   1353478
REFERENCE   9  (residues 1 to 264)
  AUTHORS   Bryda,E.C., DePari,J.A., Sant'Angelo,D.B., Murphy,D.B. and
            Passmore,H.C.
  TITLE     Multiple sites of crossing over within the Eb recombinational
            hotspot in the mouse
  JOURNAL   Mamm Genome 2 (2), 123-129 (1992)
   PUBMED   1347471
REFERENCE   10 (residues 1 to 264)
  AUTHORS   Murphy,D.B., Herzenberg,L.A., Okumura,K., Herzenberg,L.A. and
            McDevitt,H.O.
  TITLE     A new I subregion (I-J) marked by a locus (Ia-4) controlling
            surface determinants on suppressor T lymphocytes
  JOURNAL   J Exp Med 144 (3), 699-712 (1976)
   PUBMED   1085338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202562.1, AK160485.1 and CAAA01111730.1.
            
            On Sep 15, 2006 this sequence version replaced NP_034512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155968.1, AK005018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..264
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     Protein         1..264
                     /product="H-2 class II histocompatibility antigen, I-E
                     beta chain precursor"
                     /note="H-2 class II histocompatibility antigen, I-E beta
                     chain; MHC class II IE-b; cell surface glycoprotein; MHC
                     H2-IE-beta cell surface glycoprotein; major
                     histocompatibility complex H-2E beta chain; I-E beta MHC
                     class II; histocompatibility 2, class II antigen E beta,
                     promoter 1"
                     /calculated_mol_wt=27513
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2658
     Region          27..121
                     /region_name="Beta-1"
                     /note="propagated from UniProtKB/Swiss-Prot (P04230.1)"
     Region          40..114
                     /region_name="MHC_II_beta"
                     /note="Class II histocompatibility antigen, beta domain;
                     pfam00969"
                     /db_xref="CDD:425967"
     Site            46
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04230.1)"
     Region          118..216
                     /region_name="IgC1_MHC_II_beta_I-E"
                     /note="Class II major histocompatibility complex (MHC)
                     beta chain immunoglobulin domain of histocompatibility
                     antigen (HLA) I-E; member of the C1-set of Ig superfamily
                     (IgSF) domains; cd20998"
                     /db_xref="CDD:409590"
     Region          122..225
                     /region_name="Beta-2"
                     /note="propagated from UniProtKB/Swiss-Prot (P04230.1)"
     Region          123..131
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409590"
     Site            order(129,147..148,150,176..183)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409590"
     Region          141..150
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409590"
     Site            order(150,178..180,182)
                     /site_type="other"
                     /note="MHC binding domain interface [polypeptide binding]"
                     /db_xref="CDD:409590"
     Region          154..160
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409590"
     Region          162..165
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409590"
     Region          169..177
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409590"
     Region          180..190
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409590"
     Region          197..204
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409590"
     Region          211..215
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409590"
     Site            226..246
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P04230.1)"
     CDS             1..264
                     /gene="H2-Eb1"
                     /gene_synonym="Eb; H-2Eb; H2Eb; Ia-4; Ia4"
                     /coded_by="NM_010382.2:88..882"
                     /db_xref="CCDS:CCDS37584.1"
                     /db_xref="GeneID:14969"
                     /db_xref="MGI:MGI:95901"
ORIGIN      
        1 mvwlprvpcv aavillltvl sppvalvrds rpwfleycks echfyngtqr vrlleryfyn
       61 leenlrfdsd vgefravtel grpdaenwns qpefleqkra evdtvcrhny eisdkflvrr
      121 rveptvtvyp tktqplehhn llvcsvsdfy pgnievrwfr ngkeektgiv stglvrngdw
      181 tfqtlvmlet vpqsgevytc qvehpsltdp vtvewkaqst saqnkmlsgv ggfvlgllfl
      241 gaglfiyfrn qkgqsglqpt glls
//
