LOCUS       NM_010388               1411 bp    mRNA    linear   ROD 11-OCT-2020
DEFINITION  Mus musculus histocompatibility 2, class II, locus Mb2 (H2-DMb2),
            transcript variant 1, mRNA.
ACCESSION   NM_010388
VERSION     NM_010388.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1411)
  AUTHORS   Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H,
            Stuart JM and Gu W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1411)
  AUTHORS   Logunova N, Korotetskaya M, Polshakov V and Apt A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1411)
  AUTHORS   Lankar D, Vincent-Schneider H, Briken V, Yokozeki T, Raposo G and
            Bonnerot C.
  TITLE     Dynamics of major histocompatibility complex class II compartments
            during B cell receptor-mediated cell activation
  JOURNAL   J Exp Med 195 (4), 461-472 (2002)
   PUBMED   11854359
REFERENCE   4  (bases 1 to 1411)
  AUTHORS   Walter W, Scheuer C, Loos M, Reichert TE and Maeurer MJ.
  TITLE     H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal
            in I-A(q) molecules from autoimmune-prone DBA/1 mice
  JOURNAL   J Biol Chem 276 (14), 11086-11091 (2001)
   PUBMED   11148202
REFERENCE   5  (bases 1 to 1411)
  AUTHORS   Walter W, Lingnau K, Schmitt E, Loos M and Maeurer MJ.
  TITLE     MHC class II antigen presentation pathway in murine tumours: tumour
            evasion from immunosurveillance?
  JOURNAL   Br J Cancer 83 (9), 1192-1201 (2000)
   PUBMED   11027433
REFERENCE   6  (bases 1 to 1411)
  AUTHORS   Lindstedt R, Liljedahl M, Peleraux A, Peterson PA and Karlsson L.
  TITLE     The MHC class II molecule H2-M is targeted to an endosomal
            compartment by a tyrosine-based targeting motif
  JOURNAL   Immunity 3 (5), 561-572 (1995)
   PUBMED   7584146
REFERENCE   7  (bases 1 to 1411)
  AUTHORS   Hermel E, Yuan J and Monaco JJ.
  TITLE     Characterization of polymorphism within the H2-M MHC class II loci
  JOURNAL   Immunogenetics 42 (2), 136-142 (1995)
   PUBMED   7607704
REFERENCE   8  (bases 1 to 1411)
  AUTHORS   Cho SG, Attaya M and Monaco JJ.
  TITLE     New class II-like genes in the murine MHC
  JOURNAL   Nature 353 (6344), 573-576 (1991)
   PUBMED   1922366
REFERENCE   9  (bases 1 to 1411)
  AUTHORS   Cho S, Attaya M, Brown MG and Monaco JJ.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
REFERENCE   10 (bases 1 to 1411)
  AUTHORS   Strathmann M, Wilkie TM and Simon MI.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 86 (19), 7407-7409 (1989)
   PUBMED   2508088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974422.14.
            
            On Feb 22, 2019 this sequence version replaced NM_010388.4.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154923.1, BC145385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               CR974422.14        12364-12585
            223-504             CR974422.14        14766-15047
            505-789             CR974422.14        15666-15950
            790-906             CR974422.14        17621-17737
            907-942             CR974422.14        17905-17940
            943-1411            CR974422.14        18200-18668
FEATURES             Location/Qualifiers
     source          1..1411
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1411
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /note="histocompatibility 2, class II, locus Mb2"
                     /db_xref="GeneID:15000"
                     /db_xref="MGI:MGI:95923"
     exon            1..222
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..953
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /note="H2-M beta2; MHC class II antigen Mb2"
                     /codon_start=1
                     /product="histocompatibility 2, class II, locus Mb2
                     precursor"
                     /protein_id="NP_034518.1"
                     /db_xref="CCDS:CCDS37580.1"
                     /db_xref="GeneID:15000"
                     /db_xref="MGI:MGI:95923"
                     /translation="MAALWLLLLVLSLHCMGAGGFVAHVESTCVLNDAGTPQDFTYCV
                     SFNKDLLACWDPDVGKIVPCEFGVLSRLAEIISNILNEQESLIHRLQNGLQDCATHTQ
                     PFWDVLTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHS
                     NKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVK
                     VSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLPGSTYPEGRH"
     exon            223..504
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..789
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..906
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..942
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1411
                     /gene="H2-DMb2"
                     /gene_synonym="H-2Mb2; H2-Mb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgactcgggg ccacataggc agcaaggagc aaggggcctg agcaagaggt accatattta
       61 cctcagtgtg tgaagatcat ttgcccaggc tggggcagga gagaacctga ggcccttgca
      121 ggaggtgccc aggggcctgg ccttcctgca ccttcagaga gtggaacatg gctgcactct
      181 ggctgctgct gctggtcctc agtctgcact gtatgggggc aggtggcttt gtggctcatg
      241 tggaaagcac gtgcgtgctg aatgatgctg ggaccccaca ggacttcaca tactgtgttt
      301 ccttcaacaa agatctgctg gcctgctggg atccagatgt gggaaaaata gtcccctgtg
      361 aatttggggt gctgtctaga ttggctgaaa taatttcaaa tatcctcaac gaacaggaga
      421 gccttattca tcgcttgcaa aacgggcttc aggactgtgc cacccacacc caacctttct
      481 gggatgtgct gacccacaga acgagagcgc catctgtccg agtagcccaa accacacctt
      541 ttaacacaag ggagcccgtg atgctggcct gctacgtctg gggcttctat ccagcggatg
      601 tgaccatcac atggatgaag aatgggcagc ttgtcccttc ccacagcaac aaggagaaga
      661 cggctcagcc caatggagac tggacatacc agacagtctc ctacctagcc ctaacccctt
      721 cctacgggga cgtctacacc tgcgtggttc agcacagcgg gacctctgag cccatccgcg
      781 gggactggac acctgggctg tcccccatcc agacagtgaa ggtctctgtg tctgcagcca
      841 ccctgggcct gggcttcatc atcttctgtg ttggcttctt cagatggcgc aagtctcatt
      901 cctccagcta cactcctctc cccggatcca cctacccaga aggacggcac tagaaagcag
      961 aacccagaac caaggagatt cagactcctg aggattcctt catgccccca atatcttcag
     1021 gacaccccat tttcttgtgt catactgcct ctattcagtt tcccttccca atgtaatttt
     1081 ttttttgttt tttgtttttt tgagacaggg tttctctgta tagccctggc tgtcctggaa
     1141 ctcactttgt agaccaggct ggcctcaaac tcagaaatcc acctgcctct gcctccagag
     1201 tgctgggatt aaaggcgtac gccaccatgc ccggcttccg atgtgtaaca gcttgggagg
     1261 tattcataat gaagtctgtc tcaggtgttt tctgaagtga gctgatctaa ggagggggtt
     1321 caaggtcttc tgagagcccc tccttgtcac aagggcaccg tgtcataggt ggtcactaag
     1381 aaataaactg gtggaattcc tggcttcccc c
//
