LOCUS       NM_010387               1284 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus histocompatibility 2, class II, locus Mb1 (H2-DMb1),
            mRNA.
ACCESSION   NM_010387
VERSION     NM_010387.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Walter,W., Scheuer,C., Loos,M., Reichert,T.E. and Maeurer,M.J.
  TITLE     H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal
            in I-A(q) molecules from autoimmune-prone DBA/1 mice
  JOURNAL   J Biol Chem 276 (14), 11086-11091 (2001)
   PUBMED   11148202
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Walter,W., Lingnau,K., Schmitt,E., Loos,M. and Maeurer,M.J.
  TITLE     MHC class II antigen presentation pathway in murine tumours: tumour
            evasion from immunosurveillance?
  JOURNAL   Br J Cancer 83 (9), 1192-1201 (2000)
   PUBMED   11027433
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   O'Riordan,M. and Grosschedl,R.
  TITLE     Coordinate regulation of B cell differentiation by the
            transcription factors EBF and E2A
  JOURNAL   Immunity 11 (1), 21-31 (1999)
   PUBMED   10435576
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Lindstedt,R., Liljedahl,M., Peleraux,A., Peterson,P.A. and
            Karlsson,L.
  TITLE     The MHC class II molecule H2-M is targeted to an endosomal
            compartment by a tyrosine-based targeting motif
  JOURNAL   Immunity 3 (5), 561-572 (1995)
   PUBMED   7584146
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Hermel,E., Yuan,J. and Monaco,J.J.
  TITLE     Characterization of polymorphism within the H2-M MHC class II loci
  JOURNAL   Immunogenetics 42 (2), 136-142 (1995)
   PUBMED   7607704
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Cho,S.G., Attaya,M. and Monaco,J.J.
  TITLE     New class II-like genes in the murine MHC
  JOURNAL   Nature 353 (6344), 573-576 (1991)
   PUBMED   1922366
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032745.1.
            
            On Jul 2, 2014 this sequence version replaced NM_010387.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032745.1, AK170866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1284              AK032745.1         2-1285
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1284
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /note="histocompatibility 2, class II, locus Mb1"
                     /db_xref="GeneID:14999"
                     /db_xref="MGI:MGI:95922"
     exon            1..263
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..994
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /note="class II histocompatibility antigen, M beta 1
                     chain; H2-M beta 1 chain; H2-M beta1; MHC class II antigen
                     Mb1"
                     /codon_start=1
                     /product="class II histocompatibility antigen, M beta 1
                     chain precursor"
                     /protein_id="NP_034517.2"
                     /db_xref="CCDS:CCDS37581.1"
                     /db_xref="GeneID:14999"
                     /db_xref="MGI:MGI:95922"
                     /translation="MAALWLLLLVLSLDCMGAGGFVAHVESTCVLDDAGTPQDFTYCV
                     SFNKDLLACWDPDVGKIVPCEFGVLYPWAENFSRILNKEESLLQRLQNGLLDCASHTQ
                     PFWNALTHRTRAPSVRVAQTTPFNTREPVMLACYVWGFYPADVTITWMKNGQLVPSHS
                     NKEKTAQPNGDWTYQTVSYLALTPSYGDVYTCVVQHSGTSEPIRGDWTPGLSPIQTVK
                     VSVSAATLGLGFIIFCVGFFRWRKSHSSSYTPLSGSTYPEGQH"
     exon            264..545
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..830
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..947
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..983
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1284
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /note="hexamer: AATAAA"
     polyA_site      1278
                     /gene="H2-DMb1"
                     /gene_synonym="H-2Mb1; H2-Mb1"
                     /note="major polyA site"
ORIGIN      
        1 gagttactgg gtacaagttt aggatctcag gaggggctga gtgacttggc gccacataag
       61 cagcaaggag caaggggcct gagcaagagg taccatattt acctcagtgt gtgaagatca
      121 tttgtccagg ctggggcagg agagaacctg aggcccctgc aggaggtgcc caggggcctg
      181 gccttcctgc accttcagag agtgaaacat ggctgcactc tggctgctgc tgctggtcct
      241 cagtctggac tgtatggggg caggtggctt tgtggctcat gtggaaagca cgtgcgtgct
      301 ggatgatgct gggaccccac aggacttcac atactgtgtt tccttcaaca aagatctgct
      361 ggcctgctgg gatccagatg tgggaaaaat agtcccctgt gaatttgggg tgctgtatcc
      421 atgggccgaa aatttttcaa ggatcctcaa caaagaagag agccttctcc agcgtttgca
      481 aaacgggctt ctggactgtg cctcccacac ccagcccttc tggaatgcgc tgacccacag
      541 aacgagagcg ccatctgtcc gagtagccca aaccacacct tttaacacaa gggagccggt
      601 gatgctggcc tgctacgtct ggggcttcta tccagcggat gtgaccatca catggatgaa
      661 gaatgggcag cttgtccctt cccacagcaa caaggagaag acggctcagc ccaatggaga
      721 ctggacatac cagacagtct cctacctagc cctaacccct tcctacgggg acgtctacac
      781 ctgcgtggtt cagcacagcg ggacctctga gcccatccga ggggactgga cacctgggct
      841 gtcccccatc cagacagtga aggtctctgt gtctgcagcc accctgggcc tgggcttcat
      901 catcttctgt gttggcttct tcagatggcg caagtctcat tcctccagct acactcctct
      961 ctctggatcc acctacccgg aaggacagca ttagagagca gaacccggaa ccaaggagat
     1021 tcagactcct gaggattcct taatgcccca acatcttcag gacaccccac tttcttgtgt
     1081 catactgcct ctattcaggt ccccttcctg aaataaatat tagtagtttg ggggggtatt
     1141 tataatgaag tctgtcccag gtgggggagc tgaggtgagc tgaaatgagg tgggggttca
     1201 aggcctcctg agagcccctc cttgtcacga gggcaccgtg tcttaggtga tcactaagaa
     1261 ataaactggt ggacttttga tttc
//
