LOCUS       NM_010386               1658 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus histocompatibility 2, class II, locus DMa (H2-DMa),
            transcript variant 2, mRNA.
ACCESSION   NM_010386
VERSION     NM_010386.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1658)
  AUTHORS   Zhou,X., Jia,X., Huang,Z., Yang,C., Li,J., Xie,W., He,X., Ying,W.,
            Liu,C., Liu,Y., Liao,K., Hong,Y., Chen,X.L., Zhang,T., Xia,N.,
            Liu,W.H., Fu,G. and Xiao,C.
  TITLE     MHC class II regulation of CD8+ T cell tolerance and implications
            in autoimmunity and cancer immunotherapy
  JOURNAL   Cell Rep 42 (11), 113452 (2023)
   PUBMED   37976163
REFERENCE   2  (bases 1 to 1658)
  AUTHORS   Postoak,J.L., Song,W., Yang,G., Guo,X., Xiao,S., Saffold,C.E.,
            Zhang,J., Joyce,S., Manley,N.R., Wu,L. and Van Kaer,L.
  TITLE     Thymic epithelial cells require lipid kinase Vps34 for CD4 but not
            CD8 T cell selection
  JOURNAL   J Exp Med 219 (10) (2022)
   PUBMED   35997680
REFERENCE   3  (bases 1 to 1658)
  AUTHORS   Kedmi,R., Najar,T.A., Mesa,K.R., Grayson,A., Kroehling,L., Hao,Y.,
            Hao,S., Pokrovskii,M., Xu,M., Talbot,J., Wang,J., Germino,J.,
            Lareau,C.A., Satpathy,A.T., Anderson,M.S., Laufer,T.M.,
            Aifantis,I., Bartleson,J.M., Allen,P.M., Paidassi,H., Gardner,J.M.,
            Stoeckius,M. and Littman,D.R.
  TITLE     A RORgammat+ cell instructs gut microbiota-specific Treg cell
            differentiation
  JOURNAL   Nature 610 (7933), 737-743 (2022)
   PUBMED   36071167
  REMARK    Erratum:[Nature. 2022 Oct;610(7931):E7. doi:
            10.1038/s41586-022-05358-w.. PMID: 36151471]
REFERENCE   4  (bases 1 to 1658)
  AUTHORS   Akagbosu,B., Tayyebi,Z., Shibu,G., Paucar Iza,Y.A., Deep,D.,
            Parisotto,Y.F., Fisher,L., Pasolli,H.A., Thevin,V., Elmentaite,R.,
            Knott,M., Hemmers,S., Jahn,L., Friedrich,C., Verter,J., Wang,Z.M.,
            van den Brink,M., Gasteiger,G., Grunewald,T.G.P., Marie,J.C.,
            Leslie,C., Rudensky,A.Y. and Brown,C.C.
  TITLE     Novel antigen-presenting cell imparts Treg-dependent tolerance to
            gut microbiota
  JOURNAL   Nature 610 (7933), 752-760 (2022)
   PUBMED   36070798
REFERENCE   5  (bases 1 to 1658)
  AUTHORS   Toulmin,S.A., Bhadiadra,C., Paris,A.J., Lin,J.H., Katzen,J.,
            Basil,M.C., Morrisey,E.E., Worthen,G.S. and Eisenlohr,L.C.
  TITLE     Type II alveolar cell MHCII improves respiratory viral disease
            outcomes while exhibiting limited antigen presentation
  JOURNAL   Nat Commun 12 (1), 3993 (2021)
   PUBMED   34183650
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1658)
  AUTHORS   Lindstedt,R., Liljedahl,M., Peleraux,A., Peterson,P.A. and
            Karlsson,L.
  TITLE     The MHC class II molecule H2-M is targeted to an endosomal
            compartment by a tyrosine-based targeting motif
  JOURNAL   Immunity 3 (5), 561-572 (1995)
   PUBMED   7584146
REFERENCE   7  (bases 1 to 1658)
  AUTHORS   Hermel,E., Yuan,J. and Monaco,J.J.
  TITLE     Characterization of polymorphism within the H2-M MHC class II loci
  JOURNAL   Immunogenetics 42 (2), 136-142 (1995)
   PUBMED   7607704
REFERENCE   8  (bases 1 to 1658)
  AUTHORS   Cho,S.G., Attaya,M. and Monaco,J.J.
  TITLE     New class II-like genes in the murine MHC
  JOURNAL   Nature 353 (6344), 573-576 (1991)
   PUBMED   1922366
REFERENCE   9  (bases 1 to 1658)
  AUTHORS   Cho,S., Attaya,M., Brown,M.G. and Monaco,J.J.
  TITLE     A cluster of transcribed sequences between the Pb and Ob genes of
            the murine major histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5197-5201 (1991)
   PUBMED   1711220
REFERENCE   10 (bases 1 to 1658)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146950.1 and CR974422.14.
            
            On Oct 5, 2012 this sequence version replaced NM_010386.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146950.1, SRR7345562.4913078.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1637              AK146950.1         2-1638
            1638-1658           CR974422.14        6196-6216
FEATURES             Location/Qualifiers
     source          1..1658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1658
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /note="histocompatibility 2, class II, locus DMa"
                     /db_xref="GeneID:14998"
                     /db_xref="MGI:MGI:95921"
     exon            1..103
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            104..680
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /inference="alignment:Splign:2.1.0"
     CDS             593..1378
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /note="class II histocompatibility antigen, M alpha chain;
                     histocompatibility 2, class II, locus Ma; H2-M alpha; MHC
                     class II antigen DMa"
                     /codon_start=1
                     /product="class II histocompatibility antigen, M alpha
                     chain precursor"
                     /protein_id="NP_034516.3"
                     /db_xref="CCDS:CCDS37579.1"
                     /db_xref="GeneID:14998"
                     /db_xref="MGI:MGI:95921"
                     /translation="MEHEQKSGAVLLRLLRLLWLLPHSWAVLEASTPVFWDDPQNHTF
                     RHTLFCQDGIPNIGLSETYDEDELFSFDFSQNTRVPRLPDFAEWAQGQGDASAIAFDK
                     SFCEMLMREVSPKLEGQIPVSRGLPVAEVFTLKPLEFGKPNTLVCFISNLFPPTLTVN
                     WQLHSAPVEGASPTSISAVDGLTFQAFSYLNFTPEPFDLYSCTVTHEIDRYTAIAYWV
                     PQNALPSDLLENALCGVAFGLGVLGTIMGIVFFLCSQRPCSGD"
     exon            681..965
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1244
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1373
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1658
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1617..1622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /note="hexamer: AATAAA"
     polyA_site      1640
                     /gene="H2-DMa"
                     /gene_synonym="H-2Ma; H2-Ma"
                     /note="major polyA site"
ORIGIN      
        1 ggcactttct ggccagaatc cgcggggccc catgctgtgg tcccaggagg cacgcgggtc
       61 ctggctgcag cagcgggact gcagggcgag cctccctgga acgggtgaag ttgattccaa
      121 gtactcagct atggaagatg caacctaaaa cgagagacct gctgcgctcc tcttggaatt
      181 tgtagcctca cattcaatgc caactttctt tggaaggaga cttgggaggg tctgagagcc
      241 atgaggatgg tgctgaaaag actcgattcc gttctggaat tctgccgcca ggcggcgctg
      301 ctttgaagag ccaggcagct acctgctgga gcccgacctt ccaccagggg gcggaggtct
      361 ccagagaggc cctccgggcc ccgctggcct cggagccaag tcttaaagag gagcctggac
      421 ccaagcttct cctcagcgac tgatgatgtt aaactatacg cttctgtgat tggtttagcc
      481 gtggtaagac gggctgctat tggagatgct ctgttgaaac gtgatggatc tggaagggag
      541 ctgggcaccc gacactcgag tggtagctcc catttactgt gggtgttaag gtatggagca
      601 tgagcagaag tcaggagctg tgctgctgag gctgctgcgc cttctgtggc tgctgcccca
      661 ctcctgggcg gtgctcgaag catctacacc agtgttctgg gatgacccac agaaccacac
      721 attccggcac actctattct gccaggacgg gattcccaac atagggctct cggagaccta
      781 tgacgaggac gaactcttct ccttcgactt ctcccagaac accagagtgc cccgactgcc
      841 tgactttgca gagtgggctc agggacaggg ggatgcctct gccattgcat ttgacaaaag
      901 cttctgcgag atgttgatgc gggaagtgag cccgaagctt gaaggtcaaa tcccagtgtc
      961 cagaggtttg cctgtggcag aggtattcac actgaagccc ctggagtttg gcaagcccaa
     1021 cacgttggtc tgtttcatca gcaacctctt tccaccgacc ctgaccgtga actggcagct
     1081 tcactcggcc cctgtggagg gagccagccc cacatccatc tcagctgtcg atgggctgac
     1141 cttccaggct ttctcttatt taaacttcac accggaaccc tttgaccttt actcctgcac
     1201 tgtgacacac gagattgacc gctacacggc aattgcctat tgggtacccc agaacgccct
     1261 gccttcggat ctcctagaga atgccctgtg tggtgtggcc tttggcctcg gtgtgctagg
     1321 caccatcatg ggcattgtct tcttcctctg ctcccagaga ccgtgctcag gtgactgatt
     1381 cttctcaagg agatcttgga acagcacagg ccaggccagc ggggatgtcc aggcatctcg
     1441 tgactaccca aggtctctca tcggagccga agtcccaggg atccctcagg gtgtgtgcca
     1501 gcgtgcaggt gtctcagctg agggttccgc tgtccctgga cttgcatcca gaagagcctt
     1561 catcaggagc cccaggctcc acctaaccac taccttatac cttccctctt ccaggaaata
     1621 aacttcattt cttaatgtca gcgtgacctc tccctcca
//
