LOCUS       NM_010380               1736 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus histocompatibility 2, D region locus 1 (H2-D1), mRNA.
ACCESSION   NM_010380 NM_001034908 XM_289851
VERSION     NM_010380.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1736)
  AUTHORS   Racine,J.J., Bachman,J.F., Zhang,J.G., Misherghi,A., Khadour,R.,
            Kaisar,S., Bedard,O., Jenkins,C., Abbott,A., Forte,E., Rainer,P.,
            Rosenthal,N., Sattler,S. and Serreze,D.V.
  TITLE     Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8
            Develop Severe Myocarditis and Myositis in Response to Anti-PD-1
            Immune Checkpoint Inhibitor Cancer Therapy
  JOURNAL   J Immunol 212 (8), 1287-1306 (2024)
   PUBMED   38426910
REFERENCE   2  (bases 1 to 1736)
  AUTHORS   Dong,H., He,X., Zhang,L., Chen,W., Lin,Y.C., Liu,S.B., Wang,H.,
            Nguyen,L.X.T., Li,M., Zhu,Y., Zhao,D., Ghoda,L., Serody,J.,
            Vincent,B., Luznik,L., Gojo,I., Zeidner,J., Su,R., Chen,J.,
            Sharma,R., Pirrotte,P., Wu,X., Hu,W., Han,W., Shen,B., Kuo,Y.H.,
            Jin,J., Salhotra,A., Wang,J., Marcucci,G., Luo,Y.L. and Li,L.
  TITLE     Targeting PRMT9-mediated arginine methylation suppresses cancer
            stem cell maintenance and elicits cGAS-mediated anticancer immunity
  JOURNAL   Nat Cancer 5 (4), 601-624 (2024)
   PUBMED   38413714
REFERENCE   3  (bases 1 to 1736)
  AUTHORS   Middelburg,J., Ghaffari,S., Schoufour,T.A.W., Sluijter,M.,
            Schaap,G., Goynuk,B., Sala,B.M., Al-Tamimi,L., Scheeren,F.,
            Franken,K.L.M.C., Akkermans,J.J.L.L., Cabukusta,B., Joosten,S.A.,
            Derksen,I., Neefjes,J., van der Burg,S.H., Achour,A.,
            Wijdeven,R.H.M., Weidanz,J. and van Hall,T.
  TITLE     The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by
            inflammatory signals, whereas LILRB1/2 receptors are peptide
            indifferent
  JOURNAL   Cell Rep 42 (12), 113516 (2023)
   PUBMED   38048225
REFERENCE   4  (bases 1 to 1736)
  AUTHORS   Zanvit,P., van Dyk,D., Fazenbaker,C., McGlinchey,K., Luo,W.,
            Pezold,J.M., Meekin,J., Chang,C.Y., Carrasco,R.A., Breen,S.,
            Cheung,C.S., Endlich-Frazier,A., Clark,B., Chu,N.J., Vantellini,A.,
            Martin,P.L., Hoover,C.E., Riley,K., Sweet,S.M., Chain,D., Kim,Y.J.,
            Tu,E., Harder,N., Phipps,S., Damschroder,M., Gilbreth,R.N.,
            Cobbold,M., Moody,G. and Bosco,E.E.
  TITLE     Antitumor activity of AZD0754, a dnTGFbetaRII-armored,
            STEAP2-targeted CAR-T cell therapy, in prostate cancer
  JOURNAL   J Clin Invest 133 (22), e169655 (2023)
   PUBMED   37966111
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1736)
  AUTHORS   Manoharan Valerio,M., Arana,K., Guan,J., Chan,S.W., Yang,X.,
            Kurd,N., Lee,A., Shastri,N., Coscoy,L. and Robey,E.A.
  TITLE     The promiscuous development of an unconventional Qa1b-restricted T
            cell population
  JOURNAL   Front Immunol 14, 1250316 (2023)
   PUBMED   38022509
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1736)
  AUTHORS   Brownstein,D.G., Bhatt,P.N., Gras,L. and Budris,T.
  TITLE     Serial backcross analysis of genetic resistance to mousepox, using
            marker loci for Rmp-2 and Rmp-3
  JOURNAL   J Virol 66 (12), 7073-7079 (1992)
   PUBMED   1433507
REFERENCE   7  (bases 1 to 1736)
  AUTHORS   Cai,Z. and Pease,L.R.
  TITLE     Structural and functional analysis of three D/L-like class I
            molecules from H-2v: indications of an ancestral family of D/L
            genes
  JOURNAL   J Exp Med 175 (2), 583-596 (1992)
   PUBMED   1370689
REFERENCE   8  (bases 1 to 1736)
  AUTHORS   Tummuru,U., Zubairu,M.K. and Lee,D.R.
  TITLE     The multi-locus H-2Dw16 region has an organization distinct from
            the Dd region
  JOURNAL   Immunogenetics 35 (5), 296-308 (1992)
   PUBMED   1348492
REFERENCE   9  (bases 1 to 1736)
  AUTHORS   Hammerling,G.J., Hammerling,U. and Flaherty,L.
  TITLE     Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla
            region and identified by monoclonal antibodies
  JOURNAL   J Exp Med 150 (1), 108-116 (1979)
   PUBMED   312902
REFERENCE   10 (bases 1 to 1736)
  AUTHORS   Vandeberg,J.L. and Klein,J.
  TITLE     Localization of mouse Pgk-2 gene at the D end of the H-2 complex
            (1)
  JOURNAL   J Exp Zool 203 (2), 319-324 (1978)
   PUBMED   624931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK159572.1, BY225620.1 and BY579672.1.
            
            On or before Mar 20, 2007 this sequence version replaced
            NM_001034908.1, NM_010380.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK159572.1         2-2
            2-98                BY225620.1         2-98
            99-1521             AK159572.1         100-1522
            1522-1736           BY579672.1         218-432
FEATURES             Location/Qualifiers
     source          1..1736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.61 cM"
     gene            1..1736
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /note="histocompatibility 2, D region locus 1"
                     /db_xref="GeneID:14964"
                     /db_xref="MGI:MGI:95896"
     exon            1..93
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..363
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..639
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..915
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1032
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1065
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1104
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1736
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /note="hexamer: AATAAG"
     polyA_site      1595
                     /gene="H2-D1"
                     /gene_synonym="H-2D; H2-D; H2-K1"
                     /note="major polyA site"
ORIGIN      
        1 tcagacaccc gggatcccag atgggggcga tggctccgcg cacgctgctc ctgctgctgg
       61 cggccgccct ggccccgact cagacccgcg cgggcccaca ctcgatgcgg tatttcgaga
      121 ccgccgtgtc ccggcccggc ctcgaggagc cccggtacat ctctgtcggc tatgtggaca
      181 acaaggagtt cgtgcgcttc gacagcgacg cggagaatcc gagatatgag ccgcgggcgc
      241 cgtggatgga gcaggagggg ccggagtatt gggagcggga aacacagaaa gccaagggcc
      301 aagagcagtg gttccgagtg agcctgagga acctgctcgg ctactacaac cagagcgcgg
      361 gcggctctca cacactccag cagatgtctg gctgtgactt ggggtcggac tggcgcctcc
      421 tccgcgggta cctgcagttc gcctatgaag gccgcgatta catcgccctg aacgaagacc
      481 tgaaaacgtg gacggcggcg gacatggcgg cgcagatcac ccgacgcaag tgggagcaga
      541 gtggtgctgc agagcattac aaggcctacc tggagggcga gtgcgtggag tggctccaca
      601 gatacctgaa gaacgggaac gcgacgctgc tgcgcacaga ttccccaaag gcacatgtga
      661 cccatcaccc cagatctaaa ggtgaagtca ccctgaggtg ctgggccctg ggcttctacc
      721 ctgctgacat caccctgacc tggcagttga atggggagga gctgacccag gacatggagc
      781 ttgtggagac caggcctgca ggggatggaa ccttccagaa gtgggcatct gtggtggtgc
      841 ctcttgggaa ggagcagaat tacacatgcc gtgtgtacca tgaggggctg cctgagcccc
      901 tcaccctgag atgggagcct cctccgtcca ctgactctta catggtgatc gttgctgttc
      961 tgggtgtcct tggagctatg gccatcattg gagctgtggt ggcttttgtg atgaagagaa
     1021 ggagaaacac aggtggaaaa ggaggggact atgctctggc tccaggctcc cagagctctg
     1081 aaatgtctct ccgagattgt aaagcgtgaa gacagctgcc tggactgtac tgagtgacag
     1141 acgatgtgtt caggtctctc ctgtgacatc cagagccctc agttctcttt acacaacatt
     1201 gtctgatgtt ccctgtgagc ttgggttcag tgtgaagaac tgtggagccc agcctgccct
     1261 gcacaccagg accctatccc tgcactgccc tgtgttccct tccatagcca accttgctgc
     1321 tccagccaaa cactggggga catctgcatc ctgtaagctc catgctaccc tgagctgcag
     1381 ctcctcactt ccacactgag aataataatt tgaatgtggg tggctggaga gatggctcag
     1441 cgctgactgc tcttccaaag gtcctgagtt caaatcccag caaccacatg gtggctcaca
     1501 accatctgta atgggatcta acaccctctt ctgcagtgtc tgaagacagc tacagtgtac
     1561 ttacatataa taataaataa gtctttaaaa aataatttga aagtgacctt gattgttaac
     1621 atcttgatct agggctgatt tcttgttaat ttcatggatt gagaatgctt agaggttttt
     1681 ttgtttgttt gattgatttt tttgaagaaa taaatggcag atgaaggaac ttccag
//
