LOCUS       NM_207105               1193 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus histocompatibility 2, class II antigen A, beta 1
            (H2-Ab1), mRNA.
ACCESSION   NM_207105 NM_010379
VERSION     NM_207105.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1193)
  AUTHORS   Zubiaur,M., Terron-Camero,L.C., Gordillo-Gonzalez,F.,
            Andres-Leon,E., Barroso-Del Jesus,A., Canet-Antequera,L.M., Perez
            Sanchez-Canete,M.M., Martinez-Blanco,A., Dominguez-Pantoja,M.,
            Botia-Sanchez,M., Perez-Cabrera,S., Bello-Iglesias,N., Alcina,A.,
            Abadia-Molina,A.C., Matesanz,F., Zumaquero,E., Merino,R. and
            Sancho,J.
  TITLE     CD38 deficiency leads to a defective short-lived transcriptomic
            response to chronic graft-versus-host disease induction, involving
            purinergic signaling-related genes and distinct transcriptomic
            signatures associated with lupus
  JOURNAL   Front Immunol 16, 1441981 (2025)
   PUBMED   39995666
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1193)
  AUTHORS   Canesso,M.C.C., Castro,T.B.R., Nakandakari-Higa,S., Lockhart,A.,
            Luehr,J., Bortolatto,J., Parsa,R., Esterhazy,D., Lyu,M., Liu,T.T.,
            Murphy,K.M., Sonnenberg,G.F., Reis,B.S., Victora,G.D. and Mucida,D.
  TITLE     Identification of antigen-presenting cell-T cell interactions
            driving immune responses to food
  JOURNAL   Science, eado5088 (2024) In press
   PUBMED   39700315
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1193)
  AUTHORS   Al-Omari,A.A., Cook,K.W., Symonds,P., Skinner,A., Wright,A.,
            Zhu,Y., Coble,V.L., Mohammed,O.J., Choudhury,R.H., Uddin,N.,
            Ranglani,P., Parry,A., Adams,S.E., Lynn,G.M., Durrant,L.G. and
            Brentville,V.A.
  TITLE     Modi-2 a vaccine stimulating CD4 responses to homocitrullinated
            self epitopes as therapy for solid cancers
  JOURNAL   NPJ Vaccines 9 (1), 236 (2024)
   PUBMED   39604380
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1193)
  AUTHORS   Wang,Y., Zhang,S., Kang,N., Dong,L., Ni,H., Liu,S., Chong,S.,
            Ji,Z., Wan,Z., Chen,X., Wang,F., Lu,Y., Hou,B., Tong,P., Qi,H.,
            Xu,M.M. and Liu,W.
  TITLE     Progressive polyadenylation and m6A modification of Ighg1 mRNA
            maintain IgG1 antibody homeostasis in antibody-secreting cells
  JOURNAL   Immunity 57 (11), 2547-2564 (2024)
   PUBMED   39476842
REFERENCE   5  (bases 1 to 1193)
  AUTHORS   Rosenlehner,T., Pennavaria,S., Akcabozan,B., Jahani,S.,
            O'Neill,T.J., Krappmann,D., Straub,T., Kranich,J. and Obst,R.
  TITLE     Reciprocal regulation of mTORC1 signaling and ribosomal
            biosynthesis determines cell cycle progression in activated T cells
  JOURNAL   Sci Signal 17 (859), eadi8753 (2024)
   PUBMED   39436996
  REMARK    Erratum:[Sci Signal. 2024 Dec 17;17(867):eadu7437. doi:
            10.1126/scisignal.adu7437. PMID: 39689184]
REFERENCE   6  (bases 1 to 1193)
  AUTHORS   Miki,N., Hatano,M., Wakita,K., Imoto,S., Nishikawa,S., Nishikawa,S.
            and Tokuhisa,T.
  TITLE     Role of I-A molecules in early stages of B cell maturation
  JOURNAL   J Immunol 149 (3), 801-807 (1992)
   PUBMED   1378867
REFERENCE   7  (bases 1 to 1193)
  AUTHORS   Infante,A.J., Levcovitz,H., Gordon,V., Wall,K.A., Thompson,P.A. and
            Krolick,K.A.
  TITLE     Preferential use of a T cell receptor V beta gene by acetylcholine
            receptor reactive T cells from myasthenia gravis-susceptible mice
  JOURNAL   J Immunol 148 (11), 3385-3390 (1992)
   PUBMED   1375242
REFERENCE   8  (bases 1 to 1193)
  AUTHORS   Sertic,J., Zaleska-Rutczynska,Z., Vincek,V., Nadeau,J.H.,
            Figueroa,F. and Klein,J.
  TITLE     Mapping of six DNA markers on mouse chromosome 17
  JOURNAL   Mamm Genome 2 (2), 138-142 (1992)
   PUBMED   1347473
REFERENCE   9  (bases 1 to 1193)
  AUTHORS   McKenzie,I.F., Morgan,G.M., Sandrin,M.S., Michaelides,M.M.,
            Melvold,R.W. and Kohn,H.I.
  TITLE     B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse
  JOURNAL   J Exp Med 150 (6), 1323-1338 (1979)
   PUBMED   159937
REFERENCE   10 (bases 1 to 1193)
  AUTHORS   Shreffler,D.C. and David,C.S.
  TITLE     The H-2 major histocompatibility complex and the I immune response
            region: genetic variation, function, and organization
  JOURNAL   Adv Immunol 20, 125-195 (1975)
   PUBMED   47219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205244.1, AK077436.1, CK330363.1 and BB056841.1.
            
            On Apr 22, 2010 this sequence version replaced NM_207105.2.
            
            Sequence Note: This record matches the C57BL/6J reference assembly
            sequence and represents the b haplotype of this gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171281.1, AK077436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BY205244.1         20-32
            14-540              AK077436.1         2-528
            541-763             CK330363.1         423-645             c
            764-1185            AK077436.1         752-1173
            1186-1193           BB056841.1         233-240
FEATURES             Location/Qualifiers
     source          1..1193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1193
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /note="histocompatibility 2, class II antigen A, beta 1"
                     /db_xref="GeneID:14961"
                     /db_xref="MGI:MGI:103070"
     exon            1..179
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..883
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /note="H-2 class II histocompatibility antigen, A beta
                     chain; response to metastatic cancers 1; MHC class II
                     H2-IA-beta-psi; major histocompatibility complex class II
                     beta chain; histocompatibility 2, class II antigen A,
                     beta, promoter 1"
                     /codon_start=1
                     /product="histocompatibility 2, class II antigen A, beta 1
                     precursor"
                     /protein_id="NP_996988.2"
                     /db_xref="CCDS:CCDS37583.1"
                     /db_xref="GeneID:14961"
                     /db_xref="MGI:MGI:103070"
                     /translation="MALQIPSLLLSAAVVVLMVLSSPGTEGGDSERHFVYQFMGECYF
                     TNGTQRIRYVTRYIYNREEYVRYDSDVGEHRAVTELGRPDAEYWNSQPEILERTRAEL
                     DTVCRHNYEGPETHTSLRRLEQPNVVISLSRTEALNHHNTLVCSVTDFYPAKIKVRWF
                     RNGQEETVGVSSTQLIRNGDWTFQVLVMLEMTPRRGEVYTCHVEHPSLKSPITVEWRA
                     QSESAWSKMLSGIGGCVLGVIFLGLGLFIRHRSQKGPRGPPPAGLLQ"
     exon            180..452
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..734
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..845
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..869
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1193
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1164..1169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="H2-Ab1"
                     /gene_synonym="Abeta; H-2Ab; H2-Ab; I-Abeta; Ia-2; Ia2;
                     IAb; Rmcs1"
                     /note="major polyA site"
ORIGIN      
        1 atcactccag gctacagaac tttgctttct gaagggggca cagcaggtgt gagtcctggt
       61 gactgccatt acctgtgcct tagagatggc tctgcagatc cccagcctcc tcctctcggc
      121 tgctgtggtg gtgctgatgg tgctgagcag cccagggact gagggcggag actccgaaag
      181 gcatttcgtg taccagttca tgggcgagtg ctacttcacc aacgggacgc agcgcatacg
      241 atatgtgacc agatacatct acaaccggga ggagtacgtg cgctacgaca gcgacgtggg
      301 cgagcaccgc gcggtgaccg agctggggcg gccagacgcc gagtactgga acagccagcc
      361 ggagatcctg gagcgaacgc gggccgagct ggacacggtg tgcagacaca actacgaggg
      421 gccggagacc cacacctccc tgcggcggct tgaacagccc aatgtcgtca tctccctgtc
      481 caggacagag gccctcaacc accacaacac tctggtctgc tcagtgacag atttctaccc
      541 agccaagatc aaagtgcgct ggttccggaa tggccaggag gagacggtgg gggtctcatc
      601 cacacagctt attaggaatg gggactggac cttccaggtc ctggtcatgc tggagatgac
      661 ccctcggcgg ggagaggtct acacctgtca cgtggagcat cccagcctga agagccccat
      721 cactgtggag tggagggcac agtctgagtc tgcctggagc aagatgttga gcggcatcgg
      781 gggctgcgtg cttggggtga tcttcctcgg gcttggcctt ttcatccgtc acaggagtca
      841 gaaaggacct cgaggccctc ctccagcagg gctcctgcag tgactcagag tgttttgact
      901 cagttgactg tctcagactg taagacctga atgtctctgc tccgaattcc tgactgccag
      961 tccacctgcc actccgactc agagtctagc atggtactat tgtatccacc acctcagctc
     1021 ttgtgatctg gagtccccca gtctctgtct gtagctctgc tccttggtga ttccagagac
     1081 tccatctgtg tacagccgca ccccaggctt tctgtcttcg atctgtagta aaccaatgta
     1141 tgcttatccc cacctagatt acaaataaac gagactcaga ctctggttat ttg
//
