LOCUS       NM_010378               1128 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus histocompatibility 2, class II antigen A, alpha
            (H2-Aa), mRNA.
ACCESSION   NM_010378 NM_023145
VERSION     NM_010378.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1128)
  AUTHORS   Shi,H., Medler,D., Wang,J., Browning,R., Liu,A., Schneider,S.,
            Duran Bojorquez,C., Kumar,A., Li,X., Quan,J., Ludwig,S.,
            Moresco,J.J., Xing,C., Moresco,E.M.Y. and Beutler,B.
  TITLE     Suppression of melanoma by mice lacking MHC-II: Mechanisms and
            implications for cancer immunotherapy
  JOURNAL   J Exp Med 221 (12) (2024)
   PUBMED   39470607
REFERENCE   2  (bases 1 to 1128)
  AUTHORS   Ubogu,E.E., Conner,J.A., Wang,Y., Yadav,D. and Saunders,T.L.
  TITLE     Development of a major histocompatibility complex class II
            conditional knockout mouse to study cell-specific and
            time-dependent adaptive immune responses in peripheral nerves
  JOURNAL   Muscle Nerve 70 (3), 420-433 (2024)
   PUBMED   38922958
REFERENCE   3  (bases 1 to 1128)
  AUTHORS   Yadav,D., Conner,J.A., Wang,Y., Saunders,T.L. and Ubogu,E.E.
  TITLE     A novel inducible von Willebrand Factor Cre recombinase mouse
            strain to study microvascular endothelial cell-specific biological
            processes in vivo
  JOURNAL   Vascul Pharmacol 155, 107369 (2024)
   PUBMED   38554988
REFERENCE   4  (bases 1 to 1128)
  AUTHORS   Szeto,C., Zareie,P., Wirasinha,R.C., Zhang,J.B., Nguyen,A.T.,
            Riboldi-Tunnicliffe,A., La Gruta,N.L., Gras,S. and Daley,S.R.
  TITLE     Covalent TCR-peptide-MHC interactions induce T cell activation and
            redirect T cell fate in the thymus
  JOURNAL   Nat Commun 13 (1), 4951 (2022)
   PUBMED   35999236
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1128)
  AUTHORS   Schriek,P., Ching,A.C., Moily,N.S., Moffat,J., Beattie,L.,
            Steiner,T.M., Hosking,L.M., Thurman,J.M., Holers,V.M., Ishido,S.,
            Lahoud,M.H., Caminschi,I., Heath,W.R., Mintern,J.D. and
            Villadangos,J.A.
  TITLE     Marginal zone B cells acquire dendritic cell functions by
            trogocytosis
  JOURNAL   Science 375 (6581), eabf7470 (2022)
   PUBMED   35143312
REFERENCE   6  (bases 1 to 1128)
  AUTHORS   Spencer,J.S., McCormack,J.E. and Kubo,R.T.
  TITLE     Characterization of defective I-A surface expression in a mixed
            isotype expressing murine B cell lymphoma: continued expression of
            E alpha d A beta d despite competition from restored A alpha d A
            beta d pairs
  JOURNAL   Int Immunol 4 (8), 905-915 (1992)
   PUBMED   1329933
REFERENCE   7  (bases 1 to 1128)
  AUTHORS   Acha-Orbea,H. and Scarpellino,L.
  TITLE     Nonobese diabetic and nonobese nondiabetic mice have unique MHC
            class II haplotypes
  JOURNAL   Immunogenetics 34 (1), 57-59 (1991)
   PUBMED   1855817
REFERENCE   8  (bases 1 to 1128)
  AUTHORS   Hanson,I.M. and Trowsdale,J.
  TITLE     Colinearity of novel genes in the class II regions of the MHC in
            mouse and human
  JOURNAL   Immunogenetics 34 (1), 5-11 (1991)
   PUBMED   1855816
REFERENCE   9  (bases 1 to 1128)
  AUTHORS   Delovitch,T.L., Murphy,D.B. and McDevitt,H.O.
  TITLE     Immunochemical evidence for three Ia loci in the I-region of the
            H-2 complex
  JOURNAL   J Exp Med 146 (6), 1549-1560 (1977)
   PUBMED   72779
REFERENCE   10 (bases 1 to 1128)
  AUTHORS   Shreffler,D.C. and David,C.S.
  TITLE     The H-2 major histocompatibility complex and the I immune response
            region: genetic variation, function, and organization
  JOURNAL   Adv Immunol 20, 125-195 (1975)
   PUBMED   47219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974422.14, AK002532.1 and BY604245.1.
            
            On Jul 13, 2018 this sequence version replaced NM_010378.2.
            
            Sequence Note: This record matches the C57BL/6J reference assembly
            sequence and represents the b haplotype of this gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031711.1, AK002532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                CR974422.14        154854-154938       c
            86-1121             AK002532.1         85-1120
            1122-1128           BY604245.1         405-411
FEATURES             Location/Qualifiers
     source          1..1128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..1128
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /note="histocompatibility 2, class II antigen A, alpha"
                     /db_xref="GeneID:14960"
                     /db_xref="MGI:MGI:95895"
     exon            1..142
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..828
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /note="H-2 class II histocompatibility antigen, A-B alpha
                     chain; H-2 class II histocompatibility antigen, A-F alpha
                     chain; MHC class II antigen alpha chain; H-2 class II
                     histocompatibility antigen, A-K alpha chain; H-2 class II
                     histocompatibility antigen, A-Q alpha chain; H-2 class II
                     histocompatibility antigen, A-R alpha chain; H-2 class II
                     histocompatibility antigen, A-S alpha chain; H-2 class II
                     histocompatibility antigen, A-U alpha chain; MHC-II I-A(d)
                     alpha; major histocompatibility protein class II alpha
                     chain; histocompatibility 2, class II antigen A, alpha,
                     promoter 1"
                     /codon_start=1
                     /product="histocompatibility 2, class II antigen A, alpha
                     precursor"
                     /protein_id="NP_034508.2"
                     /db_xref="CCDS:CCDS28645.1"
                     /db_xref="GeneID:14960"
                     /db_xref="MGI:MGI:95895"
                     /translation="MPRSRALILGVLALTTMLSLCGGEDDIEADHVGTYGISVYQSPG
                     DIGQYTFEFDGDELFYVDLDKKETVWMLPEFGQLASFDPQGGLQNIAVVKHNLGVLTK
                     RSNSTPATNEAPQATVFPKSPVLLGQPNTLICFVDNIFPPVINITWLRNSKSVADGVY
                     ETSFFVNRDYSFHKLSYLTFIPSDDDIYDCKVEHWGLEEPVLKHWEPEIPAPMSELTE
                     TVVCALGLSVGLVGIVVGTIFIIQGLRSGGTSRHPGPL"
     exon            143..391
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            392..673
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            674..848
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1128
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1096..1101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /note="hexamer: AATAAA"
     polyA_site      1121
                     /gene="H2-Aa"
                     /gene_synonym="Aalpha; H-2Aa; H2Aa; I-Aalpha; Ia-1; Ia1;
                     IAalpha"
                     /note="major polyA site"
ORIGIN      
        1 cctcacaatc tcttgaagac tcaggagagc agcttcagag acctcccaga gaccaggatg
       61 ccgcgcagca gagctctgat tctgggggtc ctcgccctga ccaccatgct cagcctctgt
      121 ggaggtgaag acgacattga ggccgaccac gtaggcacct atggtataag tgtatatcag
      181 tctcctggag acattggcca gtacacattt gaatttgatg gtgatgagtt gttctatgtg
      241 gacttggata agaaggagac tgtctggatg cttcctgagt ttggccaatt ggcaagcttt
      301 gacccccaag gtggactgca aaacatagct gtagtaaaac acaacttggg agtcttgact
      361 aagaggtcaa attccacccc agctaccaat gaggctcctc aagcgactgt gttccccaag
      421 tcccctgtgc tgctgggtca gcccaacacc ctcatctgct ttgtggacaa catcttccct
      481 cctgtgatca acatcacatg gctcagaaat agcaagtcag tcgcagacgg tgtttatgag
      541 accagcttct tcgtcaaccg tgactattcc ttccacaagc tgtcttatct caccttcatc
      601 ccttctgacg atgacattta tgactgcaag gtggaacact ggggcctgga ggagccggtt
      661 ctgaaacact gggaacctga gattccagcc cccatgtcag agctgacaga gactgtggtc
      721 tgtgccctgg ggttgtctgt gggccttgtg ggcatcgtgg tgggcaccat cttcatcatt
      781 caaggcctgc gatcaggtgg cacctccaga cacccagggc ctttatgagt cacaccctgg
      841 aaaggaaggc gtgtgtccct cttcagggaa gaagtggtgt gctgggtgac ctggcacagt
      901 gtgttttctg gaccaattca tggtgttctt tctcttcttc aagtgacccc caacttgctt
      961 ttctcttgac cctgaggctg tccctctcac agctcacaca cccttggaat tcttccctga
     1021 tctgaatttt gttttctgtc atcttccaag ttacatctac tgcagactct ctcagagacc
     1081 ctgatccaca aaaccaataa aatctcttct tatatgttgt ctactggg
//
