LOCUS       NM_018792                864 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus H1.9 linker histone (H1f9), mRNA.
ACCESSION   NM_018792
VERSION     NM_018792.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 864)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   2  (bases 1 to 864)
  AUTHORS   Talbert,P.B., Ahmad,K., Almouzni,G., Ausio,J., Berger,F.,
            Bhalla,P.L., Bonner,W.M., Cande,W.Z., Chadwick,B.P., Chan,S.W.,
            Cross,G.A., Cui,L., Dimitrov,S.I., Doenecke,D., Eirin-Lopez,J.M.,
            Gorovsky,M.A., Hake,S.B., Hamkalo,B.A., Holec,S., Jacobsen,S.E.,
            Kamieniarz,K., Khochbin,S., Ladurner,A.G., Landsman,D.,
            Latham,J.A., Loppin,B., Malik,H.S., Marzluff,W.F., Pehrson,J.R.,
            Postberg,J., Schneider,R., Singh,M.B., Smith,M.M., Thompson,E.,
            Torres-Padilla,M.E., Tremethick,D.J., Turner,B.M., Waterborg,J.H.,
            Wollmann,H., Yelagandula,R., Zhu,B. and Henikoff,S.
  TITLE     A unified phylogeny-based nomenclature for histone variants
  JOURNAL   Epigenetics Chromatin 5, 7 (2012)
   PUBMED   22650316
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 864)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 864)
  AUTHORS   Turner,L.M., Chuong,E.B. and Hoekstra,H.E.
  TITLE     Comparative analysis of testis protein evolution in rodents
  JOURNAL   Genetics 179 (4), 2075-2089 (2008)
   PUBMED   18689890
REFERENCE   5  (bases 1 to 864)
  AUTHORS   Iguchi,N., Tanaka,H., Yamada,S., Nishimura,H. and Nishimune,Y.
  TITLE     Control of mouse hils1 gene expression during spermatogenesis:
            identification of regulatory element by transgenic mouse
  JOURNAL   Biol Reprod 70 (5), 1239-1245 (2004)
   PUBMED   14695911
  REMARK    GeneRIF: 318-base pair (bp) 5'-proximal region, corresponding to
            first 70-bp proximal TATA-less promoter, and 248 bp of
            5'-untranslated region is sufficient to confer testis- and
            spermatid-specific transcription and posttranscriptional control of
            mouse hils1 gene.
REFERENCE   6  (bases 1 to 864)
  AUTHORS   Iguchi,N., Tanaka,H., Yomogida,K. and Nishimune,Y.
  TITLE     Isolation and characterization of a novel cDNA encoding a
            DNA-binding protein (Hils1) specifically expressed in testicular
            haploid germ cells
  JOURNAL   Int J Androl 26 (6), 354-365 (2003)
   PUBMED   14636221
  REMARK    GeneRIF: Hils1 may play an important role in the structural changes
            of spermatid nuclei, such as nuclear condensation, and gene
            regulation of haploid germ cell differentiation.
REFERENCE   7  (bases 1 to 864)
  AUTHORS   Yan,W., Ma,L., Burns,K.H. and Matzuk,M.M.
  TITLE     HILS1 is a spermatid-specific linker histone H1-like protein
            implicated in chromatin remodeling during mammalian spermiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10546-10551 (2003)
   PUBMED   12920187
  REMARK    GeneRIF: HILS1 is implicated in chromatin remodeling during
            mammalian spermiogenesis.
REFERENCE   8  (bases 1 to 864)
  AUTHORS   Duclos,F., Straub,V., Moore,S.A., Venzke,D.P., Hrstka,R.F.,
            Crosbie,R.H., Durbeej,M., Lebakken,C.S., Ettinger,A.J., van der
            Meulen,J., Holt,K.H., Lim,L.E., Sanes,J.R., Davidson,B.L.,
            Faulkner,J.A., Williamson,R. and Campbell,K.P.
  TITLE     Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice
  JOURNAL   J Cell Biol 142 (6), 1461-1471 (1998)
   PUBMED   9744877
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL606480.11.
            
            On Jun 10, 2015 this sequence version replaced NM_018792.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. The protein encoded is a replication-independent
            histone that is expressed in nuclei of late maturing spermatids.
            [provided by RefSeq, Nov 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061119.1, AY286319.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 22650316
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-864               AL606480.11        21513-22376
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..864
                     /gene="H1f9"
                     /gene_synonym="H1-9; H1.9; Hils1; TISP64"
                     /note="H1.9 linker histone"
                     /db_xref="GeneID:54388"
                     /db_xref="MGI:MGI:2136691"
     exon            1..864
                     /gene="H1f9"
                     /gene_synonym="H1-9; H1.9; Hils1; TISP64"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..801
                     /gene="H1f9"
                     /gene_synonym="H1-9; H1.9; Hils1; TISP64"
                     /note="spermatid-specific linker histone H1-like protein;
                     histone H1-like protein in spermatids 1"
                     /codon_start=1
                     /product="histone H1.9"
                     /protein_id="NP_061262.1"
                     /db_xref="CCDS:CCDS25267.1"
                     /db_xref="GeneID:54388"
                     /db_xref="MGI:MGI:2136691"
                     /translation="MAQMVAGDQDAGTLWVPSQSESQTESDISTQSLRKPTMSYVILK
                     TLADKRVHNCVSLATLKKAVSITGYNMTHNTWRFKRVLQNLLDKGMIMHVTCCKGASG
                     SLCLCKERALKSNHRAKRCQDRQKSQKPQKPGQRESEPCQLLLSSKKKNDQLFKGVRR
                     VAKGNRHCHY"
     regulatory      841..846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1f9"
                     /gene_synonym="H1-9; H1.9; Hils1; TISP64"
                     /note="hexamer: AATAAA"
     polyA_site      864
                     /gene="H1f9"
                     /gene_synonym="H1-9; H1.9; Hils1; TISP64"
                     /note="major polyA site"
ORIGIN      
        1 actgcagaga taacttcacc agtctctgag cccacagcac aagtctgctg aggccaatcg
       61 tgggtgatga tcctcagtcc tctctctggc cgaggtgtgg cccagacccc cctagagagg
      121 cgcctctgag ggaagcagaa gccagaacac agcccactca ctaccgagag gaaccaggtg
      181 gactttgcca gctgccatcc tggagtatct agcacctgga gtttctacag cagtcttggg
      241 aagagaatca gagagctgtg ccgctggtgt caccatacgc agcctcaaat ggctcaaatg
      301 gtggctggag accaagatgc cggcacactg tgggtcccaa gccagagtga gagtcaaact
      361 gagtccgaca tcagtaccca aagcctgcgg aagcccacca tgtcgtatgt gattctgaag
      421 actttggctg acaagcgggt acataattgt gtgtcccttg ctaccttgaa gaaagctgtg
      481 tctatcacag ggtacaatat gacccataac acctggcgct tcaagcgtgt gctccagaat
      541 ctactcgata aaggcatgat catgcatgtg acctgctgca agggtgcctc cggctccctc
      601 tgcctgtgca aggagcgggc cctcaagtcc aaccacaggg ccaagagatg ccaggacaga
      661 cagaagagcc agaagcctca gaagcctggg cagcgtgagt ctgaaccatg ccaattgcta
      721 ctaagctcca aaaagaagaa tgaccagctt ttcaaaggag tccgtagggt ggccaaaggc
      781 aaccgccatt gccattatta aggcaggtca ggcggggtgc caggcttgcc accaagtggg
      841 aataaaacgc aacttatttc acaa
//
