LOCUS       NM_138311               1131 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus H1.8 linker histone (H1f8), transcript variant 1,
            mRNA.
ACCESSION   NM_138311
VERSION     NM_138311.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1131)
  AUTHORS   Funaya,S., Wang,Y., Suzuki,M.G., Ikawa,M. and Aoki,F.
  TITLE     Involvement of linker histone variant H1a in the regulation of
            early preimplantation development in mice
  JOURNAL   J Reprod Dev 69 (3), 178-182 (2023)
   PUBMED   37062716
REFERENCE   3  (bases 1 to 1131)
  AUTHORS   Sanchez-Saez,F., Sainz-Urruela,R., Felipe-Medina,N., Condezo,Y.B.,
            Sanchez-Martin,M., Llano,E. and Pendas,A.M.
  TITLE     The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse
            Oogenesis and Fertility
  JOURNAL   Cells 11 (22), 3706 (2022)
   PUBMED   36429134
  REMARK    GeneRIF: The Oocyte-Specific Linker Histone H1FOO Is Not Essential
            for Mouse Oogenesis and Fertility.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1131)
  AUTHORS   Gindi,N., Grossman,H., Bar-Joseph,H., Miller,I., Nemerovsky,L.,
            Hadas,R., Nevo,N., Galiani,D., Dekel,N. and Shalgi,R.
  TITLE     Fyn and argonaute 2 participate in maternal-mRNA degradation during
            mouse oocyte maturation
  JOURNAL   Cell Cycle 21 (8), 792-804 (2022)
   PUBMED   35104175
REFERENCE   5  (bases 1 to 1131)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   6  (bases 1 to 1131)
  AUTHORS   Biterge,B. and Schneider,R.
  TITLE     Histone variants: key players of chromatin
  JOURNAL   Cell Tissue Res 356 (3), 457-466 (2014)
   PUBMED   24781148
  REMARK    Review article
REFERENCE   7  (bases 1 to 1131)
  AUTHORS   Fu,G., Ghadam,P., Sirotkin,A., Khochbin,S., Skoultchi,A.I. and
            Clarke,H.J.
  TITLE     Mouse oocytes and early embryos express multiple histone H1
            subtypes
  JOURNAL   Biol Reprod 68 (5), 1569-1576 (2003)
   PUBMED   12606334
REFERENCE   8  (bases 1 to 1131)
  AUTHORS   Tanaka,M., Kihara,M., Meczekalski,B., King,G.J. and Adashi,E.Y.
  TITLE     H1oo: a pre-embryonic H1 linker histone in search of a function
  JOURNAL   Mol Cell Endocrinol 202 (1-2), 5-9 (2003)
   PUBMED   12770723
  REMARK    GeneRIF: may play a key role in the control of gene expression
            during oogenesis and early embryogenesis, presumably through the
            perturbation of chromatin structure
REFERENCE   9  (bases 1 to 1131)
  AUTHORS   Zeng,F. and Schultz,R.M.
  TITLE     Gene expression in mouse oocytes and preimplantation embryos: use
            of suppression subtractive hybridization to identify oocyte- and
            embryo-specific genes
  JOURNAL   Biol Reprod 68 (1), 31-39 (2003)
   PUBMED   12493692
REFERENCE   10 (bases 1 to 1131)
  AUTHORS   Tanaka,M., Hennebold,J.D., Macfarlane,J. and Adashi,E.Y.
  TITLE     A mammalian oocyte-specific linker histone gene H1oo: homology with
            the genes for the oocyte-specific cleavage stage histone (cs-H1) of
            sea urchin and the B4/H1M histone of the frog
  JOURNAL   Development 128 (5), 655-664 (2001)
   PUBMED   11171391
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ081178.1, AK135944.1 and
            AV357657.1.
            
            On Jun 8, 2015 this sequence version replaced NM_138311.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. The protein encoded is a replication-independent
            histone that is a member of the histone H1 family. This gene
            contains introns, unlike most histone genes and the encoded protein
            is expressed only in oocytes. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135944.1, AY007195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            replication-independent histone :: PMID: 24781148
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 CJ081178.1         14-20
            8-1120              AK135944.1         4-1116
            1121-1131           AV357657.1         230-240
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.72 cM"
     gene            1..1131
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /note="H1.8 linker histone"
                     /db_xref="GeneID:171506"
                     /db_xref="MGI:MGI:2176207"
     exon            1..152
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..967
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone H1oo; oocyte-specific histone H1; histone H1.8;
                     oocyte-specific linker histone H1; H1 histone family,
                     member O, oocyte-specific"
                     /codon_start=1
                     /product="histone H1.8 isoform 1"
                     /protein_id="NP_612184.1"
                     /db_xref="CCDS:CCDS20447.1"
                     /db_xref="GeneID:171506"
                     /db_xref="MGI:MGI:2176207"
                     /translation="MAPGSVSSVSSSSFPSRDTSPSGSCGLPGADKPGPSCRRIQAGQ
                     RNPTMLHMVLEALKAREARQGTSVVAIKVYIQHKYPTVDTTRFKYLLKQALETGVRRG
                     LLTRPAHSKAKGATGSFKLVPKPKTKKACAPKAGRGAAGAKETGSKKSGLLKKDQVGK
                     ATMEKGQKRRAYPCKAATLEMAPKKAKAKPKEVRKAPLKQDKAAGAPLTANGGQKVKR
                     SGSRQEANAHGKTKGEKSKPLASKVQNSVASLAKRKMADMAHTVTVVQGAETVQETKV
                     PTPSQDIGHKVQPIPRVRKAKTPENTQA"
     exon            153..412
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /inference="alignment:Splign:2.1.0"
     exon            413..722
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /inference="alignment:Splign:2.1.0"
     exon            723..778
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1131
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1103..1108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /note="hexamer: AATAAA"
     polyA_site      1123
                     /gene="H1f8"
                     /gene_synonym="H1-8; H1.8; H1fo; H1foo; H1oo"
                     /note="major polyA site"
ORIGIN      
        1 gctaactgag ctaactgagc gagcactggc ctggcctgct gctgcctgtg ccatggctcc
       61 tgggagtgtc tccagtgttt cttcctcctc ttttccctcc agggacacat ccccttctgg
      121 atcatgtggg ctccctggag ctgacaagcc aggtccaagt tgccgcagaa tccaagcagg
      181 ccaaaggaac ccaacaatgc tgcacatggt gctagaggct ttgaaggccc gggaggcacg
      241 ccagggcaca tcagttgtag ccatcaaggt ctacatccaa cacaagtacc cgacagtgga
      301 caccacccgt ttcaagtacc tgttgaagca agctctggaa actggcgttc gtcgaggcct
      361 cctcaccagg cctgctcact ccaaggccaa gggtgccact ggcagcttca aactagttcc
      421 aaagcccaag acaaagaaag cctgtgcccc caaagccggc aggggagctg caggtgccaa
      481 ggagacaggc tccaagaaat ctggattgct gaagaaagac caagttggca aggccacgat
      541 ggagaaaggg cagaagagga gggcttaccc ttgcaaggca gccacactgg agatggcacc
      601 taagaaagcc aaggcgaaac cgaaagaggt cagaaaggct cccctaaaac aagacaaagc
      661 agcaggggcc cctctgactg ccaatggagg ccagaaggtc aaacgcagtg ggagcaggca
      721 agaagcaaat gcccatggga aaaccaaagg tgagaaatcg aagcccttgg ccagcaaggt
      781 ccagaatagc gttgcttccc tcgccaaaag gaagatggca gacatggccc acactgtgac
      841 agttgttcag ggggctgaga cagtacagga gaccaaagtg cccactcctt cccaggacat
      901 aggacacaaa gtacaaccca tacctagggt caggaaggca aagacccctg agaacactca
      961 ggcctgagtt acttcccaag acctcctcca aggctcccag caagaaggct gaggctagta
     1021 gctagggcca gggctgggga gatggcgatt ctgaagcttt tattgtctaa taagctgtca
     1081 caatgtttaa tcataattta tcaataaaga ctttgtattc acacactggt a
//
