LOCUS       NM_027304               1338 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H1.7 linker histone (H1f7), mRNA.
ACCESSION   NM_027304
VERSION     NM_027304.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1338)
  AUTHORS   Bao,J., Rousseaux,S., Shen,J., Lin,K., Lu,Y. and Bedford,M.T.
  TITLE     The arginine methyltransferase CARM1 represses p300*ACT*CREMtau
            activity and is required for spermiogenesis
  JOURNAL   Nucleic Acids Res 46 (9), 4327-4343 (2018)
   PUBMED   29659998
REFERENCE   2  (bases 1 to 1338)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   3  (bases 1 to 1338)
  AUTHORS   Tang,M.C., Jacobs,S.A., Mattiske,D.M., Soh,Y.M., Graham,A.N.,
            Tran,A., Lim,S.L., Hudson,D.F., Kalitsis,P., O'Bryan,M.K.,
            Wong,L.H. and Mann,J.R.
  TITLE     Contribution of the two genes encoding histone variant h3.3 to
            viability and fertility in mice
  JOURNAL   PLoS Genet 11 (2), e1004964 (2015)
   PUBMED   25675407
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1338)
  AUTHORS   Biterge,B. and Schneider,R.
  TITLE     Histone variants: key players of chromatin
  JOURNAL   Cell Tissue Res 356 (3), 457-466 (2014)
   PUBMED   24781148
  REMARK    Review article
REFERENCE   5  (bases 1 to 1338)
  AUTHORS   Talbert,P.B., Ahmad,K., Almouzni,G., Ausio,J., Berger,F.,
            Bhalla,P.L., Bonner,W.M., Cande,W.Z., Chadwick,B.P., Chan,S.W.,
            Cross,G.A., Cui,L., Dimitrov,S.I., Doenecke,D., Eirin-Lopez,J.M.,
            Gorovsky,M.A., Hake,S.B., Hamkalo,B.A., Holec,S., Jacobsen,S.E.,
            Kamieniarz,K., Khochbin,S., Ladurner,A.G., Landsman,D.,
            Latham,J.A., Loppin,B., Malik,H.S., Marzluff,W.F., Pehrson,J.R.,
            Postberg,J., Schneider,R., Singh,M.B., Smith,M.M., Thompson,E.,
            Torres-Padilla,M.E., Tremethick,D.J., Turner,B.M., Waterborg,J.H.,
            Wollmann,H., Yelagandula,R., Zhu,B. and Henikoff,S.
  TITLE     A unified phylogeny-based nomenclature for histone variants
  JOURNAL   Epigenetics Chromatin 5, 7 (2012)
   PUBMED   22650316
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1338)
  AUTHORS   Turner,L.M., Chuong,E.B. and Hoekstra,H.E.
  TITLE     Comparative analysis of testis protein evolution in rodents
  JOURNAL   Genetics 179 (4), 2075-2089 (2008)
   PUBMED   18689890
REFERENCE   7  (bases 1 to 1338)
  AUTHORS   Govin,J., Escoffier,E., Rousseaux,S., Kuhn,L., Ferro,M.,
            Thevenon,J., Catena,R., Davidson,I., Garin,J., Khochbin,S. and
            Caron,C.
  TITLE     Pericentric heterochromatin reprogramming by new histone variants
            during mouse spermiogenesis
  JOURNAL   J Cell Biol 176 (3), 283-294 (2007)
   PUBMED   17261847
REFERENCE   8  (bases 1 to 1338)
  AUTHORS   Catena,R., Ronfani,L., Sassone-Corsi,P. and Davidson,I.
  TITLE     Changes in intranuclear chromatin architecture induce bipolar
            nuclear localization of histone variant H1T2 in male haploid
            spermatids
  JOURNAL   Dev Biol 296 (1), 231-238 (2006)
   PUBMED   16765935
  REMARK    GeneRIF: H1T2 can be a useful molecular marker revealing chromatin
            disorganization in spermatids.
REFERENCE   9  (bases 1 to 1338)
  AUTHORS   Tanaka,H., Iguchi,N., Isotani,A., Kitamura,K., Toyama,Y.,
            Matsuoka,Y., Onishi,M., Masai,K., Maekawa,M., Toshimori,K.,
            Okabe,M. and Nishimune,Y.
  TITLE     HANP1/H1T2, a novel histone H1-like protein involved in nuclear
            formation and sperm fertility
  JOURNAL   Mol Cell Biol 25 (16), 7107-7119 (2005)
   PUBMED   16055721
  REMARK    GeneRIF: HANP1/H1T2 is essential for nuclear formation in
            functional spermatozoa and is specifically involved in the
            replacement of histones with protamines during spermiogenesis
REFERENCE   10 (bases 1 to 1338)
  AUTHORS   Martianov,I., Brancorsini,S., Catena,R., Gansmuller,A., Kotaja,N.,
            Parvinen,M., Sassone-Corsi,P. and Davidson,I.
  TITLE     Polar nuclear localization of H1T2, a histone H1 variant, required
            for spermatid elongation and DNA condensation during spermiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 102 (8), 2808-2813 (2005)
   PUBMED   15710904
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105982.10, BC052363.1 and
            AB016273.1.
            
            On Sep 3, 2009 this sequence version replaced NM_027304.1.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-independent histone that is a member of the histone H1
            family. This gene encodes a testis specific protein that is
            required for spermatogenesis and male fertility. [provided by
            RefSeq, Oct 2015].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB016273.1, BC052363.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 24781148
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC105982.10        107189-107202       c
            15-1322             BC052363.1         1-1308
            1323-1338           AB016273.1         1295-1310
FEATURES             Location/Qualifiers
     source          1..1338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.26 cM"
     gene            1..1338
                     /gene="H1f7"
                     /gene_synonym="1700026P10Rik; H1-7; H1.7; H1fnt; H1t2;
                     Hanp1; mH1t2"
                     /note="H1.7 linker histone"
                     /db_xref="GeneID:70069"
                     /db_xref="MGI:MGI:1917319"
     exon            1..1326
                     /gene="H1f7"
                     /gene_synonym="1700026P10Rik; H1-7; H1.7; H1fnt; H1t2;
                     Hanp1; mH1t2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1238
                     /gene="H1f7"
                     /gene_synonym="1700026P10Rik; H1-7; H1.7; H1fnt; H1t2;
                     Hanp1; mH1t2"
                     /note="expressed in haploid spermatids during
                     spermiogenesis, specifically at the apical pole of round
                     and elongating spermatids; histone H1t2; haploid germ
                     cell-specific nuclear protein 1; H1 histone family, member
                     N, testis-specific; histone H1.7"
                     /codon_start=1
                     /product="testis-specific H1 histone"
                     /protein_id="NP_081580.2"
                     /db_xref="CCDS:CCDS49721.1"
                     /db_xref="GeneID:70069"
                     /db_xref="MGI:MGI:1917319"
                     /translation="MAEAVQPSGESQGAELTIQIQQPAERALRTPAKRGTQSVLRVSQ
                     LLLRAIAGHQHLTLDALKKELGNAGYEVRREISSHHEGKSTRLEKGTLLRVSGSDAAG
                     YFRVWKISKPREKAGQSRLTLGSHSSGKTVLKSPRPLRPRSRRKAAKKAREVWRRKAR
                     ALKARSRRVRTRSTSGARSRTRSRASSRATSRATSRARSRARSRAQSSARSSARSSAK
                     SSAKSSTRSSAKSWARSKARSRARSRAKDLVRSKAREQAQAREQARARAREQAHARAR
                     TQDWVRAKAQEFVSAKEQQYVRAKEQERAKAREQVRIGARDEARIKAKDYNRVRPTKE
                     DTSPRPAEEKSSNSKLREEKGQEPERPVKQTIQKPALDNAPSIQGKACTKSFTKSGQP
                     GDTESP"
     polyA_site      1324
                     /gene="H1f7"
                     /gene_synonym="1700026P10Rik; H1-7; H1.7; H1fnt; H1t2;
                     Hanp1; mH1t2"
                     /note="major polyA site"
ORIGIN      
        1 agatcaaagc aggtggcccc gcggtggggg gaagcggggc catggctgag gctgtccagc
       61 ccagtgggga atcccaaggc gcagaactta cgatccagat ccagcagcct gcagagagag
      121 ccctgagaac gccagccaag cggggtacgc agtcagtgct cagagtgtcc cagctgctgc
      181 tcagggccat tgctggccac cagcacctga ctctggatgc gctcaagaag gagctgggaa
      241 acgccggcta cgaagtgcgc cgggagatct cctctcacca cgaggggaag tccaccaggt
      301 tggagaaagg cacgctcctg agggtcagtg gcagcgacgc tgctggctac ttcagggtct
      361 ggaagatttc aaagccgagg gaaaaggcgg gacaatcccg gttgacgctg ggcagccact
      421 cttctgggaa gaccgtgctc aaatccccca gaccactcag gccccgctcg cgtcgcaagg
      481 cagccaagaa ggccagagaa gtctggagac gcaaggccag ggctttgaag gcaaggtcca
      541 ggagggtcag aacaaggtcc acatcagggg ccagatcaag gaccaggtca agagcctctt
      601 caagggccac ttcaagggcc acatcaaggg ccagatcaag agcccggtca agggcccagt
      661 caagtgccag atcaagcgcc aggtcaagcg ccaagtcaag cgccaagtca agcaccaggt
      721 ctagcgccaa gtcatgggcc aggtcaaagg ctaggtcaag ggcaaggtct agagctaagg
      781 acctagtgcg ttccaaagcc cgggaacagg ctcaggccag ggaacaggct cgtgctagag
      841 ccagggaaca ggctcatgcc agagccagga cacaagactg ggtcagggcc aaggcacagg
      901 agtttgtcag tgccaaagag cagcagtacg tcagagccaa ggagcaggag cgtgccaagg
      961 ccagggaaca ggtgcgtatc ggagccaggg atgaagccag gatcaaggca aaagattaca
     1021 acagagtacg gcctacaaag gaagacacca gtcctaggcc agcagaggag aagagttcaa
     1081 actccaaact cagggaagag aagggacagg aacccgagag gccagtaaaa cagaccatcc
     1141 agaaaccagc tctggacaac gctcccagca tacaaggaaa agcatgcaca aagtctttta
     1201 ccaaaagtgg tcagcctggg gacactgagt ctccttaatg ccagagctgt tcctctgggt
     1261 acggttgctt ttccatatgg gctccaagga gatcatctct ctttcattga agcaatttac
     1321 aagaccaaaa aaaaaaaa
//
