LOCUS       NM_015787                782 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus H1.4 linker histone, cluster member (H1f4), mRNA.
ACCESSION   NM_015787 XM_990664
VERSION     NM_015787.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 782)
  AUTHORS   Lamacova,L., Jansova,D., Jiang,Z., Dvoran,M., Aleshkina,D.,
            Iyyappan,R., Jindrova,A., Fan,H.Y., Jiao,Y. and Susor,A.
  TITLE     CPEB3 Maintains Developmental Competence of the Oocyte
  JOURNAL   Cells 13 (10), 850 (2024)
   PUBMED   38786074
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 782)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 782)
  AUTHORS   Abu Alhaija,A.A., Lone,I.N., Sekeroglu,E.O., Batur,T., Angelov,D.,
            Dimitrov,S., Hamiche,A., Firat Karalar,E.N., Ercan,M.E., Yagci,T.,
            Alotaibi,H. and Diril,M.K.
  TITLE     Development of a mouse embryonic stem cell model for investigating
            the functions of the linker histone H1-4
  JOURNAL   FEBS Open Bio 14 (2), 309-321 (2024)
   PUBMED   38098212
  REMARK    GeneRIF: Development of a mouse embryonic stem cell model for
            investigating the functions of the linker histone H1-4.
REFERENCE   4  (bases 1 to 782)
  AUTHORS   Izzo,A., Ziegler-Birling,C., Hill,P.W.S., Brondani,L., Hajkova,P.,
            Torres-Padilla,M.E. and Schneider,R.
  TITLE     Dynamic changes in H1 subtype composition during epigenetic
            reprogramming
  JOURNAL   J Cell Biol 216 (10), 3017-3028 (2017)
   PUBMED   28794128
REFERENCE   5  (bases 1 to 782)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   6  (bases 1 to 782)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 782)
  AUTHORS   Wang,Z.F., Sirotkin,A.M., Buchold,G.M., Skoultchi,A.I. and
            Marzluff,W.F.
  TITLE     The mouse histone H1 genes: gene organization and differential
            regulation
  JOURNAL   J Mol Biol 271 (1), 124-138 (1997)
   PUBMED   9300059
REFERENCE   8  (bases 1 to 782)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   9  (bases 1 to 782)
  AUTHORS   Dong,Y., Sirotkin,A.M., Yang,Y.S., Brown,D.T., Sittman,D.B. and
            Skoultchi,A.I.
  TITLE     Isolation and characterization of two replication-dependent mouse
            H1 histone genes
  JOURNAL   Nucleic Acids Res 22 (8), 1421-1428 (1994)
   PUBMED   8190634
REFERENCE   10 (bases 1 to 782)
  AUTHORS   Brown,D.T. and Sittman,D.B.
  TITLE     Identification through overexpression and tagging of the variant
            type of the mouse H1e and H1c genes
  JOURNAL   J Biol Chem 268 (1), 713-718 (1993)
   PUBMED   8416974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Feb 25, 2014 this sequence version replaced NM_015787.3.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC089600.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-782               AL592149.8         102192-102973       c
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.83 cM"
     gene            1..782
                     /gene="H1f4"
                     /gene_synonym="H1 VAR.2; H1-4; H1.4; H1e; H1s-4; H1var2;
                     Hist1h1e"
                     /note="H1.4 linker histone, cluster member"
                     /db_xref="GeneID:50709"
                     /db_xref="MGI:MGI:1931527"
     exon            1..782
                     /gene="H1f4"
                     /gene_synonym="H1 VAR.2; H1-4; H1.4; H1e; H1s-4; H1var2;
                     Hist1h1e"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..721
                     /gene="H1f4"
                     /gene_synonym="H1 VAR.2; H1-4; H1.4; H1e; H1s-4; H1var2;
                     Hist1h1e"
                     /note="histone 1, H1e; histone H1e; H1 histone family,
                     member 4; histone cluster 1, H1e"
                     /codon_start=1
                     /product="histone H1.4"
                     /protein_id="NP_056602.1"
                     /db_xref="CCDS:CCDS26355.1"
                     /db_xref="GeneID:50709"
                     /db_xref="MGI:MGI:1931527"
                     /translation="MSETAPAAPAAPAPAEKTPVKKKARKAAGGAKRKTSGPPVSELI
                     TKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGAS
                     GSFKLNKKAASGEAKPKAKRAGAAKAKKPAGAAKKPKKAAGTATAKKSTKKTPKKAKK
                     PAAAAGAKKAKSPKKAKATKAKKAPKSPAKAKTVKPKAAKPKTSKPKAAKPKKTAAKK
                     K"
     polyA_site      782
                     /gene="H1f4"
                     /gene_synonym="H1 VAR.2; H1-4; H1.4; H1e; H1s-4; H1var2;
                     Hist1h1e"
                     /note="major polyA site"
ORIGIN      
        1 cccgagtcct ggccagtccc tctgcttccg gctcgagttc tctctcctca cacgcttcgc
       61 catgtccgag accgcgcctg ctgcgcccgc cgcaccggcc cccgccgaga agacacccgt
      121 caagaagaag gcccgcaagg ccgcaggtgg cgcgaagcgc aaaacctccg gacccccggt
      181 gtccgaactc atcaccaagg ctgtggccgc ctccaaggag cgcagcggcg tgtccctggc
      241 tgcgctcaag aaggcgctgg cggccgcggg gtacgatgtg gagaagaaca acagccgcat
      301 caagctcggc ctgaagagcc tggtgagcaa gggtaccctg gtgcagacca agggcaccgg
      361 cgcctccggc tccttcaaac tcaacaagaa ggcggcttcc ggtgaggcta agcccaaagc
      421 aaaaagggca ggcgcggcca aggcgaagaa gcctgcgggc gcagccaaga agcccaagaa
      481 ggctgcgggg acagccaccg ccaagaagag caccaagaag actccaaaga aagcgaagaa
      541 gccagctgca gctgcaggag ccaaaaaagc taagagcccg aagaaggcaa aggcaactaa
      601 ggctaagaag gcgcccaaga gccctgccaa ggcgaaaacg gtaaagccta aagcggccaa
      661 accaaaaacc tccaagccta aggcagctaa gccaaagaaa accgcagcca agaaaaagta
      721 aattttcttt ggccaactgc ttagaagccc aacaacccaa aggctctttt cagagccacc
      781 ca
//
