LOCUS       NM_145713                776 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H1.3 linker histone, cluster member (H1f3), mRNA.
ACCESSION   NM_145713
VERSION     NM_145713.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 776)
  AUTHORS   Izzo,A., Ziegler-Birling,C., Hill,P.W.S., Brondani,L., Hajkova,P.,
            Torres-Padilla,M.E. and Schneider,R.
  TITLE     Dynamic changes in H1 subtype composition during epigenetic
            reprogramming
  JOURNAL   J Cell Biol 216 (10), 3017-3028 (2017)
   PUBMED   28794128
REFERENCE   2  (bases 1 to 776)
  AUTHORS   Yang,D., Sun,B., Zhang,X., Cheng,D., Yu,X., Yan,L., Li,L., An,S.,
            Jiang,H., Lasorella,A., Iavarone,A., Zhang,S., Zou,F. and Zhao,X.
  TITLE     Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and
            Tumor Growth through the Histone H1.3-H19 Cascade
  JOURNAL   Cancer Res 77 (18), 4773-4784 (2017)
   PUBMED   28687618
REFERENCE   3  (bases 1 to 776)
  AUTHORS   Pan,C. and Fan,Y.
  TITLE     Role of H1 linker histones in mammalian development and stem cell
            differentiation
  JOURNAL   Biochim Biophys Acta 1859 (3), 496-509 (2016)
   PUBMED   26689747
  REMARK    Review article
REFERENCE   4  (bases 1 to 776)
  AUTHORS   Li,Y., Liu,J., McLaughlin,N., Bachvarov,D., Saifudeen,Z. and
            El-Dahr,S.S.
  TITLE     Genome-wide analysis of the p53 gene regulatory network in the
            developing mouse kidney
  JOURNAL   Physiol Genomics 45 (20), 948-964 (2013)
   PUBMED   24003036
REFERENCE   5  (bases 1 to 776)
  AUTHORS   Cao,K., Lailler,N., Zhang,Y., Kumar,A., Uppal,K., Liu,Z., Lee,E.K.,
            Wu,H., Medrzycki,M., Pan,C., Ho,P.Y., Cooper,G.P. Jr., Dong,X.,
            Bock,C., Bouhassira,E.E. and Fan,Y.
  TITLE     High-resolution mapping of h1 linker histone variants in embryonic
            stem cells
  JOURNAL   PLoS Genet 9 (4), e1003417 (2013)
   PUBMED   23633960
REFERENCE   6  (bases 1 to 776)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 776)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   8  (bases 1 to 776)
  AUTHORS   Drabent,B., Franke,K., Bode,C., Kosciessa,U., Bouterfa,H.,
            Hameister,H. and Doenecke,D.
  TITLE     Isolation of two murine H1 histone genes and chromosomal mapping of
            the H1 gene complement
  JOURNAL   Mamm Genome 6 (8), 505-511 (1995)
   PUBMED   8589518
REFERENCE   9  (bases 1 to 776)
  AUTHORS   vanWert,J.M., Wolfe,S.A. and Grimes,S.R.
  TITLE     Testis-specific expression of the rat histone Hlt gene in
            transgenic mice
  JOURNAL   Biochemistry 34 (27), 8733-8743 (1995)
   PUBMED   7612613
REFERENCE   10 (bases 1 to 776)
  AUTHORS   Drabent,B., Bode,C. and Doenecke,D.
  TITLE     Structure and expression of the mouse testicular H1 histone gene
            (H1t)
  JOURNAL   Biochim Biophys Acta 1216 (2), 311-313 (1993)
   PUBMED   8241275
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592149.8.
            
            On Feb 26, 2014 this sequence version replaced NM_145713.3.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            [provided by RefSeq, Sep 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK155411.1, AK054269.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               AL592149.8         35638-36413
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.79 cM"
     gene            1..776
                     /gene="H1f3"
                     /gene_synonym="H1-3; H1.3; H1D; H1s-4; Hist1h1d"
                     /note="H1.3 linker histone, cluster member"
                     /db_xref="GeneID:14957"
                     /db_xref="MGI:MGI:107502"
     exon            1..776
                     /gene="H1f3"
                     /gene_synonym="H1-3; H1.3; H1D; H1s-4; Hist1h1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..724
                     /gene="H1f3"
                     /gene_synonym="H1-3; H1.3; H1D; H1s-4; Hist1h1d"
                     /note="histone 1, H1d; H1 VAR.4; histone cluster 1, H1d;
                     histone 1, family 3; H1 histone family, member 3"
                     /codon_start=1
                     /product="histone H1.3"
                     /protein_id="NP_663759.3"
                     /db_xref="CCDS:CCDS26346.1"
                     /db_xref="GeneID:14957"
                     /db_xref="MGI:MGI:107502"
                     /translation="MSETAPAAPAAPAPVEKTPVKKKAKKTGAAAGKRKASGPPVSEL
                     ITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGA
                     SGSFKLNKKAASGEAKPKAKKAGAAKAKKPAGAAKKPKKATGAATPKKTAKKTPKKAK
                     KPAAAAGAKKVSKSPKKVKAAKPKKAAKSPAKAKAPKAKASKPKASKPKATKAKKAAP
                     RKK"
     polyA_site      776
                     /gene="H1f3"
                     /gene_synonym="H1-3; H1.3; H1D; H1s-4; Hist1h1d"
                     /note="major polyA site"
ORIGIN      
        1 gaacaacctt ctctgactgt ttgtgcttac tttttgcttt actagtaaag cttagaacat
       61 gtccgagacc gctcccgcgg cgcctgctgc ccctgcacct gtggagaaga cacctgtgaa
      121 gaagaaggcg aagaagaccg gcgccgctgc tgggaagcgc aaggcgtccg gacccccggt
      181 gtccgagctc atcaccaagg ctgtggccgc ctccaaggag cgcagcggcg tgtccctggc
      241 tgcgctcaag aaggcgctgg cggccgcggg gtacgatgtg gagaagaaca acagccgcat
      301 caagctcggg ctgaagagcc tggtgagcaa gggtaccctg gtgcagacca agggcaccgg
      361 cgcctccggc tccttcaaac tcaacaagaa ggcggcttcc ggtgaggcta agcccaaggc
      421 taagaaggca ggcgcggcca aggccaagaa gcctgcggga gcagccaaga agcctaagaa
      481 ggcgactggt gctgccacac ccaaaaagac ggccaagaag actccgaaga aggcgaagaa
      541 gcctgcggcg gctgccggcg ccaagaaagt ttccaagagt cccaagaagg tgaaggctgc
      601 taagcccaag aaggcagcaa agagtccagc caaggccaag gctcccaagg ctaaggcttc
      661 caagcctaaa gcttctaagc cgaaggccac caaggcaaag aaggctgccc ctcgcaagaa
      721 gtagagtggt gcgtcctgct ttgaaaatct caaacggctc ttttcagagc caccca
//
