LOCUS       NM_015786                725 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H1.2 linker histone, cluster member (H1f2), mRNA.
ACCESSION   NM_015786
VERSION     NM_015786.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 725)
  AUTHORS   Yuan,Y., Fan,Y., Zhou,Y., Qiu,R., Kang,W., Liu,Y., Chen,Y.,
            Wang,C., Shi,J., Liu,C., Li,Y., Wu,M., Huang,K., Liu,Y. and
            Zheng,L.
  TITLE     Linker histone variant H1.2 is a brake on white adipose tissue
            browning
  JOURNAL   Nat Commun 14 (1), 3982 (2023)
   PUBMED   37414781
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 725)
  AUTHORS   Wang,Q., Chen,Y., Xie,Y., Yang,D., Sun,Y., Yuan,Y., Chen,H.,
            Zhang,Y., Huang,K. and Zheng,L.
  TITLE     Histone H1.2 promotes hepatocarcinogenesis by regulating signal
            transducer and activator of transcription 3 signaling
  JOURNAL   Cancer Sci 113 (5), 1679-1692 (2022)
   PUBMED   35294987
  REMARK    GeneRIF: Histone H1.2 promotes hepatocarcinogenesis by regulating
            signal transducer and activator of transcription 3 signaling.
REFERENCE   3  (bases 1 to 725)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 725)
  AUTHORS   Izzo,A., Ziegler-Birling,C., Hill,P.W.S., Brondani,L., Hajkova,P.,
            Torres-Padilla,M.E. and Schneider,R.
  TITLE     Dynamic changes in H1 subtype composition during epigenetic
            reprogramming
  JOURNAL   J Cell Biol 216 (10), 3017-3028 (2017)
   PUBMED   28794128
REFERENCE   5  (bases 1 to 725)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   6  (bases 1 to 725)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 725)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   8  (bases 1 to 725)
  AUTHORS   Drabent,B., Franke,K., Bode,C., Kosciessa,U., Bouterfa,H.,
            Hameister,H. and Doenecke,D.
  TITLE     Isolation of two murine H1 histone genes and chromosomal mapping of
            the H1 gene complement
  JOURNAL   Mamm Genome 6 (8), 505-511 (1995)
   PUBMED   8589518
REFERENCE   9  (bases 1 to 725)
  AUTHORS   Cheng,G.H., Nandi,A., Clerk,S. and Skoultchi,A.I.
  TITLE     Different 3'-end processing produces two independently regulated
            mRNAs from a single H1 histone gene
  JOURNAL   Proc Natl Acad Sci U S A 86 (18), 7002-7006 (1989)
   PUBMED   2780558
REFERENCE   10 (bases 1 to 725)
  AUTHORS   Yang,Y.S., Brown,D.T., Wellman,S.E. and Sittman,D.B.
  TITLE     Isolation and characterization of a mouse fully
            replication-dependent H1 gene within a genomic cluster of core
            histone genes
  JOURNAL   J Biol Chem 262 (35), 17118-17125 (1987)
   PUBMED   2824517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590388.4.
            
            On Feb 25, 2014 this sequence version replaced NM_015786.2.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a member of the histone H1 family.
            Transcripts from this gene lack polyA tails but instead contain a
            palindromic termination element. [provided by RefSeq, Feb 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC089604.1, AK155502.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-725               AL590388.4         148847-149571       c
FEATURES             Location/Qualifiers
     source          1..725
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.9 cM"
     gene            1..725
                     /gene="H1f2"
                     /gene_synonym="0610008C09Rik; H1-2; H1.2; H1c; H1var1;
                     His1a; Hist1h1c"
                     /note="H1.2 linker histone, cluster member"
                     /db_xref="GeneID:50708"
                     /db_xref="MGI:MGI:1931526"
     exon            1..725
                     /gene="H1f2"
                     /gene_synonym="0610008C09Rik; H1-2; H1.2; H1c; H1var1;
                     His1a; Hist1h1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..681
                     /gene="H1f2"
                     /gene_synonym="0610008C09Rik; H1-2; H1.2; H1c; H1var1;
                     His1a; Hist1h1c"
                     /note="histone 1, H1c; histone H1; H1 histone family,
                     member 2; H1 VAR.1; histone cluster 1, H1c"
                     /codon_start=1
                     /product="histone H1.2"
                     /protein_id="NP_056601.1"
                     /db_xref="CCDS:CCDS26361.1"
                     /db_xref="GeneID:50708"
                     /db_xref="MGI:MGI:1931526"
                     /translation="MSEAAPAAPAAAPPAEKAPAKKKAAKKPAGVRRKASGPPVSELI
                     TKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGILVQTKGTGAS
                     GSFKLNKKAASGEAKPQAKKAGAAKAKKPAGAAKKPKKATGAATPKKAAKKTPKKAKK
                     PAAAAVTKKVAKSPKKAKVTKPKKVKSASKAVKPKAAKPKVAKAKKVAAKKK"
     regulatory      670..675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1f2"
                     /gene_synonym="0610008C09Rik; H1-2; H1.2; H1c; H1var1;
                     His1a; Hist1h1c"
                     /note="hexamer: AAGAAA"
     polyA_site      695
                     /gene="H1f2"
                     /gene_synonym="0610008C09Rik; H1-2; H1.2; H1c; H1var1;
                     His1a; Hist1h1c"
     polyA_site      725
                     /gene="H1f2"
                     /gene_synonym="0610008C09Rik; H1-2; H1.2; H1c; H1var1;
                     His1a; Hist1h1c"
                     /note="major polyA site"
ORIGIN      
        1 atcggcgtac tgccactagt tcctgacttc cagagactca tcatgtctga ggctgctcct
       61 gctgcccccg ctgccgcgcc ccctgcggag aaggcgcctg ccaaaaagaa ggccgccaag
      121 aagcccgccg gggtgcgccg taaggcgtcc ggacccccgg tgtccgagct catcaccaag
      181 gctgtggccg cctccaagga gcgcagcggc gtgtccctgg ctgcgctcaa gaaggcgctg
      241 gcggccgcgg ggtacgatgt ggagaagaac aacagccgca tcaagctcgg cctgaagagc
      301 ctggtgagca agggcatcct ggtgcaaacc aagggcaccg gtgcctccgg ctccttcaaa
      361 ctcaacaaga aggcggcttc tggcgaggcc aaaccccagg ctaagaaggc aggcgcggcc
      421 aaggcgaaga agcccgcggg agcagccaag aagcctaaga aggcgactgg tgctgccaca
      481 cccaaaaagg cggccaagaa gaccccgaag aaggcgaaga agcccgcggc ggcggctgtg
      541 accaagaaag tggccaagag cccaaagaag gcgaaggtca ccaagcccaa gaaggtcaag
      601 agcgcgtcta aagccgtaaa gccaaaggct gccaagccca aggttgccaa ggccaagaag
      661 gttgcagcca agaaaaagta ggctgcctcc cctaacaatc caaaaggctc ttttcagagc
      721 cacca
//
