LOCUS       NM_198622               1126 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus H1.10 linker histone (H1f10), mRNA.
ACCESSION   NM_198622 XM_144949
VERSION     NM_198622.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1126)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1126)
  AUTHORS   Izzo,A., Ziegler-Birling,C., Hill,P.W.S., Brondani,L., Hajkova,P.,
            Torres-Padilla,M.E. and Schneider,R.
  TITLE     Dynamic changes in H1 subtype composition during epigenetic
            reprogramming
  JOURNAL   J Cell Biol 216 (10), 3017-3028 (2017)
   PUBMED   28794128
REFERENCE   3  (bases 1 to 1126)
  AUTHORS   Ichihara-Tanaka,K., Kadomatsu,K. and Kishida,S.
  TITLE     Temporally and Spatially Regulated Expression of the Linker Histone
            H1fx During Mouse Development
  JOURNAL   J Histochem Cytochem 65 (9), 513-530 (2017)
   PUBMED   28766996
  REMARK    GeneRIF: The H1fx is preferentially expressed in immature embryonic
            cells and plays some roles in cells with neural properties.
REFERENCE   4  (bases 1 to 1126)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1126)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 1126)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1126)
  AUTHORS   Talbert,P.B., Ahmad,K., Almouzni,G., Ausio,J., Berger,F.,
            Bhalla,P.L., Bonner,W.M., Cande,W.Z., Chadwick,B.P., Chan,S.W.,
            Cross,G.A., Cui,L., Dimitrov,S.I., Doenecke,D., Eirin-Lopez,J.M.,
            Gorovsky,M.A., Hake,S.B., Hamkalo,B.A., Holec,S., Jacobsen,S.E.,
            Kamieniarz,K., Khochbin,S., Ladurner,A.G., Landsman,D.,
            Latham,J.A., Loppin,B., Malik,H.S., Marzluff,W.F., Pehrson,J.R.,
            Postberg,J., Schneider,R., Singh,M.B., Smith,M.M., Thompson,E.,
            Torres-Padilla,M.E., Tremethick,D.J., Turner,B.M., Waterborg,J.H.,
            Wollmann,H., Yelagandula,R., Zhu,B. and Henikoff,S.
  TITLE     A unified phylogeny-based nomenclature for histone variants
  JOURNAL   Epigenetics Chromatin 5, 7 (2012)
   PUBMED   22650316
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1126)
  AUTHORS   Crawford,N.P., Yang,H., Mattaini,K.R. and Hunter,K.W.
  TITLE     The metastasis efficiency modifier ribosomal RNA processing 1
            homolog B (RRP1B) is a chromatin-associated factor
  JOURNAL   J Biol Chem 284 (42), 28660-28673 (2009)
   PUBMED   19710015
REFERENCE   9  (bases 1 to 1126)
  AUTHORS   Evans,D.L., Connor,M.A., Moss,L.D., Lackay,S., Leary,J.H. 3rd,
            Krunkosky,T. and Jaso-Friedmann,L.
  TITLE     Cellular expression and antimicrobial function of a
            phylogenetically conserved novel histone 1x-like protein on mouse
            cells: a potential new class of pattern recognition receptor
  JOURNAL   J Leukoc Biol 86 (1), 133-141 (2009)
   PUBMED   19389796
  REMARK    GeneRIF: expressed on the membranes of phagocytic cells, NK cells,
            and APCs as well as in the granules of macrophages; may participate
            as a bifunctional protein
REFERENCE   10 (bases 1 to 1126)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC048709.1.
            
            On Dec 17, 2003 this sequence version replaced XM_144949.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene encodes a replication-independent histone
            that is a member of the histone H1 family. [provided by RefSeq, Nov
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC048709.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 22650316
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.13 cM"
     gene            1..1126
                     /gene="H1f10"
                     /gene_synonym="Gm461; H1-10; H1.10; H1fx; H1X"
                     /note="H1.10 linker histone"
                     /db_xref="GeneID:243529"
                     /db_xref="MGI:MGI:2685307"
     exon            1..1062
                     /gene="H1f10"
                     /gene_synonym="Gm461; H1-10; H1.10; H1fx; H1X"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..693
                     /gene="H1f10"
                     /gene_synonym="Gm461; H1-10; H1.10; H1fx; H1X"
                     /codon_start=1
                     /product="H1 histone family, member X"
                     /protein_id="NP_941024.1"
                     /db_xref="CCDS:CCDS20331.1"
                     /db_xref="GeneID:243529"
                     /db_xref="MGI:MGI:2685307"
                     /translation="MSVELEEALPPTSADGTARKTAKAGGSAAPTQPKRRKNRKKNQP
                     GKYSQLVVETIRKLGERGGSSLARIYAEARKVAWFDQQNGRTYLKYSIRALVQNDTLL
                     QVKGTGANGSFKLNRKKLEGGAERRGASAASSPAPKARTAAADRTPARPQPERRAHKS
                     KKAAAAASAKKVKKAAKPSVPKVPKGRK"
     regulatory      1042..1047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1f10"
                     /gene_synonym="Gm461; H1-10; H1.10; H1fx; H1X"
                     /note="hexamer: AATAAA"
     polyA_site      1062
                     /gene="H1f10"
                     /gene_synonym="Gm461; H1-10; H1.10; H1fx; H1X"
                     /note="major polyA site"
ORIGIN      
        1 ggccgctccc gcctggagcc gccgcgcgcc cccagtcccc cggcgccgcc gcggcccctc
       61 gccttcctct tcccggcgcg gccccccggc taccgcgcgc cgcctgccgc caacccgctg
      121 gccaccatgt cggtggagct tgaggaggcc ctgccgccaa cgagcgccga cgggacggcc
      181 cgcaagacgg ccaaggccgg cggctctgcg gcgcccacgc agcccaagag aaggaagaac
      241 cgcaagaaga accagccagg caagtacagc cagctggtgg tggagaccat ccgcaagctg
      301 ggggagcgcg gcggctcgtc tctggcgcgc atctacgctg aggccaggaa ggtggcatgg
      361 ttcgaccagc agaacgggcg cacctacctc aagtactcta tccgggcgct ggtgcagaac
      421 gatacgctac tgcaggtgaa gggcaccggc gccaacggat ccttcaagct gaaccgcaag
      481 aagctggagg gcggcgcgga gcggcgcgga gcttcggcgg ccagcagccc cgcgcccaag
      541 gcgcgcacgg cggcggcgga cagaacgccc gccaggccgc agccggagcg gcgcgcgcac
      601 aagagcaaga aggcggcggc tgctgccagc gcgaagaaag tgaagaaggc ggccaaaccc
      661 agcgtgccca aggtgcccaa gggccgcaag tgacgcccct acggtctggc gacatcgtcg
      721 agttttccat ctgtctctat ccctatccgc cccccccacc ctcggtgtac cggttccgta
      781 gggttccgcc tggcccaggt ccctgatccc tgtcccctcc cccgcccctc ccccagcgat
      841 gctgcgttct gtttgcttta ggtttttgaa acggccctgg cgacgccccc attggctctc
      901 acccttggca acggccgtcg ccatggttac cggcccggcg gcgccaatgg cctggtggcg
      961 cctgcctact gtgcccgctg atggccacca ggcgcttggg ttgtgtggcg ccttgctccg
     1021 cccgctgcct tcctggggcg caataaacgg ttccaacctt gaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
