LOCUS       NM_030609                745 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus H1.1 linker histone, cluster member (H1f1), mRNA.
ACCESSION   NM_030609
VERSION     NM_030609.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 745)
  AUTHORS   Funaya,S., Wang,Y., Suzuki,M.G., Ikawa,M. and Aoki,F.
  TITLE     Involvement of linker histone variant H1a in the regulation of
            early preimplantation development in mice
  JOURNAL   J Reprod Dev 69 (3), 178-182 (2023)
   PUBMED   37062716
REFERENCE   2  (bases 1 to 745)
  AUTHORS   Brenna,A., Olejniczak,I., Chavan,R., Ripperger,J.A., Langmesser,S.,
            Cameroni,E., Hu,Z., De Virgilio,C., Dengjel,J. and Albrecht,U.
  TITLE     Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
  JOURNAL   Elife 8, e50925 (2019)
   PUBMED   31687929
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 745)
  AUTHORS   Jung,E.M., Moffat,J.J., Liu,J., Dravid,S.M., Gurumurthy,C.B. and
            Kim,W.Y.
  TITLE     Arid1b haploinsufficiency disrupts cortical interneuron development
            and mouse behavior
  JOURNAL   Nat Neurosci 20 (12), 1694-1707 (2017)
   PUBMED   29184203
REFERENCE   4  (bases 1 to 745)
  AUTHORS   Izzo,A., Ziegler-Birling,C., Hill,P.W.S., Brondani,L., Hajkova,P.,
            Torres-Padilla,M.E. and Schneider,R.
  TITLE     Dynamic changes in H1 subtype composition during epigenetic
            reprogramming
  JOURNAL   J Cell Biol 216 (10), 3017-3028 (2017)
   PUBMED   28794128
REFERENCE   5  (bases 1 to 745)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   6  (bases 1 to 745)
  AUTHORS   Marzluff,W.F., Gongidi,P., Woods,K.R., Jin,J. and Maltais,L.J.
  TITLE     The human and mouse replication-dependent histone genes
  JOURNAL   Genomics 80 (5), 487-498 (2002)
   PUBMED   12408966
REFERENCE   7  (bases 1 to 745)
  AUTHORS   Wang,Z.F., Sirotkin,A.M., Buchold,G.M., Skoultchi,A.I. and
            Marzluff,W.F.
  TITLE     The mouse histone H1 genes: gene organization and differential
            regulation
  JOURNAL   J Mol Biol 271 (1), 124-138 (1997)
   PUBMED   9300059
REFERENCE   8  (bases 1 to 745)
  AUTHORS   Zhu,D., Dix,D.J. and Eddy,E.M.
  TITLE     HSP70-2 is required for CDC2 kinase activity in meiosis I of mouse
            spermatocytes
  JOURNAL   Development 124 (15), 3007-3014 (1997)
   PUBMED   9247342
  REMARK    Erratum:[Development 1997 Sep;134(17):3218]
REFERENCE   9  (bases 1 to 745)
  AUTHORS   Wang,Z.F., Krasikov,T., Frey,M.R., Wang,J., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Characterization of the mouse histone gene cluster on chromosome
            13: 45 histone genes in three patches spread over 1Mb
  JOURNAL   Genome Res 6 (8), 688-701 (1996)
   PUBMED   8858344
REFERENCE   10 (bases 1 to 745)
  AUTHORS   Dong,Y., Sirotkin,A.M., Yang,Y.S., Brown,D.T., Sittman,D.B. and
            Skoultchi,A.I.
  TITLE     Isolation and characterization of two replication-dependent mouse
            H1 histone genes
  JOURNAL   Nucleic Acids Res 22 (8), 1421-1428 (1994)
   PUBMED   8190634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590388.4.
            
            On Feb 22, 2014 this sequence version replaced NM_030609.2.
            
            Summary: Histones are basic nuclear proteins responsible for
            nucleosome structure of the chromosomal fiber in eukaryotes. Two
            molecules of each of the four core histones (H2A, H2B, H3, and H4)
            form an octamer, around which approximately 146 bp of DNA is
            wrapped in repeating units, called nucleosomes. The linker histone,
            H1, interacts with linker DNA between nucleosomes and functions in
            the compaction of chromatin into higher order structures. This gene
            is intronless and encodes a replication-dependent histone that is a
            member of the histone H1 family. Transcripts from this gene lack
            polyA tails but instead contain a palindromic termination element.
            [provided by RefSeq, Aug 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC116820.1, SRR7652917.978007.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria        :: based on single protein-coding
                                             transcript
            replication-dependent histone :: PMID: 12408966
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-745               AL590388.4         123966-124710       c
FEATURES             Location/Qualifiers
     source          1..745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.91 cM"
     gene            1..745
                     /gene="H1f1"
                     /gene_synonym="H1-1; H1.1; H1a; H1var3; Hist1h1a"
                     /note="H1.1 linker histone, cluster member"
                     /db_xref="GeneID:80838"
                     /db_xref="MGI:MGI:1931523"
     exon            1..745
                     /gene="H1f1"
                     /gene_synonym="H1-1; H1.1; H1a; H1var3; Hist1h1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..691
                     /gene="H1f1"
                     /gene_synonym="H1-1; H1.1; H1a; H1var3; Hist1h1a"
                     /note="histone 1, H1a; histone cluster 1, H1a; H1 VAR.3;
                     H1 histone family, member 1; histone H1a"
                     /codon_start=1
                     /product="histone H1.1"
                     /protein_id="NP_085112.1"
                     /db_xref="CCDS:CCDS26369.1"
                     /db_xref="GeneID:80838"
                     /db_xref="MGI:MGI:1931523"
                     /translation="MSETAPVAQAASTATEKPAAAKKTKKPAKAAAPRKKPAGPSVSE
                     LIVQAVSSSKERSGVSLAALKKSLAAAGYDVEKNNSRIKLGLKSLVNKGTLVQTKGTG
                     AAGSFKLNKKAESKAITTKVSVKAKASGAAKKPKKTAGAAAKKTVKTPKKPKKPAVSK
                     KTSKSPKKPKVVKAKKVAKSPAKAKAVKPKASKAKVTKPKTPAKPKKAAPKKK"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1f1"
                     /gene_synonym="H1-1; H1.1; H1a; H1var3; Hist1h1a"
                     /note="hexamer: TATAAA"
     polyA_site      745
                     /gene="H1f1"
                     /gene_synonym="H1-1; H1.1; H1a; H1var3; Hist1h1a"
                     /note="major polyA site"
ORIGIN      
        1 acttcttttc ttcgtcttgg gtatagctgt tgtttattca tcagcaacca tgtcggagac
       61 ggcgccagtc gctcaggctg cttctactgc cacggagaaa cctgctgctg caaagaagac
      121 caagaagccg gcaaaagctg ccgctcctcg gaagaagccc gcgggacctt cggtgtcgga
      181 gctcatcgtg caggcagttt cttcttccaa agagcgcagt ggcgtgtcct tggccgcgct
      241 caagaagtcg ctggctgcgg cgggatacga tgtggagaag aacaacagcc gcatcaaact
      301 ggggctgaaa agcctggtga ataaaggcac actggtgcag accaagggca ccggcgctgc
      361 tggctctttt aagctgaaca agaaggctga gtccaaggcc atcaccacca aggtgtcagt
      421 gaaggcgaaa gcatccgggg ctgctaagaa acctaagaag actgctgggg ctgcagctaa
      481 gaagactgtc aagactccga agaagcccaa gaagcctgca gtttccaaga agacttccaa
      541 gagccccaag aagccgaagg tggtgaaggc caagaaggta gccaaaagcc ctgccaaggc
      601 gaaggcagtg aagcctaagg cttccaaggc gaaagtgaca aagccaaaga ccccagctaa
      661 gcccaagaag gcagcgccca agaaaaagtg aacagttgga ggcttcttct ataaataacc
      721 caacggctct tttcagagcc accaa
//
