LOCUS       NM_008197               2304 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus H1.0 linker histone (H1f0), mRNA.
ACCESSION   NM_008197
VERSION     NM_008197.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Bhandari,S.K., Wiest,N., Sallmyr,A., Du,R., Ferry,L., Defossez,P.A.
            and Tomkinson,A.E.
  TITLE     Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase
            I-deficient cells but abnormal chromatin levels of non-replicative
            histone H1
  JOURNAL   Sci Rep 13 (1), 4363 (2023)
   PUBMED   36928068
  REMARK    GeneRIF: Unchanged PCNA and DNMT1 dynamics during replication in
            DNA ligase I-deficient cells but abnormal chromatin levels of
            non-replicative histone H1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Yusufova,N., Kloetgen,A., Teater,M., Osunsade,A., Camarillo,J.M.,
            Chin,C.R., Doane,A.S., Venters,B.J., Portillo-Ledesma,S.,
            Conway,J., Phillip,J.M., Elemento,O., Scott,D.W., Beguelin,W.,
            Licht,J.D., Kelleher,N.L., Staudt,L.M., Skoultchi,A.I., Keogh,M.C.,
            Apostolou,E., Mason,C.E., Imielinski,M., Schlick,T., David,Y.,
            Tsirigos,A., Allis,C.D., Soshnev,A.A., Cesarman,E. and Melnick,A.M.
  TITLE     Histone H1 loss drives lymphoma by disrupting 3D chromatin
            architecture
  JOURNAL   Nature 589 (7841), 299-305 (2021)
   PUBMED   33299181
  REMARK    GeneRIF: Histone H1 loss drives lymphoma by disrupting 3D chromatin
            architecture.
REFERENCE   5  (bases 1 to 2304)
  AUTHORS   Ozturk,M.A. and Wade,R.C.
  TITLE     Computation of FRAP recovery times for linker histone - chromatin
            binding on the basis of Brownian dynamics simulations
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (10), 129653 (2020)
   PUBMED   32512172
  REMARK    GeneRIF: Computation of FRAP recovery times for linker histone -
            chromatin binding on the basis of Brownian dynamics simulations.
REFERENCE   6  (bases 1 to 2304)
  AUTHORS   Mayor,R., Izquierdo-Bouldstridge,A., Millan-Arino,L., Bustillos,A.,
            Sampaio,C., Luque,N. and Jordan,A.
  TITLE     Genome distribution of replication-independent histone H1 variants
            shows H1.0 associated with nucleolar domains and H1X associated
            with RNA polymerase II-enriched regions
  JOURNAL   J Biol Chem 290 (12), 7474-7491 (2015)
   PUBMED   25645921
REFERENCE   7  (bases 1 to 2304)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   8  (bases 1 to 2304)
  AUTHORS   Lord,K.A., Hoffman-Liebermann,B. and Liebermann,D.A.
  TITLE     Complexity of the immediate early response of myeloid cells to
            terminal differentiation and growth arrest includes ICAM-1, Jun-B
            and histone variants
  JOURNAL   Oncogene 5 (3), 387-396 (1990)
   PUBMED   1690380
REFERENCE   9  (bases 1 to 2304)
  AUTHORS   Breuer,B., Fischer,J. and Alonso,A.
  TITLE     Cloning and characterization of the mouse histone H1(0) promoter
            region
  JOURNAL   Gene 81 (2), 307-314 (1989)
   PUBMED   2806918
REFERENCE   10 (bases 1 to 2304)
  AUTHORS   Alonso,A., Breuer,B., Bouterfa,H. and Doenecke,D.
  TITLE     Early increase in histone H1(0) mRNA during differentiation of F9
            cells to parietal endoderm
  JOURNAL   EMBO J 7 (10), 3003-3008 (1988)
   PUBMED   2846273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB661016.1, AK051213.1 and
            AI849476.1.
            
            On Jan 27, 2006 this sequence version replaced NM_008197.2.
            
            Summary: Histones are basic nuclear proteins that are responsible
            for the nucleosome structure of the chromosomal fiber in
            eukaryotes. Nucleosomes consist of approximately 146 bp of DNA
            wrapped around a histone octamer composed of pairs of each of the
            four core histones (H2A, H2B, H3, and H4). The chromatin fiber is
            further compacted through the interaction of a linker histone, H1,
            with the DNA between the nucleosomes to form higher order chromatin
            structures. This gene is intronless and encodes a
            replication-independent histone that is a member of the histone H1
            family. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            replication-independent histone :: PMID: 25645921
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               BB661016.1         165-402             c
            239-2287            AK051213.1         2-2050
            2288-2304           AI849476.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..2304
                     /gene="H1f0"
                     /gene_synonym="D130017D06Rik; H1(0); H1-0; H1fv"
                     /note="H1.0 linker histone"
                     /db_xref="GeneID:14958"
                     /db_xref="MGI:MGI:95893"
     exon            1..2293
                     /gene="H1f0"
                     /gene_synonym="D130017D06Rik; H1(0); H1-0; H1fv"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..1095
                     /gene="H1f0"
                     /gene_synonym="D130017D06Rik; H1(0); H1-0; H1fv"
                     /note="myD196; histone H1'; histone H1(0); H1-0 histone;
                     H1 histone family, member 0"
                     /codon_start=1
                     /product="histone H1.0"
                     /protein_id="NP_032223.2"
                     /db_xref="CCDS:CCDS56990.1"
                     /db_xref="GeneID:14958"
                     /db_xref="MGI:MGI:95893"
                     /translation="MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAG
                     SSRQSIQKYIKSHYKVGENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKGDEPK
                     RSVAFKKTKKEVKKVATPKKAAKPKKAASKAPSKKPKATPVKKAKKKPAATPKKAKKP
                     KVVKVKPVKASKPKKAKTVKPKAKSSAKRASKKK"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H1f0"
                     /gene_synonym="D130017D06Rik; H1(0); H1-0; H1fv"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="H1f0"
                     /gene_synonym="D130017D06Rik; H1(0); H1-0; H1fv"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccggg gcgccagggt ccccagaagg gaagcctagg gagccgggca gagacctcga
       61 gagacggcgg gcagcgggaa ggcccgggcc gccgggaaag gtcgagtttg ctcggcggaa
      121 gaaacacaga tggcggcagc gcggcgccat tccgggccgg gagcaggcag ccagcagccc
      181 agtcctcacc gcggtccgcc cgccgccgct aaatacccgg atgcgccgcc cgagcgccag
      241 acgcagagct gggaaaaggg aggctgtgga ggcggaggca gcgccaggcg ccgggcgagc
      301 gaccgaacgg tgggggctgg gagcgcagag cagctcgcga cccgcgccgg gaggacagga
      361 gccacgcgta gcccgcgtcc ccggcagccg cacttgcgtc tggcctgcta gtggagcggg
      421 agagcagatc gcgagtcagg ttctgcacag cctccggcga gggctggccc atcggaaggc
      481 tccttgaaca gtgggagcag gccggccacc atgaccgaga actccacctc cgccccggcg
      541 gcgaagccca aacgggccaa ggcttccaag aagtccacgg accaccccaa gtattcagac
      601 atgatcgtgg ctgctatcca ggcagagaag aaccgtgccg gctcctcgcg ccagtccatc
      661 caaaagtata tcaagagcca ctacaaggtg ggtgagaacg ccgactccca gatcaagttg
      721 tccatcaagc gcctagtgac caccggtgtt ctcaagcaaa ccaaaggggt gggcgcctcg
      781 gggtccttca ggctggccaa gggcgatgag cccaaaaggt cggtggcttt caagaagacc
      841 aagaaggaag tcaagaaagt ggccactcca aagaaggcag ccaagcccaa gaaggctgcc
      901 tccaaagccc caagcaagaa acccaaagcc acccctgtca agaaggccaa gaagaagccg
      961 gctgccacgc ccaagaaagc caaaaagccc aaggttgtca aagtcaaacc agtcaaggcc
     1021 tccaaaccca agaaggccaa aaccgtgaag cccaaagcca agtcgagtgc caagagggcc
     1081 agcaagaaga agtgaagact ttgcttgggg acactccttc ctccctcctg ttttctgtaa
     1141 atacatttcc tcacttgatt ccatctgcaa ccctttgccc attctattct gactttatta
     1201 aagaggacag agtttggatc cctcatacag acattgtgga atgactcctt tttccttaac
     1261 ctattgtgca aggacagcaa acagacctca tctttgtaat gatggagacg tacttttttc
     1321 ttgatttgat attaaccttc ttacggggtt agggatggga ggggggagga tgtgtgtttc
     1381 agtcggtggt ttgtttacta tgaaggaact ggcaaagttc tggctaggtg aggggaccca
     1441 ggaactaagg tttgtcttcc aagactttct tagactgctt gtccctcgtg agcttttcaa
     1501 aacctttgat ggggagcagg tgacacccca cctagctggc caaggaggga gggaaaattc
     1561 cctggggctg ccctaccaac ggtggtaagt tggagacctg gttgcttttt ctcttctgcc
     1621 ctagtgcctc cccattgtct aaaggggcaa aggggtccaa gtgacagctg gttagagaag
     1681 ccatagcttc tcacaaccag gatctagcca ttgggaagga ggggtctttt tcagtagtct
     1741 ctggttaaat gcgagtggac ttagggggag gggtgggtaa tcagccaagt gcctcagtgt
     1801 gcctatggaa acttgggttt tttccacacg attgatggat tgcgtcctag caggactttg
     1861 tacgtttcct ttcttccctt tcctgtgtaa gatgtggctt tgcttggtgc cgcttcaggt
     1921 ctaccagctg ccacttaaaa ccctccaacc tcttttactc tttgagtttt ttttctaagt
     1981 agcggaggag ggggagaggc agggagtgga ctgtaagaca tactccagtt gattcgaatt
     2041 tgctaggtag ctttagagag gcaggattgt gtgcatgtgt gtatatgtat atatccatat
     2101 ctaagactag gacttagtct cacttcggga gctgggagaa aaaaatctgt acagttgtct
     2161 ttctcttatt ttaataaaat tagaaactcg cgcaccctac cccacccctt tttaaacaag
     2221 tgtaactagt gcccgggaga aattactgtg gttgtaattt taaaacttta aaataaaact
     2281 ggaaaggaaa aaaaaaaaaa aaaa
//
