LOCUS       NM_010376               5185 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus histocompatibility 13 (H13), transcript variant 2,
            mRNA.
ACCESSION   NM_010376
VERSION     NM_010376.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5185)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5185)
  AUTHORS   Wang,S., Jaggi,U., Tormanen,K., Hirose,S. and Ghiasi,H.
  TITLE     Absence of signal peptide peptidase in peripheral sensory neurons
            affects latency-reactivation in HSV-1 ocularly infected mice
  JOURNAL   PLoS Pathog 18 (1), e1010281 (2022)
   PUBMED   35100323
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5185)
  AUTHORS   Wang,S. and Ghiasi,H.
  TITLE     Absence of Signal Peptide Peptidase, an Essential Herpes Simplex
            Virus 1 Glycoprotein K Binding Partner, Reduces Virus Infectivity
            In Vivo
  JOURNAL   J Virol 93 (23), e01309-19 (2019)
   PUBMED   31511378
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5185)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5185)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 5185)
  AUTHORS   Wood,A.J., Roberts,R.G., Monk,D., Moore,G.E., Schulz,R. and
            Oakey,R.J.
  TITLE     A screen for retrotransposed imprinted genes reveals an association
            between X chromosome homology and maternal germ-line methylation
  JOURNAL   PLoS Genet 3 (2), e20 (2007)
   PUBMED   17291163
REFERENCE   7  (bases 1 to 5185)
  AUTHORS   Graff,R.J., Kurtz,M.E., Paul,R., Martin,D. and Roopenian,D.C.
  TITLE     Additional mapping of mouse chromosome 2 genes
  JOURNAL   Immunogenetics 33 (2), 96-100 (1991)
   PUBMED   1999355
REFERENCE   8  (bases 1 to 5185)
  AUTHORS   Graff,R.J., Martin-Morgan,D. and Kurtz,M.E.
  TITLE     Multiplicity of chromosome 2 histocompatibility genes: new loci,
            H-44 and H-45
  JOURNAL   Immunogenetics 26 (1-2), 111-114 (1987)
   PUBMED   3301647
REFERENCE   9  (bases 1 to 5185)
  AUTHORS   Graff,R.J. and Bailey,D.W.
  TITLE     The non-H-2 histocompatibility loci and their antigens
  JOURNAL   Transplant Rev 15, 26-49 (1973)
   PUBMED   4130130
  REMARK    Review article
REFERENCE   10 (bases 1 to 5185)
  AUTHORS   Vojtiskova,M., Polackova,M. and Pokorna,Z.
  TITLE     Histocompatibility antigens on mouse spermatozoa
  JOURNAL   Folia Biol (Praha) 15 (5), 322-332 (1969)
   PUBMED   4390514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845162.9.
            
            On Jun 27, 2022 this sequence version replaced NM_010376.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080966.1, AK007664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17291163
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL845162.9         150202-150486
            286-384             AL845162.9         158264-158362
            385-467             AL845162.9         161773-161855
            468-556             AL845162.9         166820-166908
            557-642             AL845162.9         169385-169470
            643-768             AL845162.9         169559-169684
            769-826             AL845162.9         170566-170623
            827-910             AL845162.9         172515-172598
            911-947             AL845162.9         175209-175245
            948-1050            AL845162.9         176204-176306
            1051-1136           AL845162.9         180905-180990
            1137-5185           AL845162.9         185344-189392
FEATURES             Location/Qualifiers
     source          1..5185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..5185
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="histocompatibility 13"
                     /db_xref="GeneID:14950"
                     /db_xref="MGI:MGI:95886"
     exon            1..285
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1239
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /EC_number="3.4.99.-"
                     /note="isoform 2 is encoded by transcript variant 2; minor
                     histocompatibility antigen H13; signal peptide peptidase
                     beta; presenilin-like aspartyl protease; presenilin-like
                     protein 3"
                     /codon_start=1
                     /product="minor histocompatibility antigen H13 isoform 2"
                     /protein_id="NP_034506.1"
                     /db_xref="CCDS:CCDS16896.1"
                     /db_xref="GeneID:14950"
                     /db_xref="MGI:MGI:95886"
                     /translation="MDSAVSDPHNGSAEAGTPANGTTRPPSTPEGIALAYGSLLLMAL
                     LPIFFGALRSVRCARGKSSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYIN
                     LLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLLFTQGSGENKEEIINYEFDT
                     KDLVCLGLSSVVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIY
                     DIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALL
                     LRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVA
                     LAKGEVAEMFSYEESNPKDPAAETESKEESTEASASKRLEKKEK"
     exon            286..384
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            385..467
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            468..556
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            557..642
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            643..768
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..826
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            827..910
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            911..947
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1050
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1136
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..5185
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1512..1517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="hexamer: ATTAAA"
     polyA_site      1567
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="major polyA site"
     regulatory      5169..5174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="hexamer: AAGAAA"
     polyA_site      5185
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
ORIGIN      
        1 gtttctttag gggaacgtgg ctttccccgc agtgcctctt ctccgtctac gttcgtgctg
       61 cggcggccgg agctggagtc ggagcccgag cgcagcctcg ccatggattc ggctgtcagc
      121 gatccgcaca acggcagcgc cgaggctggc accccagcca acggcacgac gcggccgccc
      181 tccacgcccg agggcatcgc gctggcctac ggcagcctcc tgctcatggc gctgctgccc
      241 atcttcttcg gcgccctgcg ctcggtgcgc tgcgcccgcg gcaagagctc ttcggacatg
      301 ccagaaacca tcaccagtcg agatgccgcc cgcttcccca tcatcgccag ctgcacactc
      361 ctggggctct acctcttttt caaaatattc tcccaggagt acatcaacct cttgctgtcc
      421 atgtatttct tcgtgctggg gatcctggcc ctgtcacaca ccatcagccc cttcatgaat
      481 aagttttttc cagccaactt cccaaaccgc cagtatcagc tgctcttcac acagggctct
      541 ggggaaaaca aagaagagat catcaactat gagtttgaca ctaaggacct ggtgtgcctg
      601 ggcctaagca gcgtcgttgg tgtctggtac cttctgagga agcactggat tgccaacaac
      661 ctgtttggcc tggccttctc ccttaatggg gtagagctcc tgcacctgaa caacgtgagc
      721 actggctgta tcctgctcgg aggactcttc atctatgaca tcttctgggt attcggcacc
      781 aacgtgatgg tgacagtggc caagtccttt gaggcaccaa taaaattggt gttcccccag
      841 gatctgctgg agaagggcct tgaagcagac aactttgcca tgctgggact tggagacatt
      901 gtcattccag ggatcttcat tgccttactg cttcgttttg acatcagctt gaagaagaac
      961 acgcacacct acttctacac cagcttcgcc gcctacatct tcggcctggg tctcaccatc
     1021 ttcatcatgc acatcttcaa gcacgcccag ccggctctcc tgtacctggt ccctgcctgc
     1081 atcggctttc ctgtcctggt ggcactagcc aagggagaag tggccgagat gttcagttat
     1141 gaggagtcca accctaaaga tccagcagcc gagactgaat ccaaagagga gtcaacagag
     1201 gcgtcggcat cgaagaggct agagaagaag gagaaatgag gcagcgctgc ctgacccttg
     1261 agggccagat cggacaggca ggggatgacc tgtgggcgac acagaagaga agacacctgc
     1321 aggaggcgac ggtggcccca ggatggggag caggcctctg ctgcctgttc cctctgccct
     1381 ttctctggct tcctctgctc ctcctcatcc ctgcaggcaa aggaaaccct ctgctgcttc
     1441 cttccccagg agccaggtgg gcactgaatg tggtttttag atttttgtat tgtggactgt
     1501 ctttgcctca tattaaaaac tcatcccatg gccgctaggc caccgtgctc caagggagct
     1561 ctcagcagct ctgcctagtg tttcgtgctg aactcatcgg ggctttgcga gtaccttcgt
     1621 gggtgccagg ccagaagtgg gttcccatga gcctcctttc ccagccactc ctgggggaca
     1681 gtgaaggtgg tgggcgagtg cttgctgcgc cccgctggcc ttggtatgag atgaagagag
     1741 tgtcacgggg caccccgctt cagcaaaggg acttgtaact atggacagac ggctccctgg
     1801 gcttgctgtc catctggctg gaaatcaaag gtccatcttt tccatcccca ggtctcccaa
     1861 aatacagctc aggtcttcag aaagcctgcc ctggggaggg agcagattcc agagaacaga
     1921 agaggccatc caaggtcagg caagagttag agatcccaaa gccaaagtct ccctccctcc
     1981 tgaccttcaa gcgagtccct aaagggcaag gagagggcag ctcatccctc gtccacctgc
     2041 ccaggtggaa aaactgagac tgtggaatgg ccatgacctg tgagctttcc ctggctaggg
     2101 ttcagggtta atgactaaaa tgaacagatt ggaaatggtc agagagcaaa ggctgtccag
     2161 agcctgggga ataagagtgg agggaggtga gtgtccccag tttcagatgt agaccaggtg
     2221 tgtcgatgca agcttcggat ctgtacttcg gatgctaagc tgcgcgtgct ttagcctcgc
     2281 tctacagagg agggaatggg gccgctcacc cccagacagt gactgcagct caacatacta
     2341 agcactgtgc tgtcctctta taggaccaag aagtcactgt ggctgctctg ctgggccacc
     2401 gagtcagcca cccaacttct ctgggtctaa aagtctggag aggaaagcct gaaaggctct
     2461 ctaggcaggg ggtctcttta gggccttctt ggatctctgc aggcttgtac tgccttcagg
     2521 gggaggccat gtggtcctgg aacaaagccc ctctgagggt ggcagatggg gcaggcagcc
     2581 caggcacaca gtgtggttgg ctcaacagcc cacagcccac aaaggcctca ttgagtcact
     2641 gccgaccccc agcagaggct gaggtggcag tggcgccggg cgcctgccac ctaatgaccg
     2701 tcctggctgg gccagatgtt ccacagacct tgcagcgccg atcagggcct gcctggccaa
     2761 gcagccacag aggccactcc agttccaatt aaccagcttc agctgagcaa accacgggca
     2821 gcagcggggc ccagcctggg cggtgggccc ggcccggccc ggccggccgg cagagcctct
     2881 gagtctagac tccagatgtg aaccgccacc gcctgagccc catggaaaaa tggcaccagg
     2941 ccgggcgcgc atcaggcctg catactggga ggcgggatgg gtggctgggc agggcctcag
     3001 atgggactgg tgccaggctc accctggagt gggggtggat tcttcggaag ctgctttcaa
     3061 acagatttcc cctggtttgt ggtgtcctct ctgtgccttg gtttttccag taggaggagg
     3121 ctgttagggc ttaagaccat ccctgcaaga aaccccatac tctatacatg cttaccgggt
     3181 tagcatgtgg ccagcattgt agagtgttct agaagttctt gactatccct gtgtggaata
     3241 tgcctgccat cccagcactt gtagaggcag caagctgaga taagccttgt ctacatagca
     3301 agtttcaggt cagccagcgc tccaagataa gaattagctt aaaaaattaa aaaaaaaaaa
     3361 agccagattg atccatactg gtttgtgact aatcttgaac ccgggagact taagacagga
     3421 tgatcaattc aaagtccccc ttggctacaa agagttcaaa gccagagcct gcctctagcc
     3481 aagtggagag attaattgta acaatcctat atggcaccta ccatcatctt cacagataag
     3541 gaatggcaag caggtctgca ctgacctgcc ggtgtttgac cttagtgcct ggcttatcta
     3601 aactcatgtt caccactgtg ctgaattcct gtttcttgtc tttggggaca gcatagggat
     3661 tatggggaca gggagaggat gacaatggat ggcttccagg atgagatggc agtgtcctga
     3721 catctgatcc ctttcttcag ctaaaagagg tgagagcatc ctctcaccca gttgcccttt
     3781 ggaaagtctt tctgtttcca tgcagtgtca gacaccagct aagttgataa ggacctaaca
     3841 gggagcacaa atggtggctc tccggagctg acatcctgca agatggcatt cctctgggga
     3901 gactgacgga aatgactggg tggatgtgcc aagagatgat gccacaggag atgggactcc
     3961 tgccccggtc ctggtgggca aagcaagggt ctgtgccatc cagctgccct tgcacaaaac
     4021 gacaaactca gtgctcccgc caccacccca ggaaaaaaaa agccaggctg gcaggggtct
     4081 ctgcggcagc ctgcgcctcc ttcctgttct ccaactatgg actccccgcg tgactgccgg
     4141 ccacgggagg agcggcatcc tgcggggtgc gccaggaagg gccttgcaag cgggaaggaa
     4201 agcgccacct ctctcgcccc cgccaaggcc acacctgggc tccgcaggcg gtagcgccgg
     4261 gccagcgcct ggctccagcg agtctgggcc gccctcccta cgcactgcgg gggccgccag
     4321 ctgggctggt cgctcgcgca gctccgcggc cggaagctgt tcactggggg gcgtggtccg
     4381 tgttggtccc acccaggagg gcagggtcac tgtagcccaa ggacaagctt tggaatttcg
     4441 gctggcttta cagtctccat ttgtgttttt ctttcctccc agtcccaggg gaccgaaccg
     4501 tgctaagtga gcgctatatc actgagctgt atccccgaaa cccttcactt cgatgttctt
     4561 acctagaaaa tgagggaatt gtaccccacc cccaacacct ggcccagtgc aaaatcatgc
     4621 cggcactgtg tgtgttaaat gaatgcatgc gaaggtctaa aacctccctg aggcctggcg
     4681 ttgtcttggg caaaaagctc cccgcagatg aggaatcctt tgtttcatcc ctgagctgcg
     4741 ttttcctcag tcagtggtgg ctgagaagaa acagtcctcg gaaaacatgg acacctagaa
     4801 tatcctccgt aaaagatatg gaagagtctc caagatgggg cggggggggg ggggggggaa
     4861 tgtggtagca tactcctgca atcctaaaac ccgagagtaa ggcaggagga tcgagagtaa
     4921 ggcaggagga tcgtctagag ccagctcctg atgcagattt caaggctagt ttgggctaca
     4981 taagatcctg ttgtctcaaa actgatatat ttggaggtaa aaatgctcaa aagaattaca
     5041 cttggaagat tttgcttttt ggagggtagg ggagtttgga gggagtgggt tgcttgggtt
     5101 tgagattgga acttgctatg taacccaggc tggcccagat ggaactctgt acagcagact
     5161 aggattacaa gaaactttct ctgtg
//
