LOCUS       NM_001159553            4506 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus histocompatibility 13 (H13), transcript variant 4,
            mRNA.
ACCESSION   NM_001159553
VERSION     NM_001159553.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4506)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4506)
  AUTHORS   Wang,S., Jaggi,U., Tormanen,K., Hirose,S. and Ghiasi,H.
  TITLE     Absence of signal peptide peptidase in peripheral sensory neurons
            affects latency-reactivation in HSV-1 ocularly infected mice
  JOURNAL   PLoS Pathog 18 (1), e1010281 (2022)
   PUBMED   35100323
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4506)
  AUTHORS   Wang,S. and Ghiasi,H.
  TITLE     Absence of Signal Peptide Peptidase, an Essential Herpes Simplex
            Virus 1 Glycoprotein K Binding Partner, Reduces Virus Infectivity
            In Vivo
  JOURNAL   J Virol 93 (23), e01309-19 (2019)
   PUBMED   31511378
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4506)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4506)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 4506)
  AUTHORS   Wood,A.J., Roberts,R.G., Monk,D., Moore,G.E., Schulz,R. and
            Oakey,R.J.
  TITLE     A screen for retrotransposed imprinted genes reveals an association
            between X chromosome homology and maternal germ-line methylation
  JOURNAL   PLoS Genet 3 (2), e20 (2007)
   PUBMED   17291163
REFERENCE   7  (bases 1 to 4506)
  AUTHORS   Graff,R.J., Kurtz,M.E., Paul,R., Martin,D. and Roopenian,D.C.
  TITLE     Additional mapping of mouse chromosome 2 genes
  JOURNAL   Immunogenetics 33 (2), 96-100 (1991)
   PUBMED   1999355
REFERENCE   8  (bases 1 to 4506)
  AUTHORS   Graff,R.J., Martin-Morgan,D. and Kurtz,M.E.
  TITLE     Multiplicity of chromosome 2 histocompatibility genes: new loci,
            H-44 and H-45
  JOURNAL   Immunogenetics 26 (1-2), 111-114 (1987)
   PUBMED   3301647
REFERENCE   9  (bases 1 to 4506)
  AUTHORS   Graff,R.J. and Bailey,D.W.
  TITLE     The non-H-2 histocompatibility loci and their antigens
  JOURNAL   Transplant Rev 15, 26-49 (1973)
   PUBMED   4130130
  REMARK    Review article
REFERENCE   10 (bases 1 to 4506)
  AUTHORS   Vojtiskova,M., Polackova,M. and Pokorna,Z.
  TITLE     Histocompatibility antigens on mouse spermatozoa
  JOURNAL   Folia Biol (Praha) 15 (5), 322-332 (1969)
   PUBMED   4390514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845162.9.
            
            On Jun 27, 2022 this sequence version replaced NM_001159553.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004690.1, AK051151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 17291163
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL845162.9         150202-150486
            286-384             AL845162.9         158264-158362
            385-4506            AL845162.9         161773-165894
FEATURES             Location/Qualifiers
     source          1..4506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..4506
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="histocompatibility 13"
                     /db_xref="GeneID:14950"
                     /db_xref="MGI:MGI:95886"
     exon            1..285
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..624
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /EC_number="3.4.99.-"
                     /note="isoform 4 is encoded by transcript variant 4; minor
                     histocompatibility antigen H13; signal peptide peptidase
                     beta; presenilin-like aspartyl protease; presenilin-like
                     protein 3"
                     /codon_start=1
                     /product="minor histocompatibility antigen H13 isoform 4"
                     /protein_id="NP_001153025.1"
                     /db_xref="GeneID:14950"
                     /db_xref="MGI:MGI:95886"
                     /translation="MDSAVSDPHNGSAEAGTPANGTTRPPSTPEGIALAYGSLLLMAL
                     LPIFFGALRSVRCARGKSSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYIN
                     LLLSMYFFVLGILALSHTIRSEGISRQPLKLLSQEPVQGLGWEHGLLCHSEPGLNPGC
                     KIQGNLPSRQHYT"
     exon            286..384
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            385..4506
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1230
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="major polyA site"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="hexamer: ATTAAA"
     polyA_site      2781
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
     regulatory      4485..4490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="hexamer: ATTAAA"
     polyA_site      4506
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
ORIGIN      
        1 gtttctttag gggaacgtgg ctttccccgc agtgcctctt ctccgtctac gttcgtgctg
       61 cggcggccgg agctggagtc ggagcccgag cgcagcctcg ccatggattc ggctgtcagc
      121 gatccgcaca acggcagcgc cgaggctggc accccagcca acggcacgac gcggccgccc
      181 tccacgcccg agggcatcgc gctggcctac ggcagcctcc tgctcatggc gctgctgccc
      241 atcttcttcg gcgccctgcg ctcggtgcgc tgcgcccgcg gcaagagctc ttcggacatg
      301 ccagaaacca tcaccagtcg agatgccgcc cgcttcccca tcatcgccag ctgcacactc
      361 ctggggctct acctcttttt caaaatattc tcccaggagt acatcaacct cttgctgtcc
      421 atgtatttct tcgtgctggg gatcctggcc ctgtcacaca ccatcaggtc agaaggcatc
      481 tctcgacagc ctttgaagct gctttctcag gagccagtac agggtcttgg atgggaacat
      541 ggtcttttgt gtcattcaga gccaggttta aatcctggct gtaaaatcca agggaatctt
      601 ccctcacgtc agcactatac gtgacctagg atggaacccc aaacttctca gggccaccaa
      661 ctcctaataa ggacgtacaa ggctatgtat ggtggctctt agtactcaag aggctgaggc
      721 aagttcctga gctaccatat aagacccagt cttcgaaaaa aacctaggca gaagtgtcat
      781 agagtcacca cagtgctgat gtgtgtctca tcaggaccac ttgaagcacg aggcttggct
      841 cctcatggga caggcaccta ccagcagagg gttaggaatg ccttccctta aatccagtct
      901 ctacactcca agttaacctc tttgacttca gtctccttaa ggttgtgttt tgtttttaaa
      961 aaacaagcaa gcaaactgat ggccttcatg tagaaaatgt ctctcagtca ataagtacaa
     1021 ctgtcacctt tgttaggact gctgtgatca cctgtgtcag cttgttagac acccttgact
     1081 ggctggctct gggtgttaat cctgggttag tcagggaagc tgaagttagt gtgtttgaga
     1141 cattcagtaa gatcactcag cccatttctg tctgcctgtt tgcagtagtc cacagataga
     1201 ctgaggaatg gctaggaaaa gttgtccgaa gaaaggaacg caacgtgacc tcaggtttga
     1261 gaggtaggaa gcctgggaga ggtataagga gagaggtgct ggtcaggagc ttgatgatct
     1321 ccatacagta gggatcagag ctacacagag cagaatctgc accaaggaac agtgaggttt
     1381 attcctcagg caagctggca ggatggagac aggcagagtg gtaggtagcc ttggcctctg
     1441 aatatcagtc cgtctgtccc ccgtcgtcat cgtgtgtccc cccccaccac ccgaccccca
     1501 cccggcctgc cgtaaacagt atacaaagtc ttcaaacaag cagaaagtgt cagatgggct
     1561 gctgtctccg ctgggacttt agctatgggc tttggagtaa atctagcacc atcttgacct
     1621 gcaaaatctt actctagctg cattgaaagt acggtagccc ttctcagagg atgacttgga
     1681 cctggcaagc aagaatagca ggtccagcac tcatgaggac ctgaggcaag gataggagtc
     1741 atcgctctga aactctgggt ttccttcttt tccatgctgg ccagagccat ccagggtcta
     1801 caagaggtct cccagttcct cccatagcct agcttcgccg atcagggaga gcgtgctctt
     1861 tgaaagcacc aggaacggca tatgcttgag aactaattat ttcacggtag cccagcagcc
     1921 ctgcatccaa ctgcccacaa actgttgtgg tccacatgtc tcagaacaac caattgtgtc
     1981 tctacccaac ttagaaatgt tagtgatagc tattatcaac acaaaataaa gccagcggtc
     2041 tcctaggaat agagagctta atggtaaagc ctggtaaggg taagaccctg ggtttgatcc
     2101 tagcaccaca aacaaaagtg agcagttaac tatgtaggaa gccaggcagc actacacacc
     2161 tctaatccca agcactcagg aggaagaggc aggcaaatca ccagcacggc tagctatact
     2221 gtaagaccct gtctccaaaa aaagaaagag aacagggaag gcaccggcaa gctgagtgtg
     2281 ttggctcagc ctttgatcct agtacttggg atgcagaggc agggagagca ggagctcaga
     2341 gtccccctca gctgcacagc caggtcacag cctattagtt atatgagaca gtgtagcaga
     2401 acagtaaggg ctacgtggta acatttgtga ggtagaagct ggtttggttg ttgttttcct
     2461 gctgggtgtt aaactacagc ccagtcctaa gttttgtttt ttcttttggt gttaggaatt
     2521 gaacccaggg ccacatatac acacataagc gagtcgtgtg gtctagcact gacccacctc
     2581 cccagccatg agtcattttg ttaataaaat ccagagcact ggtaatgtgc tgtggcagtc
     2641 gggagcttga gaggctgagg cgtgaggtta tcgtgagaaa gaagtaaagc caatgaattt
     2701 tattacaaga gggggaagaa tttaaccttt tttttctttt tagagtgttg atccaaaaat
     2761 taaactgact cttactcact ggaggtgtgt tttctcaagt cttttggtaa agcaaactac
     2821 agtgtttaag agtttccacg agctgtttat agccacaagt cagacttcct ctggagttga
     2881 gccataaggt ctgaggggat gagacaagga agctgaggtt caaaagaatt attatggctc
     2941 ccaggattca cagctgagaa aagcagaggc gtttgatccc agggctctct gaccacagtg
     3001 ctagaattcc ttatcacttt gtggccaaaa ttaaggggaa gagagaattt ggagaaaaca
     3061 gactcacctc tccacacatc tcaaaaatgc ccgctaaaga ctgtaagagc cacatcccag
     3121 tcatggtggc ccagaccaca cccaaatccc tccacctctg ttgccacccc actgcctgcc
     3181 tcagaccaga ccacagctca cagcgttgca ggcaggtagg agacatcttg ccttcaccta
     3241 atagttacca aaactccaac ccagccagac tctgcacatc ctgccagagc agtcgtggcc
     3301 tgtttttatc acctgtggct gagctcttgc cctactcaag tggtccacag caagaaagcc
     3361 caagtcgtct acctcaggag agcacatccc caggttcatt aaccctcgct gtctacccca
     3421 gagggagagg caccagaaca tttctcagaa gaaaacgagg aactttgtct cttatgagtc
     3481 atggagagtc ataaaaacac tgcccacagt aaaagtacaa tcagagcagg ccagcaaact
     3541 ctgcctggca tggggcatcg atgagacagg gccctgccct ccagttcaca gattcacacc
     3601 agttacatca cactagtcct cttctgtgtt gtatcttaca gcagaccctt ttcctcagtg
     3661 cttgccttga tcccaactgt ttagagggat taagacacga ggatcaaaag ctggaggcca
     3721 gcctgagcaa ctgagtgaaa ctctatttca aaatgagtaa ggcctaaatg tgtagctcgg
     3781 tggtatggca cacatacaga aatcagtgca gacatttaac acttgaagtg gaagccacgg
     3841 gtgaactcac aagataccaa gtattagctt aatcctcttc gagatccctg agagattcag
     3901 acttggtgtg agtcctggaa ttccagcact tgggagacag aagcagaagg attgttgcaa
     3961 atttgaggca ggtctgagct gtagagtgag actcttagca caaacagtaa tcctctgaga
     4021 gaggtattac aatatggtga ttgtaataag gtatctaata actcggatac agaaagagtt
     4081 gcatggagca gttgttgtaa ctttgccaag atcatacctc tgagaagtgg cagagatggg
     4141 acttgaacct aggaatcatg tctccagtct attctgctga ttaaaaacac cgaattctga
     4201 agaggctagg tagggtgagt gttccagctc ctcacactgc tctctgctct gcctctgcct
     4261 gtgtctgcac ttgtgccatg ccttcaccct tcctcacatt cagcagactg agcccctcgc
     4321 cttggctgtc ctggctgagt ctgccttccg tgggtgctca ctctatgccc tgtacccgtc
     4381 tcttctctgc ctctgataat attcattatc aaccacttca cacagtctgc aaaggatcag
     4441 gcccagaggt gactcttaaa ttcctattct ccaagccacc agaaattaaa aacaaacaaa
     4501 gaacca
//
