LOCUS       NM_001159551            5385 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus histocompatibility 13 (H13), transcript variant 1,
            mRNA.
ACCESSION   NM_001159551
VERSION     NM_001159551.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5385)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5385)
  AUTHORS   Wang,S., Jaggi,U., Tormanen,K., Hirose,S. and Ghiasi,H.
  TITLE     Absence of signal peptide peptidase in peripheral sensory neurons
            affects latency-reactivation in HSV-1 ocularly infected mice
  JOURNAL   PLoS Pathog 18 (1), e1010281 (2022)
   PUBMED   35100323
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5385)
  AUTHORS   Wang,S. and Ghiasi,H.
  TITLE     Absence of Signal Peptide Peptidase, an Essential Herpes Simplex
            Virus 1 Glycoprotein K Binding Partner, Reduces Virus Infectivity
            In Vivo
  JOURNAL   J Virol 93 (23), e01309-19 (2019)
   PUBMED   31511378
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5385)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5385)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 5385)
  AUTHORS   Wood,A.J., Roberts,R.G., Monk,D., Moore,G.E., Schulz,R. and
            Oakey,R.J.
  TITLE     A screen for retrotransposed imprinted genes reveals an association
            between X chromosome homology and maternal germ-line methylation
  JOURNAL   PLoS Genet 3 (2), e20 (2007)
   PUBMED   17291163
REFERENCE   7  (bases 1 to 5385)
  AUTHORS   Graff,R.J., Kurtz,M.E., Paul,R., Martin,D. and Roopenian,D.C.
  TITLE     Additional mapping of mouse chromosome 2 genes
  JOURNAL   Immunogenetics 33 (2), 96-100 (1991)
   PUBMED   1999355
REFERENCE   8  (bases 1 to 5385)
  AUTHORS   Graff,R.J., Martin-Morgan,D. and Kurtz,M.E.
  TITLE     Multiplicity of chromosome 2 histocompatibility genes: new loci,
            H-44 and H-45
  JOURNAL   Immunogenetics 26 (1-2), 111-114 (1987)
   PUBMED   3301647
REFERENCE   9  (bases 1 to 5385)
  AUTHORS   Graff,R.J. and Bailey,D.W.
  TITLE     The non-H-2 histocompatibility loci and their antigens
  JOURNAL   Transplant Rev 15, 26-49 (1973)
   PUBMED   4130130
  REMARK    Review article
REFERENCE   10 (bases 1 to 5385)
  AUTHORS   Vojtiskova,M., Polackova,M. and Pokorna,Z.
  TITLE     Histocompatibility antigens on mouse spermatozoa
  JOURNAL   Folia Biol (Praha) 15 (5), 322-332 (1969)
   PUBMED   4390514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845162.9.
            
            On Jun 27, 2022 this sequence version replaced NM_001159551.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049101.1, DQ168449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 17291163
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL845162.9         150202-150486
            286-384             AL845162.9         158264-158362
            385-467             AL845162.9         161773-161855
            468-556             AL845162.9         166820-166908
            557-642             AL845162.9         169385-169470
            643-768             AL845162.9         169559-169684
            769-826             AL845162.9         170566-170623
            827-910             AL845162.9         172515-172598
            911-947             AL845162.9         175209-175245
            948-1050            AL845162.9         176204-176306
            1051-1136           AL845162.9         180905-180990
            1137-1336           AL845162.9         184717-184916
            1337-5385           AL845162.9         185344-189392
FEATURES             Location/Qualifiers
     source          1..5385
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..5385
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="histocompatibility 13"
                     /db_xref="GeneID:14950"
                     /db_xref="MGI:MGI:95886"
     exon            1..285
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1287
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /EC_number="3.4.99.-"
                     /note="isoform 1 is encoded by transcript variant 1; minor
                     histocompatibility antigen H13; signal peptide peptidase
                     beta; presenilin-like aspartyl protease; presenilin-like
                     protein 3"
                     /codon_start=1
                     /product="minor histocompatibility antigen H13 isoform 1"
                     /protein_id="NP_001153023.1"
                     /db_xref="CCDS:CCDS50752.1"
                     /db_xref="GeneID:14950"
                     /db_xref="MGI:MGI:95886"
                     /translation="MDSAVSDPHNGSAEAGTPANGTTRPPSTPEGIALAYGSLLLMAL
                     LPIFFGALRSVRCARGKSSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYIN
                     LLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLLFTQGSGENKEEIINYEFDT
                     KDLVCLGLSSVVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIY
                     DIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALL
                     LRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVA
                     LAKGEVAEMFSYESSAVILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPS
                     AM"
     exon            286..384
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            385..467
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            468..556
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            557..642
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            643..768
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            769..826
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            827..910
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            911..947
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1050
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1136
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1336
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..5385
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="hexamer: ATTAAA"
     polyA_site      1767
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="major polyA site"
     regulatory      5369..5374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
                     /note="hexamer: AAGAAA"
     polyA_site      5385
                     /gene="H13"
                     /gene_synonym="1200006O09Rik; 4930443L17Rik;
                     5031424B04Rik; H-13; Hm13; PSL3; Spp"
ORIGIN      
        1 gtttctttag gggaacgtgg ctttccccgc agtgcctctt ctccgtctac gttcgtgctg
       61 cggcggccgg agctggagtc ggagcccgag cgcagcctcg ccatggattc ggctgtcagc
      121 gatccgcaca acggcagcgc cgaggctggc accccagcca acggcacgac gcggccgccc
      181 tccacgcccg agggcatcgc gctggcctac ggcagcctcc tgctcatggc gctgctgccc
      241 atcttcttcg gcgccctgcg ctcggtgcgc tgcgcccgcg gcaagagctc ttcggacatg
      301 ccagaaacca tcaccagtcg agatgccgcc cgcttcccca tcatcgccag ctgcacactc
      361 ctggggctct acctcttttt caaaatattc tcccaggagt acatcaacct cttgctgtcc
      421 atgtatttct tcgtgctggg gatcctggcc ctgtcacaca ccatcagccc cttcatgaat
      481 aagttttttc cagccaactt cccaaaccgc cagtatcagc tgctcttcac acagggctct
      541 ggggaaaaca aagaagagat catcaactat gagtttgaca ctaaggacct ggtgtgcctg
      601 ggcctaagca gcgtcgttgg tgtctggtac cttctgagga agcactggat tgccaacaac
      661 ctgtttggcc tggccttctc ccttaatggg gtagagctcc tgcacctgaa caacgtgagc
      721 actggctgta tcctgctcgg aggactcttc atctatgaca tcttctgggt attcggcacc
      781 aacgtgatgg tgacagtggc caagtccttt gaggcaccaa taaaattggt gttcccccag
      841 gatctgctgg agaagggcct tgaagcagac aactttgcca tgctgggact tggagacatt
      901 gtcattccag ggatcttcat tgccttactg cttcgttttg acatcagctt gaagaagaac
      961 acgcacacct acttctacac cagcttcgcc gcctacatct tcggcctggg tctcaccatc
     1021 ttcatcatgc acatcttcaa gcacgcccag ccggctctcc tgtacctggt ccctgcctgc
     1081 atcggctttc ctgtcctggt ggcactagcc aagggagaag tggccgagat gttcagctac
     1141 gagtcctcgg ccgtaatcct gcctcatacg ccgaggctca ctcactttcc cacagtctcg
     1201 ggctcccctg ccagcctggc cgactccatg cagcagaagc tagctggccc tcgtcgccgg
     1261 cgcccgcaga atcccagcgc catgtagtgc ccagcaggtg cccacctgcc cgcttcccca
     1321 ctgtcctggg cctaagttat gaggagtcca accctaaaga tccagcagcc gagactgaat
     1381 ccaaagagga gtcaacagag gcgtcggcat cgaagaggct agagaagaag gagaaatgag
     1441 gcagcgctgc ctgacccttg agggccagat cggacaggca ggggatgacc tgtgggcgac
     1501 acagaagaga agacacctgc aggaggcgac ggtggcccca ggatggggag caggcctctg
     1561 ctgcctgttc cctctgccct ttctctggct tcctctgctc ctcctcatcc ctgcaggcaa
     1621 aggaaaccct ctgctgcttc cttccccagg agccaggtgg gcactgaatg tggtttttag
     1681 atttttgtat tgtggactgt ctttgcctca tattaaaaac tcatcccatg gccgctaggc
     1741 caccgtgctc caagggagct ctcagcagct ctgcctagtg tttcgtgctg aactcatcgg
     1801 ggctttgcga gtaccttcgt gggtgccagg ccagaagtgg gttcccatga gcctcctttc
     1861 ccagccactc ctgggggaca gtgaaggtgg tgggcgagtg cttgctgcgc cccgctggcc
     1921 ttggtatgag atgaagagag tgtcacgggg caccccgctt cagcaaaggg acttgtaact
     1981 atggacagac ggctccctgg gcttgctgtc catctggctg gaaatcaaag gtccatcttt
     2041 tccatcccca ggtctcccaa aatacagctc aggtcttcag aaagcctgcc ctggggaggg
     2101 agcagattcc agagaacaga agaggccatc caaggtcagg caagagttag agatcccaaa
     2161 gccaaagtct ccctccctcc tgaccttcaa gcgagtccct aaagggcaag gagagggcag
     2221 ctcatccctc gtccacctgc ccaggtggaa aaactgagac tgtggaatgg ccatgacctg
     2281 tgagctttcc ctggctaggg ttcagggtta atgactaaaa tgaacagatt ggaaatggtc
     2341 agagagcaaa ggctgtccag agcctgggga ataagagtgg agggaggtga gtgtccccag
     2401 tttcagatgt agaccaggtg tgtcgatgca agcttcggat ctgtacttcg gatgctaagc
     2461 tgcgcgtgct ttagcctcgc tctacagagg agggaatggg gccgctcacc cccagacagt
     2521 gactgcagct caacatacta agcactgtgc tgtcctctta taggaccaag aagtcactgt
     2581 ggctgctctg ctgggccacc gagtcagcca cccaacttct ctgggtctaa aagtctggag
     2641 aggaaagcct gaaaggctct ctaggcaggg ggtctcttta gggccttctt ggatctctgc
     2701 aggcttgtac tgccttcagg gggaggccat gtggtcctgg aacaaagccc ctctgagggt
     2761 ggcagatggg gcaggcagcc caggcacaca gtgtggttgg ctcaacagcc cacagcccac
     2821 aaaggcctca ttgagtcact gccgaccccc agcagaggct gaggtggcag tggcgccggg
     2881 cgcctgccac ctaatgaccg tcctggctgg gccagatgtt ccacagacct tgcagcgccg
     2941 atcagggcct gcctggccaa gcagccacag aggccactcc agttccaatt aaccagcttc
     3001 agctgagcaa accacgggca gcagcggggc ccagcctggg cggtgggccc ggcccggccc
     3061 ggccggccgg cagagcctct gagtctagac tccagatgtg aaccgccacc gcctgagccc
     3121 catggaaaaa tggcaccagg ccgggcgcgc atcaggcctg catactggga ggcgggatgg
     3181 gtggctgggc agggcctcag atgggactgg tgccaggctc accctggagt gggggtggat
     3241 tcttcggaag ctgctttcaa acagatttcc cctggtttgt ggtgtcctct ctgtgccttg
     3301 gtttttccag taggaggagg ctgttagggc ttaagaccat ccctgcaaga aaccccatac
     3361 tctatacatg cttaccgggt tagcatgtgg ccagcattgt agagtgttct agaagttctt
     3421 gactatccct gtgtggaata tgcctgccat cccagcactt gtagaggcag caagctgaga
     3481 taagccttgt ctacatagca agtttcaggt cagccagcgc tccaagataa gaattagctt
     3541 aaaaaattaa aaaaaaaaaa agccagattg atccatactg gtttgtgact aatcttgaac
     3601 ccgggagact taagacagga tgatcaattc aaagtccccc ttggctacaa agagttcaaa
     3661 gccagagcct gcctctagcc aagtggagag attaattgta acaatcctat atggcaccta
     3721 ccatcatctt cacagataag gaatggcaag caggtctgca ctgacctgcc ggtgtttgac
     3781 cttagtgcct ggcttatcta aactcatgtt caccactgtg ctgaattcct gtttcttgtc
     3841 tttggggaca gcatagggat tatggggaca gggagaggat gacaatggat ggcttccagg
     3901 atgagatggc agtgtcctga catctgatcc ctttcttcag ctaaaagagg tgagagcatc
     3961 ctctcaccca gttgcccttt ggaaagtctt tctgtttcca tgcagtgtca gacaccagct
     4021 aagttgataa ggacctaaca gggagcacaa atggtggctc tccggagctg acatcctgca
     4081 agatggcatt cctctgggga gactgacgga aatgactggg tggatgtgcc aagagatgat
     4141 gccacaggag atgggactcc tgccccggtc ctggtgggca aagcaagggt ctgtgccatc
     4201 cagctgccct tgcacaaaac gacaaactca gtgctcccgc caccacccca ggaaaaaaaa
     4261 agccaggctg gcaggggtct ctgcggcagc ctgcgcctcc ttcctgttct ccaactatgg
     4321 actccccgcg tgactgccgg ccacgggagg agcggcatcc tgcggggtgc gccaggaagg
     4381 gccttgcaag cgggaaggaa agcgccacct ctctcgcccc cgccaaggcc acacctgggc
     4441 tccgcaggcg gtagcgccgg gccagcgcct ggctccagcg agtctgggcc gccctcccta
     4501 cgcactgcgg gggccgccag ctgggctggt cgctcgcgca gctccgcggc cggaagctgt
     4561 tcactggggg gcgtggtccg tgttggtccc acccaggagg gcagggtcac tgtagcccaa
     4621 ggacaagctt tggaatttcg gctggcttta cagtctccat ttgtgttttt ctttcctccc
     4681 agtcccaggg gaccgaaccg tgctaagtga gcgctatatc actgagctgt atccccgaaa
     4741 cccttcactt cgatgttctt acctagaaaa tgagggaatt gtaccccacc cccaacacct
     4801 ggcccagtgc aaaatcatgc cggcactgtg tgtgttaaat gaatgcatgc gaaggtctaa
     4861 aacctccctg aggcctggcg ttgtcttggg caaaaagctc cccgcagatg aggaatcctt
     4921 tgtttcatcc ctgagctgcg ttttcctcag tcagtggtgg ctgagaagaa acagtcctcg
     4981 gaaaacatgg acacctagaa tatcctccgt aaaagatatg gaagagtctc caagatgggg
     5041 cggggggggg ggggggggaa tgtggtagca tactcctgca atcctaaaac ccgagagtaa
     5101 ggcaggagga tcgagagtaa ggcaggagga tcgtctagag ccagctcctg atgcagattt
     5161 caaggctagt ttgggctaca taagatcctg ttgtctcaaa actgatatat ttggaggtaa
     5221 aaatgctcaa aagaattaca cttggaagat tttgcttttt ggagggtagg ggagtttgga
     5281 gggagtgggt tgcttgggtt tgagattgga acttgctatg taacccaggc tggcccagat
     5341 ggaactctgt acagcagact aggattacaa gaaactttct ctgtg
//
