LOCUS       NM_008504               1304 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus granzyme M (lymphocyte met-ase 1) (Gzmm), transcript
            variant 1, mRNA.
ACCESSION   NM_008504
VERSION     NM_008504.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Souza-Fonseca-Guimaraes,F., Krasnova,Y., Putoczki,T., Miles,K.,
            MacDonald,K.P., Town,L., Shi,W., Gobe,G.C., McDade,L., Mielke,L.A.,
            Tye,H., Masters,S.L., Belz,G.T., Huntington,N.D., Radford-Smith,G.
            and Smyth,M.J.
  TITLE     Granzyme M has a critical role in providing innate immune
            protection in ulcerative colitis
  JOURNAL   Cell Death Dis 7 (7), e2302 (2016)
   PUBMED   27441655
  REMARK    GeneRIF: GzMM has a critical role during early stages of
            inflammation in ulcerative colitis; in its absence colonic
            inflammation is enhanced.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1304)
  AUTHORS   Liu,T., Wan,R.P., Tang,L.J., Liu,S.J., Li,H.J., Zhao,Q.H.,
            Liao,W.P., Sun,X.F., Yi,Y.H. and Long,Y.S.
  TITLE     A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA
            Expression Alterations with Possible Roles in Fragile X Syndrome
  JOURNAL   Mol Neurobiol 51 (3), 1053-1063 (2015)
   PUBMED   24906954
REFERENCE   3  (bases 1 to 1304)
  AUTHORS   Prakash,M.D., Munoz,M.A., Jain,R., Tong,P.L., Koskinen,A.,
            Regner,M., Kleifeld,O., Ho,B., Olson,M., Turner,S.J., Mrass,P.,
            Weninger,W. and Bird,P.I.
  TITLE     Granzyme B promotes cytotoxic lymphocyte transmigration via
            basement membrane remodeling
  JOURNAL   Immunity 41 (6), 960-972 (2014)
   PUBMED   25526309
REFERENCE   4  (bases 1 to 1304)
  AUTHORS   Baschuk,N., Wang,N., Watt,S.V., Halse,H., House,C., Bird,P.I.,
            Strugnell,R., Trapani,J.A., Smyth,M.J. and Andrews,D.M.
  TITLE     NK cell intrinsic regulation of MIP-1alpha by granzyme M
  JOURNAL   Cell Death Dis 5 (3), e1115 (2014)
   PUBMED   24625974
  REMARK    GeneRIF: Granzyme M regulates the release of natural killer cell
            MIP-1alpha to initiate innate immune responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1304)
  AUTHORS   Anthony,D.A., Andrews,D.M., Chow,M., Watt,S.V., House,C., Akira,S.,
            Bird,P.I., Trapani,J.A. and Smyth,M.J.
  TITLE     A role for granzyme M in TLR4-driven inflammation and endotoxicosis
  JOURNAL   J Immunol 185 (3), 1794-1803 (2010)
   PUBMED   20585036
  REMARK    GeneRIF: Natural killer (NK) cell GrzM augments the inflammatory
            cascade downstream of lipopolysaccharide (LPS)-toll-like receptor
            (TLR)4 signaling, which ultimately results in lethal endotoxicosis.
REFERENCE   6  (bases 1 to 1304)
  AUTHORS   Pao,L.I., Sumaria,N., Kelly,J.M., van Dommelen,S., Cretney,E.,
            Wallace,M.E., Anthony,D.A., Uldrich,A.P., Godfrey,D.I.,
            Papadimitriou,J.M., Mullbacher,A., Degli-Esposti,M.A. and
            Smyth,M.J.
  TITLE     Functional analysis of granzyme M and its role in immunity to
            infection
  JOURNAL   J Immunol 175 (5), 3235-3243 (2005)
   PUBMED   16116214
REFERENCE   7  (bases 1 to 1304)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   8  (bases 1 to 1304)
  AUTHORS   Kelly,J.M., O'Connor,M.D., Hulett,M.D., Thia,K.Y. and Smyth,M.J.
  TITLE     Cloning and expression of the recombinant mouse natural killer cell
            granzyme Met-ase-1
  JOURNAL   Immunogenetics 44 (5), 340-350 (1996)
   PUBMED   8781119
REFERENCE   9  (bases 1 to 1304)
  AUTHORS   Thia,K.Y., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Smyth,M.J.
  TITLE     The natural killer cell serine protease gene Lmet1 maps to mouse
            chromosome 10
  JOURNAL   Immunogenetics 41 (1), 47-49 (1995)
   PUBMED   7806275
REFERENCE   10 (bases 1 to 1304)
  AUTHORS   Pilat,D., Fink,T., Obermaier-Skrobanek,B., Zimmer,M., Wekerle,H.,
            Lichter,P. and Jenne,D.E.
  TITLE     The human Met-ase gene (GZMM): structure, sequence, and close
            physical linkage to the serine protease gene cluster on 19p13.3
  JOURNAL   Genomics 24 (3), 445-450 (1994)
   PUBMED   7713495
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151828.3, BG082217.2 and
            CD742060.1.
            
            On Oct 24, 2014 this sequence version replaced NM_008504.2.
            
            Summary: The protein encoded by this gene is a member of a family
            of cytotoxic lymphocyte serine proteases called granzymes, which
            are expressed by cytotoxic T lymphocytes and natural killer cells.
            This protein belongs to a subfamily of granzymes that cleave after
            methionine residues. Natural killer cell development, homeostasis
            and cytotoxicity are normal in mice deficient for this gene, but
            they demonstrate increased susceptibility to murine
            cytomegalovirus. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB015728.1, BC139218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               AC151828.3         97394-97761
            369-983             BG082217.2         1-615
            984-1304            CD742060.1         1-321               c
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1304
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /note="granzyme M (lymphocyte met-ase 1)"
                     /db_xref="GeneID:16904"
                     /db_xref="MGI:MGI:99549"
     exon            1..446
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1186
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lymphoctye Met-ase 1"
                     /codon_start=1
                     /product="granzyme M isoform 1 precursor"
                     /protein_id="NP_032530.1"
                     /db_xref="CCDS:CCDS23984.1"
                     /db_xref="GeneID:16904"
                     /db_xref="MGI:MGI:99549"
                     /translation="MEVCWSLLLLLALKTLWAAGNRFETQIIGGREAVPHSRPYMASL
                     QKAKSHVCGGVLVHRKWVLTAAHCLSEPLQNLKLVLGLHNLHDLQDPGLTFYIREAIK
                     HPGYNHKYENDLALLKLDRRVQPSKNVKPLALPRKPRSKPAEGTWCSTAGWGMTHQGG
                     PRARALQELDLRVLDTQMCNNSRFWNGVLIDSMLCLKAGSKSQAPCKGDSGGPLVCGK
                     GQVDGILSFSSKTCTDIFKPPVATAVAPYSSWIRKVIGRWSPQSLV"
     exon            447..606
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..745
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1012
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1287
                     /gene="Gzmm"
                     /gene_synonym="Lmet1; MMET-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttgcagcc agccttatgt acaaagttgc agggccagca gtaaggctca gtgggtagag
       61 gcctgccacc aagcctagca caggacctac acggctcaag gagagaactg accctgtgag
      121 tcatcctctg tgggggttga ggtccattga gacagaccca gtgtttacct ggtgctaatc
      181 accagaatga gcatcactgg gctatagttg ctgcccccca ggcagggggc agctttgaca
      241 gcagaattgc tttctaaaac cacacagcag ggtgtgaagt aggaggagtt gacacttgtg
      301 caaggtgggt ggtactggga aggccacctg tccccacagg aagagagagt ggggaaccct
      361 ttcccccagg gaccactgat cctgtgccag gatggaggtc tgctggtccc tgctgctact
      421 gctggccctg aaaacactgt gggcagcagg caacagattt gagacccaga tcattggggg
      481 tcgagaggca gtcccgcact cccgcccata catggcctct ctacagaaag ccaagtccca
      541 tgtgtgtggg ggagtccttg tgcatcggaa gtgggtattg acagctgccc actgcctgtc
      601 tgagccgcta cagaacctga agctggtgct tggcctgcac aacctccatg atctccaaga
      661 tcctggcctc accttctaca tccgggaagc cattaaacac cctggctaca accacaaata
      721 tgagaacgac ctggcactgc ttaagctaga tagacgagtg cagcccagca agaatgtcaa
      781 accactagct ctgccaagaa agccccgatc caagccggca gaaggtacct ggtgcagcac
      841 agctggctgg ggaatgaccc accagggtgg gccccgggcc agggccctgc aggagttgga
      901 tctgcgtgtg ctggataccc aaatgtgtaa caacagccgc ttctggaacg gtgtcctcat
      961 agacagcatg ctatgcttaa aggctgggag caagagccaa gccccctgca agggtgactc
     1021 tggagggccc ctggtgtgtg gcaaaggcca ggtggatggg atcctgtctt tcagctccaa
     1081 aacctgcaca gacatcttca agccacctgt ggccactgct gtagccccct acagctcctg
     1141 gatcaggaag gtcattggtc gctggtcacc ccaatctttg gtctgatgtc ccagatcatc
     1201 tgggacacca ttcttgatag cgggggctgg gaagggacta ggtgtgcctc tgaggaccaa
     1261 taaatcctga tatatctgtt gagtccaaaa aaaaaaaaaa aaaa
//
