LOCUS       NM_008196               1104 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus granzyme K (Gzmk), mRNA.
ACCESSION   NM_008196
VERSION     NM_008196.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1104)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1104)
  AUTHORS   Turner,C.T., Zeglinski,M.R., Boivin,W., Zhao,H., Pawluk,M.A.,
            Richardson,K.C., Chandrabalan,A., Bird,P., Ramachandran,R.,
            Sehmi,R., Lima,H., Gauvreau,G. and Granville,D.J.
  TITLE     Granzyme K contributes to endothelial microvascular damage and
            leakage during skin inflammation
  JOURNAL   Br J Dermatol 189 (3), 279-291 (2023)
   PUBMED   36652225
  REMARK    GeneRIF: Granzyme K contributes to endothelial microvascular damage
            and leakage during skin inflammation.
REFERENCE   3  (bases 1 to 1104)
  AUTHORS   Uranga-Murillo,I., Tapia,E., Garzon-Tituana,M., Ramirez-Labrada,A.,
            Santiago,L., Pesini,C., Esteban,P., Roig,F.J., Galvez,E.M.,
            Bird,P.I., Pardo,J. and Arias,M.
  TITLE     Biological relevance of Granzymes A and K during E. coli sepsis
  JOURNAL   Theranostics 11 (20), 9873-9883 (2021)
   PUBMED   34815792
  REMARK    GeneRIF: Biological relevance of Granzymes A and K during E. coli
            sepsis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1104)
  AUTHORS   Turner,C.T., Zeglinski,M.R., Richardson,K.C., Zhao,H., Shen,Y.,
            Papp,A., Bird,P.I. and Granville,D.J.
  TITLE     Granzyme K Expressed by Classically Activated Macrophages
            Contributes to Inflammation and Impaired Remodeling
  JOURNAL   J Invest Dermatol 139 (4), 930-939 (2019)
   PUBMED   30395844
REFERENCE   5  (bases 1 to 1104)
  AUTHORS   Joeckel,L.T., Allison,C.C., Pellegrini,M., Bird,C.H. and Bird,P.I.
  TITLE     Granzyme K-deficient mice show no evidence of impaired antiviral
            immunity
  JOURNAL   Immunol Cell Biol 95 (8), 676-683 (2017)
   PUBMED   28428612
  REMARK    GeneRIF: these data suggest that granzyme K does not play an
            essential role in viral immunity or cytotoxicity
REFERENCE   6  (bases 1 to 1104)
  AUTHORS   Zhao,T., Zhang,H., Guo,Y. and Fan,Z.
  TITLE     Granzyme K directly processes bid to release cytochrome c and
            endonuclease G leading to mitochondria-dependent cell death
  JOURNAL   J Biol Chem 282 (16), 12104-12111 (2007)
   PUBMED   17308307
  REMARK    GeneRIF: GzmK-induced caspase-independent death occurs through
            Bid-dependent mitochondrial damage that is different from GzmA
REFERENCE   7  (bases 1 to 1104)
  AUTHORS   Hink-Schauer,C., Estebanez-Perpina,E., Wilharm,E.,
            Fuentes-Prior,P., Klinkert,W., Bode,W. and Jenne,D.E.
  TITLE     The 2.2-A crystal structure of human pro-granzyme K reveals a rigid
            zymogen with unusual features
  JOURNAL   J Biol Chem 277 (52), 50923-50933 (2002)
   PUBMED   12384499
REFERENCE   8  (bases 1 to 1104)
  AUTHORS   Wilharm,E., Tschopp,J. and Jenne,D.E.
  TITLE     Biological activities of granzyme K are conserved in the mouse and
            account for residual Z-Lys-SBzl activity in granzyme A-deficient
            mice
  JOURNAL   FEBS Lett 459 (1), 139-142 (1999)
   PUBMED   10508933
REFERENCE   9  (bases 1 to 1104)
  AUTHORS   Suemoto,T., Taniguchi,M., Shiosaka,S. and Yoshida,S.
  TITLE     cDNA cloning and expression of a novel serine protease in the mouse
            brain
  JOURNAL   Brain Res Mol Brain Res 70 (2), 273-281 (1999)
   PUBMED   10407175
REFERENCE   10 (bases 1 to 1104)
  AUTHORS   Shresta,S., Goda,P., Wesselschmidt,R. and Ley,T.J.
  TITLE     Residual cytotoxicity and granzyme K expression in granzyme
            A-deficient cytotoxic lymphocytes
  JOURNAL   J Biol Chem 272 (32), 20236-20244 (1997)
   PUBMED   9242702
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139155.3.
            
            On Feb 4, 2019 this sequence version replaced NM_008196.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117981.1, SRR5189685.235253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC139155.3         81565-81693         c
            130-277             AC139155.3         81163-81310         c
            278-428             AC139155.3         74651-74801         c
            429-698             AC139155.3         73613-73882         c
            699-1104            AC139155.3         72358-72763         c
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..1104
                     /gene="Gzmk"
                     /note="granzyme K"
                     /db_xref="GeneID:14945"
                     /db_xref="MGI:MGI:1298232"
     exon            1..129
                     /gene="Gzmk"
                     /inference="alignment:Splign:2.1.0"
     exon            130..277
                     /gene="Gzmk"
                     /inference="alignment:Splign:2.1.0"
     exon            278..428
                     /gene="Gzmk"
                     /inference="alignment:Splign:2.1.0"
     exon            429..698
                     /gene="Gzmk"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1104
                     /gene="Gzmk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtctcct tcatcaacca cgaagcaagc agtttgtccg tgctccttaa caccgaagcc
       61 ctgtaattat gaggttttct tcatgggctc tggtttccct ggtggctggc gtttatatgt
      121 cttcagagtg tttccatact gaaattattg gagggaggga agtccagccg cattccaggc
      181 catttatggc gtccatccag taccgcagca agcatatttg tggaggagtc ctgatccacc
      241 cacagtgggt gctaacagcc gcccactgct actcttggtt tcccagaggc cactctccca
      301 ccgtggtttt aggagcacat tctctttcca agaatgagcc catgaagcag acatttgaaa
      361 ttaaaaagtt catcccattc tcacgacttc agtccggttc cgcatcgcat gacatcatgc
      421 tgataaagct tcgcactgct gcagaactaa acaagaatgt ccaactgctt cacctgggat
      481 ccaaaaacta tcttagagat gggaccaaat gccaggtgac tggctgggga accaccaagc
      541 cagatctgtt aaccgcctct gataccctga gagaagtcac tgttaccatc ataagtagaa
      601 aacgctgtaa cagccaaagc tactacaacc acaaacctgt tataaccaag gacatgatat
      661 gtgcaggaga tgccagaggt caaaaggatt cctgcaaggg tgactctggt ggccctttga
      721 tctgcaaagg catcttccat gccctagtct ctcagggcta taaatgtggc atcgccaaaa
      781 agcctggaat ctatacgcta ttaactaaga aataccagac ctggatcaaa agcaagcttg
      841 ccccatcacg tgcacattga gattgcacat tgagattttc ctggatctgc cagtcacttg
      901 cttctttttc caggatgcgc ttgcagacct ggcgtcctct tcagaggcag ctggctatag
      961 ggagggcatg gaacagctgg gatggatttc tgtttctcag aaattcattt agttagggag
     1021 ccatgctctt ttttcacgtg tattaatgat ttgtttttac tgtgttcgtt catcctaaat
     1081 aaaatgtgga cgtctgtgtt tgtc
//
