LOCUS       NM_010375                941 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus granzyme G (Gzmg), mRNA.
ACCESSION   NM_010375
VERSION     NM_010375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 941)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 941)
  AUTHORS   Tsai,T.C., Lin,W., Yang,S.H., Cheng,W.T., Cheng,E.H., Lee,M.S.,
            Chong,K.Y. and Chen,C.M.
  TITLE     Granzyme G is expressed in the two-cell stage mouse embryo and is
            required for the maternal-zygotic transition
  JOURNAL   BMC Dev Biol 10, 88 (2010)
   PUBMED   20704734
  REMARK    GeneRIF: Data suggest that granzyme G is an important factor in
            early mouse embryonic development and may play a novel role in the
            elimination of maternal proteins and the triggering of zygotic gene
            expression during the maternal-zygotic transition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 941)
  AUTHORS   Szabo,R., Hobson,J.P., Christoph,K., Kosa,P., List,K. and
            Bugge,T.H.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   4  (bases 1 to 941)
  AUTHORS   Sferruzzi-Perri,A.N., Macpherson,A.M., Roberts,C.T. and
            Robertson,S.A.
  TITLE     Csf2 null mutation alters placental gene expression and trophoblast
            glycogen cell and giant cell abundance in mice
  JOURNAL   Biol Reprod 81 (1), 207-221 (2009)
   PUBMED   19228596
REFERENCE   5  (bases 1 to 941)
  AUTHORS   Gallwitz,M., Reimer,J.M. and Hellman,L.
  TITLE     Expansion of the mast cell chymase locus over the past 200 million
            years of mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 655-669 (2006)
   PUBMED   16807745
REFERENCE   6  (bases 1 to 941)
  AUTHORS   Prendergast,J.A., Helgason,C.D. and Bleackley,R.C.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
REFERENCE   7  (bases 1 to 941)
  AUTHORS   Crosby,J.L., Bleackley,R.C. and Nadeau,J.H.
  TITLE     A complex of serine protease genes expressed preferentially in
            cytotoxic T-lymphocytes is closely linked to the T-cell receptor
            alpha- and delta-chain genes on mouse chromosome 14
  JOURNAL   Genomics 6 (2), 252-259 (1990)
   PUBMED   2307468
REFERENCE   8  (bases 1 to 941)
  AUTHORS   Jenne,D.E., Masson,D., Zimmer,M., Haefliger,J.A., Li,W.H. and
            Tschopp,J.
  TITLE     Isolation and complete structure of the lymphocyte serine protease
            granzyme G, a novel member of the granzyme multigene family in
            murine cytolytic T lymphocytes. Evolutionary origin of lymphocyte
            proteases
  JOURNAL   Biochemistry 28 (19), 7953-7961 (1989)
   PUBMED   2611223
REFERENCE   9  (bases 1 to 941)
  AUTHORS   Kwon,B.S., Kestler,D., Lee,E., Wakulchik,M. and Young,J.D.
  TITLE     Isolation and sequence analysis of serine protease cDNAs from mouse
            cytolytic T lymphocytes
  JOURNAL   J Exp Med 168 (5), 1839-1854 (1988)
   PUBMED   3053963
REFERENCE   10 (bases 1 to 941)
  AUTHORS   Jenne,D., Rey,C., Haefliger,J.A., Qiao,B.Y., Groscurth,P. and
            Tschopp,J.
  TITLE     Identification and sequencing of cDNA clones encoding the
            granule-associated serine proteases granzymes D, E, and F of
            cytolytic T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4814-4818 (1988)
   PUBMED   3260382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099473.1.
            
            On Jul 13, 2005 this sequence version replaced NM_010375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099473.1, CF615985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..941
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /note="granzyme G"
                     /db_xref="GeneID:14944"
                     /db_xref="MGI:MGI:109253"
     exon            1..110
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..802
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /note="MCSP-1; CTL serine protease 1; AKA granzyme G; CTL
                     serine protease 3"
                     /codon_start=1
                     /product="granzyme G precursor"
                     /protein_id="NP_034505.1"
                     /db_xref="CCDS:CCDS27144.1"
                     /db_xref="GeneID:14944"
                     /db_xref="MGI:MGI:109253"
                     /translation="MPPILILLTLLLPLRAGAEEIIGGHEVKPHSRPYMAFIKSVDIE
                     GKKKYCGGFLVQDDFVLTAAHCRNRSMTVTLGAHNIKAKEETQQIIPVAKAIPHPAFN
                     RKHGTNDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGDVCSVAGWGKTSINATKASA
                     RLREAQLIIQEDEECKKLWYTYSKTTQICAGDPKKVQAPYEGESGGPLVCDNLAYGVV
                     SYGINRTITPGVFTKVVHFLPWISTNMKLL"
     exon            111..261
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /inference="alignment:Splign:2.1.0"
     exon            262..397
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /inference="alignment:Splign:2.1.0"
     exon            398..658
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /inference="alignment:Splign:2.1.0"
     exon            659..910
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      889..894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /note="hexamer: AATAAA"
     polyA_site      910
                     /gene="Gzmg"
                     /gene_synonym="Ctla-7; Ctla7"
                     /note="major polyA site"
ORIGIN      
        1 tccaagggca gtgtctgctc tgccctcctt catcctgagc agccttcctg ggaagatgcc
       61 accaatcctg attctcctga ccctacttct gcctctcaga gctggagcag aggagatcat
      121 cggcggccat gaggtgaagc cacactcccg cccctacatg gcgttcatta agtctgtgga
      181 tatcgaaggg aagaagaaat actgcggagg cttcttggtt caagatgatt ttgtgctgac
      241 ggctgctcac tgcagaaaca ggtcaatgac agtcacactg ggggcccaca acatcaaggc
      301 taaggaggag acacagcaga tcatccctgt ggcaaaagcc attccccatc cagcttttaa
      361 tagaaagcat ggcaccaatg acattatgtt attaaaactg gagagtaagg ccaagagaac
      421 taaagctgtg aggcccctca agttgcccag acccaatgcc agggtgaagc caggggatgt
      481 gtgcagtgtg gctggctggg ggaaaacatc catcaatgcc actaaagcat ctgcccgcct
      541 gcgagaggct caactgatca tccaggagga cgaggaatgc aaaaaactct ggtacaccta
      601 ttccaagacc acgcagatct gtgctggaga cccaaaaaaa gtacaggctc cttacgaggg
      661 tgaatcgggg ggacccctcg tgtgtgacaa cctagcttat ggagttgtat cctatggaat
      721 aaacaggaca atcactccag gagtcttcac taaggttgtg cacttcctgc cgtggataag
      781 cacaaacatg aagctgctct aacaggagtt aaaccacccg tgcctgacca gcctgtccga
      841 cctcaggcaa gaaccacatg gactgggcag caaagaatga aaattcacaa taaataacct
      901 ccagagtgca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
