LOCUS       NM_010374                934 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus granzyme F (Gzmf), mRNA.
ACCESSION   NM_010374
VERSION     NM_010374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Hay,Z.L.Z., Kim,D.D., Cimons,J.M., Knapp,J.R., Kohler,M.E.,
            Quansah,M., Zuniga,T.M., Camp,F.A., Fujita,M., Wang,X.J.,
            O'Connor,B.P. and Slansky,J.E.
  TITLE     Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen
            Receptor T Cell-Mediated Cytotoxicity
  JOURNAL   J Immunol 212 (8), 1381-1391 (2024)
   PUBMED   38416029
  REMARK    GeneRIF: Granzyme F: Exhaustion Marker and Modulator of Chimeric
            Antigen Receptor T Cell-Mediated Cytotoxicity.
REFERENCE   2  (bases 1 to 934)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 934)
  AUTHORS   Wu,H.Y., Rong,Y., Correia,K., Min,J. and Morgan,J.I.
  TITLE     Comparison of the enzymatic and functional properties of three
            cytosolic carboxypeptidase family members
  JOURNAL   J Biol Chem 290 (2), 1222-1232 (2015)
   PUBMED   25416787
  REMARK    GeneRIF: Nna1 and CCP4 remove the C-terminal glutamate from
            substrates with two or more glutamates, whereas CCP6 requires four
            or more glutamates. CCP4 behaves as a promiscuous glutamase with
            little preference for chain length or neighboring amino acid
            composition
REFERENCE   4  (bases 1 to 934)
  AUTHORS   Shi,L., Wu,L., Wang,S. and Fan,Z.
  TITLE     Granzyme F induces a novel death pathway characterized by
            Bid-independent cytochrome c release without caspase activation
  JOURNAL   Cell Death Differ 16 (12), 1694-1706 (2009)
   PUBMED   19644510
  REMARK    GeneRIF: showed that GzmF impairs mitochondrial electron transport
            to abolish ATP generation; ATP decline may contribute to a failure
            of apoptosome formation, leading to caspase inactivation.
REFERENCE   5  (bases 1 to 934)
  AUTHORS   Szabo,R., Hobson,J.P., Christoph,K., Kosa,P., List,K. and
            Bugge,T.H.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   6  (bases 1 to 934)
  AUTHORS   Prendergast,J.A., Helgason,C.D. and Bleackley,R.C.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
REFERENCE   7  (bases 1 to 934)
  AUTHORS   Prendergast,J.A., Pinkoski,M., Wolfenden,A. and Bleackley,R.C.
  TITLE     Structure and evolution of the cytotoxic cell proteinase genes
            CCP3, CCP4 and CCP5
  JOURNAL   J Mol Biol 220 (4), 867-875 (1991)
   PUBMED   1880801
REFERENCE   8  (bases 1 to 934)
  AUTHORS   Jenne,D.E., Zimmer,M., Garcia-Sanz,J.A., Tschopp,J. and Lichter,P.
  TITLE     Genomic organization and subchromosomal in situ localization of the
            murine granzyme F, a serine protease expressed in CD8+ T cells
  JOURNAL   J Immunol 147 (3), 1045-1052 (1991)
   PUBMED   1861068
REFERENCE   9  (bases 1 to 934)
  AUTHORS   Jiang,S., Hasselkus-Light,C.S., Ojcius,D.M. and Young,J.D.
  TITLE     Purification of a membrane-associated serine esterase from murine
            cytotoxic T lymphocytes by a single reverse-phase column
  JOURNAL   Protein Expr Purif 1 (1), 77-80 (1990)
   PUBMED   2152187
REFERENCE   10 (bases 1 to 934)
  AUTHORS   Crosby,J.L., Bleackley,R.C. and Nadeau,J.H.
  TITLE     A complex of serine protease genes expressed preferentially in
            cytotoxic T-lymphocytes is closely linked to the T-cell receptor
            alpha- and delta-chain genes on mouse chromosome 14
  JOURNAL   Genomics 6 (2), 252-259 (1990)
   PUBMED   2307468
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100311.1.
            
            On Oct 21, 2006 this sequence version replaced NM_010374.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100311.1, J03257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..934
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /note="granzyme F"
                     /db_xref="GeneID:14943"
                     /db_xref="MGI:MGI:109254"
     exon            1..105
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..797
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /note="C134; MCSP3; cytotoxic cell protease 4; cytotoxic
                     serine protease 3; granzyme G; AKA granzyme G; CTL serine
                     protease 3"
                     /codon_start=1
                     /product="granzyme F precursor"
                     /protein_id="NP_034504.1"
                     /db_xref="CCDS:CCDS36936.1"
                     /db_xref="GeneID:14943"
                     /db_xref="MGI:MGI:109254"
                     /translation="MPPILILLTLLLPLRAGAEEIIGGHEVKPHSRPYMARVRFVKDN
                     GKRHSCGGFLVQDYFVLTAAHCTGSSMRVILGAHNIRAKEETQQIIPVAKAIPHPAYD
                     DKDNTSDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGHVCSVAGWGRTSINATQRSS
                     CLREAQLIIQKDKECKKYFYKYFKTMQICAGDPKKIQSTYSGDSGGPLVCNNKAYGVL
                     TYGLNRTIGPGVFTKVVHYLPWISRNMKLL"
     exon            106..256
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            257..392
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            393..653
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..909
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /note="hexamer: AATAAA"
     polyA_site      903
                     /gene="Gzmf"
                     /gene_synonym="CCP4; Ctla-7; Ctla7; MCSP-3"
                     /note="major polyA site"
ORIGIN      
        1 gggcagtgtc tcctctgccc tcctccatcc tgagcagcct tcctgggaag atgccaccaa
       61 tcctgattct cctgaccctt cttctgcctc tcagagctgg agcagaggag atcatcgggg
      121 gccatgaggt caagccccac tcccgccctt acatggcacg tgtgaggttt gtgaaagata
      181 atggaaaaag acattcctgt ggaggcttcc tggttcaaga ctactttgtg ctgacggctg
      241 ctcactgcac tggaagctca atgagagtca tactgggggc ccacaacatc agggctaagg
      301 aagagacaca gcagatcatc cctgtggcaa aagccattcc ccacccagct tatgatgata
      361 aggacaacac cagtgacatc atgctattaa agctggagag taaggccaag agaactaaag
      421 ctgtgaggcc cctcaagttg cccagaccca atgcccgggt gaagccaggg catgtttgca
      481 gtgtggctgg ctgggggaga acatccatca atgcaacaca aagatcttcc tgcctacgag
      541 aggctcaact gatcatccag aaggataagg aatgcaaaaa atacttctat aagtatttca
      601 agaccatgca gatttgtgct ggagacccaa agaaaataca gtctacttac agtggtgact
      661 ccgggggacc cctcgtgtgt aacaacaaag cttatggagt tttaacctat gggctaaaca
      721 ggacaatcgg tccaggagtc ttcactaagg ttgtgcacta cctgccgtgg ataagcagga
      781 acatgaagct gctctaacag gagttaaacc acccgtgcct gaccagcctg tccgacctca
      841 ggcaagaacc atgtggagtg agcagcaaag aatgaaaatt cataataaat aacctccaga
      901 gtgcatagaa aaaaaaaaaa aaaaaaaaaa aaaa
//
