LOCUS       NM_010373                923 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus granzyme E (Gzme), mRNA.
ACCESSION   NM_010373
VERSION     NM_010373.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 923)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 923)
  AUTHORS   Szabo,R., Hobson,J.P., Christoph,K., Kosa,P., List,K. and
            Bugge,T.H.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   3  (bases 1 to 923)
  AUTHORS   Sferruzzi-Perri,A.N., Macpherson,A.M., Roberts,C.T. and
            Robertson,S.A.
  TITLE     Csf2 null mutation alters placental gene expression and trophoblast
            glycogen cell and giant cell abundance in mice
  JOURNAL   Biol Reprod 81 (1), 207-221 (2009)
   PUBMED   19228596
REFERENCE   4  (bases 1 to 923)
  AUTHORS   Gallwitz,M., Reimer,J.M. and Hellman,L.
  TITLE     Expansion of the mast cell chymase locus over the past 200 million
            years of mammalian evolution
  JOURNAL   Immunogenetics 58 (8), 655-669 (2006)
   PUBMED   16807745
REFERENCE   5  (bases 1 to 923)
  AUTHORS   Grossman,W.J., Revell,P.A., Lu,Z.H., Johnson,H., Bredemeyer,A.J.
            and Ley,T.J.
  TITLE     The orphan granzymes of humans and mice
  JOURNAL   Curr Opin Immunol 15 (5), 544-552 (2003)
   PUBMED   14499263
  REMARK    Review article
            Erratum:[Curr Opin Immunol. 2003 Dec;15(6):731]
REFERENCE   6  (bases 1 to 923)
  AUTHORS   Prendergast,J.A., Helgason,C.D. and Bleackley,R.C.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
REFERENCE   7  (bases 1 to 923)
  AUTHORS   Prendergast,J.A., Pinkoski,M., Wolfenden,A. and Bleackley,R.C.
  TITLE     Structure and evolution of the cytotoxic cell proteinase genes
            CCP3, CCP4 and CCP5
  JOURNAL   J Mol Biol 220 (4), 867-875 (1991)
   PUBMED   1880801
REFERENCE   8  (bases 1 to 923)
  AUTHORS   Crosby,J.L., Bleackley,R.C. and Nadeau,J.H.
  TITLE     A complex of serine protease genes expressed preferentially in
            cytotoxic T-lymphocytes is closely linked to the T-cell receptor
            alpha- and delta-chain genes on mouse chromosome 14
  JOURNAL   Genomics 6 (2), 252-259 (1990)
   PUBMED   2307468
REFERENCE   9  (bases 1 to 923)
  AUTHORS   Kwon,B.S., Kestler,D., Lee,E., Wakulchik,M. and Young,J.D.
  TITLE     Isolation and sequence analysis of serine protease cDNAs from mouse
            cytolytic T lymphocytes
  JOURNAL   J Exp Med 168 (5), 1839-1854 (1988)
   PUBMED   3053963
REFERENCE   10 (bases 1 to 923)
  AUTHORS   Jenne,D., Rey,C., Haefliger,J.A., Qiao,B.Y., Groscurth,P. and
            Tschopp,J.
  TITLE     Identification and sequencing of cDNA clones encoding the
            granule-associated serine proteases granzymes D, E, and F of
            cytolytic T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4814-4818 (1988)
   PUBMED   3260382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG146331.1, J03256.1, M36901.1 and AV034078.1.
            
            On Oct 21, 2006 this sequence version replaced NM_010373.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03256.1, M36901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                BG146331.1         41-128
            89-516              J03256.1           1-428
            517-904             M36901.1           409-796
            905-923             AV034078.1         304-322
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..923
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /note="granzyme E"
                     /db_xref="GeneID:14942"
                     /db_xref="MGI:MGI:109265"
     exon            1..124
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..816
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /note="D12; MCSP2; CTL serine protease 2; cytotoxic cell
                     protease 3; cytotoxic serine protease 2"
                     /codon_start=1
                     /product="granzyme E precursor"
                     /protein_id="NP_034503.2"
                     /db_xref="CCDS:CCDS27143.1"
                     /db_xref="GeneID:14942"
                     /db_xref="MGI:MGI:109265"
                     /translation="MPPVLILLTLLLPLGAGAEEIIGGHVVKPHSRPYMAFVKSVDIE
                     GNRRYCGGFLVQDDFVLTAAHCRNRTMTVTLGAHNIKAKEETQQIIPVAKAIPHPDYN
                     ATAFFSDIMLLKLESKAKRTKAVRPLKLPRPNARVKPGDVCSVAGWGSRSINDTKASA
                     RLREAQLVIQEDEECKKRFRHYTETTEICAGDLKKIKTPFKGDSGGPLVCDNKAYGLL
                     AYAKNRTISSGVFTKIVHFLPWISRNMKLL"
     exon            125..275
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..411
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..672
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..923
                     /gene="Gzme"
                     /gene_synonym="CCP3; Ctla-6; Ctla6; MCSP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctccttcct ccccttccaa gggctttgtc tcctttgctc tccttcaact gagcagcctt
       61 cctgggaaga tgccaccagt cctgattctc ctgaccctac ttctgcctct tggagctgga
      121 gcagaggaga tcatcggcgg ccatgtggtg aagccacact cccgccccta catggcgttt
      181 gttaagtctg tggatattga aggtaatagg agatactgtg gaggcttctt ggttcaagat
      241 gactttgtgc tgactgctgc tcactgcagg aacaggacaa tgacagtcac actgggggcc
      301 cacaacatca aggctaagga ggagacacag cagatcatcc ctgtggcaaa agccattccc
      361 catccagatt ataatgccac tgccttcttc agtgacatca tgctgttaaa gctggagagt
      421 aaggccaaga gaactaaagc tgtgagaccc ctcaagttgc ccagacccaa tgcccgggtg
      481 aagccagggg atgtgtgcag tgtggctggc tgggggtcaa ggtccatcaa tgacactaaa
      541 gcatctgccc gcctgcgaga ggctcaactg gtcatccagg aggatgagga atgcaaaaaa
      601 cgtttccgac actacactga gaccacagag atttgtgctg gagacttgaa gaaaataaag
      661 actcctttca agggtgactc tgggggaccc ctcgtgtgtg acaacaaagc ttatggactt
      721 ttagcctatg caaaaaacag gacaatctct tcaggagtct tcactaagat tgtgcacttc
      781 ctgccgtgga taagcaggaa catgaagctg ctctaacagg tgttaaacca cccgtgcctg
      841 accagcctgt ccgacctcag gcaagaacca cgtggagtgg gcagcaaaga atgaaaattc
      901 acaataaata acctccagac tgc
//
