LOCUS       NM_010372                937 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus granzyme D (Gzmd), mRNA.
ACCESSION   NM_010372
VERSION     NM_010372.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 937)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 937)
  AUTHORS   Lopez-Tello,J., Perez-Garcia,V., Khaira,J., Kusinski,L.C.,
            Cooper,W.N., Andreani,A., Grant,I., Fernandez de Liger,E.,
            Lam,B.Y., Hemberger,M., Sandovici,I., Constancia,M. and
            Sferruzzi-Perri,A.N.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 937)
  AUTHORS   Berezniuk,I., Lyons,P.J., Sironi,J.J., Xiao,H., Setou,M.,
            Angeletti,R.H., Ikegami,K. and Fricker,L.D.
  TITLE     Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked
            glutamates from tubulin
  JOURNAL   J Biol Chem 288 (42), 30445-30453 (2013)
   PUBMED   24022482
REFERENCE   4  (bases 1 to 937)
  AUTHORS   Ronnberg,E., Calounova,G., Guss,B., Lundequist,A. and Pejler,G.
  TITLE     Granzyme D is a novel murine mast cell protease that is highly
            induced by multiple pathways of mast cell activation
  JOURNAL   Infect Immun 81 (6), 2085-2094 (2013)
   PUBMED   23529614
  REMARK    GeneRIF: These findings identify granzyme D as a novel murine mast
            cell protease and implicate granzyme D in settings where mast cells
            are activated, such as bacterial infection and allergy.
REFERENCE   5  (bases 1 to 937)
  AUTHORS   Kimura,Y., Kurabe,N., Ikegami,K., Tsutsumi,K., Konishi,Y.,
            Kaplan,O.I., Kunitomo,H., Iino,Y., Blacque,O.E. and Setou,M.
  TITLE     Identification of tubulin deglutamylase among Caenorhabditis
            elegans and mammalian cytosolic carboxypeptidases (CCPs)
  JOURNAL   J Biol Chem 285 (30), 22936-22941 (2010)
   PUBMED   20519502
REFERENCE   6  (bases 1 to 937)
  AUTHORS   Prendergast,J.A., Helgason,C.D. and Bleackley,R.C.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
REFERENCE   7  (bases 1 to 937)
  AUTHORS   Prendergast,J.A., Pinkoski,M., Wolfenden,A. and Bleackley,R.C.
  TITLE     Structure and evolution of the cytotoxic cell proteinase genes
            CCP3, CCP4 and CCP5
  JOURNAL   J Mol Biol 220 (4), 867-875 (1991)
   PUBMED   1880801
REFERENCE   8  (bases 1 to 937)
  AUTHORS   Crosby,J.L., Bleackley,R.C. and Nadeau,J.H.
  TITLE     A complex of serine protease genes expressed preferentially in
            cytotoxic T-lymphocytes is closely linked to the T-cell receptor
            alpha- and delta-chain genes on mouse chromosome 14
  JOURNAL   Genomics 6 (2), 252-259 (1990)
   PUBMED   2307468
REFERENCE   9  (bases 1 to 937)
  AUTHORS   Jenne,D., Rey,C., Haefliger,J.A., Qiao,B.Y., Groscurth,P. and
            Tschopp,J.
  TITLE     Identification and sequencing of cDNA clones encoding the
            granule-associated serine proteases granzymes D, E, and F of
            cytolytic T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4814-4818 (1988)
   PUBMED   3260382
REFERENCE   10 (bases 1 to 937)
  AUTHORS   Jenne,D., Rey,C., Masson,D., Stanley,K.K., Herz,J., Plaetinck,G.
            and Tschopp,J.
  TITLE     cDNA cloning of granzyme C, a granule-associated serine protease of
            cytolytic T lymphocytes
  JOURNAL   J Immunol 140 (1), 318-323 (1988)
   PUBMED   3257230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131671.1.
            
            On Jul 25, 2007 this sequence version replaced NM_010372.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131671.1, J03255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-937               AK131671.1         2-938
FEATURES             Location/Qualifiers
     source          1..937
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..937
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /note="granzyme D"
                     /db_xref="GeneID:14941"
                     /db_xref="MGI:MGI:109255"
     exon            1..126
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..830
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /codon_start=1
                     /product="granzyme D precursor"
                     /protein_id="NP_034502.2"
                     /db_xref="CCDS:CCDS49502.1"
                     /db_xref="GeneID:14941"
                     /db_xref="MGI:MGI:109255"
                     /translation="MPPILILLTLLLPLRAGAEEIIGGHVVKPHSRPYMAFVMSVDIK
                     GNRIYCGGFLIQDDFVLTAAHCKNSSVQSSMTVTLGAHNITAKEETQQIIPVAKDIPH
                     PDYNATIFYSDIMLLKLESKAKRTKAVRPLKLPRSNARVKPGDVCSVAGWGSRSINDT
                     KASARLREVQLVIQEDEECKKRFRYYTETTEICAGDLKKIKTPFKGDSGGPLVCDNQA
                     YGLFAYAKNGTISSGIFTKVVHFLPWISWNMKLL"
     exon            127..277
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     exon            278..425
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     exon            426..686
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     exon            687..937
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      917..922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /note="putative"
     polyA_site      937
                     /gene="Gzmd"
                     /gene_synonym="CCP5; Ctla-5; Ctla5"
                     /note="putative"
ORIGIN      
        1 atctccttcc tcgccttcca agggctttgt ctgctctgcc ctcctccatc ctgagcagcc
       61 ttcctgggaa gatgccacca atcctgattc tcctgaccct acttctgcct ctcagagctg
      121 gagcagagga gatcatcggc ggccatgtgg tgaagccaca ctcccgcccc tacatggcat
      181 tcgttatgtc tgtggatatt aaggggaaca ggatatactg tggaggcttc ctgattcaag
      241 atgactttgt gctgacggct gctcactgca aaaacagctc tgtccaaagc tcaatgacag
      301 tcacactggg ggcccacaac atcacggcta aggaggagac acagcagatc atccctgtgg
      361 caaaagacat tccccatcca gattataatg ctactatctt ctacagtgac atcatgctgt
      421 taaagctgga gagtaaggcc aagagaacta aagctgtgag acccctcaag ttgcccagat
      481 ccaatgcccg ggtgaagcca ggggatgtgt gcagtgtggc tggctggggg tcaaggtcca
      541 tcaatgacac taaagcatct gcccgcctgc gagaggttca actggtcatc caggaggacg
      601 aggaatgcaa aaaacgtttc cgatactaca ctgagaccac agagatttgt gctggagact
      661 tgaagaaaat aaagactcct ttcaagggtg actcgggggg accccttgtg tgtgacaacc
      721 aagcatatgg acttttcgcc tatgcaaaaa acggaacaat ctcttcagga atcttcacta
      781 aggttgtgca cttcctgccg tggataagct ggaacatgaa gttgctctaa caggagttaa
      841 accacccgtg cctgaccagc ctgtccgacc tcaggcaaga accatgtgga gtgggcagca
      901 aagaatgaaa attcacaata aataacctcc agagtgc
//
