LOCUS       NM_010371                942 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus granzyme C (Gzmc), mRNA.
ACCESSION   NM_010371
VERSION     NM_010371.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 942)
  AUTHORS   Lopez-Tello J, Perez-Garcia V, Khaira J, Kusinski LC, Cooper WN,
            Andreani A, Grant I, Fernandez de Liger E, Lam BY, Hemberger M,
            Sandovici I, Constancia M and Sferruzzi-Perri AN.
  TITLE     Fetal and trophoblast PI3K p110alpha have distinct roles in
            regulating resource supply to the growing fetus in mice
  JOURNAL   Elife 8, e45282 (2019)
   PUBMED   31241463
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 942)
  AUTHORS   Plasman K, Maurer-Stroh S, Ahmad J, Hao H, Kaiserman D, Sirota FL,
            Jonckheere V, Bird PI, Gevaert K and Van Damme P.
  TITLE     Conservation of the extended substrate specificity profiles among
            homologous granzymes across species
  JOURNAL   Mol Cell Proteomics 12 (10), 2921-2934 (2013)
   PUBMED   23788529
REFERENCE   3  (bases 1 to 942)
  AUTHORS   Szabo R, Hobson JP, Christoph K, Kosa P, List K and Bugge TH.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   4  (bases 1 to 942)
  AUTHORS   Cai SF, Fehniger TA, Cao X, Mayer JC, Brune JD, French AR and Ley
            TJ.
  TITLE     Differential expression of granzyme B and C in murine cytotoxic
            lymphocytes
  JOURNAL   J Immunol 182 (10), 6287-6297 (2009)
   PUBMED   19414782
  REMARK    GeneRIF: granzyme C is activated with persistent antigenic
            stimulation, providing nonredundant backup protection for the host
            when granzyme B fails.
REFERENCE   5  (bases 1 to 942)
  AUTHORS   Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews
            AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P,
            Vandekerckhove J, Gevaert K, Whisstock JC and Bird PI.
  TITLE     Structure of granzyme C reveals an unusual mechanism of protease
            autoinhibition
  JOURNAL   Proc Natl Acad Sci U S A 106 (14), 5587-5592 (2009)
   PUBMED   19299505
REFERENCE   6  (bases 1 to 942)
  AUTHORS   Prendergast JA, Helgason CD and Bleackley RC.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
REFERENCE   7  (bases 1 to 942)
  AUTHORS   Crosby JL, Bleackley RC and Nadeau JH.
  TITLE     A complex of serine protease genes expressed preferentially in
            cytotoxic T-lymphocytes is closely linked to the T-cell receptor
            alpha- and delta-chain genes on mouse chromosome 14
  JOURNAL   Genomics 6 (2), 252-259 (1990)
   PUBMED   2307468
REFERENCE   8  (bases 1 to 942)
  AUTHORS   Lobe CG, Upton C, Duggan B, Ehrman N, Letellier M, Bell J, McFadden
            G and Bleackley RC.
  TITLE     Organization of two genes encoding cytotoxic T lymphocyte-specific
            serine proteases CCPI and CCPII
  JOURNAL   Biochemistry 27 (18), 6941-6946 (1988)
   PUBMED   3264185
REFERENCE   9  (bases 1 to 942)
  AUTHORS   Jenne D, Rey C, Haefliger JA, Qiao BY, Groscurth P and Tschopp J.
  TITLE     Identification and sequencing of cDNA clones encoding the
            granule-associated serine proteases granzymes D, E, and F of
            cytolytic T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4814-4818 (1988)
   PUBMED   3260382
REFERENCE   10 (bases 1 to 942)
  AUTHORS   Jenne D, Rey C, Masson D, Stanley KK, Herz J, Plaetinck G and
            Tschopp J.
  TITLE     cDNA cloning of granzyme C, a granule-associated serine protease of
            cytolytic T lymphocytes
  JOURNAL   J Immunol 140 (1), 318-323 (1988)
   PUBMED   3257230
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA096882.1, CJ141626.1,
            BC120755.1, AI323531.1 and BG089964.1.
            
            [WARNING] On Jun 2, 2023 this sequence was replaced by NM_010371.4.
            
            On Sep 23, 2015 this sequence version replaced NM_010371.2.
            
            Summary: This gene encodes a member of the peptidase S1 family of
            serine proteases. The encoded preproprotein is proteolytically
            processed to generate a mature protein product. This product,
            expressed by activated T cells, may induce apoptosis of target
            cells. This gene is present in a gene cluster with other members of
            the granzyme subfamily on chromosome 14. [provided by RefSeq, Sep
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18459.1, X12822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AA096882.1         1-4
            5-428               CJ141626.1         2-425
            429-872             BC120755.1         378-821
            873-935             AI323531.1         1-63                c
            936-942             BG089964.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..942
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /note="granzyme C"
                     /db_xref="GeneID:14940"
                     /db_xref="MGI:MGI:109256"
     exon            1..130
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..822
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /EC_number="3.4.21.-"
                     /note="cytotoxic cell protease 2"
                     /codon_start=1
                     /product="granzyme C preproprotein"
                     /protein_id="NP_034501.2"
                     /db_xref="CCDS:CCDS27146.1"
                     /db_xref="GeneID:14940"
                     /db_xref="MGI:MGI:109256"
                     /translation="MPPVLILLTLLLPLRAGAEEIIGGNEISPHSRPYMAYYEFLKVG
                     GKKMFCGGFLVRDKFVLTAAHCKGSSMTVTLGAHNIKAKEETQQIIPVAKAIPHPDYN
                     PDDRSNDIMLLKLVRNAKRTRAVRPLNLPRRNAHVKPGDECYVAGWGKVTPDGEFPKT
                     LHEVKLTVQKDQVCESQFQSSYNRANEICVGDSKIKGASFEEDSGGPLVCKRAAAGIV
                     SYGQTDGSAPQVFTRVLSFVSWIKKTMKHS"
     exon            131..281
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     exon            282..417
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     exon            418..678
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     exon            679..936
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      911..916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
     polyA_site      936
                     /gene="Gzmc"
                     /gene_synonym="B10; CCP2; Ctla-5; Ctla5"
ORIGIN      
        1 ccacacctcc ttcctcccct tccaagggct ttgtctactc tgccctcctc catcctgagc
       61 agccttcctg ggaagatgcc accagtcctg attctcctga ccctacttct gcctctcaga
      121 gctggagcag aggagataat cggaggcaat gagatcagtc cacattcccg tccctacatg
      181 gcatattatg agtttctgaa agttggtggg aagaagatgt tctgcggagg cttcctggtt
      241 cgagacaaat tcgtgctaac agctgctcac tgcaaaggaa gctcaatgac agtcacactg
      301 ggggctcaca acatcaaggc taaggaggag acacagcaga tcatccctgt ggcaaaagcc
      361 attccccatc cagactataa tcctgatgac cgttctaatg acatcatgct attaaagctg
      421 gtgagaaatg ccaagaggac tagagctgtg aggcccctca acctgcccag gcgcaatgct
      481 catgtgaagc caggggatga gtgctatgtg gctggttggg gaaaggtaac cccggacggg
      541 gaattcccaa aaacactgca cgaagttaag ctgacagtac agaaggatca ggtgtgtgag
      601 tcccagttcc aaagttctta caacagagct aatgagatat gtgtgggaga ctcaaagatc
      661 aagggagctt cctttgagga ggattctgga ggcccgcttg tgtgtaaaag agcagctgca
      721 ggcatcgtct cctacgggca aactgatgga tcagctccac aagtcttcac aagagttttg
      781 agttttgtat cgtggataaa gaaaacgatg aaacacagct aactacaaga agcaaactag
      841 atcctgatct gaccagccat cttccccata gctgagtcca ggattgctct aggacagatg
      901 gcagcaactg aataaagaac tttctctgac tgcaaaaaaa aa
//
