LOCUS       NM_013542               1528 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus granzyme B (Gzmb), mRNA.
ACCESSION   NM_013542
VERSION     NM_013542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1528)
  AUTHORS   Xue,J., Xu,L., Zhong,H., Bai,M., Li,X., Yao,R., Wang,Z., Zhao,Z.,
            Li,H., Zhu,H., Hu,F. and Su,Y.
  TITLE     Impaired regulatory function of granzyme B-producing B cells
            against T cell inflammatory responses in lupus mice
  JOURNAL   Lupus Sci Med 10 (2) (2023)
   PUBMED   37500293
REFERENCE   2  (bases 1 to 1528)
  AUTHORS   Aydin,S., Pareja,J., Schallenberg,V.M., Klopstein,A., Gruber,T.,
            Page,N., Bouillet,E., Blanchard,N., Liblau,R., Korbelin,J.,
            Schwaninger,M., Johnson,A.J., Schenk,M., Deutsch,U., Merkler,D. and
            Engelhardt,B.
  TITLE     Antigen recognition detains CD8+ T cells at the blood-brain barrier
            and contributes to its breakdown
  JOURNAL   Nat Commun 14 (1), 3106 (2023)
   PUBMED   37253744
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1528)
  AUTHORS   Nakagawa,N., Fujisawa,Y., Xiang,H., Kitamura,H. and Nishida,K.
  TITLE     Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B
            Transcriptional Regulation in Cytotoxic T Cells
  JOURNAL   Int J Mol Sci 24 (11), 9457 (2023)
   PUBMED   37298408
  REMARK    GeneRIF: Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme
            B Transcriptional Regulation in Cytotoxic T Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1528)
  AUTHORS   Abdelwahab,T., Stadler,D., Knopper,K., Arampatzi,P., Saliba,A.E.,
            Kastenmuller,W., Martini,R. and Groh,J.
  TITLE     Cytotoxic CNS-associated T cells drive axon degeneration by
            targeting perturbed oligodendrocytes in PLP1 mutant mice
  JOURNAL   iScience 26 (5), 106698 (2023)
   PUBMED   37182098
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1528)
  AUTHORS   Hofland,T., Danelli,L., Cornish,G., Donnarumma,T., Hunt,D.M., de
            Carvalho,L.P.S. and Kassiotis,G.
  TITLE     CD4+ T cell memory is impaired by species-specific cytotoxic
            differentiation, but not by TCF-1 loss
  JOURNAL   Front Immunol 14, 1168125 (2023)
   PUBMED   37122720
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1528)
  AUTHORS   Leff,S.E., Brannan,C.I., Reed,M.L., Ozcelik,T., Francke,U.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Maternal imprinting of the mouse Snrpn gene and conserved linkage
            homology with the human Prader-Willi syndrome region
  JOURNAL   Nat Genet 2 (4), 259-264 (1992)
   PUBMED   1303276
REFERENCE   7  (bases 1 to 1528)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   8  (bases 1 to 1528)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   9  (bases 1 to 1528)
  AUTHORS   Gleditsch,L. and Bogen,B.
  TITLE     A Tcra congenic mouse: V alpha epitope expression is influenced by
            both Tcra haplotypes and background genes
  JOURNAL   Immunogenetics 35 (3), 153-160 (1992)
   PUBMED   1371498
REFERENCE   10 (bases 1 to 1528)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091783.9, BY227723.1,
            AK157856.1 and BU758224.1.
            
            On Sep 20, 2016 this sequence version replaced NM_013542.2.
            
            Summary: This gene encodes a member of the granzyme subfamily of
            proteins, part of the peptidase S1 family of serine proteases. The
            encoded preproprotein is secreted by natural killer (NK) cells and
            cytotoxic T lymphocytes (CTLs) and proteolytically processed to
            generate the active protease, which induces target cell apoptosis.
            This protein also processes cytokines and degrades extracellular
            matrix proteins, and these roles are implicated in chronic
            inflammation and wound healing. Mice lacking a functional copy of
            this gene exhibit impaired immune cell-mediated cytolysis.
            [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002085.1, AK157856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC091783.9         201468-201472       c
            6-408               BY227723.1         7-409
            409-1508            AK157856.1         317-1416
            1509-1528           BU758224.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1528
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /note="granzyme B"
                     /db_xref="GeneID:14939"
                     /db_xref="MGI:MGI:109267"
     exon            1..240
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..929
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /EC_number="3.4.21.79"
                     /note="granzyme B(G,H); fragmentin-2; cytotoxic cell
                     protease 1"
                     /codon_start=1
                     /product="granzyme B(G,H) preproprotein"
                     /protein_id="NP_038570.1"
                     /db_xref="CCDS:CCDS27147.1"
                     /db_xref="GeneID:14939"
                     /db_xref="MGI:MGI:109267"
                     /translation="MKILLLLLTLSLASRTKAGEIIGGHEVKPHSRPYMALLSIKDQQ
                     PEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNP
                     KTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTL
                     QEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVS
                     YGYKDGSPPRAFTKVSSFLSWIKKTMKSS"
     exon            241..388
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /inference="alignment:Splign:2.1.0"
     exon            389..524
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /inference="alignment:Splign:2.1.0"
     exon            525..785
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /inference="alignment:Splign:2.1.0"
     exon            786..1512
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1380..1385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /note="hexamer: TATAAA"
     polyA_site      1403
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /note="major polyA site"
     regulatory      1486..1491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /note="hexamer: AATAAA"
     polyA_site      1512
                     /gene="Gzmb"
                     /gene_synonym="CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB"
                     /note="major polyA site"
ORIGIN      
        1 gaagacgtca tcaggcaggg gcagtagggc aggagttttc atagaaagca tgtgatgaag
       61 catcataaaa gcagagaggg ggtacaaggt cacagagccc cctctgcctt cttcctctcc
      121 tagaggttaa aagagagcaa ggacaacact cttgacgctg ggacctaggc ggccttccgg
      181 ggaagatgaa gatcctcctg ctactgctga ccttgtctct ggcctccagg acaaaggcag
      241 gggagatcat cgggggacat gaagtcaagc cccactctcg accctacatg gccttacttt
      301 cgatcaagga tcagcagcct gaggcgatat gtgggggctt ccttattcga gaggactttg
      361 tgctgactgc tgctcactgt gaaggaagta taataaatgt cactttgggg gcccacaaca
      421 tcaaagaaca ggagaagacc cagcaagtca tccctatggt aaaatgcatt ccccacccag
      481 actataatcc taagacattc tccaatgaca tcatgctgct aaagctgaag agtaaggcca
      541 agaggactag agctgtgagg cccctcaacc tgcccaggcg caatgtcaat gtgaagccag
      601 gagatgtgtg ctatgtggct ggttggggaa ggatggcccc aatgggcaaa tactcaaaca
      661 cgctacaaga ggttgagctg acagtacaga aggatcggga gtgtgagtcc tactttaaaa
      721 atcgttacaa caaaaccaat cagatatgtg cgggggaccc aaagaccaaa cgtgcttcct
      781 ttcgggggga ttctggaggc ccgcttgtgt gtaaaaaagt ggctgcaggc atagtttcct
      841 atggatataa ggatggttca cctccacgtg ctttcaccaa agtctcgagt ttcttatcct
      901 ggataaagaa aacaatgaaa agcagctaac tacagaagca acatggatcc tgctctgatt
      961 acccatcgtc cctagagctg agtccaggat tgctctagga caggtggcag gatctgaata
     1021 aaggactgca aagactggct tcatgtccat tcacaaggac cagctctgtc cttggcaggc
     1081 caatggaaca cctcttctgc caccatgctg tgacaaccca actgacatct tcctatggaa
     1141 gtttgccctc tccacaaaag aagtagaatg tttgcattgg agctgggcat gctctgcttc
     1201 ccctcagtgc cccgagaatg ttatctaatg ctagtcatca ttaatagctc cctacagaac
     1261 tttcatacag ttgcacccaa gttgctgatg tgttctctag aatagagcaa gaaatagtaa
     1321 acagaattcc ttttgcctct ctgtactatt ttcccccaaa taccaagatt tgtatgtttt
     1381 ataaagctaa tttccttatc aaatgacatc ttttaatttt tacattaatg gcttattttc
     1441 aaggtacaac ctgatttttt tatggacaaa aatgatgtaa aatcaaataa aactaattaa
     1501 tatatccatt aaaaaaaaaa aaaaaaaa
//
