LOCUS       NM_010370                906 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus granzyme A (Gzma), mRNA.
ACCESSION   NM_010370 XM_906760
VERSION     NM_010370.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Kaur,G., Helmer,R.A., Martinez-Marin,D., Sennoune,S.R.,
            Washburn,R.L., Martinez-Zaguilan,R., Dufour,J.M. and Chilton,B.S.
  TITLE     Helicase-like transcription factor (Hltf)-deletion activates
            Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic beta
            cells resulting in neonatal lethality
  JOURNAL   PLoS One 18 (8), e0286109 (2023)
   PUBMED   37624843
  REMARK    GeneRIF: Helicase-like transcription factor (Hltf)-deletion
            activates Hmgb1-Rage axis and granzyme A-mediated killing of
            pancreatic beta cells resulting in neonatal lethality.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Calvo,J., Santiago,L., Arias,M., Pardo,J., Albareda,J.,
            Martinez-Lostao,L. and Garcia-Alvarez,F.
  TITLE     Granzyme-A deficiency attenuates experimental osteoarthritis in
            mice, but perforin deficiency does not
  JOURNAL   Jt Dis Relat Surg 34 (2), 271-278 (2023)
   PUBMED   37462629
  REMARK    GeneRIF: Granzyme-A deficiency attenuates experimental
            osteoarthritis in mice, but perforin deficiency does not.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Nagakubo,D., Hirakawa,M., Iwanami,N. and Boehm,T.
  TITLE     Limits to in vivo fate changes of epithelia in thymus and
            parathyroid by ectopic expression of transcription factors Gcm2 and
            Foxn1
  JOURNAL   Sci Rep 12 (1), 13554 (2022)
   PUBMED   35941210
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Rehm,A., Wirges,A., Hoser,D., Fischer,C., Herda,S., Gerlach,K.,
            Sauer,S., Willimsky,G. and Hopken,U.E.
  TITLE     EBAG9 controls CD8+ T cell memory formation responding to tumor
            challenge in mice
  JOURNAL   JCI Insight 7 (11), e155534 (2022)
   PUBMED   35482418
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Gao,Y., Xu,Q., Li,X., Guo,Y., Zhang,B., Jin,Y., Zhu,C., Shen,Y.,
            Yang,P., Shi,Y., Jin,R., Liu,D., Ouyang,Y., Liu,X., Wang,W.,
            Chen,D. and Yang,T.
  TITLE     Heterogeneity induced GZMA-F2R communication inefficient impairs
            antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal
            suppression in hepatocellular carcinoma
  JOURNAL   Cell Death Dis 13 (3), 213 (2022)
   PUBMED   35256589
  REMARK    GeneRIF: Heterogeneity induced GZMA-F2R communication inefficient
            impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1
            signal suppression in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Hershberger,R.J., Gershenfeld,H.K., Weissman,I.L. and Su,L.
  TITLE     Genomic organization of the mouse granzyme A gene. Two mRNAs encode
            the same mature granzyme A with different leader peptides
  JOURNAL   J Biol Chem 267 (35), 25488-25493 (1992)
   PUBMED   1460043
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Douville,P., Seldin,M.F. and Carbonetto,S.
  TITLE     Genetic mapping of the integrin alpha 1 gene (Vla1) to mouse
            chromosome 13
  JOURNAL   Genomics 14 (2), 503-505 (1992)
   PUBMED   1427867
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Prendergast,J.A., Helgason,C.D. and Bleackley,R.C.
  TITLE     Quantitative polymerase chain reaction analysis of cytotoxic cell
            proteinase gene transcripts in T cells. Pattern of expression is
            dependent on the nature of the stimulus
  JOURNAL   J Biol Chem 267 (8), 5090-5095 (1992)
   PUBMED   1544892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061146.1 and EH095037.1.
            
            On Apr 13, 2018 this sequence version replaced NM_010370.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061146.1, X14799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               BC061146.1         1-878
            879-906             EH095037.1         5-32                c
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..906
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /note="granzyme A"
                     /db_xref="GeneID:14938"
                     /db_xref="MGI:MGI:109266"
     exon            1..100
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..813
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /EC_number="3.4.21.78"
                     /note="H factor; fragmentin-1; t cell-specific serine
                     protease 1; autocrine thymic lymphoma granzyme-like serine
                     protease; BLT esterase; Hanukah factor; serine esterase 1"
                     /codon_start=1
                     /product="granzyme A precursor"
                     /protein_id="NP_034500.1"
                     /db_xref="CCDS:CCDS26782.1"
                     /db_xref="GeneID:14938"
                     /db_xref="MGI:MGI:109266"
                     /translation="MRNASGPRGPSLATLLFLLLIPEGGCERIIGGDTVVPHSRPYMA
                     LLKLSSNTICAGALIEKNWVLTAAHCNVGKRSKFILGAHSINKEPEQQILTVKKAFPY
                     PCYDEYTREGDLQLVRLKKKATVNRNVAILHLPKKGDDVKPGTRCRVAGWGRFGNKSA
                     PSETLREVNITVIDRKICNDEKHYNFHPVIGLNMICAGDLRGGKDSCNGDSGSPLLCD
                     GILRGITSFGGEKCGDRRWPGVYTFLSDKHLNWIKKIMKGSV"
     exon            101..245
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..384
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..654
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..881
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /note="hexamer: AATAAA"
     polyA_site      879
                     /gene="Gzma"
                     /gene_synonym="Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1"
                     /note="major polyA site"
ORIGIN      
        1 atccctgctg attggggtgg gagagccacg atgaggaacg cctctggtcc ccgggggcca
       61 tctcttgcta ctctcctttt tcttctgctt attcctgaag gaggctgtga aagaatcatt
      121 ggaggagaca cggttgttcc tcactcaaga ccgtatatgg ctctacttaa acttagttca
      181 aataccatct gtgctggcgc tttgattgaa aagaactggg tgttgactgc tgcccactgt
      241 aacgtgggaa agagatctaa gttcattctt ggggctcact caatcaataa ggagccagaa
      301 caacagatat tgactgttaa gaaagcattt ccctatccat gctatgatga atatacacgt
      361 gagggggatc tacaacttgt acggctaaag aaaaaagcaa cagttaacag aaatgtggct
      421 atccttcacc tacctaaaaa gggagatgat gtgaaaccag gaaccagatg ccgagtagca
      481 ggatggggga gatttggcaa taagtcagct ccctctgaaa ctctgagaga agtcaacatc
      541 actgtcatag acagaaaaat ctgcaatgat gaaaaacact ataattttca tcctgtaatt
      601 ggactaaaca tgatttgtgc aggggacctc cgtggtggaa aggactcctg caatggggat
      661 tctggcagcc ctctgctatg tgatggtatt ttgcgaggca tcacctcttt tggtggagag
      721 aagtgtggag atcgccgatg gcctggtgtc tatactttcc tctcagataa acacctcaat
      781 tggataaaga agattatgaa gggttctgtg taaatgtatg tctttcactc catccctgtc
      841 acttctgtgt ctgatcacaa ataaaatcaa cttgaatggc taaaaaaaaa aaaaaaaaaa
      901 aaaaaa
//
