LOCUS       NM_028986               4152 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GDNF-inducible zinc finger protein 1 (Gzf1),
            transcript variant 2, mRNA.
ACCESSION   NM_028986
VERSION     NM_028986.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Patel,N., Shamseldin,H.E., Sakati,N., Khan,A.O., Softa,A.,
            Al-Fadhli,F.M., Hashem,M., Abdulwahab,F.M., Alshidi,T., Alomar,R.,
            Alobeid,E., Wakil,S.M., Colak,D. and Alkuraya,F.S.
  TITLE     GZF1 Mutations Expand the Genetic Heterogeneity of Larsen Syndrome
  JOURNAL   Am J Hum Genet 100 (5), 831-836 (2017)
   PUBMED   28475863
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Lee,S.H., Jang,M.K., Kim,O.S., Lee,O.H., Kim,N.Y., Yoo,K.H.,
            Lee,D.G., Shong,Y.H. and Mouradian,M.M.
  TITLE     Activation of the GDNF-inducible transcription factor (GIF) gene
            promoter by glucocorticoid and progesterone
  JOURNAL   J Steroid Biochem Mol Biol 115 (1-2), 30-35 (2009)
   PUBMED   19429458
  REMARK    GeneRIF: Progesterone receptors and glucocorticoid receptors, but
            not estrogen receptors, up-regulate transcription from the
            GDNF-inducible zinc finger protein promoter
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Fukuda,N., Ichihara,M., Morinaga,T., Kawai,K., Hayashi,H.,
            Murakumo,Y., Matsuo,S. and Takahashi,M.
  TITLE     Identification of a novel glial cell line-derived neurotrophic
            factor-inducible gene required for renal branching morphogenesis
  JOURNAL   J Biol Chem 278 (50), 50386-50392 (2003)
   PUBMED   14522971
  REMARK    GeneRIF: induction of GZF1 expression via the is required for renal
            branching morphogenesis
            Erratum:[J Biol Chem. 2004 Jan 23;279(4):3120]
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4152)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY123697.1, AK052820.1 and BC096015.1.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_028986.4.
            
            On Apr 24, 2009 this sequence version replaced NM_028986.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096015.1, AK141153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY123697.1         2-45
            45-3930             AK052820.1         2-3887
            3931-4152           BC096015.1         3851-4072
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.53 cM"
     gene            1..4152
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /note="GDNF-inducible zinc finger protein 1"
                     /db_xref="GeneID:74533"
                     /db_xref="MGI:MGI:1921783"
     exon            1..96
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /inference="alignment:Splign:2.1.0"
     exon            97..1471
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2234
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /note="zinc finger protein 336"
                     /codon_start=1
                     /product="GDNF-inducible zinc finger protein 1"
                     /protein_id="NP_083262.1"
                     /db_xref="CCDS:CCDS16841.1"
                     /db_xref="GeneID:74533"
                     /db_xref="MGI:MGI:1921783"
                     /translation="MESGTVLLESKSSPLNLLHEMHELRLLGHLCDVTVSIENQGVHE
                     DFMAHKAVLAATSKFFKEVFLNEKSADGTRTNVYLNEVQAVDFASFLEFVYTAKVRVE
                     EDRVQQMLEVAEKLKCLDLSETCLQLKKQMLESVLLELQNFSESQEVEASSGPQVSVT
                     PSSKASVPGEDAHSNGLVDSSDYPIERLGNGLSPETPSKKCKEKLDKKKDVAKPPFPK
                     IRRASGRLAGKKVFVEIPKKKYTRRLREQQKSAEEAAENDKCPQDQSPDNERMETEPA
                     AKSEACPASVELEESLQKVEGEKEEEEGKDGEEKKKSNFQCTVCDKAFLYEKSFLKHI
                     KYHHGVATEVVYRCDTCGQTFANRCNLKSHQRHVHSSERHFPCEMCAKKFKRKKDVKR
                     HVLQVHEGGGERHRCGQCGKGLSSKTALRLHERTHTGDKPYGCTKCDAKFSQPSALKT
                     HLRVHTGERPFVCDECGARFTQNHMLIYHKRCHTGERPFMCETCGKSFASKEYLKHHN
                     RIHTGSKPFKCEVCLRTFAQRNSLYQHIKVHTGERPYCCDQCGKQFTQVNALQRHHRI
                     HTGEKPYMCNACGRTFTDKSTLRRHTSIHDKNTPWKSFLVIVDGSPKNDEGHKTEQPD
                     DEYASPKLSDRLLSFGENSHFNNLLEVQGNVPAVQENSSTGAACKAVVSQDALLTTSI
                     SALGELTPQAVSMPAHLPSLTNME"
     exon            1472..1566
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1734
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1892
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..4135
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4113..4118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /note="hexamer: AATAAA"
     polyA_site      4135
                     /gene="Gzf1"
                     /gene_synonym="8430437G08Rik; mGZF1; Zfp336"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcgct cgtggcgacc aatccgcgga ccctgcggtc cgctgtccct gctggcctgg
       61 gccagggtac gggtccgtgg aggcactggc taagagctgc ttttagaagg aagatggaaa
      121 gtggcacagt tttgctggaa tccaaatctt caccactcaa ccttctgcat gagatgcatg
      181 agctccgcct tctgggccac ttgtgtgatg tcactgttag catagagaac cagggtgtcc
      241 atgaagactt catggcccat aaagcagtgc tggcggccac cagcaagttt tttaaggagg
      301 tgttcctaaa cgagaagagt gcagatggaa ccaggactaa tgtttacttg aatgaagttc
      361 aggctgttga ctttgcttcg tttctggagt ttgtctatac tgccaaagtg cgggtagaag
      421 aagaccgtgt gcagcagatg ctcgaagtgg ctgagaagct aaagtgtttg gacctgtctg
      481 aaacatgctt gcagctaaag aagcagatgc tggagtctgt ccttttggaa ttgcagaatt
      541 tctctgagtc tcaggaggtg gaggccagca gtggccccca ggtgagtgtg acccccagct
      601 ccaaagcaag tgtaccaggg gaggatgctc actccaatgg ccttgtagat tcctccgact
      661 acccaataga gagactgggc aatgggctct caccagaaac accatccaag aagtgtaagg
      721 agaaactgga caagaagaaa gatgtggcta agcctccctt ccctaaaatc agaagagcaa
      781 gtgggaggct ggctggaaaa aaggtgtttg tggaaatccc caaaaagaaa tatacaagaa
      841 ggctccgaga acagcagaaa agtgctgagg aagccgcaga gaatgacaag tgtcctcagg
      901 accaaagccc agacaatgag aggatggaga ctgagccagc tgccaaaagt gaggcttgcc
      961 ctgctagtgt agaactggag gaaagcctgc agaaagtgga gggggagaag gaagaggaag
     1021 aaggaaagga cggggaggag aagaagaaga gtaacttcca gtgcacagtc tgtgacaagg
     1081 ccttcctgta cgagaagagt ttcctgaaac atatcaagta ccaccatggt gtggccaccg
     1141 aagtggtgta ccgatgtgac acttgtggcc agacctttgc caaccgctgc aacctgaaga
     1201 gccaccagcg ccacgtgcac agcagcgagc gccacttccc gtgtgaaatg tgtgccaaga
     1261 agttcaaacg caagaaagat gtgaaacggc atgtgctgca ggtgcatgag ggtggtggcg
     1321 agcggcaccg ctgtggccag tgtggcaaag gcctgagctc caagactgct ctgcggctgc
     1381 acgagcgcac acacacaggc gacaagccct atggctgtac caagtgtgat gccaagttct
     1441 cacagccatc agctcttaaa acccacctga gagttcatac aggggaaaga ccttttgtct
     1501 gtgatgaatg tggtgcaaga ttcactcaga accacatgct gatttatcat aaaaggtgcc
     1561 acacaggtga aaggcctttc atgtgtgaga catgtggcaa gagttttgct tctaaggagt
     1621 acttaaagca tcataacaga atccacactg gatcgaagcc ctttaaatgt gaagtgtgct
     1681 tgcggacctt tgctcagcgc aattccctgt accagcatat taaagtccac acgggagagc
     1741 ggccttattg ttgtgaccag tgtgggaagc agttcaccca ggtaaatgcc ctccagcgcc
     1801 accatcgcat ccacactggg gagaagccat acatgtgcaa tgcatgtgga cggactttta
     1861 ctgacaagtc tactctccgg aggcatacct caatacatga taagaatacg ccgtggaagt
     1921 ctttccttgt cattgtagat ggctcaccca agaatgatga agggcataag acagaacaac
     1981 ccgatgatga atatgcatca cccaaacttt cagatcgatt actatctttt ggtgaaaata
     2041 gccatttcaa caacttactg gaagtccaag gcaatgtgcc tgccgtgcag gagaacagct
     2101 ctacaggcgc tgcttgcaaa gcagtggtgt ctcaggacgc tctgcttacc acttccatca
     2161 gtgcccttgg tgagctcacc ccacaggcag tttccatgcc tgcacacctt ccctccttga
     2221 ccaatatgga gtgagaactt gaagttgtgt gccaagcagt ctgtgtaatt gctgtattcc
     2281 aggtgatgcc aggggctgag gaaaagttgt ctgtgcaaaa atgtaggcaa gactggcctt
     2341 gcaggtttct tcagacttcc atgaccttgc acgtctcttt cacacttgaa cattctgtta
     2401 acattctgat ctgcatgatc tcagctacat ttcatcagca aacacggcag ttagcatagc
     2461 tcatttaacc ctggtgtagc cgtacatgtc aatcacacta atgcttgatt ctcttgacgt
     2521 ctaaaccact gcttgtctta atcatagagt acacagcatt gacccagctt gggaaagtgc
     2581 tgttcgtggt ctcctggtct cgccctgcct tatgcttcca tgtgtgttta cttcactctg
     2641 gtccctttag ggcgtttttc tacagggtta aagtagaact ggggccactt atttttagct
     2701 gattcttcct gagataaaag caaataagat ttattctggg aaccctagaa tggggttgaa
     2761 gaagtagatg attccgttcg tttctctcca accccctttt gtaggcacga aaagatgaat
     2821 ggcgggtgga acatgttcag ggtagtacct tagcatgtgt acaggtaagg agtctgtcat
     2881 aacatccaat ttgggatgag ctgttgaatt ttgttcccta aatcagatta agtcaaagct
     2941 gtcctaccaa agaatccagc agacagttgt ctctctacag aagtgtgaga aataaagcct
     3001 aggtgtcaga gcatttagct aggtacattt tcacaaacag catgatgagt gagcctggca
     3061 aatcttgact attttgccag gcttttttat aatgtccaga gctccccaaa cccccatttt
     3121 cacaggggaa gatgacacaa actagtaact gctacaaatt cacctctaga agaatgcaag
     3181 actctagagc agtggctctc aatgaccctt tcagaggttg ccctaagcta tcagacaatc
     3241 caggatattt aattatgatt cttaacagta gcaaaattag ttatgaagta gcaatggaaa
     3301 taactgtatg gctgggagtc accacaacat gaggaactgt ataaaagggt cccagcatta
     3361 ggaaggctga gaacccttga actagagggg accagaagcc ttggtatgct caacttctat
     3421 gccttaacaa gcggatcata aggaaccagg gatgttgttt caaatgttcc tttggctttc
     3481 tcatgctgaa tttagtaatt gttcaacaaa tttcctatga aaaatgcatt ttatggtact
     3541 tgctatccct gatacatggt tgcagggcca tggatgggta tgtggaccct gtgccacctg
     3601 tgacccttaa gcattaattt taagagggcc ttaaaggggg aattcttatg ctttctggtt
     3661 gcctttcctc tctgctttta ctaaacttgc tgtgaaaaca ctctggtttc taagggaatg
     3721 actcctaatg ttcagggtga agatagatca cacaatgata gaaactgaga gttctcactc
     3781 agtgatcact ttgtggtact accctcagga gctggcgagg ccaccaaaag gggttccagg
     3841 tgctggtaat gtttcccact tgctcttgaa agttcagggc tgaattattt cacattcggt
     3901 tatgacctgg caatctagtt gtgtttacag acaaaaacag acaaaaagac tagtgattgg
     3961 catatgacca ttttatctgg taagagaaaa cctgcccagc tgatgtactg tgttatggaa
     4021 taaagtcatc ttgatgagaa ggaatttaaa caatagatta ttttgttacc tattggaaga
     4081 actgtcttga atttgtttct ttagaagttc taaataaaat tgtttaatgt gctaaaaaaa
     4141 aaaaaaaaaa aa
//
